123 completed, 15 unknown, 13 terminated, 9 withdrawn. 58 Phase 4, 47 Phase 3, 28 Phase 2, 14 Not applicable, 12 Phase 1.
Follow Timolol: new trials by email Literature Review of Timolol trials Research Report on Timolol
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Effects of Timolol On Healing and Cosmesis of Mohs Scalp Wounds: An Open Label Trial Topical Timolol, Normal Saline - Surgical Wounds, Mohs Surgery | Phase 2 | Not yet recruiting | Geisinger Clinic | 45 | 2026-12-01 | 2026-10-14 |
| A Phase 2a Study Comparing the Efficacy, Safety and Tolerability of Pregabalin Eye Drops Comparing With Timolol Eye Drops in Adults With Glaucoma or High Eye Pressure. Arm 1: TB0001 ophthalmic solution 0.9%, Arm 2: TB0001 ophthalmic solution 1.2%, TB0001 ophthalmic solution 1.5% - Primary Open - Angle Glaucoma (POAG), Ocular Hypertension (OHT) | Phase 2 | Recruiting | Tavo Biotherapeutics | 96 | 2026-10-23 | 2026-11-03 |
| Efficacy and Safety of Topical Timolol in Secondary Intention Surgical Wounds Healing Timolol 0.5% Ophthalmic Solution, Hydrogel of placebo - Mohs Micrographic Surgery, Excision Margin | Phase 2 | Not yet recruiting | University of California, Davis | 220 | 2026-10-01 | 2026-08-18 |
| Adaptive Optics OCT Evaluation of Rhopressa's Effects on the Retinal Ganglion Cells in Glaucoma Patients Netarsudil 0.02% Ophthalmic Solution [RHOPRESSA], Timolol Maleate 0.25% Ophthalmic Solution - Open Angle Glaucoma (OAG), Glaucoma | Phase 4 | Recruiting | Brett King | 13 | 2026-10-01 | 2026-10-28 |
| Efficacy of 0.5% Topical Timolol Eye Drops in the Treatment of Post-Inflammatory Erythema Following Acne Vulgaris Timolol 0.5% Ophthalmic Solution, Intense Pulsed Light - Post Inflammtory Erythema, Acne Vulgaris | Early Phase 1 | Recruiting | Pham Ngoc Thach University of Medicine | 60 | 2026-03-09 | 2026-04-01 |
| Study of Corneal Biomechanics in Glaucoma Patients Using Brillouin Microscopy Prostaglandin Analogue -Containing IOP-Lowering Therapy, Beta Blocker, Brillouin Microscopy - Glaucoma | Recruiting | University of Maryland, Baltimore | 60 | 2025-09-01 | 2026-08-10 | |
| Study of an Investigational Product, QLS-111, Provided as an Eyedrop, for Treatment of Normal Tension Glaucoma (NTG) QLS-111 ophthalmic solution (0.015%), Timolol Maleate PF 0.5% Ophthalmic Solution (Timolol) - Normal Tension Glaucoma (NTG), Low-Tension Glaucoma, Bilateral | Phase 2 | Completed | Qlaris Bio, Inc. | 37 | 2025-08-13 | 2026-04-03 |
| Prophylactic Use of Timolol Maleate to Prevent Intraocular Pressure Elevation After Nd:YAG Laser Posterior Capsulotomy Timolol Maleate, No intervention - Capsule Opacification, Ocular Hypertension | Not applicable | Completed | CMH Multan Institute of Medical Sciences | 210 | 2025-03-10 | 2026-07-27 |
| Efficacy and Safety of Add-on Timolol for EGFR-TKI and ALK-TKI Induced Paronychia Timolol 0.5% eye drops and betamethasone valerate 0.1% cream, Betamethasone valerate 0.1% cream - Paronychia, EGFR-TKI | Phase 3 | Recruiting | Queen Mary Hospital, Hong Kong | 40 | 2024-10-09 | 2024-10-18 |
| How Much Does Reduced Dosing of Latanoprost and Dorzolamide-timolol Affect Pressure? dorzolamide/timolol - Glaucoma, Open-Angle, Glaucoma; Drugs | Phase 4 | Terminated | CT Glaucoma Associates | 36 | 2024-04-22 | 2024-08-23 |
| Enhanced Dermatological Care to Reduce Rash and Paronychia in Epidermal Growth Factor Receptor (EGRF)-Mutated Non-Small Cell Lung Cancer (NSCLC) Treated First-line With Amivantamab Plus Lazertinib Amivantamab IV, Amivantamab SC, Lazertinib - Carcinoma, Non-Small-Cell Lung | Phase 2 | Active not recruiting | Janssen Research & Development, LLC | 305 | 2024-02-16 | 2026-11-03 |
| Comparison of Fractional CO2 Laser Monotherapy and Its Combination With Either Topical Vitamin C or Topical Timolol in the Treatment of Post-Acne Erythema: A Split Face Study topical Timolol maleate 0.5% eye drops, topical Vitamin C 15%, Fractional CO2 laser - Post-acne Erythema | Phase 2 | Completed | Cairo University | 40 | 2023-08-30 | 2026-10-20 |
| Efficacy and Safety of Timolol for TKI Induced Paronychia Topical Timolol, Betamethasone Valerate - Paronychia | Phase 3 | Unknown | Queen Mary Hospital, Hong Kong | 40 | 2023-04-01 | 2023-12-20 |
| Assessing the Impact of Dosage Frequency of Propranolol on Sleep Patterns in Patients With Infantile Hemangiomas Propranolol three times a day, Propranolol twice a day, Timolol - Infantile Hemangioma | Phase 4 | Terminated | The University of Texas Health Science Center, Houston | 52 | 2022-06-23 | 2026-03-13 |
| The Efficacy of Topical Timolol Combined With Cryotherapy in EGFR Inhibitors-induced Paronychia - a Double-blinded, Intrapatient Left-to-right Controlled Study Timolol maleate 0.5% ophthalmic solution, Cryotherapy with liquid nitrogen - Paronychia, Epidermal Growth Factor Receptor Inhibitor | Not applicable | Completed | Taipei Medical University WanFang Hospital | 8 | 2021-12-21 | 2023-05-06 |
| Effects of Netarsudil and Timolol on Retinal Blood Vessel Density and Visual Acuity Netarsudil 0.02% QD, Timolol maleate 0.5% BID - OAG - Open-Angle Glaucoma, OHT - Ocular Hypertension | Not applicable | Withdrawn | University of California, San Diego | 2021-12-01 | 2022-03-31 | |
| Comparison of Efficacy and Ocular Surface Assessment Between BRIDIN-plus and Combigan in Glaucoma or Ocular Hypertensive BRIDIN-plus Eye drops, Combigan Eye drops - Glaucoma, Ocular Hypertensive | Phase 4 | Completed | CHA University | 60 | 2021-10-08 | 2025-03-26 |
| Combined Intravitreal Bevacizumab With Topical Timolol-Dorzolamide Eye Drops in Diabetic Macular Edema Injections of 1.25 mg of intravitreal bevacizumab with Timolol and Dorzolamide, Injections of 1.25 mg of intravitreal bevacizumab with artificial tears - Diabetic Macular Edema | Phase 2 / Phase 3 | Unknown | Shahid Beheshti University of Medical Sciences | 62 | 2021-10-06 | 2021-10-19 |
| A Study to Evaluate Safety and Tolerability of QLS-101 in NTG QLS-101, Timolol maleate PF 0.5% ophthalmic solution - Normal Tension Glaucoma (NTG) | Phase 2 | Completed | Qlaris Bio, Inc. | 30 | 2021-09-15 | 2025-01-20 |
| Preservative-free Fixed-dose Combination of Tafluprost 0.0015% / Timolol 0.5% in Patients With Open-angle Glaucoma or Ocular Hypertension: Clinical Effectiveness, Tolerability and Safety in a Real World Setting Tafluprost, timolol maleate - Ocular Surface Disease, Primary Open Angle Glaucoma | Completed | Santen Pharmaceutical (Taiwan) Co., LTD | 50 | 2021-09-01 | 2022-10-31 |
Showing 20 of 170. Sign in to see all of them.
Ocular Hypertension (86) · Glaucoma, Open-Angle (79) · Glaucoma (77) · Hemangioma, Capillary (7) · Hemangioma (5) · Hypertension (5) · Eye Diseases (4) · Low Tension Glaucoma (4) · Paronychia (3) · Patient Compliance (3) · Acne Vulgaris (2) · Exfoliation Syndrome (2) · Fibrosis (2) · Glaucoma, Angle-Closure (2) · Hypertension, Portal (2)
Alcon Research (31) · Allergan (18) · Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (8) · Aristotle University Of Thessaloniki (4) · Santen Oy (4) · Bausch & Lomb Incorporated (3) · Pharmaceutical Research Network (3) · Qlaris Bio, Inc. (3) · Bp Consulting, Inc (2) · ForSight Vision5, Inc. (2) · Inotek Pharmaceuticals Corporation (2) · Laboratorios Sophia S.A de C.V. (2) · Medical University of Vienna (2) · Ocular Therapeutix, Inc. (2) · Queen Mary Hospital, Hong Kong (2)
United States (75) · Canada (13) · Germany (10) · Spain (10) · France (8) · Italy (7) · South Korea (7) · United Kingdom (7) · Austria (5) · Greece (5) · Taiwan (5) · China (4) · Finland (4) · Hong Kong (4) · Belgium (3)
William C. Stewart, MD (5) · Abayomi Ogundele, PharmD (2) · Anastasios G Konstas, MD, PhD (2) · Anna Grau (2) · Auli Ropo, M.D. (2) · Carl B Camras, MD (2) · Elizabeth D. Sharpe, MD (2) · Jason Vittitow (2) · Luca Rossetti, MD (2) · Michelle Chen, PhD (2) · Pamela Smith, B.S. (2) · Rivkah R Isseroff, MD (2) · Severine Durier, Pharm.D (2)
PMID 19427617, PMID 19476406, PMID 29194198, PMID 35643967, PMID 36378864, PMID 12614754, PMID 14509472, PMID 16303952, PMID 16306522, PMID 17102003, PMID 17459480, PMID 18538406, PMID 19049301, PMID 19303163, PMID 19365194, PMID 20142538, PMID 20346127, PMID 20505839, PMID 21773673, PMID 21851642, PMID 21878847, PMID 21960068, PMID 22332206, PMID 22458918, PMID 22935601, PMID 24855336, PMID 25429421, PMID 25447269, PMID 25613811, PMID 26875002, PMID 27210275, PMID 27450828, PMID 27457257, PMID 2788589, PMID 27913991, PMID 28239491, PMID 29680880, PMID 32376427, PMID 32513257, PMID 33389369, PMID 33548303, PMID 33551214, PMID 33891615, PMID 34724172, PMID 34798680, PMID 34985175, PMID 35076329, PMID 38261740, PMID 38376643, PMID 40341017
2014 (3), 2009 (1), 2016 (1), 2023 (1), R01DK046580 (1), R01EY014957 (1), R01EY022124 (1), R21EY035483 (1), U54NS065705 (1)