10 completed, 5 terminated. 15 Phase 3, 7 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 15 | Completed 10, Terminated 5 |
| Phase 2 | 7 | Completed 5, Terminated 2 |
Follow Hypotension, Orthostatic: new trials by email Literature Review of Hypotension, Orthostatic trials Research Report on Hypotension, Orthostatic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Levodopa on Cardiovascular Autonomic Function in Parkinson's Disease Autonomic testing on and off levodopa - Parkinson Disease, Orthostatic Hypotension | Phase 2 / Phase 3 | Completed | University of Utah | 40 | 2022-05-11 | 2024-12-05 |
| Phase 3 Open-Label Extension Study of TD-9855 for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure ampreloxetine - Symptomatic Neurogenic Orthostatic Hypotension | Phase 3 | Terminated | Theravance Biopharma | 110 | 2019-09-19 | 2022-11-30 |
| Phase 3 Clinical Effect Durability of TD-9855 for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure ampreloxetine, Placebo - Symptomatic Neurogenic Orthostatic Hypotension, MSA | Phase 3 | Terminated | Theravance Biopharma | 203 | 2019-02-22 | 2023-01-20 |
| Treatment of Post-SCI Hypotension Midodrine Hydrochloride - Spinal Cord Injury, Autonomic Dysreflexia | Phase 2 / Phase 3 | Completed | James J. Peters Veterans Affairs Medical Center | 66 | 2017-06-01 | 2025-02-21 |
| Blood Pressure, Cerebral Blood Flow and Cognition in Spinal Cord Injury Midodrine, Placebo - Spinal Cord Injury | Phase 3 | Completed | James J. Peters Veterans Affairs Medical Center | 19 | 2014-03-01 | 2025-02-21 |
| Efficacy of L-threo DOPS on Orthostatic Hypotension Symptoms and Other Non-motor Symptoms in Patients With MSA L-Threo DOPS, placebo - Multiple System Atrophy | Phase 2 / Phase 3 | Completed | University Hospital, Toulouse | 107 | 2014-01-21 | 2026-04-08 |
| Phase 3 Study to Evaluate the Efficacy and Safety of Droxidopa on Orthostatic Hypotension Treatment in Hemodialysis Patients Droxidopa, Placebo - Orthostatic Hypotension | Phase 3 | Terminated | TSH Biopharm Corporation Limited | 25 | 2012-06-01 | 2013-03-13 |
| Evaluating the Effectiveness of Intravenous Immunoglobulin Therapy in Autoimmune Autonomic Ganglionopathy Double blinded IVIg, Double blinded Placebo, Single Blinded IVIg - Autoimmune Autonomic Ganglionopathy (AAG) | Phase 2 / Phase 3 | Completed | Beth Israel Deaconess Medical Center | 6 | 2012-02-01 | 2017-07-02 |
| A Two Part Study (306A/306B) to Assess Droxidopa in Treatment of NOH in Patients With Parkinson's Disease Droxidopa, Placebo - Orthostatic Hypotension, Parkinson's Disease | Phase 3 | Completed | Chelsea Therapeutics | 225 | 2010-06-01 | 2014-05-20 |
| A Clinical Study for Patients With Neurogenic Orthostatic Hypotension (NOH) Using Droxidopa Placebo, Droxidopa - Symptomatic Neurogenic Orthostatic Hypotension (NOH), Non-diabetic Neuropathy | Phase 3 | Completed | Chelsea Therapeutics | 263 | 2008-09-01 | 2014-05-16 |
| Open-Label Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) Droxidopa, Placebo - Neurogenic Orthostatic Hypotension, Non-Diabetic Autonomic Neuropathy | Phase 3 | Completed | Chelsea Therapeutics | 103 | 2008-01-01 | 2014-05-16 |
| Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) Placebo, Droxidopa - Symptomatic Neurogenic Orthostatic Hypotension (NOH), Non-diabetic Neuropathy | Phase 3 | Completed | Chelsea Therapeutics | 181 | 2008-01-01 | 2014-05-20 |
| Effects of Pulsatile Intravenous Insulin Therapy on Metabolic Integrity in Patients With Diabetes Mellitus Pulsatile Intravenous Insulin Therapy (Humulin R, Novolog) - Diabetes Mellitus, With Complications | Phase 2 / Phase 3 | Terminated | Florida Atlantic University | 152 | 2006-11-01 | 2016-08-10 |
| Treatment of Orthostatic Hypotension Droxidopa Oral Product - Autonomic Nervous System Diseases, Orthostatic Hypotension | Phase 2 / Phase 3 | Terminated | Vanderbilt University | 8 | 2004-01-01 | 2022-03-02 |
| Prevention of Low Blood Pressure in Persons With Tetraplegia N-Nitro L-arginine-methylester (L-NAME), Head-up Tilt maneuver - Hypotension, Spinal Cord Injury | Phase 2 / Phase 3 | Completed | US Department of Veterans Affairs | 16 | 2003-06-01 | 2014-05-19 |
Pure Autonomic Failure (6) · Dizziness (4) · Hypotension (4) · Multiple System Atrophy (4) · Parkinson Disease (4) · dopamine beta hydroxylase deficiency (4) · Spinal Cord Injuries (3) · Autonomic Nervous System Diseases (2) · Syncope (2) · Asthenia (1) · Autonomic Dysreflexia (1) · Diabetes Complications (1) · Diabetes Mellitus (1) · Diabetes Mellitus, Type 1 (1)
Cardiovascular Diseases (15) · Nervous System Diseases (15) · Primary Dysautonomias (15) · Vascular Diseases (15) · Orthostatic Intolerance (14) · Autonomic Nervous System Diseases (13) · Central Nervous System Diseases (11) · Hypotension (11) · Basal Ganglia Diseases (8) · Brain Diseases (8) · Movement Disorders (8) · Neurodegenerative Diseases (8) · Synucleinopathies (8) · Neurologic Manifestations (5) · Pathological Conditions, Signs and Symptoms (5)
Droxidopa (7) · Midodrine (2) · ampreloxetine (2) · Immunoglobulins, Intravenous (1) · Insulin (1) · Insulin Aspart (1) · Mannitol (1) · NG-Nitroarginine Methyl Ester (1) · Sugars (1)
Chelsea Therapeutics (4) · James J. Peters Veterans Affairs Medical Center (2) · Theravance Biopharma (2) · Beth Israel Deaconess Medical Center (1) · Florida Atlantic University (1) · TSH Biopharm Corporation Limited (1) · US Department of Veterans Affairs (1) · University Hospital, Toulouse (1) · University of Utah (1) · Vanderbilt University (1)
United States (13) · Canada (5) · Australia (4) · New Zealand (4) · France (3) · Austria (2) · Bulgaria (2) · Denmark (2) · Estonia (2) · Germany (2) · Israel (2) · Italy (2) · Poland (2) · Portugal (2) · Russia (2)
Roy Freeman, MD (2) · Alberto Vasquez, MD (1) · Alvin McElveen, MD (1) · Betty Tuller, PhD (1) · Brent Goodman, MD (1) · Christopher J Mathias, MD (1) · Christopher J. Mathias, MD (1) · David Robertson, MD (1) · Horacio Kaufmann Kaufmann, MD (1) · Horacio Kaufmann, MD (1) · Jill M Wecht, Ed.D (1) · Jill M Wecht, Ed.D. (1) · Lawrence A. Hewitt, Ph.D. (1)
PMID 27538531, PMID 28494751, PMID 17385265, PMID 17965289, PMID 19651280, PMID 21762873, PMID 23700789, PMID 24326693, PMID 25350981, PMID 30003579, PMID 32203065, PMID 33177997, PMID 35366432, PMID 38712567, PMID 41269291, PMID 42475649
2018 (1), 2019 (1), P01HL056693 (1), U54NS065736 (1)