Intraabdominal Infections: Clinical Trials

359 completed, 111 unknown, 37 recruiting, 31 terminated. 226 Not applicable, 57 Phase 4, 39 Phase 3, 35 Phase 2, 15 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	226	Completed 116, Unknown 50, Recruiting 18, Terminated 16, Not yet recruiting 12, Active not recruiting 6, Withdrawn 6, Enrolling by invitation 1, Suspended 1
Phase 4	57	Completed 37, Terminated 7, Unknown 6, Recruiting 3, Not yet recruiting 2, Active not recruiting 1, Withdrawn 1
Phase 3	39	Completed 30, Unknown 4, Not yet recruiting 2, Terminated 2, Recruiting 1
Phase 2	35	Completed 23, Unknown 4, Terminated 3, Not yet recruiting 2, Active not recruiting 1, Recruiting 1, Withdrawn 1
Phase 1	15	Completed 4, Withdrawn 4, Unknown 3, Active not recruiting 1, Not yet recruiting 1, Recruiting 1, Terminated 1
Early Phase 1	2	Completed 2

Follow Intraabdominal Infections: new trials by email Literature Review of Intraabdominal Infections trials Research Report on Intraabdominal Infections

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Piperacillin/Tazobactam Versus Ceftriaxone and Metronidazole for Children With Perforated Appendicitis Piperacillin/Tazobactam, Ceftriaxone + Metronidazole - Appendicitis Perforated, Appendectomy, Laparoscopic	Phase 3	Not yet recruiting	McMaster Children's Hospital	180	2027-04-01	2026-10-09
Povidone-iodine Irrigation for Prevention of Intra-abdominal Abscess in Pediatric Perforated Appendicitis: a Multi-center Stepped Wedge Cluster Randomized Study Irrigation with PVI, Usual care - Acute, Perforated Appendicitis	Phase 4	Not yet recruiting	The University of Texas Health Science Center, Houston	1750	2027-03-01	2025-02-10
Perforated Appendicitis and Postoperative Antibiotics Pilot Trial Postoperative antibiotico-prophylaxis, No postoperative antibiotics - Perforated Appendicitis	Not applicable	Not yet recruiting	London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's	100	2027-01-01	2026-09-17
Comparative Study Between Laparoscopic and Open Appendectomy of Complicated Appendicitis Laparoscopic Appendectomy, Open Appendectomy - Appendicitis, Perforated Appendicitis	Not applicable	Not yet recruiting	Assiut University	100	2026-11-01	2026-10-16
Laparoscopic vs Open Appendectomy in Obese Patients Open Appendectomy, Laparoscopic Appendectomy - Acute Appendicitis, Appendicitis (Diagnosis)	Not applicable	Not yet recruiting	University of Health Sciences Lahore	166	2026-10-02	2026-09-16
Patient Choice Between Antibiotics and Appendectomy in Uncomplicated Appendicitis (FRENCH 47 - ALACARTE) Shared decision-making, amoxicillin-clavulanate, Appendectomy - Acute Appendicitis	Phase 2	Not yet recruiting	Assistance Publique - Hôpitaux de Paris	560	2026-10-01	2026-10-05
Immediate Laparoscopic Appendectomy Versus Interval Laparoscopic Appendectomy for Early Appendicular Mass Immediate Laparoscopic Appendectomy, Interval Laparoscopic Appendectomy - Appendicular Mass, Acute Appendicitis	Not applicable	Not yet recruiting	Assiut University	100	2026-10-01	2026-09-23
Video-Based Grading of Intraoperative Adverse Events in Pediatric Laparoscopic Appendectomy Laparoscopic appendectomy - Appendicitis, Acute, Appendectomy		Recruiting	Ahmet Burak Doğan, MD	80	2026-09-01	2026-09-04
Prospective Comparison of Pro-Adrenomedullin, C-Reactive Protein, and Neutrophil-to-Lymphocyte Ratio for Diagnosing Acute Appendicitis Serum Pro-Adrenomedullin Measurement - Acute Appendicitis		Recruiting	Bursa Yuksek Ihtisas Training and Research Hospital	400	2026-08-01	2026-10-26
Laparoscopic Appendectomy: Outcomes of 10 mmHg Versus 15 mmHg Intra-abdominal Pressure Laparoscopic appendectomy with 10 mmHg pneumoperitoneum, Laparoscopic appendectomy with 15 mmHg pneumoperitoneum - Appendectomy, Laparoscopic, Intra Abdominal Pressure	Not applicable	Not yet recruiting	Ankara Etlik City Hospital	150	2026-07-27	2026-07-27
Primary Versus Delayed Wound Closure in Complicated Appendectomy (The HIEDI-Yemen Trial) Primary Closure with HIEDI, Delayed Primary Closure with HIEDI - Appendicitis, Surgical Wound Infection	Not applicable	Not yet recruiting	Sana'a University	200	2026-07-01	2026-07-07
Effect of Endotracheal Tube Cuff Pressure Management on Postoperative Sore Throat in Pediatric Laparoscopic Appendectomy Pressure Transducer, Traditional Palpation Method - Appendicitis Acute, Postoperative Sore Throat, Cough, Hoarseness	Not applicable	Recruiting	Ankara Etlik City Hospital	60	2026-06-30	2026-07-07
Intraperitoneal Hydrocortisone for Postoperative Pain and CRP Following Caesarean Section hydrocortisone, Nornal Saline - Postoperative Pain, Caesarean Section	Phase 4	Completed	Raditsya Mada Gautama, MD	50	2026-06-25	2026-10-23
Feasibility and Safety of a Pediatric ERAS Protocol for Laparoscopic Appendectomy Comprehensive 20-Item Pediatric ERAS Protocol - Appendectomy, Laparoscopic, Acute Appendicitis	Not applicable	Recruiting	Ahmet Burak Doğan, MD	100	2026-06-15	2026-10-15
TACTILE : Validation of a Teleconsultation-Based Predictive Score for the Diagnosis of Acute Appendicitis in Children Using Artificial Intelligence Methods Score-based appendicitis risk classification in teleconsultation - Acute Appendicitis	Not applicable	Not yet recruiting	University Hospital, Angers	1500	2026-06-01	2026-03-18
AIDE: Decision Support for Anastomosis or Colostomy in Emergency Surgery for Complicated Acute Diverticulitis Primary anastomosis, Hartmann's procedure - Complicated Diverticulitis, Acute Diverticulitis		Not yet recruiting	IRCCS San Raffaele Roma	150	2026-05-31	2026-06-16
Effect Of Specimen Extraction Site And Local Anesthesia On Postoperative Pain In Laparoscopic Appendectomy Port-site local anesthesia infiltration, Port-Site Saline Infiltration (Placebo) - Appendectomy, Laparoscopic, Appendicitis Acute	Not applicable	Recruiting	YUNUS YÜKSEL	300	2026-04-24	2026-09-17
Diagnosis of Abdominal Pain Using RNA Levels: The NATURAL Study TruNAV, an RNA-based blood test for host immune activation by infections - Intra Abdominal Infections, Appendicitis Acute		Recruiting	True Bearing Diagnostics, Inc.	1000	2026-04-17	2026-05-12
Comparative Study on the Diagnostic Validity of the Alvarado Score, Appendicitis Inflammatory Response (AIR), and Adult Appendicitis Score (AAS) in Acute Appendicitis at East Lancashire Hospitals NHS Trust (ELHT) Acute Appendicitis		Completed	East Lancashire Hospitals NHS Trust	300	2026-04-13	2026-09-04
First Appendectomy Using Revolve Surgical Robotic Arm Revolve Surgical System - RSS - Appendicitis Acute	Not applicable	Not yet recruiting	Unity Health Toronto	3	2026-04-01	2026-03-06

Showing 20 of 599. Sign in to see all of them.

Narrower conditions

Appendicitis (400)  ·  Peritonitis (116)  ·  Sepsis (41)  ·  Infections (25)  ·  Urinary Tract Infections (16)  ·  Abdominal Pain (14)  ·  Disease (14)  ·  Pain, Postoperative (14)  ·  Pneumonia (14)  ·  Abdomen, Acute (13)  ·  Pain (13)  ·  Cholecystitis (12)  ·  Surgical Wound Infection (12)  ·  Abdominal Abscess (11)

Broader conditions

Infections (574)  ·  Digestive System Diseases (515)  ·  Gastrointestinal Diseases (408)  ·  Intestinal Diseases (408)  ·  Gastroenteritis (402)  ·  Cecal Diseases (400)  ·  Pathological Conditions, Signs and Symptoms (198)  ·  Pathologic Processes (150)  ·  Peritoneal Diseases (121)  ·  Signs and Symptoms (64)  ·  Neurologic Manifestations (61)  ·  Inflammation (57)  ·  Systemic Inflammatory Response Syndrome (50)  ·  Respiratory Tract Diseases (44)

Interventions

Appendectomy (47)  ·  Metronidazole (31)  ·  Ertapenem (12)  ·  Piperacillin, Tazobactam Drug Combination (11)  ·  Amoxicillin-Potassium Clavulanate Combination (10)  ·  Ceftriaxone (10)  ·  Anti-Bacterial Agents (9)  ·  Saline Solution (9)  ·  Tigecycline (9)  ·  Ciprofloxacin (8)  ·  Moxifloxacin (8)  ·  Surgical Procedures, Operative (8)  ·  Laparoscopy (7)  ·  Meropenem (7)  ·  Blood Specimen Collection (6)

Sponsors

Assiut University (11)  ·  Pfizer (10)  ·  Central Hospital, Nancy, France (9)  ·  Children's Mercy Hospital Kansas City (8)  ·  Wyeth is now a wholly owned subsidiary of Pfizer (8)  ·  Turku University Hospital (7)  ·  Helsinki University Central Hospital (6)  ·  Mansoura University (6)  ·  Bayer (5)  ·  Chinese University of Hong Kong (5)  ·  National Taiwan University Hospital (5)  ·  Peking University First Hospital (5)  ·  Cirujanos la Serena (4)  ·  Duke University (4)  ·  Fatih Sultan Mehmet Training and Research Hospital (4)

Countries

United States (98)  ·  Turkey (Türkiye) (46)  ·  France (45)  ·  China (42)  ·  United Kingdom (24)  ·  Egypt (22)  ·  Italy (22)  ·  Canada (20)  ·  Finland (19)  ·  Germany (17)  ·  South Korea (16)  ·  Denmark (15)  ·  Spain (15)  ·  Greece (13)  ·  Israel (11)

Top investigators

Paulina Salminen, MD, PhD (5)  ·  Shawn D St. Peter, MD (4)  ·  David R Flum, MD, MPH (3)  ·  Ewen M Harrison, FRCS, PhD (3)  ·  Santiago Horgan, MD (3)  ·  Benno Mann, PD Dr. med. (2)  ·  Jaroslaw Kobiela, Prof. (2)  ·  Jie Dong (2)  ·  Kyoung Ho Lee, MD (2)

Results publications

PMID 19306980, PMID 19670912, PMID 20211892, PMID 21946218, PMID 2239906, PMID 26677396, PMID 33017106, PMID 34312724, PMID 40741675, PMID 41028542, PMID 10227782, PMID 10231213, PMID 10571434, PMID 10686977, PMID 10843398, PMID 11172350, PMID 11222424, PMID 11257737, PMID 11427329, PMID 11445675, PMID 12470410, PMID 12538172, PMID 12617727, PMID 12771877, PMID 1303622, PMID 14758472, PMID 15108726, PMID 15109590, PMID 15313139, PMID 15319657, PMID 15343467, PMID 15347256, PMID 15448528, PMID 15480707, PMID 15529188, PMID 15529837, PMID 15631364, PMID 15635603, PMID 15673849, PMID 15836853, PMID 15943731, PMID 16034862, PMID 16108734, PMID 16110717, PMID 16823647, PMID 16927930, PMID 16967294, PMID 17040666, PMID 17342966, PMID 17359318

NIH funding

2009 (2), 2016 (2), 2019 (2), 2008 (1), 2025 (1), K12TR004908 (1), R01GM081510 (1), R01GM145674 (1)