16 completed, 3 terminated, 2 unknown, 1 active not recruiting. 9 Phase 4, 5 Phase 2, 3 Not applicable, 2 Early Phase 1, 2 Phase 1.
Follow Aminocaproic Acid: new trials by email Literature Review of Aminocaproic Acid trials Research Report on Aminocaproic Acid
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation Bupivacaine, Lidocaine, Thrombin - Postoperative Pain | Phase 4 | Not yet recruiting | NYU Langone Health | 40 | 2026-08-01 | 2026-06-12 |
| Evaluating Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation Tranexamic acid, Aminocaproic acid, Recombinant Human Thrombin - Opioid Pain Medication | Phase 4 | Terminated | NYU Langone Health | 46 | 2021-03-24 | 2024-06-26 |
| Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS) The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care: - Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension | Recruiting | Duke University | 5000 | 2020-03-05 | 2026-08-21 | |
| Oral Tranexamic Acid vs. Oral Aminocaproic Acid to Reduce Blood Loss After Total Hip Replacement Aminocaproic Acid 1000Mg Tab, Tranexamic acid tablets - Blood Loss, Surgical | Phase 2 | Completed | Carlos A Acosta-Olivo | 90 | 2020-02-06 | 2021-04-28 |
| Oral Tranexamic Acid vs. Oral Aminocaproic Acid to Reduce Blood Loss and Transfusion After Total Knee Replacement. Oral Tranexamic Acid, Oral Aminocaproic Acid - Knee Osteoarthritis, Blood Clot | Phase 2 | Completed | Universidad Autonoma de Nuevo Leon | 92 | 2017-10-15 | 2019-07-30 |
| Activated Factor Seven in Traumatic Retro Peritoneal Hematoma ventilators, aminocaproic acid, Novo Seven - Traumatic Bleeding | Completed | King Abdul Aziz Specialist Hospital | 80 | 2017-05-05 | 2020-06-11 | |
| Management of Intracerebral Hemorrhage With Aminocaproic Acid - Pilot Study ɛ-Aminocaproic Acid - Intracerebral Hemorrhage | Phase 1 | Withdrawn | The University of Texas Health Science Center at San Antonio | 2016-06-01 | 2017-07-11 | |
| A Pilot Study Comparing Anti-Inflammatory Effects Of TXA Versus EACA In Pediatric Congenital Heart Surgery Tranexamic acid, Epsilon Aminocaproic Acid - Pediatric Cardiac Surgery, Complication of Extracorporeal Circulation | Phase 4 | Completed | Wake Forest University Health Sciences | 22 | 2016-02-01 | 2024-10-24 |
| TXA vs. Amicar in Total Knee and Hip Arthroplasty Amicar, TXA - Blood Loss, Hip Arthritis | Phase 4 | Completed | Duke University | 246 | 2015-01-01 | 2018-12-05 |
| Efficacy of Amicar for Children Having Craniofacial Surgery Amicar (ε-aminocaproic acid), normal saline - Craniosynostosis | Phase 2 | Active not recruiting | Children's National Research Institute | 22 | 2014-10-01 | 2026-04-07 |
| PRevention Of BLeeding in hEmatological Malignancies With Antifibrinolytic (Epsilon Aminocaproic Acid) EACA, Platelet transfusion - Hematological Malignancies, Thrombocytopenia | Phase 2 | Terminated | Emory University | 29 | 2014-05-23 | 2022-07-19 |
| Clinical Efficacy of Tranexamic Acid and ε-Aminocaproic Acid in Reducing Blood Loss Following Total Knee Replacement Tranexamic Acid (TXA), ε-Aminocaproic Acid (EACA) - Osteoarthritis | Phase 4 | Completed | Miller Orthopedic Specialists | 194 | 2014-01-01 | 2016-03-21 |
| Randomized Clinical Trial With Aminocaproic Acid in the Prevention of Exodontic Bleeding in Anticoagulants Patients Aminocaproic acid, Routine dental care, lidocaine and epinephrine - Oral Hemorrhage | Phase 4 | Unknown | Grupo de Estudos Multicentricos em Onco-Hematologia | 154 | 2013-12-01 | 2014-09-12 |
| Fibrinolysis Before Cardiopulmonary Bypass? Epsilonaminocaproic acid, Placebo - Pathologic Fibrinolysis | Phase 4 | Completed | Stanford University | 40 | 2013-07-01 | 2016-06-30 |
| Dosing of Amicar and Measure of Fibrinolysis by TEG During Cardiac Surgery epsilon-aminocaproic acid (EACA) - Aortic Disease | Early Phase 1 | Terminated | University of Pennsylvania | 8 | 2013-01-01 | 2019-05-02 |
| Epsilon Aminocaproic Acid Vs. Tranexamic Acid Vs. Placebo for Prevention of Blood Loss in Total Knee Arthroplasty Tranexamic Acid, Epsilon Aminocaproic Acid, Normal Saline - Osteoarthritis | Not applicable | Unknown | Heekin Orthopedic Research Institute | 54 | 2012-04-01 | 2016-07-26 |
| Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care: - Adenovirus, Anesthesia | Completed | Daniel Benjamin | 3520 | 2011-11-01 | 2023-09-06 | |
| Effects of Aminocaproic Acid (ACA) on Rosacea-specific Inflammation Topical aminocaproic acid (ACA) mixed with Vanicream, Vehicle cream - Rosacea | Early Phase 1 | Completed | University of California, San Diego | 15 | 2011-07-01 | 2019-09-13 |
| Comparison of Tranexamic to Epsilon Aminocaproic Acid: a Prospective Analysis of Blood Conservation in Cardiac Surgery Tranexamic Acid, Aminocaproic Acid - Cardiopulmonary Bypass | Not applicable | Completed | Loma Linda University | 100 | 2010-03-01 | 2020-10-19 |
| Amicar Pharmacokinetics of Children Having Craniofacial Surgery Epsilon-Aminocaproic Acid - Craniosynostosis | Phase 1 | Completed | Paul Stricker | 18 | 2009-05-01 | 2012-11-01 |
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Hemorrhage (5) · Arrhythmias, Cardiac (2) · Craniosynostoses (2) · Heart Failure (2) · Hemophilia A (2) · Hyperaldosteronism (2) · Hypertension (2) · Hypokalemia (2) · Inflammation (2) · Menorrhagia (2) · Osteoarthritis (2) · Pain (2) · Pneumonia (2) · Pulmonary Arterial Hypertension (2) · Scoliosis (2)
NYU Langone Health (3) · Duke University (2) · Carlos A Acosta-Olivo (1) · Children's National Research Institute (1) · Daniel Benjamin (1) · Emory University (1) · Grupo de Estudos Multicentricos em Onco-Hematologia (1) · Heekin Orthopedic Research Institute (1) · King Abdul Aziz Specialist Hospital (1) · Loma Linda University (1) · Miller Orthopedic Specialists (1) · National Heart, Lung, and Blood Institute (NHLBI) (1) · Paul Stricker (1) · Stanford University (1) · State University of New York - Upstate Medical University (1)
United States (19) · Canada (2) · Mexico (2) · Brazil (1) · Israel (1) · Saudi Arabia (1) · Singapore (1) · United Kingdom (1)
David Chiu, MD (2) · Ana G. Antun, MD, MSc (1) · Andrew VanBergen, M.D. (1) · Baron S Lonner, MD (1) · Carlos Acosta-Olivo, PhD (1) · Chi Hornik (1) · Chi Hornik, PharmD (1) · Clifford K Boese, MD (1) · Felix Vilchez-Cavazos, MD PhD (1) · Jason Gatling, MD (1) · Jean-Louis Caron, MD, FRCS(C) (1) · Mias Pretorius, MBChB (1) · Nancy A Nussmeier, MD (1) · Paul Stricker, MD (1) · Peter L Bailey, MD' (1)
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K23HL070058 (1)