23 completed, 4 unknown, 3 terminated, 2 not yet recruiting. 35 Phase 2, 5 Phase 1, 5 Phase 3.
Follow Intraabdominal Infections: new trials by email Literature Review of Intraabdominal Infections trials Research Report on Intraabdominal Infections
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Patient Choice Between Antibiotics and Appendectomy in Uncomplicated Appendicitis (FRENCH 47 - ALACARTE) Shared decision-making, amoxicillin-clavulanate, Appendectomy - Acute Appendicitis | Phase 2 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 560 | 2026-10-01 | 2026-10-05 |
| Efficacy of Fuzheng Tongfu Jiedu Prescription for Treating Gastrointestinal Dysfunction Associated With Sepsis Fuzheng Tongfu Jiedu prescription (FZTFJD), Placebo - Sepsis Abdominal, Gastrointestinal Dysfunction | Phase 1 / Phase 2 | Not yet recruiting | Dongzhimen Hospital, Beijing | 70 | 2025-04-25 | 2025-04-18 |
| Piperacillin/Tazobactam Versus ceftriAxone and Metronidazole for Children With Perforated Appendicitis (ALPACA) Piperacillin/tazobactam, Normal saline, CefTRIAXone Injection - Appendicitis Perforated | Phase 2 | Completed | McMaster Children's Hospital | 16 | 2024-09-09 | 2026-07-07 |
| Antibiotic Instillation in Appendicitis Ceftriaxone, Intra-peritoneal Fluid Aspiration - Complicated Appendicitis, Acute Appendicitis | Phase 2 | Completed | Johns Hopkins All Children's Hospital | 190 | 2023-01-05 | 2025-03-13 |
| Pharmacokinetics of Meropenem and Aztreonam After Intraperitoneal Administration Via Cycler-therapy in APD Patients Without Peritonitis Meropenem 1000 mg, Aztreonam 2000 mg, automated peritoneal dialysis with following long time dwell - Peritoneal Dialysis Associated Peritonitis, Peritoneal Dialysis (PD) | Phase 2 / Phase 3 | Completed | Karl Landsteiner Insitute for Nephrology and Haemato-Oncology | 12 | 2021-08-31 | 2025-08-11 |
| Laparoscopically Guided Rectus Sheath Block in Pediatric Appendicitis Rectus Sheath Block with 0.25% bupivicaine with 1:200 000 epinephrine, Local Anesthetic Infiltration with 0.25% bupivicaine with 1:200 000 epinephrine - Appendicitis Acute | Phase 2 | Completed | University of Alberta | 42 | 2021-05-28 | 2024-03-12 |
| A Phase 2 Study Evaluating Efficacy, Safety and Tolerability of Different Doses and Regimens of Allocetra-OTS for the Treatment of Organ Failure in Adult Sepsis Patients Allocetra-OTS, Placebo - Sepsis, Community-acquired Pneumonia | Phase 2 | Completed | Enlivex Therapeutics Ltd. | 148 | 2020-11-30 | 2025-08-19 |
| Use of Antibiotic Irrigation to Decrease Wound Infections in Pediatric Perforated Appendicitis antibiotic rinse with suction, suction only - Perforated Appendicitis | Phase 2 | Active not recruiting | Prisma Health-Upstate | 200 | 2019-07-25 | 2026-01-27 |
| The Role of Contrast Enhanced Ultrasound in Appendicitis Sulfur hexafluoride lipid-type A microspheres - Acute Appendicitis | Phase 2 | Completed | Children's Mercy Hospital Kansas City | 37 | 2019-01-04 | 2023-09-08 |
| Non-operative Treatment of Acute Non-perforated Appendicitis Meronem and flagyl, Appendectomy - Acute Appendicitis | Phase 2 / Phase 3 | Completed | King Edward Medical University | 180 | 2018-09-01 | 2021-02-18 |
| LYS228 PK, Clinical Response, Safety and Tolerability in Patients With Complicated Intra-abdominal Infection (cIAI) LYS228, Standard of care therapy - Intra-abdominal Infections | Phase 2 | Terminated | Novartis Pharmaceuticals | 3 | 2018-05-15 | 2021-10-11 |
| Intraperitoneal Administration of Fosfomycin, Metronidazole and Molgramostim Versus Intravenous Antibiotics for Perforated Appendicitis Combination of fosfomycin, metronidazole and rhGM-CSF (administered together intraperitoneally) and three days of antibiotics p.o., Standard antibiotics intravenously - Appendicitis Perforated | Phase 2 | Completed | Herlev Hospital | 13 | 2018-02-14 | 2018-10-16 |
| Prospective, Randomized Trial of Personalized Medicine With Pentaglobin® After Surgical Infectious Source Control in Patients With Peritonitis Pentaglobin®/Standard of Care - Peritonitis, Sepsis | Phase 2 | Recruiting | RWTH Aachen University | 200 | 2017-11-20 | 2026-06-11 |
| The Effects of Oral Vitamin D Supplementation on the Prevention of Peritoneal Dialysis-related Peritonitis Cholecalciferol (2000iu qd), Routine therapy for PD - Peritoneal Dialysis-associated Peritonitis, Vitamin D Deficiency | Phase 2 | Completed | Peking University First Hospital | 60 | 2017-09-30 | 2021-08-18 |
| Narcotic vs. Non-narcotic Pain Regimens After Pediatric Appendectomy Non-narcotic pain control - Appendicitis, Pain, Postoperative | Phase 1 / Phase 2 | Withdrawn | University of Utah | 2017-09-05 | 2020-02-07 | |
| The Safety and Pharmacokinetics of Intraperitoneal Administration in Patients Undergoing Appendectomy for Uncomplicated Appendicitis A combination of fosfomycin, metronidazole and GM-CSF i.p. - Appendicitis | Phase 2 | Completed | Herlev Hospital | 14 | 2017-02-24 | 2019-05-29 |
| Clinical Trial Comparing ERAT vs Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis Ertapenem, Levofloxacin and Metronidazole, Endoscopic retrograde appendicitis therapy (ERAT), Appendectomy - Acute Appendicitis | Phase 2 | Unknown | First Affiliated Hospital Xi'an Jiaotong University | 240 | 2016-05-01 | 2016-06-03 |
| Dilute Povidone-iodine Irrigation vs No Irrigation for Children With Acute, Perforated Appendicitis Povidone-iodine irrigation, No irrigation - Acute, Perforated Appendicitis | Phase 2 | Completed | The University of Texas Health Science Center, Houston | 100 | 2016-04-01 | 2019-04-17 |
| Nebulized Analgesia for Laparoscopic Appendectomy Trial Ropivacaine, Normal saline - Appendicitis | Phase 1 / Phase 2 | Unknown | McGill University Health Centre/Research Institute of the McGill University Health Centre | 200 | 2016-01-01 | 2016-03-22 |
| Comparative Evaluation of Intra-operative Peritoneal Lavage With Super Oxidized Solution and Normal Saline in Peritonitis Cases Super Oxidized Solution in group I - Peritonitis | Phase 2 | Completed | Maharishi Markendeswar University (Deemed to be University) | 290 | 2014-12-01 | 2016-08-30 |
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Appendicitis (16) · Peritonitis (8) · Sepsis (5) · Infections (4) · Ototoxicity (2) · Abdominal Abscess (1) · Abscess (1) · Agnosia (1) · Bacterial Infections (1) · Burns (1) · Cholecystitis, Acute (1) · Community-Acquired Pneumonia (1) · Deafness (1) · Enterocolitis, Necrotizing (1)
Infections (31) · Digestive System Diseases (26) · Gastroenteritis (17) · Gastrointestinal Diseases (17) · Intestinal Diseases (17) · Cecal Diseases (16) · Pathologic Processes (10) · Pathological Conditions, Signs and Symptoms (10) · Peritoneal Diseases (8) · Inflammation (6) · Systemic Inflammatory Response Syndrome (4) · Respiratory Tract Diseases (3) · Respiratory Tract Infections (3) · Bacterial Infections and Mycoses (2)
Metronidazole (6) · Meropenem (4) · Appendectomy (3) · Piperacillin, Tazobactam Drug Combination (3) · Saline Solution (3) · Acetylcysteine (2) · Ceftriaxone (2) · Clindamycin (2) · Ertapenem (2) · Gentamicins (2) · Ropivacaine (2) · 3-(aminomethyl)-7-(3-hydroxypropoxy)-1-hydroxy-1,3-dihydro-2,1-benzoxaborole (1) · Amoxicillin-Potassium Clavulanate Combination (1) · Ampicillin (1) · Aztreonam (1)
Herlev Hospital (2) · Merck Sharp & Dohme LLC (2) · TC Erciyes University (2) · Assistance Publique - Hôpitaux de Paris (1) · Astellas Pharma Inc (1) · Children's Mercy Hospital Kansas City (1) · Critical Biologics Corporation (1) · Dongzhimen Hospital, Beijing (1) · Enlivex Therapeutics Ltd. (1) · First Affiliated Hospital Xi'an Jiaotong University (1) · GlaxoSmithKline (1) · Göteborg University (1) · Helsinki University Central Hospital (1) · Johns Hopkins All Children's Hospital (1) · Karl Landsteiner Insitute for Nephrology and Haemato-Oncology (1)
United States (11) · Canada (5) · China (4) · France (4) · Austria (3) · Belgium (3) · Denmark (3) · Spain (3) · Turkey (Türkiye) (3) · Finland (2) · Germany (2) · Israel (2) · Italy (2) · Mexico (2) · Czechia (1)
Bulent Tokgoz, MD (1) · Danny Benjamin, MD, PhD, MPH (1) · Gernot Marx, Univ.-Prof. (1) · Ismail Kocyigit, MD (1) · Jie Dong (1) · Jin Liu, Dr (1) · Kent Lundholm (1) · KuoJen Tsao, MD (1) · Martin F Wiesholzer, MD (1) · Martin Sanchez-Aguilar, MSc (1) · Michael H Livingston, MD, MSc (1)
PMID 11427329, PMID 17359318, PMID 19358184, PMID 21551083, PMID 21958060, PMID 22249106, PMID 22955430, PMID 23772043, PMID 25073872, PMID 25581711, PMID 26270686, PMID 27437029, PMID 27503659, PMID 30061293, PMID 30366723, PMID 30832742, PMID 31040341, PMID 31567357, PMID 31779675, PMID 32432123, PMID 32914187, PMID 33902072, PMID 41202087
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