41 completed, 6 unknown, 5 withdrawn, 4 not yet recruiting. 20 Phase 3, 12 Phase 4, 8 Phase 2, 7 Not applicable, 5 Phase 1.
Follow Tigecycline: new trials by email Literature Review of Tigecycline trials Research Report on Tigecycline
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Testing a Novel Combination Treatment (Arm D) Versus Standard of Care for Intensive Phase Treatment for Mycobacterium Abscessus Pulmonary Disease in People With or Without Cystic Fibrosis in the Finding the Optimal Regimen for Mycobacterium Abscessus Treatment (FORMaT) Adaptive Platform Trial Sulbactam 25mg/kg -Durlobactam 25mg/kg (Every 6 hours), Ceftriaxone for Injection, Amoxicillin - Mycobacterium Abscessus Pulmonary Disease, Mycobacterium Abscessus Infection | Phase 2 | Not yet recruiting | The University of Queensland | 300 | 2027-04-01 | 2026-03-20 |
| Targeted Versus Standard Peri-operative Antibiotic Prophylaxis in Patients Colonized With Carbapenemase Producing Enterobacterales Undergoing Liver Transplantation Ceftazidime - Avibactam ( CAZ-AVI), Meropenem-Vaborbactam, Imipenem+Relebactam - Liver Transplant, Carbapenem-resistant Enterobacterales | Phase 3 | Not yet recruiting | IRCCS Azienda Ospedaliero-Universitaria di Bologna | 168 | 2026-10-01 | 2026-08-12 |
| Comparing Efficacy and Safety of (Meropenem + Colistin) Versus (Imipenem/Cilastatin + Tigecycline) on Eradication of Multi-Drug Resistance Bacteria "Imipenem/cilastatin" and "Tigecycline", "colistin" and "meropenem" - MDR Bacteria | Phase 2 | Not yet recruiting | Ain Shams University | 60 | 2026-04-01 | 2026-04-13 |
| Comparative Study of Clinical Outcomes and Safety Between Colistin and Tigecycline Colistimethate Sodium, Tigecycline - Infection in ICU | Phase 4 | Active not recruiting | Beni-Suef University | 132 | 2024-12-01 | 2025-03-25 |
| Comparing Tigecycline Vs. Colistimethate in CNS Infections Tigecycline (Tygacil), Colistimethate sodium (CMS) - Central Nervous System Infections | Not yet recruiting | Ain Shams University | 70 | 2024-12-01 | 2024-11-25 | |
| Predictors of Antimicrobial Resistance in the Respiratory Intensive Care Unit of Alexandria Main University Hospital chest x ray, chest X ray, Tigecycline (Tygacil) - Identify the Predictors of Antibiotic Resistance | Completed | Mohamed Sabry | 50 | 2024-10-01 | 2024-12-27 | |
| Comparing Oral Versus Parenteral Antimicrobial Therapy Amoxicillin, amoxicillin-clavulanate, cefadroxil, cefpodoxime, cefalexin, ciprofloxacin, delafloxacin, doxycycline, levofloxacin, linezolid, Ampicillin, ampicillin-sulbactam, cefazolin, cefepime, ceftaroline, ceftazidime, ceftazidime-avibactam, dalbavancin, daptomycin, ertapenem - Endovascular Infection, Bone and Joint Infection | Phase 4 | Terminated | West Virginia University | 94 | 2023-08-04 | 2025-08-26 |
| Efficacy of Taurolidine Containing Lock Solution for Prevention of Central Venous Catheter Infection in ICU Patients Saline, Tigecycline and heparin, Taurolidine-citrate-heparin - Taurolidine, Lock Solution | Not applicable | Completed | Tanta University | 120 | 2023-05-01 | 2026-01-26 |
| Clinical Effectiveness of Tigecycline for Scrub Typhus. doxycycline, Tigecycline (Tygacil) - Scrub Typhus | Not applicable | Completed | Jin Soo Lee | 27 | 2022-11-19 | 2026-08-11 |
| Antibiotic Therapy for Infectious Diseases Tigecycline - Infectious Disease | Unknown | Shandong University | 300 | 2021-06-01 | 2021-06-24 | |
| Management of Ventilation Acquired Pneumonia Caused by Pseudomonas and Acinetobacter Organisms in a Pediatric Center extended meropenem infusion in combination with other options such as Polymyxin, Tigecycline, Ertapenem, or Amikacin., two β-lactam antibiotics plus a single non-β-lactam antibiotic, Control group received standard therapy - Ventilation Acquired Pneumonia | Phase 3 | Completed | Beni-Suef University | 64 | 2021-01-01 | 2024-12-18 |
| Personalized Treatment of Urogenital Cancers Depends on the Microbiome Tigecycline 50 MG, Placebo - Microbial Disease | Not applicable | Recruiting | Zealand University Hospital | 28 | 2020-05-01 | 2024-01-30 |
| Finding the Optimal Regimen for Mycobacterium Abscessus Treatment Amikacin, Tigecycline, Imipenem - Pulmonary Disease Due to Mycobacteria (Diagnosis) | Phase 2 / Phase 3 | Recruiting | The University of Queensland | 300 | 2020-03-02 | 2026-05-11 |
| A Randomized Controlled Trial Comparing Imipenem and Tigecycline Versus Imipenem and Tigecycline With GM-CSF for the Management of Spontaneous Bacterial Peritonitis Presenting With Septic Shock. Imipenem, Tigecycline, GMCSF - Spontaneous Bacterial Peritonitis | Not applicable | Unknown | Institute of Liver and Biliary Sciences, India | 90 | 2019-12-20 | 2021-02-16 |
| Delafloxacin IV and OS Administration Compared to Best Available Therapy in Patients With Surgical Site Infections Delafloxacin, Vancomycin, Linezolid - Surgical Site Infection | Phase 3 | Terminated | Menarini Group | 268 | 2019-09-25 | 2022-02-02 |
| Comparative Clinical Study Between Colistin-Tigecycline Combined Therapy Versus Colistin-Meropenem Combined Therapy in Treatment of Blood Stream Infections With Multidrug-Resistant Klebsiella Pneumoniae Colistin, Meropenem, Tigecycline - Treatment of Blood Stream Infections Due to Multidrug-Resistant Klebsiella Pneumoniae | Phase 4 | Unknown | Al-Azhar University | 60 | 2019-09-21 | 2020-07-29 |
| The Combined Antibiotic Therapy for Carbapenem Resistant Klebsiella Pneumoniae Fosfomycin, Tigecycline, Polymyxin B - Antibiotic Resistant Infection | Early Phase 1 | Unknown | Shanghai 10th People's Hospital | 80 | 2019-01-01 | 2019-05-15 |
| Study of Tigecycline Pharmacokinetics in Patients Undergoing Continuous Renal Replacement Therapy(CRRT) Tigecycline - Bacterial Infection, Critically Ill | Unknown | Zhujiang Hospital | 20 | 2016-08-01 | 2016-10-13 | |
| The Comparison of Outcomes of Antibiotic Drugs and Appendectomy (CODA) Trial Cefoxitin, Ertapenem, Moxifloxacin, Tigecycline, Ticarcillin-Clavulanic Acid; Metronidazole plus Cefazolin, Cefuroxime, Ceftriaxone, Cefotaxime, Ciprofloxacin, or Levofloxacin, Appendectomy - Appendicitis | Not applicable | Completed | University of Washington | 1552 | 2016-05-01 | 2023-05-06 |
| A Study of Plazomicin Compared With Colistin in Patients With Infection Due to Carbapenem-Resistant Enterobacteriaceae (CRE) plazomicin, colistin, meropenem - Bloodstream Infections (BSI) Due to CRE, Hospital-Acquired Bacterial Pneumonia (HABP) Due to CRE | Phase 3 | Completed | Achaogen, Inc. | 69 | 2014-09-16 | 2018-10-16 |
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Infections (9) · Bacterial Infections (8) · Cross Infection (5) · Intraabdominal Infections (5) · Pneumonia, Bacterial (5) · Skin Diseases, Infectious (5) · Cellulitis (4) · Peritonitis (4) · Pneumonia (4) · Skin Diseases, Bacterial (4) · Abdominal Abscess (3) · Appendicitis (3) · Community-Acquired Infections (3) · Cholecystitis (2) · Diverticulitis (2)
Wyeth is now a wholly owned subsidiary of Pfizer (22) · Pfizer (9) · Ain Shams University (2) · Beni-Suef University (2) · The University of Queensland (2) · University of California, San Diego (2) · Achaogen, Inc. (1) · Al-Azhar University (1) · CPL Associates (1) · Federico II University (1) · Gary E. Stein, Pharm.D. (1) · IRCCS Azienda Ospedaliero-Universitaria di Bologna (1) · Institute of Liver and Biliary Sciences, India (1) · Jin Soo Lee (1) · Mahidol University (1)
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Aaron Schimmer, MD (1) · Arif R. Sarwari, MD, MSc, MBA (1) · David A Talan, MD (1) · David R Flum, MD, MPH (1) · Dennis G Maki, M.D. (1) · Gary Stein, PharmD (1) · Guglielmo Borgia (1) · Jeanne Breen, MD (1) · Jin-Soo Lee, MD., PhD. (1) · Joy J. Juskowich, MD (1) · Li Hua, master (1)
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