46 completed, 11 unknown, 5 terminated, 3 recruiting. 27 Phase 3, 22 Phase 4, 15 Phase 2, 6 Not applicable, 3 Phase 1.
Follow Ertapenem: new trials by email Literature Review of Ertapenem trials Research Report on Ertapenem
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cefotetan Therapy for Escherichia Coli Infections Cefotetan, Carbapenems, Beta Lactam Antibiotics - E Coli Infection, ESBL Producing E.Coli | Phase 2 | Recruiting | Oregon Health and Science University | 50 | 2026-06-26 | 2026-10-16 |
| Does Staphylococcus Aureus Bacteremia Early Dual Therapy Improve Outcomes? Early Dual IV Antibiotic Therapy - MRSA, Early Dual IV Antibiotic Therapy - MSSA, Single Agent IV Antibiotic Therapy - MRSA - Staphylococcus Aureus Bacteremia | Phase 4 | Enrolling by invitation | West Virginia University | 300 | 2025-09-15 | 2026-09-17 |
| PRevention Of Trauma-related Infections Through an Embedded Clinical Trials Network Ertapenem, Cefazolin and Metronidazole. - Surgical Site Infection | Phase 4 | Not yet recruiting | The University of Texas Health Science Center, Houston | 300 | 2025-05-01 | 2025-04-11 |
| Combination Cefazolin With Ertapenem for Methicillin-susceptible Staphylococcus Aureus Bacteremia Ertapenem, Placebo - Staphylococcus Aureus Bacteremia, Staphylococcus Aureus Septicemia | Phase 2 | Recruiting | Todd C. Lee MD MPH FIDSA | 60 | 2024-05-20 | 2026-09-11 |
| Comparing Oral Versus Parenteral Antimicrobial Therapy Amoxicillin, amoxicillin-clavulanate, cefadroxil, cefpodoxime, cefalexin, ciprofloxacin, delafloxacin, doxycycline, levofloxacin, linezolid, Ampicillin, ampicillin-sulbactam, cefazolin, cefepime, ceftaroline, ceftazidime, ceftazidime-avibactam, dalbavancin, daptomycin, ertapenem - Endovascular Infection, Bone and Joint Infection | Phase 4 | Terminated | West Virginia University | 94 | 2023-08-04 | 2025-08-26 |
| Safety Study of Intravenous Ertapenem in Combination With Zidebactam (WCK 6777) Ertapenem, Placebo, WCK 6777 - Bacterial Infection | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 54 | 2023-04-19 | 2025-01-20 |
| Management of Ventilation Acquired Pneumonia Caused by Pseudomonas and Acinetobacter Organisms in a Pediatric Center extended meropenem infusion in combination with other options such as Polymyxin, Tigecycline, Ertapenem, or Amikacin., two β-lactam antibiotics plus a single non-β-lactam antibiotic, Control group received standard therapy - Ventilation Acquired Pneumonia | Phase 3 | Completed | Beni-Suef University | 64 | 2021-01-01 | 2024-12-18 |
| Prophylactic Antibiotics for Urinary Tract Infections After Robot-Assisted Radical Cystectomy Clindamycin, Diary, Ertapenem - Bladder Carcinoma, Refractory Bladder Carcinoma | Phase 4 | Completed | Roswell Park Cancer Institute | 89 | 2020-09-02 | 2026-09-29 |
| Combination Antibiotic Therapy Compared to Monotherapy in the Treatment of Acute COPD Beta-Lactams, Fluoroquinolone - COPD Exacerbation Acute | Phase 2 / Phase 3 | Completed | Haiphong University of Medicine and Pharmacy | 170 | 2020-01-01 | 2021-05-10 |
| Study to Assess the Efficacy, Safety and Pharmacokinetics of Orally Administered Tebipenem Pivoxil Hydrobromide (SPR994) Compared to Intravenous Ertapenem in Participants With Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP) TBPM-PI-HBr, Ertapenem, Dummy Infusion - Complicated Urinary Tract Infection, Acute Pyelonephritis | Phase 3 | Completed | Spero Therapeutics | 1372 | 2019-06-03 | 2022-07-25 |
| Ertapenem for Initial Empirical Treatment of Third Generation Cephalosporin Resistant Enterobacteriaceae Bacteremia Ertapenem, Carbapenems - Bacteremia, Infection, Bacterial | Completed | Phramongkutklao College of Medicine and Hospital | 427 | 2019-05-15 | 2023-03-29 | |
| Piperacillin/Tazobactam Versus Carbapenems in Non-bacteremic UTI Due to -ESBL-producing Enterobacteriaceae Meropenem, Ertapenem 1000 MG, Piperacillin, Tazobactam 4-0.5G Solution for Injection - Urinary Tract Infections, Enterobacteriaceae Infections | Phase 4 | Suspended | Universidad del Norte | 198 | 2019-04-01 | 2024-12-06 |
| A Study to Assess Efficacy and Safety Intravenous Benapenem in Patients With Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP) Benapenem, Ertapenem - Complicated Urinary Tract Infection Including Acute Pyelonephritis | Phase 2 / Phase 3 | Completed | Sihuan Pharmaceutical Holdings Group Ltd. | 112 | 2018-12-13 | 2020-08-10 |
| Sulopenem Followed by Sulopenem-etzadroxil/Probenecid vs Ertapenem Followed by Cipro for Complicated UTI in Adults Sulopenem, Sulopenem-Etzadroxil/Probenecid, Ertapenem - Complicated Urinary Tract Infections | Phase 3 | Completed | Iterum Therapeutics, International Limited | 1395 | 2018-09-18 | 2020-12-29 |
| Sulopenem Versus Ertapenem for Complicated Intra-abdominal Infection (cIAI) Ertapenem, Sulopenem-Etzadroxil/Probenecid, Ciprofloxacin - Intra Abdominal Infections | Phase 3 | Completed | Iterum Therapeutics, International Limited | 674 | 2018-09-18 | 2020-12-01 |
| A Single Center, Prospective Clinical Trial of Intravenous Ertapenem in the Treatment of Hurley Stage II or III Hidradenitis Suppurativa Ertapenem - Hidradenitis Suppurativa | Withdrawn | Henry Ford Health System | 2018-03-01 | 2022-02-24 | ||
| Study to Evaluate EBA, Safety and Tolerability of Carbapenems in Adults With Pulmonary Tuberculosis Meropenem 6g IV over 6 hours, Ertapenem 1g IM, Meropenem 3g IV - Pulmonary Tuberculosis | Phase 2 | Completed | TASK Applied Science | 134 | 2017-11-09 | 2023-06-09 |
| New AntiBiotic Treatment Options for Uncomplicated Anogenital GOnorrhoea Ertapenem 1000 MG, Fosfomycin Oral Suspension, Gentamicin Sulfate, Injectable - Gonorrhea | Phase 3 | Completed | Public Health Service of Amsterdam | 346 | 2017-09-18 | 2021-08-06 |
| Antibiotics vs. Placebo in Acute Uncomplicated Appendicitis Ertapenem, Placebo - Acute Appendicitis | Not applicable | Enrolling by invitation | Turku University Hospital | 147 | 2017-08-09 | 2020-11-10 |
| Ertapenem Administered Subcutaneously Versus Intravenously Ertapenem - Urinary Tract Infections | Phase 3 | Terminated | Instituto Nacional de Cancer, Brazil | 30 | 2017-06-01 | 2022-08-11 |
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Urinary Tract Infections (10) · Appendicitis (7) · Infections (5) · Intraabdominal Infections (5) · Escherichia coli Infections (4) · Bacteremia (3) · Bacterial Infections (3) · Sepsis (3) · Soft Tissue Infections (3) · Surgical Wound Infection (3) · Community-Acquired Pneumonia (2) · Diabetes Complications (2) · Diabetic Foot (2) · Enterobacteriaceae Infections (2) · Kidney Failure, Chronic (2)
Merck Sharp & Dohme LLC (14) · Tetraphase Pharmaceuticals, Inc (3) · Turku University Hospital (3) · Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (2) · Iterum Therapeutics, International Limited (2) · Mahidol University (2) · National University Hospital, Singapore (2) · West Virginia University (2) · A.O. Ospedale Papa Giovanni XXIII (1) · Albany College of Pharmacy and Health Sciences (1) · Assistance Publique - Hôpitaux de Paris (1) · Assistance Publique Hopitaux De Marseille (1) · Bayer (1) · Beni-Suef University (1) · Catholic University of the Sacred Heart (1)
United States (21) · Latvia (8) · Bulgaria (6) · Estonia (6) · France (6) · Hungary (6) · Romania (6) · China (5) · Germany (5) · Russia (5) · Thailand (5) · Ukraine (5) · Finland (4) · Georgia (4) · Italy (4)
Patrick T Horn, MD, PhD (2) · Paulina Salminen, MD, PhD (2) · Andres F Estupinan Bohorquez, MD (1) · Antonio Daniele Pinna, MD (1) · Arif R Sawari, MD, MSc, MBA (1) · Arif R. Sarwari, MD, MSc, MBA (1) · Brant T Heniford, M.D. (1) · Bruce A Mueller, Pharm.D. (1) · Chang-Seop Lee, MD/Prof. (1) · Cristina Puggioli, MD (1) · Dale A Fisher (1)
PMID 40741675, PMID 16291062, PMID 21501482, PMID 21576440, PMID 22189340, PMID 22563210, PMID 23578794, PMID 23631512, PMID 24323468, PMID 24342651, PMID 24439136, PMID 25151205, PMID 26080338, PMID 26544316, PMID 26888908, PMID 27324263, PMID 27851857, PMID 28249572, PMID 28591824, PMID 28601833, PMID 29146633, PMID 29356761, PMID 29992286, PMID 30264120, PMID 30391919, PMID 30558607, PMID 30561562, PMID 31570004, PMID 31641767, PMID 31730164, PMID 32074268, PMID 33427870, PMID 35065063, PMID 35388666, PMID 35576384, PMID 35612859, PMID 35796152, PMID 35815898, PMID 35820778, PMID 36068705, PMID 36197656, PMID 37252945, PMID 37328522, PMID 37379001, PMID 38215770, PMID 38630471, PMID 38630482, PMID 40279497, PMID 41419216, PMID 41433510
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