9 completed, 5 unknown, 2 terminated, 1 recruiting. 7 Phase 2, 5 Phase 3, 2 Phase 4, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 7 | Completed 5, Recruiting 1, Unknown 1 |
| Phase 3 | 5 | Completed 3, Recruiting 1, Unknown 1 |
| Phase 4 | 2 | Terminated 1, Unknown 1 |
| Phase 1 | 1 | Terminated 1 |
Follow Infantile Hemangioma: new trials by email Literature Review of Infantile Hemangioma trials Research Report on Infantile Hemangioma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Different Initial Doses of Oral Propranolol in the Treatment of Ulcerated Infantile Hemangioma propranolol - Infantile Hemangioma | Phase 2 / Phase 3 | Recruiting | West China Hospital | 32 | 2025-01-01 | 2026-09-21 |
| Assessing the Impact of Dosage Frequency of Propranolol on Sleep Patterns in Patients With Infantile Hemangiomas Propranolol three times a day, Propranolol twice a day, Timolol - Infantile Hemangioma | Phase 4 | Terminated | The University of Texas Health Science Center, Houston | 52 | 2022-06-23 | 2026-03-13 |
| ''Efficacy of Propranolol in the Treatment of Infantile Hemangioma" Propranolol Therapy for Infantile Hemangioma - Infantile Hemangioma | Phase 2 | Unknown | Assiut University | 100 | 2021-01-01 | 2020-12-24 |
| Timolol Maleate Gel for the Treatment of Infantile Hemangioma Timolol Maleate Gel+Placebo, Timolol Maleate Gel, Placebo - Infantile Hemangioma | Phase 2 / Phase 3 | Completed | Auson Pharmaceuticals Inc. | 168 | 2020-10-28 | 2024-11-07 |
| Evaluation of the Efficacy of Captopril Versus Propranolol and Timolol as a Treatment of Infantile Capillary Hemangioma oral propranolol, Oral Captopril, intralesional propranolol injection - Infantile Hemangioma | Phase 4 | Unknown | Ain Shams University | 100 | 2019-10-01 | 2020-02-28 |
| Hemangiol, Post Marketing Surveillance Study Infantile Hemangioma | Completed | University Hospital, Montpellier | 500 | 2019-07-01 | 2020-12-02 | |
| Optimizing Timolol Maleate Treatment of Infantile Hemangioma by Doppler Ultrasound Examination Timolol Maleate 0.5% Oph Soln - Infantile Hemangioma | Unknown | XiaoXi Lin | 150 | 2019-02-16 | 2019-02-19 | |
| Efficacy, Safety and Pharmacokinetics of Topical Timolol in Infants With Infantile Hemangioma (IH) 0.25% Timolol Maleate Gel Forming Solution, 0.5% Timolol Maleate Gel Forming Solution - Infantile Hemangioma | Phase 2 | Completed | Kanecia Obie Zimmerman | 105 | 2017-05-05 | 2024-03-12 |
| Comparative Study to Evaluate the Effectiveness of Atenolol and Propranolol in the Treatment of Infantile Hemangiomas oral propranolol, oral atenolol - Infantile Hemangioma | Phase 3 | Unknown | Post Graduate Institute of Medical Education and Research, Chandigarh | 60 | 2017-03-24 | 2018-08-28 |
| A Prospective Study on the Incidence and Related Risk Factors of Infantile Hemangioma in China Infantile Hemangioma, Capillary Hemangioma | Unknown | Zhujiang Hospital | 10000 | 2015-12-01 | 2017-06-02 | |
| Nadolol Versus Propranolol in Children With Infantile Hemangiomas Nadolol, Propranolol - Infantile Hemangioma | Phase 3 | Completed | The Hospital for Sick Children | 74 | 2015-09-01 | 2020-10-28 |
| Timolol for the Prevention of Proliferation of Infantile Hemangioma (TiPPIH Trial) topical 0.5% Timolol maleate, Control (placebo) group - Infantile Hemangioma, Very Low Birth Weight Infants | Phase 1 | Terminated | Alice K. Gong | 26 | 2012-07-01 | 2016-11-15 |
| Optical Tomographic Imaging of Infantile Hemangiomas Infantile Hemangioma | Completed | Columbia University | 15 | 2012-05-01 | 2018-08-06 | |
| Study in Infants With Infantile Hemangioma to Compare Propranolol Gel to Placebo propranolol gel, Placebo - Infantile Hemangioma | Phase 2 | Completed | Pierre Fabre Dermatology | 82 | 2012-01-01 | 2014-10-30 |
| Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care: - Adenovirus, Anesthesia | Completed | Daniel Benjamin | 3520 | 2011-11-01 | 2023-09-06 | |
| Study to Demonstrate the Efficacy and Safety of Propranolol Oral Solution in Infants With Proliferating Infantile Hemangiomas Requiring Systemic Therapy Propranolol, Placebo - Infantile Hemangioma | Phase 2 / Phase 3 | Completed | Pierre Fabre Dermatology | 512 | 2010-01-01 | 2015-12-10 |
| Nadolol for Proliferating Infantile Hemangiomas Nadolol - Infantile Hemangioma | Phase 2 | Completed | The Hospital for Sick Children | 20 | 2009-11-01 | 2021-08-19 |
Hemangioma, Capillary (17) · Hemangioma (6) · Adenoviridae Infections (1) · Anxiety Disorders (1) · Arrhythmias, Cardiac (1) · Autistic Disorder (1) · Bipolar Disorder (1) · Bradycardia (1) · Central Nervous System Infections (1) · Cytomegalovirus Retinitis (1) · Endocarditis (1) · Epilepsy (1) · Headache (1) · Healthcare-Associated Pneumonia (1) · Heart Arrest (1)
Neoplasms by Histologic Type (17) · Neoplasms, Vascular Tissue (17) · Neoplasms (16) · Hemangioma (11) · Brain Diseases (2) · Cardiovascular Diseases (2) · Central Nervous System Diseases (2) · Female Urogenital Diseases and Pregnancy Complications (2) · Hematologic Diseases (2) · Hemic and Lymphatic Diseases (2) · Hemorrhagic Disorders (2) · Nervous System Diseases (2) · Pathologic Processes (2) · Pathological Conditions, Signs and Symptoms (2) · Urogenital Diseases (2)
Propranolol (5) · Timolol (4) · Nadolol (2) · Alfentanil (1) · Amikacin (1) · Aminocaproic Acid (1) · Atenolol (1) · Bosentan (1) · Captopril (1) · Cefepime (1) · Cidofovir (1) · Ciprofloxacin (1) · Clozapine (1) · Fosfomycin (1) · Haloperidol (1)
Pierre Fabre Dermatology (2) · The Hospital for Sick Children (2) · Ain Shams University (1) · Alice K. Gong (1) · Assiut University (1) · Auson Pharmaceuticals Inc. (1) · Columbia University (1) · Daniel Benjamin (1) · Kanecia Obie Zimmerman (1) · Post Graduate Institute of Medical Education and Research, Chandigarh (1) · The University of Texas Health Science Center, Houston (1) · University Hospital, Montpellier (1) · West China Hospital (1) · XiaoXi Lin (1) · Zhujiang Hospital (1)
United States (6) · Canada (4) · China (4) · France (3) · Egypt (2) · Poland (2) · Spain (2) · Australia (1) · Czechia (1) · Germany (1) · Hungary (1) · India (1) · Israel (1) · Italy (1) · Lithuania (1)
Alice K Gong, M.D. (1) · Alice K Gong, MD (1) · Chi Hornik, PharmD (1) · Christine Labreze, MD (1) · Elena Pope, MD (1) · Elena Pope, MD, MSc (1) · Kanecia Zimmerman, MD, MHS (1) · Kristin Holland, MD (1) · Maria Garzon, MD (1) · Matthew R Greives, MD (1) · Rana Atta, BSc (1) · Tangde Zhang, Doctor (1) · Xiaoxi Lin, PhD (1)
PMID 24614374, PMID 24949994, PMID 25693013, PMID 26039810, PMID 26926644, PMID 27522443, PMID 28137820, PMID 28290120, PMID 28779462, PMID 29084742, PMID 29271816, PMID 29435949, PMID 29677389, PMID 30790601, PMID 31317556, PMID 31548185, PMID 31814149, PMID 32324313, PMID 32497307, PMID 33029806, PMID 33118199, PMID 33903114, PMID 34302290, PMID 34747977, PMID 35370711, PMID 35491971, PMID 41247430