13 completed, 2 terminated, 1 recruiting, 1 unknown. 10 Phase 2, 3 Phase 1, 3 Phase 3, 2 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 10 | Completed 7, Recruiting 1, Terminated 1, Unknown 1 |
| Phase 1 | 3 | Completed 2, Terminated 1 |
| Phase 3 | 3 | Completed 3 |
| Not applicable | 2 | Completed 2 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety and Tolerability of Adjunctive TBO-309 in Reperfusion for Stroke TBO-309 - Acute Ischemic Stroke | Phase 2 | Recruiting | The Florey Institute of Neuroscience and Mental Health | 80 | 2023-09-27 | 2025-12-01 |
| First in Human Study of CT-1500 in Healthy Participants CT-1500, Placebo - Healthy | Phase 1 | Completed | Circadian Therapeutics Ltd | 64 | 2021-11-08 | 2022-07-15 |
| Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study of Oral ASN51 in Healthy Subjects and Subjects With Alzheimer's Disease ASN51, Placebo - Alzheimer Disease | Phase 1 | Terminated | Asceneuron Pty Ltd. | 25 | 2021-06-02 | 2023-01-17 |
| Evaluation of R:GEN as Intervention in Subjects With Early Stages of AMD for Safety and Exploratory Efficacy Outcomes R:GEN Laser System - Early Age Related Macular Degeneration (Disorder) | Not applicable | Completed | Lutronic Vision, Inc | 31 | 2021-02-15 | 2023-05-16 |
| DIRECT-SAFE: A Randomized Controlled Trial of DIRECT Endovascular Clot Retrieval Versus Standard Bridging Thrombolysis With Endovascular Clot Retrieval Direct endovascular clot retrieval, Bridging thrombolysis followed by ECR - Ischemic Stroke | Phase 3 | Completed | Neuroscience Trials Australia | 295 | 2018-04-27 | 2022-06-16 |
| STOP-MSU: Stopping Haemorrhage With Tranexamic Acid for Hyperacute Onset Presentation Including Mobile Stroke Units Tranexamic Acid, Normal saline - Intracerebral Haemorrhage | Phase 2 | Completed | Neuroscience Trials Australia | 201 | 2018-03-19 | 2023-09-28 |
| Deferiprone to Delay Dementia (The 3D Study) Deferiprone 600mg delayed release tablets, Placebo Oral Tablet - Mild Cognitive Impairment, Prodromal Alzheimer's Disease | Phase 2 | Completed | Neuroscience Trials Australia | 81 | 2018-01-19 | 2024-07-03 |
| Determining the Optimal Dose of Tenecteplase Before Endovascular Therapy for Ischaemic Stroke (EXTEND-IA TNK Part 2) Tenecteplase - Ischemic Stroke | Phase 2 | Completed | Neuroscience Trials Australia | 300 | 2017-12-06 | 2020-03-04 |
| Trial of EXenatide in Acute Ischaemic Stroke Exenatide Injection - Acute Ischemic Stroke | Phase 2 | Unknown | Neuroscience Trials Australia | 350 | 2017-11-23 | 2021-09-14 |
| Safety and Tolerability of Antiretroviral (Triumeq) in Patients With Amyotrophic Lateral Sclerosis (ALS). Triumeq - Amyotrophic Lateral Sclerosis | Phase 2 | Completed | Neuroscience Trials Australia | 43 | 2016-10-01 | 2019-08-22 |
| A Dose Ranging Pilot Study for Intracerebroventricular (ICV) Delivery of Valproate in Subjects With Temporal Seizures Valproate - Epilepsy | Phase 1 / Phase 2 | Completed | Cerebral Therapeutics LLC | 6 | 2016-08-01 | 2023-03-16 |
| Tenecteplase Versus Alteplase Before Endovascular Therapy for Ischemic Stroke Tenecteplase, Tissue Plasminogen Activator - Ischemic Stroke | Phase 2 | Completed | Neuroscience Trials Australia | 202 | 2015-03-23 | 2018-03-30 |
| EXTEND (International): Extending the Time for Thrombolysis in Emergency Neurological Deficits (International) Tissue Plasminogen Activator (Alteplase), Placebo - Stroke | Phase 3 | Completed | Neuroscience Trials Australia | 45 | 2012-12-06 | 2018-08-31 |
| STOP-AUST: The Spot Sign and Tranexamic Acid On Preventing ICH Growth - AUStralasia Trial Tranexamic Acid, Placebo - Intracerebral Haemorrhage, Stroke | Phase 2 | Completed | Neuroscience Trials Australia | 100 | 2012-12-01 | 2020-02-26 |
| Extending the Time for Thrombolysis in Emergency Neurological Deficits - Intra-Arterial Intra-arterial Clot Retrieval with Solitaire device, intravenous tissue plasminogen activator (tPA) - Ischemic Stroke | Phase 2 | Terminated | Neuroscience Trials Australia | 70 | 2012-06-01 | 2015-04-21 |
| Extending the Time for Thrombolysis in Emergency Neurological Deficits Tissue Plasminogen Activator (Alteplase), Placebo - Stroke | Phase 3 | Completed | Neuroscience Trials Australia | 180 | 2010-06-01 | 2018-08-31 |
| A Very Early Rehabilitation Trial Standard Care + VEM, Standard care - Stroke | Not applicable | Completed | Neuroscience Trials Australia | 2014 | 2006-06-01 | 2015-04-15 |
Stroke (9) · Ischemic Stroke (8) · Brain Diseases (4) · Cardiovascular Diseases (4) · Central Nervous System Diseases (4) · Cerebrovascular Disorders (4) · Nervous System Diseases (4) · Vascular Diseases (4) · Alzheimer Disease (2) · Brain Infarction (2) · Brain Ischemia (2) · Cerebral Hemorrhage (2) · Cerebral Infarction (2) · Ischemia (2) · Pathologic Processes (2)
Tissue Plasminogen Activator (3) · Tenecteplase (2) · Tranexamic Acid (2) · Deferiprone (1) · Epilim (1) · Exenatide (1) · Lamivudine (1) · Saline Solution (1) · Sodium Chloride (1) · Standard of Care (1) · Valproic Acid (1) · abacavir (1) · abacavir, dolutegravir, and lamivudine drug combination (1) · dolutegravir (1)
Australia (16) · New Zealand (6) · Finland (4) · Taiwan (2) · Vietnam (2) · China (1) · Singapore (1)
Geoffrey Donnan, MD (2) · Geoffrey Donnan, MD FRACP (2) · Stephen Davis, MD FRACP (2) · Amanda Thrift, PhD (1) · Ashley I. Bush (1) · Atte Meretoja, MD (1) · Bernard Yan, MD (1) · Candice Delcourt, Dr (1) · Christopher Bladin (1) · Geoffrey A Donnan, MD (1) · Helen Dewey, MD (1) · Henry Zhao, MD (1) · Janice Collier, PhD (1) · Julian Gold, MD (1) · Julie Bernhardt, PhD (1)
PMID 34906976, PMID 36289001, PMID 30523735, PMID 31067369, PMID 33408145, PMID 34786868, PMID 35017305, PMID 36878701, PMID 37870112, PMID 38502892, PMID 23981692, PMID 24207098, PMID 25671797, PMID 26283667, PMID 26936861, PMID 28438076, PMID 28952914, PMID 29312109, PMID 29694815, PMID 31467520, PMID 31564231, PMID 32078683, PMID 32395709, PMID 33023423, PMID 33128912, PMID 34184251, PMID 34670118, PMID 35135060, PMID 35300248, PMID 35810757, PMID 38011235, PMID 38648814, PMID 39495531, PMID 42132478
2018 (1)