36 completed, 6 terminated, 6 unknown, 3 not yet recruiting. 57 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 57 | Completed 36, Terminated 6, Unknown 6, Not yet recruiting 3, Recruiting 3, Active not recruiting 1, Enrolling by invitation 1, Suspended 1 |
Follow Hyperoxia: new trials by email Literature Review of Hyperoxia trials Research Report on Hyperoxia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| ORI-Guided Oxygen Therapy During One-Lung Ventilation ORI-Guided FiO2 Titration, Conventional SpO₂-Guided FiO₂ Titration - Thoracic Surgery With One-lung Ventilation | Not applicable | Not yet recruiting | Konkuk University Medical Center | 58 | 2026-08-01 | 2026-07-22 |
| Oxygen Reserve Index-Guided Oxygen Titration During Surgery in the Beach Chair Position ORi-Guided FiO₂ Titration, SpO₂-Guided FiO₂ Titration - Hyperoxemia, Intraoperative Oxygen Therapy | Not applicable | Not yet recruiting | Fatih Sultan Mehmet Training and Research Hospital | 80 | 2026-02-15 | 2026-02-11 |
| Effect of Hydrogen Gas on Hyperbaric Oxygen Toxicity Inhaled Hydrogen-Enriched Oxygen Gas, Inhaled Nitrogen-Enriched Oxygen Gas - Oxygen Toxicity, Oxidative Stress | Not applicable | Not yet recruiting | Blekinge Institute of Technology | 32 | 2026-01-01 | 2025-12-04 |
| Cerebral Hemodynamic Effects of Oxygen and Antioxidants (CHEOXANT) Oxygen, Vitamin C (Ascorbic Acid) - Oxygen, Hyperoxemia | Not applicable | Completed | Erasme University Hospital | 13 | 2025-09-01 | 2026-05-19 |
| Can Atelectasis Be Prevented With Oxygen Reserve Index (ORI) Monitoring? Peripheral Oxygen Saturation (SpO₂) Group, Peripheral Oxygen Saturation and Oxygen Reserve Index (SpO₂-ORI) Group - Atelectasis, Lung Ultrasonography Score | Not applicable | Completed | Antalya Training and Research Hospital | 58 | 2025-07-15 | 2025-12-10 |
| Hyperoxia vs Normoxia During Cardiopulmonary Bypass Hyperoxia group, Normoxia group (control) - AKI, Renal Replacement Therapy | Not applicable | Completed | University of Padova | 104 | 2025-07-01 | 2026-04-03 |
| Hyperoxia During Outpatient Pulmonary Rehabilitation in Chronic Lung Disease - Does it Matter? Oxygen, Room Air (placebo) - Chronic Obstructive Pulmonary Disease (COPD) | Not applicable | Recruiting | Eastern Switzerland University of Applied Sciences | 32 | 2025-01-06 | 2026-09-10 |
| Automated Versus Manual Oxygen Control in Preterm Babies on Respiratory Support automated oxygen vs manual oxygen - Preterm | Not applicable | Completed | Aga Khan University Hospital, Pakistan | 26 | 2024-10-03 | 2025-09-30 |
| Acute Effects of Supplemental Oxygen on Memory Testing in Healthy Adult Volunteers Cross Over Assignment Supplemental Oxygen and Supplemental Air - Cognition | Not applicable | Completed | Inogen Inc. | 40 | 2024-05-28 | 2025-01-31 |
| Strategy to Avoid Excessive Oxygen Using an Autonomous Oxygen Titration Intervention Automated Titration (O2matic) - Critical Illness, Wounds and Injury | Not applicable | Completed | University of Colorado, Denver | 300 | 2024-04-29 | 2026-10-14 |
| Electronic Optimization of Inspired Oxygen During Mechanical Ventilation, a Pragmatic Randomized Trial (OPTI-Oxygen) FiO2 titration using electronic alert system - Hyperoxia | Not applicable | Suspended | Ohio State University | 936 | 2024-01-15 | 2025-04-11 |
| HYPER MIND - Hyperoxia Effects on Cerebral Hemodynamics Normobaric Hyperoxic Stimulus (NBHO) - Hyperoxemia, Cerebrovascular Circulation | Not applicable | Recruiting | Erasme University Hospital | 80 | 2024-01-01 | 2026-01-29 |
| Oxygen as a Metabolic Modulator: Divergent Physiological Adaptations to Hypoxic and Hyperoxic Tabata Training. FIO2 modulation during HIIT protocol on assault bike - Hyperoxia / High FiO₂ Exposure, Interval Training | Not applicable | Completed | Haute Ecole Bruxelles-Brabant | 23 | 2023-01-10 | 2026-04-30 |
| Oxygen Reserve Index Guided FiO₂ Titration in One-Lung Ventilation Oxygen Reserve Index (ORi)-guided oxygen titration - One Lung Ventilation in Thoracic Surgery | Not applicable | Completed | Gazi University | 60 | 2022-08-05 | 2026-01-22 |
| NICU Oxygen Control Study Automatic control of inspired oxygen - Hyperoxia, Hypoxia | Not applicable | Completed | University of Missouri-Columbia | 48 | 2022-05-24 | 2025-07-04 |
| Delayed Cord Clamping With Oxygen In Extremely Low Gestation Infants Delayed Cord Clamping with Low Oxygen concentration, Delayed Cord Clamping with High Oxygen concentration - IVH- Intraventricular Hemorrhage, Extreme Prematurity | Not applicable | Active not recruiting | Sharp HealthCare | 140 | 2021-11-17 | 2026-10-15 |
| Influence of Oxygen on Perioperative Outcome in Patients Undergoing General Anaesthesia for Elective Non-cardiac Surgery Oxygen - Coronary Artery Disease, Anesthesia | Not applicable | Recruiting | Insel Gruppe AG, University Hospital Bern | 110 | 2021-05-07 | 2024-12-13 |
| Comparison of Two FiO2 (1 or 0.5) for Tracheal Extubation in Post-anesthesia Care Unit FiO2 0.5, FiO2 1 - Anesthesia, Atelectasis | Not applicable | Completed | University Hospital, Caen | 119 | 2021-04-09 | 2026-04-02 |
| The Effectiveness of the Use of Oxygen Reserve Index in Preventing Hyperoxia in the Intensive Care Unit. Titration of fraction of inspired oxygen (FiO2) guided by ORI and oxygen saturation - Hyperoxia, Complication | Not applicable | Completed | Tepecik Training and Research Hospital | 60 | 2021-03-01 | 2023-04-11 |
| Effect of ORI-guided Oxygen Titration on Oxidative Stress in Rhinoplasty Surgery FiO₂ titration, under the guidance of ORI, Conventional oxygen administration - Rhinoplasty, Oxidative Stress | Not applicable | Completed | Dr. Lutfi Kirdar Kartal Training and Research Hospital | 60 | 2021-03-01 | 2025-09-08 |
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Hypoxia (17) · Premature Birth (6) · Respiratory Insufficiency (5) · Coronary Artery Disease (4) · Hypercapnia (3) · Obstetric Labor, Premature (3) · Postoperative Complications (3) · Pulmonary Atelectasis (3) · Pulmonary Disease, Chronic Obstructive (3) · Critical Illness (2) · Hypocapnia (2) · Respiratory Aspiration (2) · Sprains and Strains (2) · Angina Pectoris (1)
Pathological Conditions, Signs and Symptoms (57) · Signs and Symptoms (57) · Signs and Symptoms, Respiratory (57) · Respiratory Tract Diseases (13) · Pathologic Processes (11) · Respiration Disorders (9) · Cardiovascular Diseases (7) · Heart Diseases (7) · Lung Diseases (7) · Female Urogenital Diseases and Pregnancy Complications (6) · Obstetric Labor Complications (6) · Pregnancy Complications (6) · Urogenital Diseases (6) · Myocardial Ischemia (5) · Vascular Diseases (5)
Oxygen (9) · Oxygen Saturation (4) · Ascorbic Acid (1) · Carbon Dioxide (1) · Control Groups (1) · Hyperbaric Oxygenation (1) · Lactoperoxidase (1) · Oximetry (1) · Population Groups (1) · Respiration, Artificial (1) · Sodium Chloride (1) · Umbilical Cord Clamping (1)
University of Edinburgh (4) · Insel Gruppe AG, University Hospital Bern (3) · Beth Israel Deaconess Medical Center (2) · Erasme University Hospital (2) · Hvidovre University Hospital (2) · Laval University (2) · Norwegian University of Science and Technology (2) · Tepecik Training and Research Hospital (2) · University Hospital, Angers (2) · Aga Khan University Hospital, Pakistan (1) · Alexander Averyanov (1) · Amsterdam UMC, location VUmc (1) · Antalya Training and Research Hospital (1) · Assiut University (1) · Bakirkoy Dr. Sadi Konuk Research and Training Hospital (1)
Turkey (Türkiye) (9) · United States (9) · Switzerland (5) · United Kingdom (5) · Belgium (4) · France (4) · Canada (2) · Denmark (2) · Netherlands (2) · Norway (2) · Sweden (2) · Austria (1) · China (1) · Egypt (1) · Germany (1)
Dominik P Guensch, MD (2) · Ali Shabbir Hussain (1) · Anita Simonds, FRCP (1) · Anup Katheria, MD (1) · Axel R Franz, MD (1) · Azadeh Fayazi, MD (1) · Balthasar Eberle, MD (1) · Beatrice de la Grandville (1)
PMID 17486089, PMID 18609057, PMID 19821224, PMID 23475767, PMID 28219612, PMID 28760799, PMID 29254495, PMID 29730991, PMID 30916028, PMID 31410497, PMID 31440853, PMID 31527093, PMID 31650500, PMID 31767144, PMID 32089047, PMID 34051711, PMID 34112721, PMID 34460936, PMID 36525683, PMID 37142388, PMID 37364027, PMID 37535937, PMID 37588173, PMID 37863418, PMID 39911528, PMID 40374283, PMID 40473278, PMID 40690234, PMID 41188744, PMID 41919002, PMID 42289654, PMID 42546017
R03HD105224 (1)