140 completed, 51 unknown, 39 recruiting, 13 not yet recruiting. 176 Not applicable, 29 Phase 2, 11 Phase 1, 10 Phase 3, 7 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of "DBT-LIVE", an Identity Skills Training Program, for Borderline Personality Disorder. DBT LIVE, TAU - Treatment 1:Dialectical Behavior Therapy (DBT), Treatment as Usual | Not applicable | Not yet recruiting | Universidad Europea de Valencia | 112 | 2027-01-01 | 2026-07-06 |
| ADEPT Psilocybin-Assisted Therapy With DBT for Borderline Personality Disorder Psilocybin, Psilocybin-Assisted Therapy With Dialectical Behavior Therapy - Borderline Personality Disorder, Borderline Personality Pathology | Phase 1 | Not yet recruiting | University of Minnesota | 18 | 2026-12-01 | 2026-09-22 |
| Testing a Peer-led Trauma-focused Intervention for Significant Others of Those With BPD Trauma Recovery Program (official title TBD) - Posttraumatic Stress Disorder, Family Members | Phase 1 | Not yet recruiting | York University | 60 | 2026-10-01 | 2026-07-29 |
| Ketamine Infusion for Symptomatic Improvement in Severe Borderline Personality Disorder IV Ketamine (0.5 mg/kg) Infusion - Two Doses Administered 24 Hours Apart for Severe Borderline Personality Disorder - Infusion of Ketamine in Severe Borderline Personality Disorder, Borderline Personality Disorder (BPD) | Phase 2 | Not yet recruiting | University Hospital, Toulouse | 38 | 2026-09-01 | 2026-05-12 |
| Combining Transcranial Magnetic Stimulation With Emotion Regulation Skills Training in Borderline Personality Disorder Transcranial Magnetic Stimulation (TMS), Emotion Regulation Skills Training - Borderline Personality Disorder (BPD) | Not applicable | Not yet recruiting | Massachusetts General Hospital | 12 | 2026-08-01 | 2026-07-20 |
| Ketamine With Dialectical Behavioural Therapy (DBT) for Suicidality in Individuals With Treatment-Resistant Depression and Borderline Personality Disorder (KET-DBT) Ketamine Hydrochloride, Midazolam Hydrochloride, Dialectical Behavioral Therapy (DBT) - Borderline Personality Disorder (BPD), Treatment-Resistant Major Depressive Disorder | Phase 2 | Recruiting | Joshua Rosenblat | 120 | 2026-07-16 | 2026-07-29 |
| A Pilot Trial of One-Day Accelerated TMS and D-cycloserine in Suicidal Patients With Borderline Personality Disorder TMS, D-Cycloserine (DCS) - Borderline Personality Disorder (BPD) | Phase 1 / Phase 2 | Recruiting | Mclean Hospital | 20 | 2026-06-10 | 2026-08-05 |
| Extended Group Written Exposure Therapy for Comorbid PTSD and BPD (Traits) Group Written Exposure Therapy - Posttraumatic Stress Disorder (PTSD), Borderline Personality Disorder (BPD) | Not applicable | Not yet recruiting | St. Joseph's Healthcare Hamilton | 63 | 2026-06-01 | 2026-05-08 |
| Pilot Study for the Evaluation of a New Psychotherapeutic Treatment for Borderline Personality Disorder Patients With Post-traumatic Stress Symptoms Standard Mentalization-Based Treatment, Trauma-Focused Mentalization-Based Treatment - Borderline Personality Disorder (BPD), PTSD - Post Traumatic Stress Disorder | Not applicable | Not yet recruiting | Eva Rüfenacht | 40 | 2026-06-01 | 2026-02-06 |
| Conceptualizing Borderline Personality Disorder as a Relationship Use Disorder Relationship-use questionnaire - Borderline Personality Disorder, Borderline Personality Disorder (BPD) | Not applicable | Recruiting | University Hospital, Montpellier | 194 | 2026-06-01 | 2026-06-22 |
| The Role of Gender in Borderline Personality Disorder Borderline Personality Disorder (BPD) | Recruiting | University Hospital Heidelberg | 15 | 2026-05-29 | 2026-06-10 | |
| Pilot Study on Auricular Acupuncture in Hospitalized Adults With Borderline Personality Disorder Auricular acupuncture program based on the N.A.D.A. protocol - Borderline Personality Disorder | Not applicable | Not yet recruiting | Jenny Gentizon | 15 | 2026-04-15 | 2026-03-17 |
| Long Term Follow-up of Mentalization-Based Treatment: Exploring Variability in Outcomes, Long-term Value and Experiences 10+ Year After Receiving MBT Day Hospital or MBT Intensive Outpatient Borderline Personality Disorder | Recruiting | De Viersprong | 113 | 2026-04-02 | 2026-09-30 | |
| Intensive Dialectical Behavior Therapy for Self-Harm and Suicidal Behavior in Youth: A Pilot Study Intensive Dialectical Behavior Therapy - Self-Harm, Deliberate, Suicidal Behavior | Not applicable | Enrolling by invitation | Haukeland University Hospital | 12 | 2026-03-02 | 2026-08-13 |
| Internal Family Systems Therapy for Borderline Personality Disorder Internal family systems therapy - Borderline Personality Disorder (BPD) | Not applicable | Recruiting | Waypoint Centre for Mental Health Care | 15 | 2026-02-01 | 2026-01-16 |
| Physical Activity in the Management of Personality Disorders Karate, Pedometer-based walking, Treatment as usual (TAU) - Borderline Personality Disorder (BPD), Avoidant Personality Disorders | Not applicable | Recruiting | Julie Midtgaard | 60 | 2026-02-01 | 2026-02-03 |
| Symptom Assessment in Adolescents Placed on Child Welfare Complex Post-Traumatic Stress Disorder (CPTSD), Borderline Personality Disorder (BPD) | Recruiting | University Hospital, Strasbourg, France | 200 | 2026-01-30 | 2026-08-31 | |
| Home-Based tDCS for Depression in BPD tDCS, Treatment as Usual (TAU), Psychoeducation - Major Depressive Disorder (MDD), Borderline Personality Disorders | Not applicable | Recruiting | Ciusss de L'Est de l'Île de Montréal | 60 | 2026-01-01 | 2026-05-06 |
| CULTURALLY ADAPTED DIALECTICAL BEHAVIOR THERAPY FOR LOW-MIDDLE-INCOME COUNTRIES Culturally adapted DBT - Borderline Personality Disorder (BPD), Dialectical Behavior Therapy | Not applicable | Not yet recruiting | Pakistan Association of Cognitive Therapists | 220 | 2025-11-20 | 2025-11-28 |
| Effectiveness of Autobiographical Rewriting Workshops on the Socio-Professional Functioning of Patients With Borderline Personality Disorder Undergoing Third-Wave Cognitive and Behavioral Therapy: A Randomized Controlled Trial Autobiographical Rewriting Workshops, Non-specific writing workshops - Borderline Personality Disorder, Borderline Personality Disorder (BPD) | Not applicable | Not yet recruiting | University Hospital, Montpellier | 140 | 2025-10-01 | 2025-09-30 |
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Self-Injurious Behavior (31) · Stress Disorders, Post-Traumatic (22) · Suicide (21) · Depression (16) · Personality Disorders (16) · Depressive Disorder, Major (12) · Emotional Regulation (12) · Bipolar Disorder (11) · Anxiety Disorders (8) · Impulsive Behavior (8) · Attention Deficit Disorder with Hyperactivity (6) · Suicide, Attempted (6) · Schizophrenia (5) · Suicidal Ideation (5)
Mental Disorders (272) · Personality Disorders (259) · Behavior (77) · Behavioral Symptoms (60) · Trauma and Stressor Related Disorders (25) · Stress Disorders, Traumatic (24) · Mood Disorders (23) · Social Behavior (18) · Depressive Disorder (13) · Self-Control (12) · Bipolar and Related Disorders (11) · Self-Injurious Behavior (11) · Pathological Conditions, Signs and Symptoms (9) · Neurodevelopmental Disorders (8) · Chemically-Induced Disorders (7)
Dialectical Behavior Therapy (21) · Therapeutics (21) · Transcranial Magnetic Stimulation (8) · Mentalization-Based Therapy (7) · Cognitive Behavioral Therapy (5) · Exercise (4) · Transcranial Direct Current Stimulation (4) · Hydrocortisone (3) · Ketamine (3) · Olanzapine (3) · Psychological Tests (3) · Schema Therapy (3) · brexpiprazole (3) · Acetylcysteine (2) · Citalopram (2)
University Hospital, Montpellier (8) · University of Minnesota (7) · Centre for Addiction and Mental Health (6) · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (5) · Icahn School of Medicine at Mount Sinai (5) · University Hospital, Strasbourg, France (5) · University Hospital, Toulouse (5) · Yale University (5) · Central Institute of Mental Health, Mannheim (4) · Charite University, Berlin, Germany (4) · Ciusss de L'Est de l'Île de Montréal (4) · IRCCS Centro San Giovanni di Dio Fatebenefratelli (4) · Mclean Hospital (4) · Region Skane (4) · State University of New York - Upstate Medical University (4)
United States (80) · Germany (37) · France (31) · Canada (24) · Spain (19) · Denmark (10) · Sweden (9) · Switzerland (9) · Norway (8) · United Kingdom (8) · Netherlands (7) · Italy (6) · Czechia (4) · Mexico (4) · Chile (3)
Marianne Goodman, MD (3) · Alexandra Philipsen, Prof. (2) · Harold Koenigsberg, MD (2) · Harold W Koenigsberg, MD (2) · Jon E Grant, MD, JD, MPH (2) · Lars Mehlum, MD PhD (2) · S. Charles Schulz, MD (2) · Sarah K Fineberg, MD PhD (2) · Shannon Sauer-Zavala, PhD (2) · Sofie Westling, MD, PhD (2) · Alessandra Minelli, Prof (1) · Alex Behn, PhD (1) · Alexandra Pham-Scottez, MD (1)
PMID 32368793, PMID 36375174, PMID 33884617, PMID 21095016, PMID 22967772, PMID 39558901, PMID 40014392, PMID 10668619, PMID 11781034, PMID 14979218, PMID 16013747, PMID 17257517, PMID 18251623, PMID 19043153, PMID 19274605, PMID 19590999, PMID 19752590, PMID 19755574, PMID 19807718, PMID 20420716, PMID 20435966, PMID 20590434, PMID 21051128, PMID 21076562, PMID 21451348, PMID 21479777, PMID 21535995, PMID 22503959, PMID 22581157, PMID 23444147, PMID 24114797, PMID 24503285, PMID 24562087, PMID 24752034, PMID 24885904, PMID 25038629, PMID 25324025, PMID 25526809, PMID 25806661, PMID 25907157, PMID 26062135, PMID 26487284, PMID 26595344, PMID 26759718, PMID 26854478, PMID 26970970, PMID 27405522, PMID 27439618, PMID 27845529, PMID 27903136
2019 (2), R01MH061017 (2), 2002 (1), 2017 (1), 2025 (1), K23MH106648 (1), K23MH126211 (1), KL2RR025754-04 (1), R01DA014997 (1), R01MH034486 (1), R01MH063746 (1), R01MH095806 (1), R01MH129302 (1), R21MH119530 (1), R33MH125130 (1)