42 completed. 42 Phase 3, 9 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 42 | Completed 42 |
| Phase 2 | 9 | Completed 9 |
Follow Lung Injury: new trials by email Literature Review of Lung Injury trials Research Report on Lung Injury
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of Nebulised Inhalational Steroids in Neonates With Meconium Aspiration Syndrome Budesonide, Normal Saline - Meconium Aspiration Syndrome | Phase 3 | Completed | Khyber Teaching Hospital | 60 | 2025-11-28 | 2026-08-13 |
| Nebulized Heparin for Prevention of Acute Lung Injury in Smoke Inhalation Injury Heparin, Normal Saline - Smoke Inhalation Injury, Acute Lung Injury | Phase 3 | Completed | Ain Shams University | 88 | 2023-06-01 | 2024-12-12 |
| Tigerase® Efficacy and Safety as Part of Complex Therapy in Patients With COVID-19 Tigerase® and best available care, Best available care - COVID-19, Coronavirus Disease 2019 | Phase 3 | Completed | AO GENERIUM | 100 | 2020-06-01 | 2020-10-14 |
| Intravenous Aviptadil for Critical COVID-19 With Respiratory Failure Aviptadil by intravenous infusion + standard of care, Normal Saline Infusion + standard of care - Critical COVID-19 With Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS) | Phase 2 / Phase 3 | Completed | APR Applied Pharma Research s.a. | 203 | 2020-05-15 | 2023-07-24 |
| Healthcare Worker Exposure Response and Outcomes of Hydroxychloroquine Hydroxychloroquine, Placebo oral tablet - COVID-19 | Phase 3 | Completed | Adrian Hernandez | 1360 | 2020-04-22 | 2021-10-12 |
| Treatment of COVID-19 Patients With Anti-interleukin Drugs Usual Care, Anakinra, Siltuximab - COVID-19 | Phase 3 | Completed | University Hospital, Ghent | 342 | 2020-04-03 | 2023-03-14 |
| Mid and Standard Frequency Ventilation in Infants With Respiratory Distress Syndrome Mid frequency ventilation, Standard frequency ventilation - Ventilator-Induced Lung Injury, Respiratory Distress Syndrome | Phase 2 / Phase 3 | Completed | University of Alabama at Birmingham | 60 | 2017-08-02 | 2024-10-15 |
| A Study to Assess the Safety and Effectiveness of Palivizumab Administered to Children at High Risk of Severe Respiratory Syncytial Virus (RSV) Infection in the Russian Federation and the Republic of Belarus Palivizumab - Respiratory Syncytial Virus (RSV) | Phase 3 | Completed | AbbVie | 50 | 2016-11-09 | 2018-03-13 |
| L-citrulline for Prevention of Sequelae of Acute Lung Injury in Pediatrics Undergoing Cardiopulmonary Bypass for Heart Defects L-citrulline, Placebo - Acute Lung Injury | Phase 3 | Completed | Asklepion Pharmaceuticals, LLC | 189 | 2016-08-01 | 2023-02-23 |
| Efficacy of Weekly Rifapentine and Isoniazid for Tuberculosis Prevention Weekly INH / RRT given by DOT - Silicosis, Tuberculosis | Phase 3 | Completed | Huashan Hospital | 566 | 2015-03-01 | 2020-06-30 |
| The MENDS2 Study, Maximizing the Efficacy of Sedation and Reducing Neurological Dysfunction and Mortality in Septic Patients With Acute Respiratory Failure Dexmedetomidine, Propofol - Sepsis, Delirium | Phase 3 | Completed | Vanderbilt University Medical Center | 438 | 2013-05-15 | 2021-06-07 |
| Pragmatic, Randomized Optimal Platelet and Plasma Ratios 1:1:1 Blood Transfusion Ratio, 1:1:2 Blood Transfusion Ratio - Trauma | Phase 3 | Completed | The University of Texas Health Science Center, Houston | 680 | 2012-08-01 | 2019-02-08 |
| Vitamin D Supplementation for Extremely Preterm Infants Cholecalciferol, Placebo - Vitamin D Deficiency, Preterm Infants | Phase 2 / Phase 3 | Completed | University of Alabama at Birmingham | 100 | 2012-06-01 | 2017-02-10 |
| Oral Vitamin A Supplementation for Prevention of Bronchopulmonary Dysplasia in Preterm Infants Vitamin A - Bronchopulmonary Dysplasia (BPD), Prematurity | Phase 3 | Completed | Erhan Calisici | 209 | 2012-03-01 | 2026-05-11 |
| Perioperative Fluid Management: Goal-directed Versus Restrictive Strategy Goal-directed therapy, Restrictive fluid therapy - Complication, Postoperative | Phase 3 | Completed | University Hospital, Geneva | 400 | 2012-01-01 | 2019-09-12 |
| Hydrocortisone for BPD Hydrocortisone, Placebo - Infant, Newborn, Infant, Small for Gestational Age | Phase 3 | Completed | NICHD Neonatal Research Network | 800 | 2011-08-11 | 2025-02-27 |
| Inhaled Nitric Oxide to Prevent and Treat Bronchopulmonary Dysplasia Nitric Oxide, respiratory support - Pulmonary Disease | Phase 2 / Phase 3 | Completed | Fudan University | 400 | 2011-05-01 | 2013-01-28 |
| Clinical Effect of the Association of Noninvasive Ventilation and High Flow Nasal Oxygen Therapy in Resuscitation of Patients With Acute Lung Injury (FLORALI Study) O2 conventional, O2-HFN : high flow nasal oxygen therapy, O2-HFN/NPPV : association of high flow nasal oxygen therapy and non invasive positive pressure ventilation - Acute Lung Injury, Acute Respiratory Failure | Phase 2 / Phase 3 | Completed | Poitiers University Hospital | 313 | 2011-03-01 | 2016-10-11 |
| CALIPSO: Calfactant for Acute Lung Injury in Pediatric Stem Cell Transplant and Oncology Patients Calfactant, Air placebo - Acute Lung Injury | Phase 2 / Phase 3 | Completed | Milton S. Hershey Medical Center | 43 | 2010-06-01 | 2018-03-16 |
| Efficacy and Safety of Inhaled Budesonide in Very Preterm Infants at Risk for Bronchopulmonary Dysplasia Budesonide - Bronchopulmonary Dysplasia | Phase 3 | Completed | University Children's Hospital Tuebingen | 863 | 2010-04-01 | 2016-07-06 |
Showing 20 of 42. Sign in to see all of them.
Bronchopulmonary Dysplasia (24) · Acute Lung Injury (14) · Premature Birth (13) · Respiratory Distress Syndrome (10) · Lung Diseases (6) · COVID-19 (4) · Respiratory Insufficiency (4) · Coronavirus Infections (3) · Respiratory Tract Diseases (3) · Coronaviridae Infections (2) · Heart Defects, Congenital (2) · Hyaline Membrane Disease (2) · Infant, Newborn, Diseases (2) · Retinopathy of Prematurity (2)
Respiratory Tract Diseases (39) · Lung Diseases (36) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (27) · Infant, Premature, Diseases (24) · Infant, Newborn, Diseases (23) · Ventilator-Induced Lung Injury (23) · Female Urogenital Diseases and Pregnancy Complications (15) · Urogenital Diseases (15) · Pregnancy Complications (14) · Respiration Disorders (14) · Obstetric Labor Complications (13) · Obstetric Labor, Premature (13) · Infections (7) · Pathological Conditions, Signs and Symptoms (7)
Endothelium-Dependent Relaxing Factors (3) · Nitric Oxide (3) · Budesonide (2) · Continuous Positive Airway Pressure (2) · Hydrocortisone (2) · Palivizumab (2) · Saline Solution (2) · Standard of Care (2) · calfactant (2) · salicylhydroxamic acid (2) · Air (1) · Beclomethasone (1) · Breath Holding (1) · Cholecalciferol (1) · Citrulline (1)
NICHD Neonatal Research Network (4) · National Heart, Lung, and Blood Institute (NHLBI) (3) · Assistance Publique - Hôpitaux de Paris (2) · Mallinckrodt (2) · McMaster University (2) · Roberta Ballard (2) · University of Alabama at Birmingham (2) · AO GENERIUM (1) · APR Applied Pharma Research s.a. (1) · AbbVie (1) · Abbott (1) · Adrian Hernandez (1) · Ain Shams University (1) · Asklepion Pharmaceuticals, LLC (1) · Centre Leon Berard (1)
United States (22) · Canada (6) · France (6) · Belgium (3) · Netherlands (3) · Austria (2) · China (2) · Germany (2) · Israel (2) · Russia (2) · United Kingdom (2) · Australia (1) · Czechia (1) · Egypt (1) · Finland (1)
Seetha Shankaran, MD (4) · Barbara J. Stoll, MD (3) · Aaron Chiu, MD (2) · Abhik Das, PhD (2) · Avroy A. Fanaroff, MD (2) · Bradley Yoder, MD (2) · Charles R. Bauer, MD (2) · David K. Stevenson, MD (2) · Edward F. Donovan, MD (2) · Haresh Kirpalani, MD, MSc (2) · James A. Lemons, MD (2) · Jon E. Tyson, MD MPH (2) · Richard A. Ehrenkranz, MD (2) · Roberta A Ballard, MD (2) · Robin S Roberts, MTech (2)
PMID 10400143, PMID 10545589, PMID 15767942, PMID 16014597, PMID 16651303, PMID 16870913, PMID 16870914, PMID 16939737, PMID 18245420, PMID 19117884, PMID 19841125, PMID 19841128, PMID 20138299, PMID 20405117, PMID 20472937, PMID 20472939, PMID 20587676, PMID 22307571, PMID 22371462, PMID 22738947, PMID 22943074, PMID 23268664, PMID 23944299, PMID 24335442, PMID 24388320, PMID 24725582, PMID 24876196, PMID 24996573, PMID 25425651, PMID 25554820, PMID 25647203, PMID 25981908, PMID 26162889, PMID 26431718, PMID 26465983, PMID 26500107, PMID 26916176, PMID 27079965, PMID 27344218, PMID 27440140, PMID 27583380, PMID 27650090, PMID 28100402, PMID 28279433, PMID 28384828, PMID 28600154, PMID 28731937, PMID 28930959, PMID 28973344, PMID 29275926
U10HD021364 (4), U10HD021373 (4), U10HD021385 (4), U10HD027851 (4), U10HD027853 (4), U10HD027856 (4), U10HD027880 (4), U10HD021397 (3), U10HD027871 (3), U10HD027904 (3), 2016 (2), M01RR000750 (2), M01RR008084 (2), U01HD019897 (2), U10HD021415 (2)