23 completed, 12 unknown, 11 recruiting, 8 terminated. 26 Not applicable, 3 Phase 3, 2 Phase 2, 2 Phase 4, 1 Early Phase 1.
Follow Hydrocephalus, Normal Pressure: new trials by email Literature Review of Hydrocephalus, Normal Pressure trials Research Report on Hydrocephalus, Normal Pressure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Addressing Health Disparities in Normal Pressure Hydrocephalus (NPH) in Maryland patients will receive NPH education, primary care physicians (PCPs) will receive professional NPH education, A community health worker will assist PCP - Normal Pressure Hydrocephalus, Hakim Syndrome | Not applicable | Not yet recruiting | Johns Hopkins Bloomberg School of Public Health | 660 | 2027-08-01 | 2026-05-07 |
| Prediction of Response to Shunt Surgery in Normal Pressure Hydrocephalus Using Radscale and Lumbar Puncture Idiopathic Normal Pressure Hydrocephalus, Normal Pressure Hydrocephalus | Not yet recruiting | Assiut University | 40 | 2026-10-01 | 2026-09-22 | |
| Examining the Feasibility of Using Pressure Gradient Regulated Automated Cerebral Spinal Fluid Drainage During External Lumbar Drain Trials Intellidrop Automated CSF Drainage System - NPH (Normal Pressure Hydrocephalus) | Not applicable | Recruiting | University of Texas Southwestern Medical Center | 10 | 2026-05-14 | 2026-06-02 |
| Non-invasive Diagnostics of Shunt Obstruction in Adult Hydrocephalus Intervention group "Virtual OFF", Control group (no change in shunt setting) - Normal Pressure Hydrocephalus Patients, Normal Pressure Hydrocephalus | Not applicable | Not yet recruiting | Göteborg University | 60 | 2025-09-15 | 2025-09-15 |
| Analysis of Cerebrospinal Fluid Dynamics in Normal Pressure Hydrocephalus Cerebrospinal fluid drainge - Normal Pressure Hydrocephalus | Not applicable | Recruiting | Chungnam National University Hospital | 22 | 2025-09-11 | 2026-09-21 |
| White Matter Distortion and Dementia Biomarkers in Normal Pressure Hydrocephalus (NPH) Ventriculoperitoneal Shunt (VP), Brain and Skin Biopsy, MRI Brain - Normal Pressure Hydrocephalus | Recruiting | Imperial College London | 100 | 2025-03-25 | 2026-03-27 | |
| The Use of Q-Collar to Increase CSF Drainage in Low-pressure Hydrocephalus Patients Q-collar - Low Pressure Hydrocephalus | Not applicable | Withdrawn | University of Kansas Medical Center | 2024-12-01 | 2025-07-08 | |
| Evaluation of the Safety and Effectiveness of the CereVasc® eShunt® System in Normal Pressure Hydrocephalus CereVasc eShunt System, VP Shunt - Normal Pressure Hydrocephalus | Not applicable | Active not recruiting | CereVasc Inc | 230 | 2024-11-26 | 2026-06-25 |
| Proteinopathies Expression in Skin of Neurodegenerative Disorders Immunohistochemistry and immunofluorescence - Alzheimer Disease, Frontotemporal Dementia | Recruiting | Universidad Autonoma de San Luis Potosí | 40 | 2023-12-20 | 2024-12-16 | |
| Role of Brain Specific Biomarkers in Hydrocephalus Lumbar puncture, External lumbar drainage, Ventriculo-peritoneal shunt placement - Hydrocephalus, Normal Pressure, Biochemical Lesions Head Region | Completed | University Hospital Hradec Kralove | 32 | 2023-11-01 | 2025-02-21 | |
| European Study of Prodromal iNPH Shunt surgery - Normal Pressure Hydrocephalus, Hydrocephalus | Recruiting | Johan Virhammar | 140 | 2023-11-01 | 2026-04-30 | |
| Post Market Clinical Follow-up of CODMAN CERTAS Programmable Valve CODMAN CERTAS Plus Programmable Valve - Hydrocephalus, Hydrocephalus in Children | Active not recruiting | Integra LifeSciences Corporation | 160 | 2023-01-24 | 2026-02-27 | |
| Neurosurgical Outcome Network Aneurysms, Arteriovenous Malformations | Recruiting | Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta | 4500 | 2022-12-05 | 2026-03-30 | |
| Normal Pressure Hydrocephalus Biomarkers Investigation Measurement of oxysterol profile, including 20 molecules, in liquor before and after surgery - Normal Pressure Hydrocephalus, Cognitive Impairment | Unknown | University of Roma La Sapienza | 30 | 2022-10-30 | 2022-10-03 | |
| Study of Changes in CSF Ionic Composition After Aneurysmal Meningeal Hemorrhage Concurrent evaluation of blood and CSF ionograms to determine if there is a correlation between CSF change and the development of hyoponatremia between day 0 and day 14. - Subarachnoid Hemorrhage | Unknown | Hospices Civils de Lyon | 80 | 2022-10-01 | 2023-07-12 | |
| US Pilot Study of the CereVasc® eShunt® System in Normal Pressure Hydrocephalus eShunt Implant - Hydrocephalus, Normal Pressure, Hydrocephalus | Not applicable | Active not recruiting | CereVasc Inc | 50 | 2022-04-20 | 2025-06-19 |
| The Effects of Exercise on Gait Characteristics, Balance, and Performance in Patients With Normal Pressure Hydrocephalus Exercise Program - NPH (Normal Pressure Hydrocephalus) | Not applicable | Completed | Dokuz Eylul University | 41 | 2022-04-07 | 2026-10-05 |
| Pilot Study of the CereVasc® eShunt® System in Normal Pressure Hydrocephalus eShunt Implant - Hydrocephalus, Normal Pressure, Hydrocephalus | Not applicable | Active not recruiting | CereVasc Inc | 30 | 2022-03-10 | 2026-03-18 |
| Acetazolamide Trial in Normal Pressure Hydrocephalus Acetazolamide, Placebo - Idiopathic Normal Pressure Hydrocephalus (INPH) | Phase 2 | Completed | Uppsala University Hospital | 50 | 2022-02-17 | 2026-05-06 |
| The Role of the Glymphatic System Avaluated Thourgh mr Imaging in the Diagnosis and Management of NPH Hydrocephalus, Normal Pressure Hydrocephalus | Completed | Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta | 29 | 2021-06-15 | 2026-02-11 |
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Hydrocephalus (21) · Dementia (5) · Alzheimer Disease (3) · Parkinson Disease (3) · Brain Diseases (2) · Central Nervous System Diseases (2) · Cognitive Dysfunction (2) · Frontotemporal Dementia (2) · Mobility Limitation (2) · Multiple System Atrophy (2) · Parkinsonian Disorders (2) · Plaque, Amyloid (2) · Pseudotumor Cerebri (2) · Subarachnoid Hemorrhage (2)
Nervous System Diseases (62) · Brain Diseases (61) · Central Nervous System Diseases (61) · Hydrocephalus (42) · Mental Disorders (14) · Neurocognitive Disorders (12) · Pathological Conditions, Signs and Symptoms (11) · Neurodegenerative Diseases (7) · Signs and Symptoms (7) · Dementia (5) · Movement Disorders (5) · Basal Ganglia Diseases (4) · Cardiovascular Diseases (4) · Neurologic Manifestations (4) · Pathologic Processes (4)
Ventriculoperitoneal Shunt (4) · Acetazolamide (2) · Hydrodynamics (2) · Spinal Puncture (2) · Ventriculostomy (2) · flutemetamol (2) · Cerebrovascular Circulation (1) · Control Groups (1) · Fluorescent Antibody Technique (1) · Immunohistochemistry (1) · Occupational Therapy (1) · Physical Therapy Modalities (1) · Physicians, Primary Care (1) · Resistance Training (1) · Speech Therapy (1)
Umeå University (5) · CereVasc Inc (3) · Johns Hopkins University (3) · Centre Hospitalier Universitaire, Amiens (2) · Codman & Shurtleff (2) · Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta (2) · GE Healthcare (2) · Integra LifeSciences Corporation (2) · NeuroDx Development (2) · University Hospital Hradec Kralove (2) · University of South Florida (2) · University of Valencia (2) · Vanderbilt University Medical Center (2) · Assiut University (1) · Chungnam National University Hospital (1)
United States (21) · Sweden (10) · France (5) · Germany (4) · Italy (4) · Czechia (3) · Spain (3) · Argentina (2) · Denmark (2) · Finland (2) · Israel (2) · Netherlands (2) · South Korea (2) · United Kingdom (2) · Belgium (1)
Jan Malm, MD, PhD (2) · Johan Virhammar, MD, PhD (2) · Kim A Mansfield, MS (2) · Miroslav Cihlo, M.D. (2) · Naomi Abel, MD (2) · Anders Behrens, M.D., M.Sc. (1) · Anthony Marmarou, Ph.D. (1) · Carine W. Maurer, MD, PhD (1) · Carsten I Wikkelsoe, MD (1) · Clemens MF Dirven, Prof. PhD (1) · DaiWai Olson, PhD, RN, CCRN, FNCS (1) · Daniele Rigamonti, MD (1) · Daniele Rigamonti, MD FACS (1) · Daniele Rigamonti, MD, FACS (1)
PMID 20097391, PMID 40135887, PMID 41734937, PMID 1114545, PMID 18092331, PMID 18092336, PMID 18282655, PMID 18402070, PMID 19388301, PMID 19713705, PMID 20404696, PMID 21660204, PMID 22038765, PMID 23250963, PMID 23415160, PMID 23510566, PMID 24118122, PMID 24379955, PMID 24729303, PMID 25279138, PMID 26003249, PMID 26578001, PMID 27490149, PMID 28486988, PMID 28889317, PMID 28892272, PMID 28919849, PMID 29710721, PMID 30248058, PMID 30738407, PMID 30792248, PMID 31141553, PMID 31167811, PMID 31561378, PMID 31997040, PMID 32747697, PMID 3351510, PMID 33720890, PMID 34093167, PMID 34275898, PMID 34809666, PMID 35164790, PMID 35230552, PMID 35325129, PMID 35418936, PMID 35431542, PMID 35733946, PMID 35901765, PMID 36552981, PMID 37976516
R43NS067770 (1)