105 completed, 12 unknown, 11 recruiting, 4 terminated. 104 Not applicable, 21 Phase 3, 9 Phase 2, 3 Phase 1, 2 Early Phase 1.
Follow Diet, Fat-Restricted: new trials by email Literature Review of Diet, Fat-Restricted trials Research Report on Diet, Fat-Restricted
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study Of Milk Consumption In Metabolic Syndrome Full-fat diet, Low-fat diet - Metabolic Syndrome | Not applicable | Recruiting | Mayo Clinic | 40 | 2026-04-13 | 2026-04-16 |
| Plant-Based Online Weight Loss Through Education and Resources Program and Study Low-fat, vegan diet - Type 2 Diabetes, Overweight and Obese Adults | Not applicable | Recruiting | Physicians Committee for Responsible Medicine | 100 | 2026-01-02 | 2026-09-17 |
| COAST Study - Cholesterol Optimization After Stroke low-fat diet, supplements, statins, ezetimibe, bempedoic acid, PCSK9 inhibitors, fibrates, or other lipid-lowering agents - Stroke (CVA) or Transient Ischemic Attack, Cerebral Hemorrhage | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 500 | 2026-01-01 | 2025-12-01 | |
| Interaction Between Dairy and Gut Hormone Response on Cognitive Performance in Children. Fat-Free Milk, Low-Fat Milk, Full-fat Milk - Children, Healthy | Not applicable | Recruiting | Toronto Metropolitan University | 48 | 2025-11-15 | 2025-12-09 |
| Manipulation of Whey Permeate Formulation for Better Fluid Retention. Water, Semi-skimmed milk, Whey permeate - Beverage Hydration Index | Not applicable | Completed | Northumbria University | 13 | 2025-05-20 | 2025-09-11 |
| Integrating Metabolic and Vascular Sensors to Monitor Cardiometabolic Disorders After Nutrition Interventions Mediterranean diet (MED), high-fat/low carb diet (HF/LC), and low-fat diet (LF), The integrated sweat sensor and vascular sensor (wearable), continuous glucose monitor (CGM) - NAFLD (Nonalcoholic Fatty Liver Disease) | Not applicable | Not yet recruiting | VA Greater Los Angeles Healthcare System | 54 | 2025-05-01 | 2025-04-17 |
| Metabolic Impact and Compliance of Controlled, Varying, Mediterranean Diets in Pre-Surgical Prostate Cancer Populations (PROVISIONS) Low fat diet, Lower carbohydrate diet - Prostate Cancer | Not applicable | Recruiting | University of Miami | 20 | 2025-04-17 | 2026-04-23 |
| Effect of Indianized Version of Mediterranean Diet vs. Low Fat Diet on Hepatic Steatosis in Overweight Children and Adolescent With MASLD Indianized version of Mediterranean Diet, Low Fat Diet, Physical Activity - Metabolic Dysfunction-Associated Steatotic Liver Disease | Not applicable | Recruiting | Institute of Liver and Biliary Sciences, India | 134 | 2025-02-15 | 2026-01-06 |
| Influence of Beverage Choice on Hydration Status Cognition and Learning in Children Distilled water, Semi-skimmed milk, Whey permeate - Dehydration in Children, Thirst | Not applicable | Completed | Northumbria University | 13 | 2024-11-26 | 2025-09-11 |
| Multi Center Clinical Study on the Lipid-lowering Efficacy and Safety of Menggongzi Tibetan Tea Special Drink Menggongzi Tibetan Tea Special Drink, Atorvastatin Calcium 20Mg Tab, Low fat diet - Hyperlipidemias | Not applicable | Unknown | The First Affiliated Hospital with Nanjing Medical University | 129 | 2024-10-01 | 2024-09-25 |
| Effect of a Low-carbohydrate Diet on Weight Loss in People Using the Injectable GLP-1 Agonist Semaglutide for Weight Loss Low Carbohydrate, Low Fat - Weight Loss | Not applicable | Completed | INQUIS Clinical Research | 60 | 2024-09-12 | 2026-02-18 |
| Diet Order Effects of Low Fat vs. Low Carb Diets on Body Fat Change Low-carbohydrate Diet, Low-fat Diet - Overweight, Obesity | Not applicable | Recruiting | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 42 | 2024-08-28 | 2026-10-06 |
| Dietary Reversal of the Reprometabolic Syndrome Low-fat diet - Obesity & Overweight, Infertility, Female | Not applicable | Active not recruiting | University of Colorado, Denver | 30 | 2024-08-10 | 2025-11-14 |
| Aronia and Non-alcoholic Fatty Liver Disease Aronia juice, Mediterranean diet, Low-fat diet - Non-Alcoholic Fatty Liver Disease | Not applicable | Unknown | Istanbul Kent University | 54 | 2024-06-15 | 2024-06-10 |
| A Randomized Controlled Trial Comparing Fat-free Versus Balanced (WHO) Diet in Gallstone Disease Fat-free diet, Balanced WHO diet - Gallstone Disease, Gallstone; Colic | Not applicable | Unknown | University Hospital of Crete | 242 | 2024-03-27 | 2024-05-09 |
| The Effect of a Low-fat Vegan Dietary Intervention on Intracellular Lipid, Insulin Sensitivity, and Glycemic Control in Type 2 Diabetes low-fat vegan diet - Diabetes Mellitus, Type 2, Diabetes Mellitus Type 2 in Obese | Not applicable | Completed | Physicians Committee for Responsible Medicine | 26 | 2024-02-13 | 2026-01-20 |
| Effect of Bergamot and Plant Sterols Extract on Serum Lipid Profile Diet, Diet supplementation - Dyslipidemia, Cardiac Disease | Not applicable | Completed | Istanbul Bilgi University | 61 | 2024-01-04 | 2025-08-03 |
| Ketogenic Diet and Diabetes Demonstration Project Ketogenic diet, Low Fat diet - Type 2 Diabetes, PreDiabetes | Not applicable | Recruiting | University of New Mexico | 40 | 2023-09-05 | 2026-09-03 |
| The CARING Study: Creating and Restoring Health Through Nutrition Guidance Low-fat, vegan diet - Type2diabetes, Type 2 Diabetes Treated With Insulin | Not applicable | Recruiting | Physicians Committee for Responsible Medicine | 700 | 2023-07-11 | 2026-04-13 |
| Diet Impact on Hepatic Transcriptomics and Lipidomics in Pre-diabetes Low fat diet, High fat diet - Pre-diabetes | Not applicable | Completed | Laval University | 6 | 2023-06-09 | 2026-08-26 |
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Obesity (35) · Cardiovascular Diseases (25) · Heart Diseases (20) · Insulin Resistance (18) · Diabetes Mellitus, Type 2 (13) · Coronary Disease (12) · Myocardial Ischemia (12) · Non-alcoholic Fatty Liver Disease (12) · Overweight (12) · Metabolic Syndrome (10) · Weight Loss (10) · Diabetes Mellitus (9) · Breast Neoplasms (8) · Hypertension (7) · Dyslipidemias (6)
National Heart, Lung, and Blood Institute (NHLBI) (10) · Physicians Committee for Responsible Medicine (7) · Stanford University (5) · Boston Children's Hospital (4) · Duke University (4) · Oregon Health and Science University (4) · University of Alabama at Birmingham (3) · University of North Carolina, Chapel Hill (3) · Aarhus University Hospital (2) · Albert Einstein College of Medicine (2) · Laval University (2) · Mayo Clinic (2) · National Cancer Institute (NCI) (2) · Northumbria University (2) · The University of Texas Health Science Center at San Antonio (2)
United States (74) · Canada (6) · United Kingdom (6) · China (5) · Spain (4) · Denmark (3) · Germany (3) · Italy (3) · Turkey (Türkiye) (3) · Chile (2) · Australia (1) · Belgium (1) · Brazil (1) · Greece (1) · India (1)
David S Ludwig, MD, PhD (4) · Cara B Ebbeling, PhD (2) · Catrin Roberts, PhD (2) · Christopher D Gardner, PhD (2) · Abhimanyu Garg, MD (1) · Ajjai Alva, M.D. (1) · Albert Oberman (1) · Alexander Leaf (1) · Alp Ikizler, MD (1) · Amy M Goss, PhD (1) · Andrea M Haqq, MD (1) · Andres J Acosta Cardenas (1) · Andrew McHill, PhD (1)
PMID 10946017, PMID 11159775, PMID 12200749, PMID 16210719, PMID 16467232, PMID 16467233, PMID 16467234, PMID 16481635, PMID 16481636, PMID 16585662, PMID 16609086, PMID 16651474, PMID 16740651, PMID 16873779, PMID 16880313, PMID 16963151, PMID 17087620, PMID 17276177, PMID 17341712, PMID 17405972, PMID 17502530, PMID 17507345, PMID 17582069, PMID 17605096, PMID 17846352, PMID 17925539, PMID 18000186, PMID 18227370, PMID 18235052, PMID 18299491, PMID 18319414, PMID 18489937, PMID 18501061, PMID 18502208, PMID 18504339, PMID 18580399, PMID 18663162, PMID 18676075, PMID 18834717, PMID 18926128, PMID 19001024, PMID 19001202, PMID 19005970, PMID 19167953, PMID 19193613, PMID 19204221, PMID 19212822, PMID 19221190, PMID 19228873, PMID 19339401
1DP3DK113358-01 (1), K23DK114460 (1), N01CN025427 (1), P01HL023619 (1), P20RR011104 (1), P50CA092131 (1), R01AG060157 (1), R01DK059240 (1), R01DK064986 (1), R01DK072428 (1), R01DK091831 (1), R01DK115483 (1), R01DK128457 (1), R01HD040787 (1), R01HD046741 (1)