12 completed, 2 terminated, 1 recruiting, 1 unknown. 7 Not applicable, 3 Phase 2, 3 Phase 3, 2 Phase 1, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 7 | Completed 7 |
| Phase 2 | 3 | Completed 1, Recruiting 1, Withdrawn 1 |
| Phase 3 | 3 | Completed 2, Terminated 1 |
| Phase 1 | 2 | Completed 2 |
| Phase 4 | 1 | Terminated 1 |
Follow nitrox: new trials by email Literature Review of nitrox trials Research Report on nitrox
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Cardiovascular Consequences of Sleep Apnea Plus COPD (Overlap Syndrome) bi-level positive pressure non invasive ventilation, Oxygen gas - Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease | Phase 2 | Recruiting | University of California, San Diego | 240 | 2024-02-13 | 2026-06-03 |
| Hyperoxia on Ventilation During Recovery From General Anesthesia Oxygen gas - Ventilatory Depression, Postoperative Respiratory Failure | Not applicable | Completed | Stanford University | 10 | 2023-08-08 | 2024-03-13 |
| Multiple N-of-1 Trials of (Intermittent) Hypoxia Therapy in Parkinson's Disease Hypoxic Gas Mixture - Parkinson Disease, Effect of Drug | Phase 1 / Phase 2 | Completed | Radboud University Medical Center | 29 | 2022-02-22 | 2023-07-21 |
| Normoxemic Versus Hyperoxemic Extracorporeal Oxygenation in Patients Supported by Veino-arterial ECMO for Cardiogenic Shock Oxygen gas - Cardiogenic Shock, Extracorporeal Membrane Oxygenation | Phase 3 | Completed | Centre Hospitalier Universitaire de Besancon | 60 | 2022-01-09 | 2024-12-30 |
| Supplemental Oxygen in Hypovolemia Oxygen gas, Air - Hypovolemia, Hyperoxia | Phase 1 | Completed | Oslo University Hospital | 15 | 2021-11-26 | 2022-07-05 |
| Evaluation of SpO2 Measurement Using a Smartwatch Hypoxic gas mixture, Hypercapnic and hypoxic gas mixture, SpO2 measurement - Hypoxia, Hypercapnia | Not applicable | Completed | Czech Technical University in Prague | 24 | 2021-02-15 | 2022-01-28 |
| iNOPulse for COVID-19 Inhaled nitric oxide (iNO), Nitrogen gas, Oxygen gas - COVID-19, Hypoxemia | Phase 2 | Withdrawn | Roger Alvarez | 2020-12-01 | 2020-08-19 | |
| Comparing Mortality for Low vs High Peripheral Oxygen Saturation in COPD-patients With Acute Exacerbation Oxygen gas - COPD Exacerbation, Chronic Obstructive Pulmonary Disease Exacerbation | Phase 4 | Terminated | Esbjerg Hospital - University Hospital of Southern Denmark | 23 | 2020-02-03 | 2026-03-11 |
| Air Versus Oxygen for Intermediate-Risk Pulmonary Embolism (AIRE) Oxygen gas - Pulmonary Embolism | Phase 3 | Completed | Ministry of Health, Spain | 70 | 2019-07-11 | 2022-08-18 |
| Acute Maternal Hyperoxygenation in CHD Oxygen gas - Congenital Heart Disease | Not applicable | Completed | The Hospital for Sick Children | 53 | 2019-04-26 | 2026-04-28 |
| Acute Maternal Hyperoxygenation for Fetal Transposition of the Great Arteries (TGA) Oxygen gas - TGA - Transposition of Great Arteries | Not applicable | Completed | The Hospital for Sick Children | 34 | 2018-09-20 | 2026-04-28 |
| Elective Percutaneous Coronary Intervention With or Without Supplemental OXYgen Oxygen gas, Ambient air - Coronary Artery Disease | Phase 3 | Terminated | Karolinska Institutet | 65 | 2018-01-01 | 2020-10-05 |
| Pulmonary Disease Requiring Ambulatory Oxygen Therapy -Resilience and Quality of Life Oxygen gas - Pulmonary Disease | Unknown | Kuopio University Hospital | 43 | 2017-11-01 | 2023-10-26 | |
| Supplementary Oxygen in Surgical and Medical Wards Evaluated by 30-day Mortality Oxygen gas - Oxygen Toxicity, Oxygen Deficiency | Completed | Hannibal Troensegaard | 11196 | 2014-01-01 | 2021-01-12 | |
| Effect of Systemic Oxygen on Corneal Epithelial Wound Healing in Diabetic Patients Undergoing Pars Plana Vitrectomy Dexamethasone 0.1%, Neomycin Sulfate and Polymyxin B Sulfate topical eye drops four times daily, Homatropine 2% eye drops thrice daily, Oxygen gas - Corneal Diseases | Not applicable | Completed | Universiti Sains Malaysia | 32 | 2013-10-01 | 2015-01-26 |
| Effect of Hyperoxia and Hypergravity on Lung Ventilation and Perfusion hypergravity, gas mixture - Atelectasis | Not applicable | Completed | Direction Centrale du Service de Santé des Armées | 20 | 2011-10-01 | 2013-11-25 |
| Vitamin B12 and Folate Administration on Homocysteine Concentrations After Nitrous Oxide Anesthesia B12-Folic Acid, nitrous oxide, Nitrous oxide (NO) and placebo, Placebo - Cardiovascular Abnormalities | Not applicable | Completed | Washington University School of Medicine | 63 | 2009-03-01 | 2020-09-16 |
Hypoxia (4) · Hyperoxia (2) · Pulmonary Disease, Chronic Obstructive (2) · Respiratory Insufficiency (2) · COVID-19 (1) · Cardiovascular Abnormalities (1) · Corneal Diseases (1) · Coronary Artery Disease (1) · Diabetes Mellitus (1) · Heart Defects, Congenital (1) · Hypercapnia (1) · Hypovolemia (1) · Hypoxia, Brain (1) · Lung Diseases (1) · Movement Disorders (1)
The Hospital for Sick Children (2) · Centre Hospitalier Universitaire de Besancon (1) · Czech Technical University in Prague (1) · Direction Centrale du Service de Santé des Armées (1) · Esbjerg Hospital - University Hospital of Southern Denmark (1) · Hannibal Troensegaard (1) · Karolinska Institutet (1) · Kuopio University Hospital (1) · Ministry of Health, Spain (1) · Oslo University Hospital (1) · Radboud University Medical Center (1) · Roger Alvarez (1) · Stanford University (1) · Universiti Sains Malaysia (1) · University of California, San Diego (1)
United States (4) · Canada (2) · Denmark (2) · France (2) · Czechia (1) · Finland (1) · Netherlands (1) · Norway (1) · Spain (1) · Sweden (1)
Mike Seed, MBBS (2) · Anthony Doufas, MD, PhD (1) · Atul Malhotra, MD (1) · Daniel Garin, MD, PhD (1) · Edgar Jaeggi, MD (1) · Edgar Jaeggi, MD, FRCP(C) (1) · Merja Kokki, V (1) · Peter Hallas, MD (1) · Peter Nagele, MD (1) · Roger A Alvarez, D.O. (1) · Simon Thorgaard-Rasmussen, MD (1) · Sune Laugesen, MD (1) · Veronika Rafl Huttova (1) · Wee-Min Teh, MD (1)
PMID 23322670, PMID 28506763, PMID 28787294, PMID 30966908, PMID 32508541, PMID 33933036, PMID 35836147, PMID 36249475, PMID 37717936, PMID 37947905, PMID 39498807, PMID 40616033, PMID 41175776
2019 (2)