8 terminated. 8 Phase 1, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 8 | Terminated 8 |
| Phase 2 | 4 | Terminated 4 |
Follow Hypoxia: new trials by email Literature Review of Hypoxia trials Research Report on Hypoxia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Metformin Treatment in Infants After Perinatal Brain Injury Metformin Hydrochloride - Hypoxic Ischemic Encephalopathy of Newborn, Premature Birth | Phase 1 | Terminated | The Hospital for Sick Children | 1 | 2023-05-02 | 2024-03-07 |
| A Study of NKT2152, a HIF2α Inhibitor, in Patients With Advanced Clear Cell Renal Cell Carcinoma Oral NKT2152 - ccRCC, Clear Cell Renal Cell Carcinoma | Phase 1 / Phase 2 | Terminated | NiKang Therapeutics, Inc. | 120 | 2021-10-26 | 2025-11-12 |
| TIBOHCA: Safety, Tolerability and Pharmacokinetics of 2-Iminobiotin (2-IB) After OHCA 2-Iminobiotin - Cardiac Arrest, Hypoxic Ischemic Brain Injury | Phase 1 / Phase 2 | Terminated | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 21 | 2016-05-01 | 2021-02-18 |
| Topiramate in Neonates Receiving Whole Body Cooling for Hypoxic Ischemic Encephalopathy Topiramate, Placebo - Hypoxic Ischemic Encephalopathy | Phase 1 / Phase 2 | Terminated | Kristin R Hoffman | 34 | 2013-02-01 | 2024-06-11 |
| Safety Study of Clostridium Novyi-NT Spores to Treat Patients With Solid Tumors That Have Not Responded to Standard Therapies Clostridium novyi-NT spores - Solid Tumor Malignancies | Phase 1 | Terminated | BioMed Valley Discoveries, Inc | 5 | 2011-04-01 | 2016-01-20 |
| One Time Injection of Bacteria to Treat Solid Tumors That Have Not Responded to Standard Therapy Clostridium novyi-NT spores - Tumors | Phase 1 | Terminated | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 2 | 2006-07-01 | 2016-10-14 |
| Pilot Study of Pentoxifylline for Hepatopulmonary Syndrome pentoxifylline - Hepatopulmonary Syndrome | Phase 1 | Terminated | University of Alabama at Birmingham | 9 | 2004-06-01 | 2015-03-09 |
| Inhaled Nitric Oxide in Neonates With Elevated A-a DO2 Gradients Not Requiring Mechanical Ventilation nitric oxide for inhalation, Oxygen - Lung Disease, Hypoxemia | Phase 1 / Phase 2 | Terminated | Mallinckrodt | 7 | 2002-05-01 | 2016-10-19 |
Hypoxia-Ischemia, Brain (3) · Necrosis (2) · Neoplasms (2) · Acidosis, Respiratory (1) · Carcinoma, Renal Cell (1) · Colonic Neoplasms (1) · Fibrosis (1) · Heart Arrest (1) · Hepatopulmonary Syndrome (1) · Kidney Neoplasms (1) · Lung Diseases (1) · Lung Neoplasms (1) · Neoplasm Metastasis (1) · Pancreatic Neoplasms (1)
Pathological Conditions, Signs and Symptoms (8) · Signs and Symptoms (8) · Signs and Symptoms, Respiratory (8) · Brain Diseases (3) · Brain Ischemia (3) · Cardiovascular Diseases (3) · Central Nervous System Diseases (3) · Cerebrovascular Disorders (3) · Female Urogenital Diseases and Pregnancy Complications (3) · Hypoxia, Brain (3) · Nervous System Diseases (3) · Pathologic Processes (3) · Respiratory Tract Diseases (3) · Urogenital Diseases (3)
2-iminobiotin (1) · Bacterial Load (1) · Endothelium-Dependent Relaxing Factors (1) · Inhalation (1) · Metformin (1) · Nitric Oxide (1) · Oxygen (1) · Pentoxifylline (1) · Topiramate (1)
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · BioMed Valley Discoveries, Inc (1) · Kristin R Hoffman (1) · Mallinckrodt (1) · NiKang Therapeutics, Inc. (1) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (1) · The Hospital for Sick Children (1) · University of Alabama at Birmingham (1)
United States (6) · Canada (1) · Netherlands (1)
Brian T Kalish, MD (1) · Janneke Horn, MD, PhD (1) · Kristin R Hoffman, MD (1) · Luis A Diaz, MD (1) · Michael B Fallon, MD (1) · Waldemar Carlo, MD (1)
R03DK065958 (1)