7 unknown, 4 terminated, 3 completed, 1 enrolling by invitation. 4 Phase 2, 3 Not applicable, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 4 | Terminated 3, Completed 1 |
| Not applicable | 3 | Unknown 3 |
| Phase 1 | 2 | Completed 1, Terminated 1 |
Follow Hepatopulmonary Syndrome: new trials by email Literature Review of Hepatopulmonary Syndrome trials Research Report on Hepatopulmonary Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Analysis of Clinical Features of Chronic Liver Disease Complicated With Hepatopulmonary Syndrome Proteomic sequencing - Hepatopulmonary Syndrome (HPS) | Unknown | Sun Jie | 500 | 2023-04-01 | 2023-07-06 | |
| Efficacy and Safety of Pentoxifylline in Improving Oxygenation in Hepatopulmonary Syndrome Pentoxifylline, Placebo - Hepatopulmonary Syndrome | Not applicable | Unknown | Institute of Liver and Biliary Sciences, India | 40 | 2022-05-05 | 2022-05-13 |
| Letrozole in Patients With Hepatopulmonary Syndrome Letrozole, Placebo - Hepatopulmonary Syndrome | Phase 2 | Terminated | Mayo Clinic | 1 | 2021-02-18 | 2024-05-14 |
| Supine Exercise in Hepatopulmonary Syndrome Patients With Orthodeoxia Upright Exercise, Supine Exercise - Hepatopulmonary Syndrome | Not applicable | Unknown | Unity Health Toronto | 10 | 2019-07-24 | 2023-05-10 |
| Midodrine in Hepatopulmonary Syndrome Midodrine - Hepatopulmonary Syndrome (HPS) | Phase 1 | Completed | Mayo Clinic | 10 | 2018-08-02 | 2021-01-06 |
| International Registry of Congenital Portosystemic Shunt (IRCPSS) Shunt Closure - Congenital Portosystemic Shunt, CPSS (Congenital Portosystemic Shunt) | Enrolling by invitation | Prof. Valérie Mc Lin | 500 | 2018-04-26 | 2025-06-18 | |
| Investigation of the Prevalence of Hepatopulmonary Syndrome in Cirrhosis Patients Caused by Hepatitis B in Western China Hepatopulmonary Syndrome | Unknown | Southwest Hospital, China | 300 | 2017-07-27 | 2018-02-19 | |
| Hepatopulmonary Syndrome and Postoperative Complications After Liver Transplantation : A Case-control Study Hepatopulmonary Syndrome, Liver Cirrhosis | Unknown | Hospices Civils de Lyon | 142 | 2015-10-01 | 2017-03-28 | |
| Effect of Transjugular Intrahepatic Portosystemic Shunt on Oxygenation in Cirrhotic Patients With Hepatopulmonary Syndrome Transjugular intrahepatic portosystemic shunt - Hepatopulmonary Syndrome | Completed | West China Hospital | 64 | 2014-06-01 | 2018-08-31 | |
| Sorafenib for Hepatopulmonary Syndrome Sorafenib, Placebo - Hepatopulmonary Syndrome | Phase 2 | Terminated | University of Pennsylvania | 28 | 2014-03-01 | 2019-04-25 |
| Efficacy of Pentoxifylline and Rifaximin Combination in Pentoxifylline Refractory Clinical and Subclinical Hepatopulmonary Syndrome pentoxifylline and rifaximin, Pentoxifylline and placebo - Hepatopulmonary Syndrome | Not applicable | Unknown | Institute of Liver and Biliary Sciences, India | 80 | 2012-09-01 | 2013-12-17 |
| Bosentan for Treatment of Hepatopulmonary Syndrome in Patients With Liver Cirrhosis bosentan, Placebo - Hepatopulmonary Syndrome, Liver Cirrhosis | Phase 2 | Terminated | Medical University of Vienna | 6 | 2011-10-01 | 2016-09-28 |
| A Pilot Study of Norfloxacin for Hepatopulmonary Syndrome Norfloxacin, Placebo - Hepatopulmonary Syndrome | Phase 2 | Completed | Unity Health Toronto | 9 | 2006-10-01 | 2016-12-07 |
| Echocardiographic Assessment of Intrapulmonary Vasodilatation: Agitated Saline Versus Polygeline echocardiography for intrapulmonary vasodilatation - Liver, Cirrhosis | Unknown | Medical University of Vienna | 100 | 2006-06-01 | 2007-09-17 | |
| Pilot Study of Pentoxifylline for Hepatopulmonary Syndrome pentoxifylline - Hepatopulmonary Syndrome | Phase 1 | Terminated | University of Alabama at Birmingham | 9 | 2004-06-01 | 2015-03-09 |
Fibrosis (3) · Liver Cirrhosis (2) · Congenital Portosystemic Shunt (1) · Hepatic Encephalopathy (1) · Hepatitis B, Chronic (1) · Hyperammonemia (1) · Hyperandrogenism (1) · Hyperinsulinism (1) · Hypertension, Pulmonary (1) · Hypoglycemia (1) · Hypoxia (1) · Insulin Resistance (1) · Liver Neoplasms (1) · Platypnea Orthodeoxia Syndrome (1)
Digestive System Diseases (15) · Liver Diseases (15) · Lung Diseases (15) · Respiratory Tract Diseases (15) · Pathological Conditions, Signs and Symptoms (7) · Pathologic Processes (6) · Disease Attributes (2) · Fibrosis (2) · Signs and Symptoms (2) · Signs and Symptoms, Respiratory (2) · 46, XX Disorders of Sex Development (1) · Adrenogenital Syndrome (1) · Blood-Borne Infections (1) · Brain Diseases (1) · Brain Diseases, Metabolic (1)
Pentoxifylline (3) · Bosentan (1) · Letrozole (1) · Midodrine (1) · Norfloxacin (1) · Portasystemic Shunt, Transjugular Intrahepatic (1) · Rifaximin (1) · Sorafenib (1)
Institute of Liver and Biliary Sciences, India (2) · Mayo Clinic (2) · Medical University of Vienna (2) · Unity Health Toronto (2) · Hospices Civils de Lyon (1) · Prof. Valérie Mc Lin (1) · Southwest Hospital, China (1) · Sun Jie (1) · University of Alabama at Birmingham (1) · University of Pennsylvania (1) · West China Hospital (1)
United States (5) · Canada (3) · China (3) · India (3) · Austria (2) · Australia (1) · Belgium (1) · France (1) · Germany (1) · Hungary (1) · Israel (1) · Italy (1) · Japan (1) · Netherlands (1) · Spain (1)
Dr Naveen Kumar, MD (1) · Hilary M DuBrock, M.D. (1) · Hilary M DuBrock, MD (1) · Lu K Zhi, PhD (1) · Marie Faughnan, MD MSc FRCPC (1) · Michael B Fallon, MD (1) · Peter Schenk, MD (1) · Samir Gupta, MD, MSc (1) · Steven M Kawut, MD, MS (1) · Valentin H Fuhrmann, MD (1)
PMID 18668653, PMID 20816858, PMID 34625098
2018 (1), R03DK065958 (1), UM1HL116886 (1)