49 completed, 17 unknown, 6 terminated, 5 active not recruiting. 39 Not applicable, 14 Phase 4, 6 Phase 2, 6 Phase 3, 1 Phase 1.
Follow Knee Arthritis: new trials by email Literature Review of Knee Arthritis trials Research Report on Knee Arthritis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of GNSC-001 Intra-articular Injection for Knee Osteoarthritis Gene Therapy GNSC-001, Placebo - Knee Arthritis Osteoarthritis, Knee Arthritis, Osteoarthritis | Phase 2 / Phase 3 | Not yet recruiting | Genascence Corporation | 240 | 2027-07-01 | 2026-09-21 |
| Role of Suzetrigine as a Part of a Multimodal Regimen to Reduce Pain and Opioid Use After Total Knee Arthroplasty Suzetrigine - Knee Arthritis, Knee Osteoarthritis | Phase 4 | Not yet recruiting | Emory University | 75 | 2026-07-01 | 2026-06-03 |
| Implant-Related Infections in Patients With Skeletal Sarcomas Implant Infection, Skeletal Sarcoma | Enrolling by invitation | Vastra Gotaland Region | 40 | 2025-02-05 | 2025-12-04 | |
| Genicular Artery Embolization (GAE) for Osteoarthritic Knee Pain Genicular artery embolization (GAE) - Knee Osteoarthritis, Knee Pain Chronic | Not applicable | Withdrawn | Andrew Picel | 2025-01-15 | 2025-02-24 | |
| Two-level ESPB in Total Knee Arthroplasty 2 x 20 ml of Ropivacaine 0.2% Injectable Solution, 2 x 20ml of Ropivacaine 0.2% Injectable Solution - Knee Osteoarthritis, Knee Pain Chronic | Phase 4 | Completed | Poznan University of Medical Sciences | 60 | 2024-11-07 | 2025-11-25 |
| Effect of Bupivacaine Liposomes or Bupivacaine for Femoral Triangle or Adductor Block on Analgesia After Total Knee Replacement Bupivacaine liposome, Nerve block mode : adductor block, Bupivacaine - Knee Arthropathy, Knee Arthritis | Phase 4 | Not yet recruiting | Huazhong University of Science and Technology | 144 | 2024-11-05 | 2024-10-24 |
| Dexamethasone vs. Dexmedetomidine for ESPB in Pain Management After Knee Arthroplasty 0.9% Sodium Chloride Injection, Dexamethasone, Dexmedetomidine - Knee Osteoarthritis, Knee Arthritis | Phase 4 | Completed | Poznan University of Medical Sciences | 90 | 2024-08-13 | 2026-03-30 |
| Dexamethasone for iPACK Block With ACB in Total Knee Arthroplasty Ropivacaine, Ropivacaine+Dexamethasone - Knee Osteoarthritis, Knee Pain Chronic | Phase 4 | Completed | Poznan University of Medical Sciences | 60 | 2024-08-13 | 2025-07-23 |
| Non-Invasive Distractor During Knee Arthroscopy Non-Invasive Knee Joint Distraction, Manual Joint Distraction - Knee Arthritis, Knee Arthropathy | Not applicable | Unknown | The Taylor Collaboration | 14 | 2024-06-01 | 2024-06-14 |
| Comparison of Two Robotic-Assisted Total Knee Arthroplasty Systems Stryker Triathlon with MAKO Robotic-Arm, DePuy Attune with VELYS Robotic-Assistance - Knee Osteoarthritis, Knee Arthritis | Not applicable | Not yet recruiting | Southeast Orthopedic Specialists | 120 | 2024-05-01 | 2024-04-17 |
| ESPB vs iPACK+ACB in Total Knee Arthroplasty Ropivacaine 0.2% Injectable Solution, control group - Knee Arthritis, Knee Arthropathy | Phase 4 | Unknown | Poznan University of Medical Sciences | 60 | 2024-04-01 | 2024-03-08 |
| Erector Spinae Plane Block Vs. IPACK Block with Adductor Canal Block for Total Knee Arthroplasty Control Test - spinal anesthesia, Ropivacaine 0.2% Injectable Solution ESPB, Ropivacaine 0.2% Injectable Solution iPACK+ACB - Knee Osteoarthritis, Knee Pain Chronic | Phase 4 | Completed | Poznan University of Medical Sciences | 90 | 2024-03-30 | 2024-09-26 |
| Persona IQ Cohort Study Persona IQ - Osteo Arthritis Knee, Knee Arthritis | Active not recruiting | Zimmer Biomet | 200 | 2024-02-20 | 2026-06-04 | |
| The Roles of MRI, DYNEELAX and Stress X-ray in First-Line Diagnosis of Cruciate Ligament Injury knee stability test (DYNEELAX) - Knee Injuries, Anterior Cruciate Ligament Injuries | Unknown | Kaohsiung Veterans General Hospital. | 50 | 2024-01-01 | 2024-02-14 | |
| Follow-up Study for Participants of Jointstem Investigator Initiated Trial by Arthroscopy JOINTSTEM - Degenerative Arthritis, Knee Arthritis | Not applicable | Not yet recruiting | R-Bio | 14 | 2023-12-01 | 2022-09-28 |
| Methylprednisolone Taper After Total Knee Replacement Methylprednisolone, Standard of Care - Knee Arthritis | Phase 4 | Completed | Emory University | 101 | 2023-10-16 | 2025-09-18 |
| The Effect of PPB Using 10, 20 and 30 ml of Lidocaine, Study on Volunteers Popliteal Plexus Block with 10 ml, Popliteal Plexus Block with 20 ml, Popliteal Plexus Block with 30 ml - Knee Arthritis, Anesthesia, Local | Phase 4 | Completed | Charlotte Runge | 40 | 2023-09-29 | 2024-04-11 |
| Maximal Rate of Force Development of Ankle Muscles and Functional Ability in Patients With Knee Osteoarthritis Maximal Rate of Force Development Test for Ankle Muscles - Knee Osteoarthritis, Knee Arthritis | Completed | Ahram Canadian University | 126 | 2023-07-20 | 2024-08-06 | |
| QIST Collaborative - Arthroplasty Research Cohort (ARC) Study Hip/Knee Replacement - Hip Arthritis, Knee Arthritis | Recruiting | Northumbria Healthcare NHS Foundation Trust | 5000 | 2023-07-13 | 2024-11-18 | |
| Investigator Initiated Trial to Evaluate Cartilage Regeneration by Arthroscopy After JOINTSTEM Administration JOINTSTEM, Saline - Degenerative Arthritis, Knee Arthritis | Not applicable | Unknown | R-Bio | 21 | 2023-07-01 | 2022-09-28 |
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Osteoarthritis, Knee (41) · Osteoarthritis (16) · Knee Injuries (6) · Arthritis (4) · Arthritis, Rheumatoid (4) · Pain (4) · Obesity (2) · Osteoarthritis, Hip (2) · Acute Pain (1) · Agnosia (1) · Anterior Cruciate Ligament Injuries (1) · Arterial Occlusive Diseases (1) · Arthralgia (1) · Arthritis, Gouty (1) · Arthritis, Infectious (1)
Musculoskeletal Diseases (51) · Joint Diseases (50) · Rheumatic Diseases (48) · Arthritis (47) · Osteoarthritis (32) · Pathological Conditions, Signs and Symptoms (15) · Signs and Symptoms (12) · Neurologic Manifestations (10) · Wounds and Injuries (8) · Leg Injuries (7) · Nervous System Diseases (5) · Pathologic Processes (5) · Autoimmune Diseases (4) · Connective Tissue Diseases (4) · Immune System Diseases (4)
Ropivacaine (5) · Sodium Chloride (5) · Arthroplasty, Replacement, Knee (3) · Anesthesia, Spinal (2) · Control Groups (2) · Saline Solution (2) · Aminocaproic Acid (1) · Arthroplasty (1) · Ascorbic Acid (1) · Biomechanical Phenomena (1) · Bupivacaine (1) · Cannabidiol (1) · Cholecalciferol (1) · Dexamethasone (1) · Dexmedetomidine (1)
Poznan University of Medical Sciences (6) · Zimmer Biomet (3) · Aksaray University Training and Research Hospital (2) · Bezmialem Vakif University (2) · Biomet Orthopedics, LLC (2) · Duke University (2) · Emory University (2) · Medical University of Warsaw (2) · Ottawa Hospital Research Institute (2) · R-Bio (2) · 4Life Research, LLC (1) · ASST Gaetano Pini-CTO (1) · Acibadem University (1) · Aesculap AG (1) · Ahram Canadian University (1)
United States (27) · Poland (9) · Turkey (Türkiye) (7) · France (6) · Canada (4) · China (4) · United Kingdom (4) · Egypt (3) · Italy (3) · Denmark (2) · Germany (2) · Taiwan (2) · Croatia (1) · Russia (1) · Saudi Arabia (1)
Ajay Premkumar, MD (2) · Malgorzata Domagalska, Ph.D. (2) · Malgorzata Reysner, M.D. Ph.D. (2) · Simon Garceau, MD (2) · Abeer Abdelrahman, Ph.D (1) · Adam Freedhand, MD (1) · Ana M Valdes, PhD (1) · Andrew C Picel, MD (1) · Andrew Price, FRCS PhD (1) · Annabelle Visperas, BS (1) · Artur Stolarczyk, PhD (1) · Bradley Myers, PT, DPT, DSc (1)
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