105 completed. 105 Phase 3, 17 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 105 | Completed 105 |
| Phase 2 | 17 | Completed 17 |
Follow Ischemic Stroke: new trials by email Literature Review of Ischemic Stroke trials Research Report on Ischemic Stroke
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Heparin for RAO Post-Transradial Angiography in AIS Heparin - Therapeutic dosage, Saline (0.9% NaCl) - Acute Ischemic Stroke | Phase 3 | Completed | Xiang Luo | 440 | 2025-08-04 | 2026-03-24 |
| Efficacy and Safety of Early Combined Therapy With PCSK9 Inhibitors and Statins in Acute Ischemic Stroke PCSK9 inhibitors combined with atorvastatin/rosuvastatin, Atorvastatin/Rosuvastatin - Acute Ischemic Stroke | Phase 2 / Phase 3 | Completed | Xiang Luo | 429 | 2024-11-29 | 2026-06-09 |
| "The Effect of Trimetazidine on the Clinical Outcome of Acute Ischemic Stroke Patients" Trimetazidine - Acute Ischemic Stroke | Phase 3 | Completed | Ain Shams University | 60 | 2024-09-01 | 2025-09-08 |
| Emergency Stroke Unit for Acute Cerebrovascular Events ( ESU-ACE-C ) Emergency Stroke Unit based on 0.23-T MRI, Standard stroke unit adherent to guidelines - Ischemic Stroke, Acute | Phase 3 | Completed | Beijing Tiantan Hospital | 1622 | 2024-08-08 | 2025-08-22 |
| Y-3 for Injection in the Treatment of Acute Ischemic Stroke Y-3 for injection, Placebo control group - Acute Ischemic Stroke | Phase 3 | Completed | Beijing Tiantan Hospital | 998 | 2024-07-24 | 2026-07-07 |
| Tirofiban After Successful MT Recanalization in AIS Tirofiban, Saline placebo - Acute Ischemic Stroke, Vessel Occlusion | Phase 2 / Phase 3 | Completed | Xiang Luo | 1380 | 2024-04-09 | 2026-03-11 |
| Ticagrelor With Aspirin Dual Antiplatelet Therapy Combined With Intravenous Thrombolysis for Ischemic Stroke Early Dual Antiplatelet Therapy, Placebo - Ischemic Stroke, Acute | Phase 3 | Completed | Beijing Tiantan Hospital | 1382 | 2024-04-03 | 2026-01-22 |
| Advancing Stroke Safety and Efficacy Through Early Tirofiban Administration After Intravenous Thrombolysis (ASSET-IT) Intravenous thrombolysis plus tirofiban, Intravenous thrombolysis plus placebo - Acute Ischemic Stroke | Phase 3 | Completed | The First Affiliated Hospital of University of Science and Technology of China | 832 | 2024-03-14 | 2025-05-04 |
| The Role of Peripheral Afferents in Modulating Post-stroke Central Pain Lidocaine 20mg/ml, Levobupivacaine Hydrochloride 1.25 MG/ML, Sodium Chloride 0.9% Inj - Stroke | Phase 3 | Completed | Institut National de la Santé Et de la Recherche Médicale, France | 33 | 2024-02-09 | 2026-10-19 |
| Effect of Interleukin-6 Receptor Inhibition in Patients With Ischemic Stroke Undergoing Endovascular Treatment Tocilizumab, NaCl 0.9% 100ml - Interleukin-6, Ischemic Stroke | Phase 2 / Phase 3 | Completed | Suzhou Municipal Hospital of Anhui Province | 108 | 2024-02-02 | 2024-09-25 |
| Endovascular Treatment With or Without Preceding Intravenous Tenecteplase (TNK) in Patients With Late-window acUte Ischemic Stroke Due to Middle Cerebral Artery Occlusion Tenecteplase, direct EVT - Ischemic Stroke, Acute, Thrombolysis | Phase 3 | Completed | Beijing Tiantan Hospital | 391 | 2024-01-25 | 2025-11-26 |
| Tenecteplase Reperfusion Therapy in Acute Ischaemic Cerebrovascular Events-5 Tenecteplase, Best Practice (which may include intravenous Alteplase) - Ischemic Stroke, Acute | Phase 3 | Completed | Beijing Tiantan Hospital | 452 | 2024-01-24 | 2025-11-26 |
| Intravenous Tirofiban Versus Thrombolysis Before Mechanical Thrombectomy in Stroke Tirofiban, Thrombolysis - Stroke, Acute Ischemic | Phase 2 / Phase 3 | Completed | Xinqiao Hospital of Chongqing | 1014 | 2023-11-28 | 2026-09-14 |
| CHemical OptImization of Cerebral Embolectomy 2 (CHOICE 2). Intraarterial alteplase - Stroke, Acute Ischemic, Stroke, Acute | Phase 3 | Completed | Hospital Clinic of Barcelona | 440 | 2023-11-18 | 2026-09-18 |
| Normobaric Hyperoxia Combined With Intravenous Thrombolysis for Acute Ischemic Stroke (OPENS-3) Normobaric Hyperoxia, Nasal oxygen, Intravenous thrombolysis(rt-PA) - Acute Ischemic Stroke | Phase 3 | Completed | Ji Xunming,MD,PhD | 1230 | 2023-08-17 | 2026-07-30 |
| Intra-arterial Alteplase for Acute Ischemic Stroke After Mechanical Thrombectomy Alteplase - Stroke, Acute Ischemic | Phase 3 | Completed | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 324 | 2023-08-01 | 2026-08-12 |
| Efficacy and Safety of Minocycline in Patients With Moderate to Severe Acute Ischemic Stroke Minocycline hydrochloride capsule, Placebo capsules of Minocycline hydrochloride capsules - Ischemic Stroke, Acute | Phase 3 | Completed | Beijing Tiantan Hospital | 1724 | 2023-05-19 | 2025-05-14 |
| Evaluate the Efficacy and Safety of TTYP01 Tablets in the Treatment of Acute Ischemic Stroke TTYP01 tablets, Placebo (Simulant TTYP01 Tablets) - Acute Ischemic Stroke | Phase 3 | Completed | Shanghai Auzone Biological Technology Co., Ltd. | 614 | 2023-04-25 | 2025-02-03 |
| Intra-arterial Tenecteplase During First Thrombectomy Attempt for Acute Stroke (BRETIS-TNK II) Tenecteplase - Stroke, Ischemic | Phase 3 | Completed | General Hospital of Shenyang Military Region | 380 | 2023-03-21 | 2025-03-28 |
| Safety and Efficacy of Intra-arterial Tenecteplase for Noncomplete Reperfusion of Intracranial Occlusions Tenecteplase - Ischemic Stroke | Phase 3 | Completed | Insel Gruppe AG, University Hospital Bern | 156 | 2023-03-21 | 2026-02-10 |
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Stroke (38) · Brain Ischemia (6) · Hypertension (4) · Recurrence (4) · Atherosclerosis (3) · Hypercholesterolemia (3) · Hyperlipidemias (3) · Brain Edema (2) · Cardiovascular Diseases (2) · Carotid Stenosis (2) · Hemorrhagic Stroke (2) · Ischemic Attack, Transient (2) · Stroke, Lacunar (2) · Acute Coronary Syndrome (1)
Brain Diseases (104) · Central Nervous System Diseases (104) · Cerebrovascular Disorders (104) · Nervous System Diseases (104) · Vascular Diseases (104) · Cardiovascular Diseases (103) · Stroke (67) · Pathological Conditions, Signs and Symptoms (13) · Pathologic Processes (10) · Disease Attributes (5) · Infarction (5) · Metabolic Diseases (5) · Necrosis (5) · Nutritional and Metabolic Diseases (5) · Brain Ischemia (4)
Clopidogrel (12) · Aspirin (11) · Tissue Plasminogen Activator (11) · Tenecteplase (10) · Ticagrelor (6) · Injections (4) · Cilostazol (3) · Sodium Chloride (3) · Tirofiban (3) · Hydroxymethylglutaryl-CoA Reductase Inhibitors (2) · Lidocaine (2) · Minocycline (2) · Rivaroxaban (2) · Stents (2) · TNK-tissue plasminogen activator (2)
Beijing Tiantan Hospital (12) · Kafrelsheikh University (6) · Assistance Publique - Hôpitaux de Paris (4) · General Hospital of Shenyang Military Region (3) · Neuroscience Trials Australia (3) · Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan (3) · Xiang Luo (3) · Mazandaran University of Medical Sciences (2) · Pharmasoft (2) · PhotoThera, Inc (2) · The First Affiliated Hospital of University of Science and Technology of China (2) · Xinqiao Hospital of Chongqing (2) · Acorda Therapeutics (1) · Acticor Biotech (1) · Ain Shams University (1)
China (39) · United States (15) · France (11) · Germany (10) · Spain (9) · Egypt (8) · Russia (8) · Australia (7) · Canada (7) · Austria (6) · Switzerland (6) · Finland (5) · Japan (5) · Sweden (5) · United Kingdom (5)
Masayasu Matsumoto, MD, PhD (3) · Yongjun Wang, MD (3) · Geoffrey Donnan, MD FRACP (2) · Stephen Davis, MD FRACP (2) · Yilong Wang, MD, PhD (2) · Yongjun Wang (2) · Ahmed I Elbassiouny, MD (1) · Alfonso Ciccone, MD (1) · Ana Morales, MD (1) · Andrea Comenducci, MD (1) · Angel Chamorro, MD, PhD (1) · Angel Chamorro, MD, PhD. (1) · Askiel Bruno, MD, MS (1)
PMID 31867054, PMID 18190818, PMID 21899409, PMID 2375765, PMID 31067369, PMID 16731270, PMID 24168957, PMID 29766770, PMID 30523735, PMID 33464335, PMID 34515113, PMID 34786868, PMID 35224730, PMID 39147573, PMID 11306611, PMID 12271462, PMID 15800226, PMID 16614616, PMID 17050890, PMID 17290030, PMID 18235078, PMID 18774745, PMID 19097942, PMID 19233936, PMID 19536360, PMID 19628804, PMID 20446946, PMID 20466199, PMID 20594935, PMID 20875651, PMID 21371282, PMID 21737808, PMID 21909339, PMID 22435369, PMID 22474060, PMID 22499292, PMID 22632907, PMID 22700528, PMID 22738918, PMID 22750086, PMID 22826359, PMID 22931315, PMID 22977278, PMID 22984008, PMID 22991350, PMID 23009193, PMID 23034910, PMID 23237679, PMID 23387822, PMID 23506245
2016 (2), 2023 (2), 2008 (1), 2017 (1), U01NS058728 (1), U01NS069498 (1), U01NS100699 (1)