5 completed, 2 recruiting, 2 terminated, 2 unknown. 13 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 13 | Completed 5, Recruiting 2, Terminated 2, Unknown 2, Enrolling by invitation 1, Not yet recruiting 1 |
Follow Fractures, Open: new trials by email Literature Review of Fractures, Open trials Research Report on Fractures, Open
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Volume Reduction for Open Fracture Irrigation 0.9% Sodium Chloride - Open Fracture | Phase 4 | Recruiting | Inova Health Care Services | 200 | 2026-03-02 | 2026-04-13 |
| Powdered Intrawound Vancomycin in Open Fractures Trial Vancomycin 1000 MG - Open Fracture, Trauma | Phase 4 | Not yet recruiting | University of Manitoba | 350 | 2024-11-01 | 2024-09-19 |
| Antibiotic Prophylaxis in Pediatric Open Fractures Cefazolin, Cephalexin - Fractures, Open, Infections | Phase 4 | Enrolling by invitation | St. Louis University | 800 | 2023-09-11 | 2025-10-20 |
| Acute Application of Antibiotic Powder in Open Fracture Wounds Vancomycin, Tobramycin - Fractures, Open, Wounds and Injuries--Infections | Phase 4 | Completed | University of Colorado, Denver | 20 | 2021-06-14 | 2026-03-06 |
| Placement of Antibiotic Powder in Wounds During the Emergency Room Vancomycin - Open Fracture | Phase 4 | Recruiting | The University of Texas Health Science Center at San Antonio | 200 | 2020-10-05 | 2026-09-30 |
| Pre-operative Alcohol Skin Solutions in Fractured Extremities DuraPrep, ChloraPrep - Surgical Site Infection, Unplanned Fracture-Related Reoperation | Phase 4 | Completed | University of Maryland, Baltimore | 8485 | 2018-08-21 | 2024-10-04 |
| Noninferiority Comparison of Prophylactic Open Fracture Antimicrobial Regimens Ceftriaxone, Ampicillin/sulbactam, Piperacillin/tazobactam - Open Fracture, Post-Op Wound Infection | Phase 4 | Terminated | Mercy Health Ohio | 17 | 2018-07-09 | 2020-09-11 |
| Pre-operative Aqueous Antiseptic Skin Solutions in Open Fractures 10% povidone-iodine (1% free iodine) in purified water, 4% chlorhexidine gluconate (CHG) in purified water - Surgical Site Infection, Unplanned Fracture-Related Reoperation | Phase 4 | Completed | University of Maryland, Baltimore | 1638 | 2018-04-08 | 2023-03-31 |
| The New Skin Stretching Device for Treatment of Limb Tension Wounds Skin stretching device (SSD), Skin grafting - Trauma, Fractures, Open | Phase 4 | Unknown | The First Affiliated Hospital of Dalian Medical University | 100 | 2017-05-11 | 2017-05-05 |
| Antibiotic Prophylaxis in Open Fractures Ceftaroline - Open Fractures | Phase 4 | Unknown | Olayemi Osiyemi MD | 50 | 2016-12-01 | 2016-10-28 |
| Local Application of Vancomycin Powder in Grade I-IIIA Open Fractures Vancomycin - Fractures, Open, Surgical Wound Infection | Phase 4 | Terminated | University of Tennessee | 11 | 2015-03-01 | 2018-11-29 |
| Preemptive Analgesia With OxyContin Versus Placebo Before Surgery for Long Bone Fractures Oxycodone hydrochloride - Fractures | Phase 4 | Completed | Rambam Health Care Campus | 65 | 2007-04-01 | 2015-02-05 |
| Efficacy of DBM on Fractures of the Shinbone (Tibia) Grafton DBM, Reamings - Closed Fracture, Open Fracture | Phase 4 | Completed | Emory University | 16 | 2006-03-01 | 2013-09-24 |
Surgical Wound Infection (5) · Fractures, Bone (4) · Infections (4) · Wounds and Injuries (4) · Fractures, Closed (2) · Wound Infection (2) · Hip Fractures (1)
Fractures, Bone (9) · Wounds and Injuries (9) · Pathologic Processes (5) · Pathological Conditions, Signs and Symptoms (5) · Postoperative Complications (5) · Infections (4) · Wound Infection (3) · Femoral Fractures (1) · Hip Injuries (1) · Leg Injuries (1)
Vancomycin (4) · Cefazolin (2) · Ceftaroline (1) · Ceftriaxone (1) · Cephalexin (1) · Chromogranins (1) · Clindamycin (1) · DuraPrep (1) · Gentamicins (1) · Oxycodone (1) · Piperacillin, Tazobactam Drug Combination (1) · Povidone-Iodine (1) · Saline Solution (1) · Skin Transplantation (1) · Sodium Chloride (1)
University of Maryland, Baltimore (2) · Emory University (1) · Inova Health Care Services (1) · Mercy Health Ohio (1) · Olayemi Osiyemi MD (1) · Rambam Health Care Campus (1) · St. Louis University (1) · The First Affiliated Hospital of Dalian Medical University (1) · The University of Texas Health Science Center at San Antonio (1) · University of Colorado, Denver (1) · University of Manitoba (1) · University of Tennessee (1)
United States (10) · Canada (3) · China (1) · Israel (1) · Spain (1)
Gerard Slobogean, MD (2) · Mohit Bhandari, MD (2) · Sheila Sprague, PhD (2) · Abraham Goch, MD (1) · Allison R Lauver, PharmD (1) · Chad W Donley, MD (1) · David J Gemmel, PhD (1) · Dirk W Kiner, MD (1) · Gabriel Larose, MD, MSc, FRCSC (1) · Madison Price, MD (1) · Natalie I Rine, PharmD (1) · Nicholas Alfonso, MD (1) · Olayemi Osiyemi, MD (1) · Paul T Miller, PharmD (1) · Robert A De Lorenzo, MD (1)
PMID 32259266, PMID 32787892, PMID 33648577, PMID 36244384, PMID 37002119, PMID 38294973