12 completed, 2 not yet recruiting. 14 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 14 | Completed 12, Not yet recruiting 2 |
Follow Knee Arthritis: new trials by email Literature Review of Knee Arthritis trials Research Report on Knee Arthritis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Role of Suzetrigine as a Part of a Multimodal Regimen to Reduce Pain and Opioid Use After Total Knee Arthroplasty Suzetrigine - Knee Arthritis, Knee Osteoarthritis | Phase 4 | Not yet recruiting | Emory University | 75 | 2026-07-01 | 2026-06-03 |
| Two-level ESPB in Total Knee Arthroplasty 2 x 20 ml of Ropivacaine 0.2% Injectable Solution, 2 x 20ml of Ropivacaine 0.2% Injectable Solution - Knee Osteoarthritis, Knee Pain Chronic | Phase 4 | Completed | Poznan University of Medical Sciences | 60 | 2024-11-07 | 2025-11-25 |
| Effect of Bupivacaine Liposomes or Bupivacaine for Femoral Triangle or Adductor Block on Analgesia After Total Knee Replacement Bupivacaine liposome, Nerve block mode : adductor block, Bupivacaine - Knee Arthropathy, Knee Arthritis | Phase 4 | Not yet recruiting | Huazhong University of Science and Technology | 144 | 2024-11-05 | 2024-10-24 |
| Dexamethasone vs. Dexmedetomidine for ESPB in Pain Management After Knee Arthroplasty 0.9% Sodium Chloride Injection, Dexamethasone, Dexmedetomidine - Knee Osteoarthritis, Knee Arthritis | Phase 4 | Completed | Poznan University of Medical Sciences | 90 | 2024-08-13 | 2026-03-30 |
| Dexamethasone for iPACK Block With ACB in Total Knee Arthroplasty Ropivacaine, Ropivacaine+Dexamethasone - Knee Osteoarthritis, Knee Pain Chronic | Phase 4 | Completed | Poznan University of Medical Sciences | 60 | 2024-08-13 | 2025-07-23 |
| Erector Spinae Plane Block Vs. IPACK Block with Adductor Canal Block for Total Knee Arthroplasty Control Test - spinal anesthesia, Ropivacaine 0.2% Injectable Solution ESPB, Ropivacaine 0.2% Injectable Solution iPACK+ACB - Knee Osteoarthritis, Knee Pain Chronic | Phase 4 | Completed | Poznan University of Medical Sciences | 90 | 2024-03-30 | 2024-09-26 |
| ESPB vs iPACK+ACB in Total Knee Arthroplasty Ropivacaine 0.2% Injectable Solution, control group - Knee Arthritis, Knee Arthropathy | Phase 4 | Completed | Poznan University of Medical Sciences | 60 | 2024-03-08 | 2026-11-06 |
| Methylprednisolone Taper After Total Knee Replacement Methylprednisolone, Standard of Care - Knee Arthritis | Phase 4 | Completed | Emory University | 101 | 2023-10-16 | 2025-09-18 |
| The Effect of PPB Using 10, 20 and 30 ml of Lidocaine, Study on Volunteers Popliteal Plexus Block with 10 ml, Popliteal Plexus Block with 20 ml, Popliteal Plexus Block with 30 ml - Knee Arthritis, Anesthesia, Local | Phase 4 | Completed | Charlotte Runge | 40 | 2023-09-29 | 2024-04-11 |
| Pain Management After Adductor Canal Block for Total Knee Arthroplasty Ropivacaine 0.2% Injectable Solution, 0.9%sodium chloride - Knee Osteoarthritis, Knee Arthritis | Phase 4 | Completed | Poznan University of Medical Sciences | 361 | 2020-06-18 | 2023-10-17 |
| Spinal Anesthesia Versus Combined Sciatic-femoral Nerve Block for Outpatient Knee Arthroscopy prilocaine, mepivacaine, Sciatic-femoral Nerve Block - Knee Arthritis | Phase 4 | Completed | ASST Gaetano Pini-CTO | 100 | 2015-01-01 | 2015-05-08 |
| TXA vs. Amicar in Total Knee and Hip Arthroplasty Amicar, TXA - Blood Loss, Hip Arthritis | Phase 4 | Completed | Duke University | 246 | 2015-01-01 | 2018-12-05 |
| Perioperative Analgesia for Knee Arthroplasty (PAKA) Femoral Nerve Block, peri-articular infiltration - Knee Arthritis | Phase 4 | Completed | University of Warwick | 46 | 2010-10-01 | 2012-03-22 |
| Knee Arthroplasty Performed With Conventional and Customized Instrumentation Customized Patient Instrumentation, Traditional Instrumentation - Knee Arthritis | Phase 4 | Completed | Anderson Orthopaedic Research Institute | 70 | 2010-05-01 | 2013-12-18 |
Osteoarthritis, Knee (7) · Agnosia (1) · Hemorrhage (1) · Pain, Postoperative (1)
Arthritis (7) · Joint Diseases (7) · Musculoskeletal Diseases (7) · Osteoarthritis (7) · Rheumatic Diseases (7) · Pathological Conditions, Signs and Symptoms (3) · Neurologic Manifestations (2) · Pathologic Processes (2) · Signs and Symptoms (2) · Nervous System Diseases (1) · Neurobehavioral Manifestations (1) · Pain (1) · Perceptual Disorders (1) · Postoperative Complications (1)
Ropivacaine (5) · Anesthesia, Spinal (2) · Sodium Chloride (2) · Aminocaproic Acid (1) · Bupivacaine (1) · Control Groups (1) · Dexamethasone (1) · Dexmedetomidine (1) · Mepivacaine (1) · Methylprednisolone (1) · Prilocaine (1) · Saline Solution (1) · Standard of Care (1) · Tranexamic Acid (1)
Poznan University of Medical Sciences (6) · Emory University (2) · ASST Gaetano Pini-CTO (1) · Anderson Orthopaedic Research Institute (1) · Charlotte Runge (1) · Duke University (1) · Huazhong University of Science and Technology (1) · University of Warwick (1)
Poland (6) · United States (4) · China (1) · Denmark (1) · Italy (1) · United Kingdom (1)
Ajay Premkumar, MD (2) · Malgorzata Domagalska, Ph.D. (2) · Malgorzata Reysner, M.D. Ph.D. (2) · Malgorzata Domagalska, M.D. PhD. (1) · Matthew Costa (1) · William G Hamilton, MD (1)