16 completed, 6 recruiting, 4 unknown, 3 not yet recruiting. 16 Not applicable, 4 Phase 2, 3 Phase 4, 1 Early Phase 1, 1 Phase 3.
Follow Autonomic Dysreflexia: new trials by email Literature Review of Autonomic Dysreflexia trials Research Report on Autonomic Dysreflexia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| NO AD: Use of Nitric Oxide (NO) Donors for the Prevention of Autonomic Dysreflexia (AD) During Bowel Care Following SCI Glyceryl Trinitrate Only Product in Oromucosal Dose Form, Placebo sublingual spray - Spinal Cord Injuries, Autonomic Dysreflexia | Phase 2 | Not yet recruiting | Simon Fraser University | 26 | 2026-12-01 | 2026-04-23 |
| Cardiac Morphology and Function in Individuals With Autonomic Dysreflexia Autonomic Dysreflexia, Spinal Cord Injuries and Disorders (SCI/D) | Recruiting | Swiss Paraplegic Research, Nottwil | 48 | 2026-06-01 | 2026-08-27 | |
| Non-invasive Spinal Cord Stimulation and Blood Pressure Regulation After Spinal Cord Injury Spinal Cord Transcutaneous Stimulation - Spinal Cord Injury, Orthostatic Hypertension | Not applicable | Recruiting | University of Louisville | 40 | 2026-04-01 | 2026-04-28 |
| Deciphering Preserved Autonomic Function After Multiple Sclerosis Tests of sympathetic inhibition, Tests of sympathetic activation, Testing of autonomic dysreflexia - Multiple Sclerosis, Control Subjects | Not applicable | Recruiting | Mayo Clinic | 13 | 2025-09-17 | 2026-05-28 |
| Comparing CPAP and BiPAP for Sleep-Disordered Breathing in People with Cervical Spinal Cord Injuries CPAP, BiPAP - Spinal Cord Injuries (SCI), Sleep Disordered Breathing (SDB) | Not applicable | Not yet recruiting | University of British Columbia | 32 | 2025-08-01 | 2025-02-10 |
| Autonomic Dysreflexia in Spinal Cord Injuries: UDS Filling Speed Impact Urodynamic test - Spinal Cord Injuries, Autonomic Dysreflexia | Recruiting | Pusan National University Yangsan Hospital | 30 | 2025-01-08 | 2026-01-14 | |
| Cardiopulmonary Changes Following Spinal Cord Stimulation in Individuals With Spinal Cord Injury Transcutaneous Spinal Cord Stimulation (tSCS) - Spinal Cord Injuries, Cardiovascular Diseases | Not applicable | Not yet recruiting | University of British Columbia | 22 | 2024-08-01 | 2024-04-23 |
| Early BOTOX After Spinal Cord Injury Bladder chemodenervation (Botox), Bladder Sham (Saline) Injection Procedure - Spinal Cord Injuries | Early Phase 1 | Enrolling by invitation | University of Washington | 10 | 2024-07-27 | 2026-09-09 |
| Non-invasive Spinal Cord Stimulation for Recovery of Autonomic Function After Spinal Cord Injury TESCoN or SCONE device - Thoracic stimulation, TESCoN or SCONE device - Lumbosacral stimulation - Spinal Cord Injury, Autonomic Dysfunction | Not applicable | Recruiting | University of British Columbia | 30 | 2023-10-03 | 2025-12-08 |
| Prevention of Complications Due to Autonomic Dysreflexia in SCI Individuals Clinical Examination - Autonomic Dysreflexia, Spinal Cord Injuries | Not applicable | Unknown | Assoc. Prof. Jiri Kriz, MD, PhD | 40 | 2023-01-01 | 2023-03-14 |
| Mild Intermittent Hypoxia: A Prophylactic for Autonomic Dysfunction in Individuals With Spinal Cord Injuries Mild Intermittent Hypoxia, Sham - Spinal Cord Injuries, Autonomic Dysreflexia | Not applicable | Recruiting | VA Office of Research and Development | 24 | 2022-10-01 | 2026-08-14 |
| Heart Rate Variability and Anxiety During Urinary Bladder Catheterization Self-catheterization, Catheterization performed by urology nurse, participant blinded to time of procedure, Catheterization performed by urology nurse, participant aware of time of procedure - Spinal Cord Injuries, Urinary Bladder, Neurogenic | Not applicable | Completed | University of British Columbia | 22 | 2022-07-15 | 2026-04-28 |
| Transcutaneous Spinal Cord Neuromodulation to Normalize Autonomic Phenotypes Tests of sympathetic inhibition, Tests of sympathetic activation, Testing of autonomic dysreflexia - Spinal Cord Injuries, Autonomic Imbalance | Not applicable | Completed | Spaulding Rehabilitation Hospital | 4 | 2022-02-17 | 2023-04-14 |
| Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury Targeted Epidural Spinal Stimulation - Spinal Cord Injuries | Not applicable | Unknown | Aaron Phillips | 8 | 2021-12-01 | 2021-12-21 |
| Recovery of Bladder and Sexual Function After Human Spinal Cord Injury Spinal Cord Epidural Stimulation - Urinary Bladder, Neurogenic, Blood Pressure | Not applicable | Completed | University of Louisville | 61 | 2021-01-04 | 2026-05-01 |
| Deciphering Preserved Autonomic Function After Spinal Cord Injury Tests of sympathetic inhibition, Tests of sympathetic activation, Testing of autonomic dysreflexia - Spinal Cord Injuries, Autonomic Imbalance | Not applicable | Completed | Mayo Clinic | 62 | 2020-11-13 | 2026-09-16 |
| Spinal Cord Stimulation and Autonomic Response in People With SCI. Epidural spinal cord stimulation, Trnascutaneous electrical spinal cord stimulation. - Spinal Cord Injuries, Autonomic Dysreflexia | Not applicable | Unknown | University of Calgary | 46 | 2020-02-01 | 2019-12-17 |
| Mecamylamine for Autonomic Dysreflexia Prophylaxis Mecamylamine Oral Tablet - Spinal Cord Injuries | Phase 4 | Unknown | Wayne State University | 5 | 2019-06-13 | 2019-10-07 |
| Treatment of Post-SCI Hypotension Midodrine Hydrochloride - Spinal Cord Injury, Autonomic Dysreflexia | Phase 2 / Phase 3 | Completed | James J. Peters Veterans Affairs Medical Center | 66 | 2017-06-01 | 2025-02-21 |
| A Longitudinal Examination of Aging With a Spinal Cord Injury: Cardiovascular, Cerebrovascular and Cognitive Consequences Longitudinal - Spinal Cord Injury | Completed | James J. Peters Veterans Affairs Medical Center | 92 | 2016-12-01 | 2023-06-26 |
Showing 20 of 30. Sign in to see all of them.
Spinal Cord Injuries (25) · Hypotension, Orthostatic (6) · Brain Injuries, Traumatic (3) · Urinary Bladder, Neurogenic (3) · Hypotension (2) · Anxiety Disorders (1) · Cardiovascular Diseases (1) · Disease (1) · Dystonia (1) · Fecal Incontinence (1) · Multiple Sclerosis (1) · Muscle Weakness (1) · Pain (1) · Parkinson Disease (1)
Autonomic Nervous System Diseases (30) · Nervous System Diseases (30) · Trauma, Nervous System (30) · Central Nervous System Diseases (26) · Spinal Cord Diseases (25) · Wounds and Injuries (25) · Pathological Conditions, Signs and Symptoms (7) · Vascular Diseases (7) · Cardiovascular Diseases (6) · Neurologic Manifestations (6) · Orthostatic Intolerance (6) · Signs and Symptoms (6) · Brain Diseases (5) · Hypotension (5) · Primary Dysautonomias (5)
Botulinum Toxins, Type A (2) · Midodrine (2) · Deep Brain Stimulation (1) · Injections (1) · Intermittent Urethral Catheterization (1) · Lidocaine (1) · Mecamylamine (1) · Physical Examination (1) · Prazosin (1) · Pyridostigmine Bromide (1) · Sodium Chloride (1) · fesoterodine (1) · mirabegron (1) · salicylhydroxamic acid (1)
James J. Peters Veterans Affairs Medical Center (6) · University of British Columbia (6) · Mayo Clinic (2) · Simon Fraser University (2) · University of Louisville (2) · Aaron Phillips (1) · Assoc. Prof. Jiri Kriz, MD, PhD (1) · Jonathan Jagid (1) · New York Institute of Technology (1) · Pusan National University Yangsan Hospital (1) · Rick Hansen Institute (1) · Spaulding Rehabilitation Hospital (1) · Swiss Paraplegic Research, Nottwil (1) · University of Calgary (1) · University of Washington (1)
United States (16) · Canada (10) · Czechia (1) · South Korea (1) · Switzerland (1)
Andrei Krassioukov, MD,PhD,FRCPC (3) · Jill M Wecht, Ed.D. (3) · Ryan Solinsky, MD (2) · Aaron Phillips, PhD (1) · Alexander Ovechkin (1) · Andrei Krassioukov, MD, PhD, FRCPC (1) · Andrei V. Krassioukov, M.D, PhD (1) · Charles Hubscher, PhD (1) · Claire C Yang, MD (1) · Gino Panza, PhD (1) · Jayme Mancini, PhD DO (1) · Jill M Wecht, Ed.D (1) · Jill M Wecht, EdD (1)
PMID 12186831, PMID 15741979, PMID 17082357, PMID 17852230, PMID 1898695, PMID 20674807, PMID 22045363, PMID 23098715, PMID 23737201, PMID 23912611, PMID 24175653, PMID 26718236, PMID 27137412, PMID 28802811, PMID 29651418, PMID 29867586, PMID 30467135, PMID 32906175, PMID 33566672, PMID 35366432, PMID 38712567, PMID 40032720, PMID 40766908, PMID 42152086, PMID 42203266
K23HD102663 (1), OT2OD024898 (1)