281 completed, 79 unknown, 50 recruiting, 25 terminated. 193 Not applicable, 38 Phase 2, 34 Phase 1, 33 Phase 4, 21 Phase 3.
Follow Cecal Diseases: new trials by email Literature Review of Cecal Diseases trials Research Report on Cecal Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Piperacillin/Tazobactam Versus Ceftriaxone and Metronidazole for Children With Perforated Appendicitis Piperacillin/Tazobactam, Ceftriaxone + Metronidazole - Appendicitis Perforated, Appendectomy, Laparoscopic | Phase 3 | Not yet recruiting | McMaster Children's Hospital | 180 | 2027-04-01 | 2026-10-09 |
| Povidone-iodine Irrigation for Prevention of Intra-abdominal Abscess in Pediatric Perforated Appendicitis: a Multi-center Stepped Wedge Cluster Randomized Study Irrigation with PVI, Usual care - Acute, Perforated Appendicitis | Phase 4 | Not yet recruiting | The University of Texas Health Science Center, Houston | 1750 | 2027-03-01 | 2025-02-10 |
| Pressurized Intraperitoneal Aerosolized Chemotherapy With Mitomycin for the Treatment of Unresectable Appendix or Colorectal Cancer With Peritoneal Metastases, The IMPACT Trial Bevacizumab, Biopsy Procedure, Biospecimen Collection - Metastatic Appendix Carcinoma, Metastatic Colorectal Carcinoma | Phase 3 | Recruiting | City of Hope Medical Center | 129 | 2027-01-04 | 2026-11-05 |
| Perforated Appendicitis and Postoperative Antibiotics Pilot Trial Postoperative antibiotico-prophylaxis, No postoperative antibiotics - Perforated Appendicitis | Not applicable | Not yet recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 100 | 2027-01-01 | 2026-09-17 |
| Comparative Study Between Laparoscopic and Open Appendectomy of Complicated Appendicitis Laparoscopic Appendectomy, Open Appendectomy - Appendicitis, Perforated Appendicitis | Not applicable | Not yet recruiting | Assiut University | 100 | 2026-11-01 | 2026-10-16 |
| Laparoscopic vs Open Appendectomy in Obese Patients Open Appendectomy, Laparoscopic Appendectomy - Acute Appendicitis, Appendicitis (Diagnosis) | Not applicable | Not yet recruiting | University of Health Sciences Lahore | 166 | 2026-10-02 | 2026-09-16 |
| Patient Choice Between Antibiotics and Appendectomy in Uncomplicated Appendicitis (FRENCH 47 - ALACARTE) Shared decision-making, amoxicillin-clavulanate, Appendectomy - Acute Appendicitis | Phase 2 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 560 | 2026-10-01 | 2026-10-05 |
| Immediate Laparoscopic Appendectomy Versus Interval Laparoscopic Appendectomy for Early Appendicular Mass Immediate Laparoscopic Appendectomy, Interval Laparoscopic Appendectomy - Appendicular Mass, Acute Appendicitis | Not applicable | Not yet recruiting | Assiut University | 100 | 2026-10-01 | 2026-09-23 |
| Video-Based Grading of Intraoperative Adverse Events in Pediatric Laparoscopic Appendectomy Laparoscopic appendectomy - Appendicitis, Acute, Appendectomy | Recruiting | Ahmet Burak Doğan, MD | 80 | 2026-09-01 | 2026-09-04 | |
| Safety and Efficacy of PIPAC Using Single Agent Mitomycin in Solid Tumors Mitomycin C (MMC), Pressurized Intraperitoneal Aerosolized Chemotherapy (PIPAC) - Peritoneal Carcinomatosis | Phase 1 | Recruiting | H. Lee Moffitt Cancer Center and Research Institute | 24 | 2026-08-05 | 2026-09-16 |
| Prospective Comparison of Pro-Adrenomedullin, C-Reactive Protein, and Neutrophil-to-Lymphocyte Ratio for Diagnosing Acute Appendicitis Serum Pro-Adrenomedullin Measurement - Acute Appendicitis | Recruiting | Bursa Yuksek Ihtisas Training and Research Hospital | 400 | 2026-08-01 | 2026-10-26 | |
| Laparoscopic Appendectomy: Outcomes of 10 mmHg Versus 15 mmHg Intra-abdominal Pressure Laparoscopic appendectomy with 10 mmHg pneumoperitoneum, Laparoscopic appendectomy with 15 mmHg pneumoperitoneum - Appendectomy, Laparoscopic, Intra Abdominal Pressure | Not applicable | Not yet recruiting | Ankara Etlik City Hospital | 150 | 2026-07-27 | 2026-07-27 |
| Systemic and Tissue Inflammatory Biomarkers in Acute Appendicitis appendectomy - Acute Appendicitis | Recruiting | Haydarpasa Numune Training and Research Hospital | 60 | 2026-07-12 | 2026-11-09 | |
| Primary Versus Delayed Wound Closure in Complicated Appendectomy (The HIEDI-Yemen Trial) Primary Closure with HIEDI, Delayed Primary Closure with HIEDI - Appendicitis, Surgical Wound Infection | Not applicable | Not yet recruiting | Sana'a University | 200 | 2026-07-01 | 2026-07-07 |
| Effect of Endotracheal Tube Cuff Pressure Management on Postoperative Sore Throat in Pediatric Laparoscopic Appendectomy Pressure Transducer, Traditional Palpation Method - Appendicitis Acute, Postoperative Sore Throat, Cough, Hoarseness | Not applicable | Recruiting | Ankara Etlik City Hospital | 60 | 2026-06-30 | 2026-07-07 |
| Feasibility and Safety of a Pediatric ERAS Protocol for Laparoscopic Appendectomy Comprehensive 20-Item Pediatric ERAS Protocol - Appendectomy, Laparoscopic, Acute Appendicitis | Not applicable | Recruiting | Ahmet Burak Doğan, MD | 100 | 2026-06-15 | 2026-10-15 |
| TACTILE : Validation of a Teleconsultation-Based Predictive Score for the Diagnosis of Acute Appendicitis in Children Using Artificial Intelligence Methods Score-based appendicitis risk classification in teleconsultation - Acute Appendicitis | Not applicable | Not yet recruiting | University Hospital, Angers | 1500 | 2026-06-01 | 2026-03-18 |
| Technical Feasibility of Modified Early Post-Operative Intraperitoneal Chemotherapy (mEPIC) Modified early post-operative intraperitoneal chemotherapy (mEPIC) - Peritoneal Carcinomatosis, Appendiceal Neoplasms | Phase 2 | Recruiting | Ciusss de L'Est de l'Île de Montréal | 25 | 2026-05-01 | 2026-05-14 |
| Molecular Profiling for Risk Stratification in Appendiceal Cancer DNA Methylation Profiling, m6A Epitranscriptomic Profiling - Appendiceal Cancer, Appendiceal Adenocarcinoma | Recruiting | City of Hope Medical Center | 400 | 2026-05-01 | 2026-06-29 | |
| Effect Of Specimen Extraction Site And Local Anesthesia On Postoperative Pain In Laparoscopic Appendectomy Port-site local anesthesia infiltration, Port-Site Saline Infiltration (Placebo) - Appendectomy, Laparoscopic, Appendicitis Acute | Not applicable | Recruiting | YUNUS YÜKSEL | 300 | 2026-04-24 | 2026-09-17 |
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Appendicitis (401) · Appendiceal Neoplasms (85) · Stomach Neoplasms (40) · Colorectal Neoplasms (38) · Colonic Neoplasms (37) · Pancreatic Neoplasms (34) · Rectal Neoplasms (32) · Esophageal Neoplasms (29) · Gallbladder Neoplasms (25) · Neoplasms (23) · Bile Duct Neoplasms (22) · Anus Neoplasms (21) · Carcinoma, Hepatocellular (21) · Carcinoma, Non-Small-Cell Lung (16) · Breast Neoplasms (15)
Digestive System Diseases (486) · Intestinal Diseases (485) · Gastrointestinal Diseases (484) · Gastroenteritis (400) · Infections (400) · Intraabdominal Infections (395) · Pathological Conditions, Signs and Symptoms (128) · Digestive System Neoplasms (88) · Neoplasms by Site (87) · Intestinal Neoplasms (86) · Cecal Neoplasms (84) · Pathologic Processes (80) · Gastrointestinal Neoplasms (76) · Neoplasms (73)
Appendectomy (49) · Metronidazole (25) · Mitomycin (11) · Oxaliplatin (11) · Amoxicillin-Potassium Clavulanate Combination (8) · Anti-Bacterial Agents (8) · Ceftriaxone (8) · Surgical Procedures, Operative (8) · Ertapenem (7) · Hyperthermic Intraperitoneal Chemotherapy (7) · Laparoscopy (7) · Leucovorin (7) · Piperacillin, Tazobactam Drug Combination (7) · Fluorouracil (6) · Irinotecan (6)
Assiut University (9) · National Cancer Institute (NCI) (9) · Children's Mercy Hospital Kansas City (8) · Wake Forest University Health Sciences (8) · Turku University Hospital (7) · Mansoura University (6) · Helsinki University Central Hospital (5) · University of Washington (5) · Cirujanos la Serena (4) · Fatih Sultan Mehmet Training and Research Hospital (4) · Herlev Hospital (4) · National Taiwan University Hospital (4) · University of California, San Diego (4) · Zagazig University (4) · Ankara City Hospital Bilkent (3)
United States (142) · Turkey (Türkiye) (42) · France (22) · China (18) · Egypt (18) · United Kingdom (17) · Finland (16) · Canada (15) · South Korea (15) · Spain (14) · Denmark (13) · Italy (12) · Netherlands (11) · Croatia (9) · Germany (9)
Paulina Salminen, MD, PhD (5) · Shawn D St. Peter, MD (4) · David R Flum, MD, MPH (3) · Ewen M Harrison, FRCS, PhD (3) · Santiago Horgan, MD (3) · Andrew M Blakely, M.D. (2) · Benno Mann, PD Dr. med. (2) · Dominique Elias, MD (2) · Franco M. Muggia, MD (2) · Kyoung Ho Lee, MD (2) · Kyuseok Kim, MD (2) · Marcelo A Beltran, M.D. (2)
PMID 19306980, PMID 19670912, PMID 20211892, PMID 21946218, PMID 2239906, PMID 33017106, PMID 34312724, PMID 40741675, PMID 10231213, PMID 10571434, PMID 10686977, PMID 11172350, PMID 11222424, PMID 11257737, PMID 11427329, PMID 11919233, PMID 12115365, PMID 12393999, PMID 1303622, PMID 14981738, PMID 15109590, PMID 15313139, PMID 15343467, PMID 15347256, PMID 15480707, PMID 15529837, PMID 15631364, PMID 15635603, PMID 15943731, PMID 16034862, PMID 16108734, PMID 16110717, PMID 16849762, PMID 17040666, PMID 1742380, PMID 17453494, PMID 17877828, PMID 18470481, PMID 18493824, PMID 18553045, PMID 18723709, PMID 19040944, PMID 19141492, PMID 19358184, PMID 19490638, PMID 19573663, PMID 19672084, PMID 19690306, PMID 19760332, PMID 20108149
P30CA016087 (2), P30CA033572 (2), P30CA068485 (2), 2009 (1), 2017 (1), 2019 (1), 2025 (1), K01AT008219 (1), K12TR004908 (1), P01CA087971 (1), P30CA012197 (1), P30CA013330 (1), P30CA015083 (1), P30CA015704 (1), P30CA016672 (1)