82 completed, 23 terminated, 20 recruiting, 14 unknown. 48 Phase 2, 31 Not applicable, 15 Phase 1, 13 Phase 3, 9 Phase 4.
Follow Hemangioma: new trials by email Literature Review of Hemangioma trials Research Report on Hemangioma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Rapamycin Dose-Ranging Efficacy Study in Port Wine Stains Rapamycin cream, Pulsed dyed laser - Port Wine Stains | Phase 2 | Not yet recruiting | AFT Pharmaceuticals, Ltd. | 30 | 2026-11-13 | 2026-10-27 |
| Study to Establish Safety, Tolerability and Pharmacokinetics of NRL-1049 in Healthy Adult Participants Following Multiple-Dose Administration NRL-1049, Placebo - Cerebral Cavernous Malformation | Phase 1 | Not yet recruiting | Neurelis, Inc. | 40 | 2026-11-11 | 2026-10-30 |
| Using an Artificial Intelligence (AI) Tool for Melanoma Diagnosis Clinical decision support tool - Malignant Melanoma of Skin, Other and Unspecified Malignant Neoplasm of Skin | Phase 3 | Recruiting | Memorial Sloan Kettering Cancer Center | 14000 | 2026-10-15 | 2026-10-22 |
| Preoperative Embolization for Highly Vascular Brain Tumors Preoperative Endovascular Embolization - Brain Neoplasms, Meningioma | Not applicable | Not yet recruiting | Assiut University | 55 | 2026-10-01 | 2026-09-17 |
| Neurocutaneous Syndromes in Children: Prevalence and Clinical Characteristics Sturge-Weber Syndrome, Neurocutaneous Syndromes | Not yet recruiting | Assiut University | 100 | 2026-09-20 | 2026-09-28 | |
| A Phase 2 Study of Sirolimus for Injection (Albumin-bound) in Patients With Progressive or Symptomatic Epithelioid Hemangioendothelioma Sirolimus for injection (Albumin-bound) - Epithelioid Hemangioendothelioma | Phase 2 | Not yet recruiting | CSPC ZhongQi Pharmaceutical Technology Co., Ltd. | 40 | 2026-08-01 | 2026-07-06 |
| Maximizing Laser Therapy Success for Port-Wine Birthmarks in Pediatric Patients Pulse Dye laser, Pulse Dye Laser (PDL) pulse width stacking, Pulse Dye Laser (PDL) followed by Nd:YAG (Neodymium-doped Yttrium Aluminum Garnet laser) laser. - Port Wine Stains | Not applicable | Recruiting | University of Texas Southwestern Medical Center | 200 | 2026-07-01 | 2026-06-05 |
| Abrupt Discontinuation Versus Gradual Tapering of Propranolol in Infantile Hemangioma Abrupt Discontinuation of Propranolol, Gradual Tapering of Propranolol - Infantile Hemangioma (IH) | Phase 4 | Not yet recruiting | West China Hospital | 110 | 2026-07-01 | 2026-06-24 |
| Biological Collection of the Rare Diseases of the Brain and Eye Vessels Cohort - 2 Biocollection, Neurological evaluation and Biocollection - CADASIL, Cavernous Angioma | Not applicable | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 600 | 2026-06-30 | 2026-06-16 |
| Risk Stratification and Treatment Decisions in Infantile Hemangioma With Minimal or Arrested Growth Routine Clinical Assessment and Risk Stratification - Infantile Hemangioma (IH) | Not yet recruiting | West China Hospital | 150 | 2026-06-20 | 2026-07-02 | |
| Low- vs High-Dose Sirolimus With Prednisolone for KHE and KMP Sirolimus (RAPAMUNE) - Kaposiform Hemangioendothelioma (KHE), Kasabach Merritt Phenomenon | Phase 2 / Phase 3 | Recruiting | Yi Ji | 76 | 2026-06-16 | 2026-06-18 |
| Screening LUMBAR Syndrome in Infants With Infantile Hemangiomas MRI - LUMBAR Syndrome | Not yet recruiting | West China Hospital | 70 | 2026-06-01 | 2026-06-01 | |
| A Study to Evaluate the Efficacy and Safety of Everolimus in Patients With Teratment-refractory Vascular Anomalies Everolimus - Vascular Malformations, Arteriovenous Malformations | Phase 2 | Not yet recruiting | Yonsei University | 67 | 2026-04-01 | 2026-03-17 |
| SARC046: A Phase II Trial of Nab-Sirolimus in Patients With Progressing or Symptomatic Epithelioid Hemangioendothelioma nab-Sirolimus - Epithelioid Hemangioendothelioma (EHE) | Phase 2 | Recruiting | Sarcoma Alliance for Research through Collaboration | 41 | 2026-02-24 | 2026-05-26 |
| Radiological Diagnosis of Pediatric Neck Swellings Lipoma, Branchial Cleft Anomalies | Active not recruiting | Sohag University | 50 | 2026-02-20 | 2026-07-30 | |
| Fluctuational Imaging for the Diagnosis of Hepatic Hemangioma: A Multicenter, Prospective Study Hemangioma | Recruiting | Yonsei University | 400 | 2026-01-02 | 2026-02-18 | |
| Daratumumab for Familial Cerebral Cavernous Malformations: A Single-Arm Safety and Efficacy Study Daratumumab - Cavernous Malformation, Cerebral | Early Phase 1 | Not yet recruiting | Beijing Tiantan Hospital | 10 | 2025-07-01 | 2025-06-18 |
| Aggressive Spinal Hemangioma Aggressive Spinal Hemangiomas | Not yet recruiting | Assiut University | 30 | 2025-06-30 | 2025-05-30 | |
| Uncovering Genes Behind Cartilage Tumors and Vascular Anomalies Using Genomic Sequencing Enchondromatosis | Recruiting | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | 100 | 2025-01-27 | 2026-10-01 | |
| Efficacy and Safety of Different Initial Doses of Oral Propranolol in the Treatment of Ulcerated Infantile Hemangioma propranolol - Infantile Hemangioma | Phase 2 / Phase 3 | Recruiting | West China Hospital | 32 | 2025-01-01 | 2026-09-21 |
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Hemangioma, Capillary (47) · Sturge-Weber Syndrome (17) · Hemangioblastoma (16) · Hemangioma, Cavernous, Central Nervous System (16) · Hemangioendothelioma, Epithelioid (13) · von Hippel-Lindau Disease (11) · Vascular Malformations (9) · Hemangiosarcoma (8) · Sarcoma (8) · Arteriovenous Malformations (7) · Hemangioma, Cavernous (7) · Port-Wine Stain (7) · Hemangioendothelioma (6) · Kaposiform Hemangioendothelioma (6)
Neoplasms by Histologic Type (162) · Neoplasms, Vascular Tissue (162) · Neoplasms (159) · Cardiovascular Diseases (64) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (61) · Nervous System Diseases (61) · Congenital Abnormalities (57) · Vascular Diseases (56) · Hemic and Lymphatic Diseases (33) · Cardiovascular Abnormalities (32) · Central Nervous System Diseases (31) · Brain Diseases (30) · Angiomatosis (28) · Hematologic Diseases (28)
Propranolol (17) · Timolol (10) · Sirolimus (8) · Prednisolone (6) · Adrenergic beta-Antagonists (3) · Lasers, Dye (3) · Methylprednisolone (3) · Prednisone (3) · Sunitinib (3) · Adrenal Cortex Hormones (2) · Atenolol (2) · Bleomycin (2) · Blood Specimen Collection (2) · Cannabidiol (2) · Doxorubicin (2)
West China Hospital (9) · Medical College of Wisconsin (6) · Assiut University (4) · National Institute of Neurological Disorders and Stroke (NINDS) (4) · University of California, Irvine (4) · Anne Comi, MD (3) · M.D. Anderson Cancer Center (3) · The Hospital for Sick Children (3) · University Hospital, Montpellier (3) · University of California, San Francisco (3) · University of Chicago (3) · Assistance Publique - Hôpitaux de Paris (2) · Beijing Tiantan Hospital (2) · Boston Children's Hospital (2) · Children's Hospital of Fudan University (2)
United States (80) · China (24) · France (17) · Canada (8) · Spain (7) · Italy (5) · United Kingdom (5) · Egypt (4) · Germany (4) · Brazil (3) · Poland (3) · Russia (3) · South Korea (3) · Australia (2) · Austria (2)
Beth Drolet, MD (4) · Anne M Comi, M.D. (3) · Maria Garzon, MD (3) · Yi Ji, MD, PhD (3) · Anne Lucky, MD (2) · Anne M Comi, MD (2) · Beth A Drolet, MD (2) · Denise Adams, MD (2) · Denise Metry, MD (2) · Eric Jonasch, MD (2) · Eulalia Baselga, MD (2) · Ilona J Frieden, MD (2) · Issam A Awad, MD (2) · Issam Awad, MD (2) · Julie Powell, MD (2)
PMID 35030255, PMID 22871490, PMID 28486787, PMID 31401903, PMID 31489702, PMID 32014025, PMID 33580918, PMID 19419474, PMID 19833796, PMID 20157038, PMID 20598318, PMID 20828712, PMID 22105611, PMID 22456397, PMID 23301692, PMID 23455486, PMID 24323376, PMID 24347141, PMID 24401931, PMID 24526257, PMID 24579662, PMID 24614374, PMID 24949994, PMID 25007365, PMID 25472749, PMID 25556204, PMID 25565562, PMID 25693013, PMID 26039810, PMID 26649337, PMID 26795600, PMID 26813215, PMID 26916576, PMID 26926644, PMID 27062495, PMID 27235002, PMID 27272077, PMID 27522443, PMID 27885682, PMID 28095550, PMID 28137820, PMID 28213875, PMID 28290120, PMID 28318403, PMID 28387823, PMID 28423174, PMID 28489816, PMID 28534135, PMID 28541265, PMID 28779462
U54NS065705 (5), 2008 (1), 2017 (1), 2025 (1), N01CM62206 (1), P30CA008748 (1), P30CA046592 (1), R01CA293974 (1), R01GM095657 (1), R01NS114552 (1), U01CA069856 (1), U01NS104157 (1), ZIAEB000073 (1)