152 completed. 152 Phase 2, 23 Phase 1, 17 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 152 | Completed 152 |
| Phase 1 | 23 | Completed 23 |
| Phase 3 | 17 | Completed 17 |
Follow Ischemic Stroke: new trials by email Literature Review of Ischemic Stroke trials Research Report on Ischemic Stroke
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| HRS-7450 Injection Phase II Clinical Trial for Acute Ischemic Stroke. HRS-7450 Injection, HRS-7450 Injection Placebo - Acute Ischemic Stroke | Phase 2 | Completed | Fujian Shengdi Pharmaceutical Co., Ltd. | 210 | 2025-10-31 | 2026-10-20 |
| Combined Antiplatelet Strategy in Acute Ischemic Stroke Following Thrombectomy and/or Intravenous Thrombolysis (CoPRIME) aspirin + clopidogrel, Aspirin - Acute Ischemic Stroke | Phase 2 | Completed | University of Alberta | 3 | 2025-09-02 | 2026-09-28 |
| Clopidogrel Plus Aspirin in Acute Ischemic Stroke Following Thrombectomy and/or Intravenous Thrombolysis (CoPrime) aspirin + clopidogrel, Aspirin - Acute Ischemic Stroke | Phase 2 | Completed | University of Alberta | 3 | 2025-09-02 | 2026-07-16 |
| A Clinical Study to Investigate the Effect of Oral Neflamapimod on Motor Recovery After Acute Ischaemic Stroke Neflamapimod, Placebo - Moderate to Severe Acute Ischaemic Stroke, Ischaemic Stroke | Phase 2 | Completed | EIP Pharma Inc | 45 | 2025-06-20 | 2026-10-28 |
| A Trial to Assess the Efficacy and Safety of OTR4132-MD in Patients With Acute Ischemic Stroke OTR4132, Placebo - Endovascular Thrombectomy, Ischemic Cerebrovascular Accident | Phase 2 | Completed | Organ, Tissue, Regeneration, Repair and Replacement | 60 | 2025-03-14 | 2026-06-26 |
| A Phase Ⅱb Study of XY03-EA Tablets in Acute Ischemic Stroke XY03-EA 150 mg (per dose), XY03-EA 300 mg (Regimen A), XY03-EA 300 mg (Regimen B) - Stroke, Ischemic | Phase 2 | Completed | Shijiazhuang Yiling Pharmaceutical Co. Ltd | 360 | 2024-12-15 | 2026-09-09 |
| Efficacy and Safety of Early Combined Therapy With PCSK9 Inhibitors and Statins in Acute Ischemic Stroke PCSK9 inhibitors combined with atorvastatin/rosuvastatin, Atorvastatin/Rosuvastatin - Acute Ischemic Stroke | Phase 2 / Phase 3 | Completed | Xiang Luo | 429 | 2024-11-29 | 2026-06-09 |
| Lesion Network MApping Navigated Continuous Theta-burst STimulation for Motor REcovery in Acute Ischemic Stroke Continuous Theta-burst Stimulation, Sham stimulation - Stroke, Acute Ischemic | Phase 2 | Completed | Beijing Tiantan Hospital | 60 | 2024-10-21 | 2026-04-08 |
| Albumin for Patients With Acute Large Vessel Occlusive Stroke Undergoing Endovascular Reperfusion Therapy Intravenous infusion of human albumin, Saline - Acute Ischemic Stroke | Phase 2 | Completed | Capital Medical University | 134 | 2024-08-10 | 2025-04-02 |
| Efficacy and Safety of Early Initiation of Butylphthalide Treatment in Patients With Acute Ischemic Stroke. Butylphthalide treatment initiation time - Acute Ischemic Stroke | Phase 2 | Completed | Xiangya Hospital of Central South University | 204 | 2024-07-29 | 2025-11-25 |
| Emergency Stroke Unit for Acute Cerebrovascular Events ( ESU-ACE-A ) Emergency Stroke Unit based on 0.23-T MRI, Standard stroke unit adherent to guidelines - Ischemic Stroke, Acute | Phase 2 | Completed | Beijing Tiantan Hospital | 218 | 2024-07-26 | 2025-03-04 |
| The Effect of GD-iExo-003 in Acute Ischemic Stroke exosomes derived from human induced pluripotent stem cell for injection, a placebo of exosomes derived from human induced pluripotent stem cell for injection - Acute Ischemic Stroke | Phase 1 / Phase 2 | Completed | Xuanwu Hospital, Beijing | 29 | 2024-06-05 | 2026-09-10 |
| Tirofiban After Successful MT Recanalization in AIS Tirofiban, Saline placebo - Acute Ischemic Stroke, Vessel Occlusion | Phase 2 / Phase 3 | Completed | Xiang Luo | 1380 | 2024-04-09 | 2026-03-11 |
| Effect of Interleukin-6 Receptor Inhibition in Patients With Ischemic Stroke Undergoing Endovascular Treatment Tocilizumab, NaCl 0.9% 100ml - Interleukin-6, Ischemic Stroke | Phase 2 / Phase 3 | Completed | Suzhou Municipal Hospital of Anhui Province | 108 | 2024-02-02 | 2024-09-25 |
| Safety and Efficacy of SHPL-49 Injection in Participants With Acute Ischemic Stroke 3 ampoules of SHPL-49 Injection, 6 ampoules of SHPL-49 Injection, 0.9% Sodium Chloride Injection - Acute Ischemic Stroke | Phase 2 | Completed | Shanghai Hutchison Pharmaceuticals Limited | 270 | 2023-12-29 | 2025-10-28 |
| Intravenous Tirofiban Versus Thrombolysis Before Mechanical Thrombectomy in Stroke Tirofiban, Thrombolysis - Stroke, Acute Ischemic | Phase 2 / Phase 3 | Completed | Xinqiao Hospital of Chongqing | 1014 | 2023-11-28 | 2026-09-14 |
| Intravenous N-Acetylcysteine for the Treatment of Acute Ischemic Stroke Acetylcysteine, Dextrose in Water - Acute Ischemic Stroke | Phase 2 | Completed | Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | 4 | 2023-11-02 | 2026-02-19 |
| Ischemic Post-conditioning in Acute Ischemic Stroke Thrombectomy (PROTECT-2) Mechanical thrombectomy combined with ischemic post-conditioning, Mechanical thrombectomy alone - Acute Ischemic Stroke | Phase 2 | Completed | Capital Medical University | 160 | 2023-11-01 | 2026-10-21 |
| Glucagon-like Peptide 1 Receptor Agonist in Acute Large Vessel Occlusion Stroke Treated by Reperfusion Therapies Semaglutide - Stroke, Stroke, Acute | Phase 2 | Completed | Chinese University of Hong Kong | 140 | 2023-08-01 | 2025-03-07 |
| MLC1501 Study Assessing Efficacy in Post STrOke Subjects With mOtor Deficits Placebo, MLC1501 - Stroke, Stroke, Ischemic | Phase 2 | Completed | Moleac Pte Ltd. | 303 | 2023-07-21 | 2025-12-09 |
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Stroke (66) · Ischemia (7) · Thrombosis (5) · Brain Infarction (4) · Cerebral Infarction (4) · Cerebrovascular Disorders (4) · Intracranial Hemorrhages (4) · Hemorrhage (3) · Hemorrhagic Stroke (3) · Hypothermia (3) · Ischemic Attack, Transient (3) · Aphasia (2) · Brain Diseases (2) · Brain Edema (2)
Cardiovascular Diseases (151) · Nervous System Diseases (151) · Brain Diseases (150) · Central Nervous System Diseases (150) · Vascular Diseases (150) · Cerebrovascular Disorders (148) · Stroke (86) · Pathological Conditions, Signs and Symptoms (33) · Pathologic Processes (28) · Infarction (13) · Necrosis (13) · Brain Ischemia (12) · Ischemia (12) · Signs and Symptoms (9) · Brain Infarction (7)
Tenecteplase (9) · Tissue Plasminogen Activator (8) · Sodium Chloride (7) · Aspirin (6) · Injections (4) · TNK-tissue plasminogen activator (4) · Clopidogrel (3) · Eptifibatide (3) · Glyburide (3) · Tirofiban (3) · Warfarin (3) · salivary plasminogen activator alpha 1, Desmodus rotundus (3) · Continuous Positive Airway Pressure (2) · Edaravone (2) · Erythropoietin (2)
Beijing Tiantan Hospital (5) · Capital Medical University (4) · General Hospital of Shenyang Military Region (3) · The University of Texas Health Science Center, Houston (3) · Acticor Biotech (2) · Ajou University School of Medicine (2) · Assistance Publique - Hôpitaux de Paris (2) · Astellas Pharma Inc (2) · Biogen (2) · Christina Kruuse (2) · Huashan Hospital (2) · Lumosa Therapeutics Co., Ltd. (2) · Neuroscience Trials Australia (2) · PAION Deutschland GmbH (2) · Remedy Pharmaceuticals, Inc. (2)
United States (51) · China (36) · Germany (18) · Spain (15) · Australia (13) · United Kingdom (12) · France (11) · South Korea (11) · Canada (10) · Austria (7) · Belgium (7) · Japan (6) · Taiwan (5) · Czechia (4) · Denmark (4)
Andrea Comenducci, MD (2) · Brian Buck (2) · Christina R Kruuse, MD, PhD (2) · Gang Zhao, MD (2) · Jong Sung Kim, MD, Phd (2) · Mahesh Kate (2) · Sven Poli, Dr. med. (2) · Alexander Dromerick, MD (1) · Andrew D Barreto, MD (1) · Andrew D. Barreto, MD (1) · Andrey A Belkin, MD, PhD. (1) · Angel Chamorro, MD, PhD. (1) · Antony J. Furlan, MD (1)
PMID 22474060, PMID 22738918, PMID 25378424, PMID 25677596, PMID 33408145, PMID 33464335, PMID 34906976, PMID 35017305, PMID 36289001, PMID 36878701, PMID 38502892, PMID 40497495, PMID 41446320, PMID 42044230, PMID 10718099, PMID 11519775, PMID 12750546, PMID 15569863, PMID 15692126, PMID 16574919, PMID 16574922, PMID 16614616, PMID 16908730, PMID 18296121, PMID 18790527, PMID 18815396, PMID 19233036, PMID 19236467, PMID 19640572, PMID 19834014, PMID 19837031, PMID 20185783, PMID 20472172, PMID 20651267, PMID 21079608, PMID 21086713, PMID 21102461, PMID 21216670, PMID 21295494, PMID 21886365, PMID 22198979, PMID 22223235, PMID 22435369, PMID 22659021, PMID 22700528, PMID 22960888, PMID 23394476, PMID 23418571, PMID 23652269, PMID 23887841
2016 (3), 2015 (2), 2018 (1), 2019 (1), P50NS044227 (1), P50NS044283 (1), R01NS042607 (1), R01NS050192 (1), U01NS077179 (1), U01NS077352 (1), U01NS088312 (1), U01NS102353 (1), U54NS057405 (1)