149 completed, 58 unknown, 48 recruiting, 20 active not recruiting. 140 Not applicable, 42 Phase 2, 22 Phase 1, 20 Phase 3, 5 Phase 4.
Follow Ataxia: new trials by email Literature Review of Ataxia trials Research Report on Ataxia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Can Acute Photobiomodulation Improve Balance and Cognition in Individuals With Ataxia: a Pilot Feasibility Placebo Randomized Controlled Trial. Photobiomodulation, Sham photobiomodulation - Ataxia | Not applicable | Not yet recruiting | University of Central Lancashire | 20 | 2027-01-01 | 2026-09-22 |
| Umbilical Cord Mesenchymal Stem Cells Therapy (19#iSCLife®-SA) for Patients With Spinocerebellar Ataxia Intravenous infusion, Intrathecal injection, umbilical cord mesenchymal stem cell - Spinocerebellar Ataxia Type 1, Spinocerebellar Ataxia Type 2 | Phase 2 | Not yet recruiting | Sclnow Biotechnology Co., Ltd. | 45 | 2026-12-31 | 2026-04-23 |
| Multi-Modal Digital Monitoring of Disease Symptoms in Spinocerebellar Ataxia Spinocerebellar Ataxia (SCA) | Not yet recruiting | BioSensics | 25 | 2026-12-15 | 2026-10-01 | |
| Aprepitant for the Treatment of CLIFAHDD Aprepitant Powder for Oral Suspension - CLIFAHDD, Congenital Contractures of the Limbs and Face, Hypotonia, and Developmental Delay | Early Phase 1 | Recruiting | The University of Texas Health Science Center at San Antonio | 5 | 2026-10-31 | 2026-10-05 |
| Digital Patient Engagement in Technology-Supported Neurorehabilitation Stroke, Parkinson Disease (PD) | Not yet recruiting | Catholic University, Italy | 129 | 2026-10-01 | 2026-09-15 | |
| Rare Disease Registry Database for Movement Disorders in Southern Anhui Province Motor Neuron Diseases, Spinocerebellar Ataxias | Recruiting | First Affiliated Hospital of Wannan Medical College | 180 | 2026-09-30 | 2026-10-23 | |
| Bilateral Anodal Cerebellar tDCS for Multidomain Dysfunctions in Patients With Multiple Sclerosis Bilateral Cerebellar Transcranial Direct Current Stimulation (ctDCS), Sham Bilateral Cerebellar tDCS - Multiple Sclerosis | Not applicable | Not yet recruiting | University of Sharjah | 40 | 2026-09-01 | 2026-04-29 |
| Biomarkers for Babies and Young Children With Ataxia Telangiectasia Ataxia Telangiectasia | Not yet recruiting | University of Nottingham | 56 | 2026-09-01 | 2026-07-16 | |
| Pivotal Study of N-acetyl-L-leucine for CACNA1A N-Acetyl-L-Leucine, Placebo - CACNA1A, Spinocerebellar Ataxia Type 6 | Phase 3 | Recruiting | IntraBio Inc | 60 | 2026-08-17 | 2026-09-08 |
| Optimizing Parameters of Transcranial Temporal Interference Stimulation for Spinocerebellar Ataxia Type 3 Transcranial Temporal Interference Stimulation (tTIS) - Spinocerebellar Ataxia Type 3 | Not applicable | Not yet recruiting | First Affiliated Hospital of Fujian Medical University | 24 | 2026-08-07 | 2026-09-01 |
| Safety and Efficacy of Mutation-targeted Precision Genetic Therapy for Ataxia-Telangiectasia (A-T) Antisense oligonucleotide targeting the ATM gene - Ataxia Telangiectasia | Phase 1 / Phase 2 | Recruiting | Timothy Yu | 10 | 2026-08-01 | 2026-05-28 |
| Individualized Neuro-Modulation Paired With Cerebellar Therapy Therapy - Cerebellar Ataxia, Cerebellar Diseases | Not applicable | Recruiting | Hugo W. Moser Research Institute at Kennedy Krieger, Inc. | 30 | 2026-06-30 | 2026-06-11 |
| Prospective Natural History Study of POLG Disease PolG, Primary Mitochondrial Myopathy | Recruiting | The POLG Foundation | 300 | 2026-06-17 | 2026-09-15 | |
| Robotic Neurorehabilitation in Patients With Ataxia Robot-Assisted Neurorehabilitation, Conventional Neurorehabilitation - Ataxia - Other | Not applicable | Active not recruiting | Somogy Megyei Kaposi Mór Teaching Hospital | 100 | 2026-06-02 | 2026-07-29 |
| Interposed Nucleus aDBS for Ataxia Deep Brain Stimulation - Spinocerebellar Ataxia (SCA), Spinocerebellar Ataxia Type 6 | Not applicable | Recruiting | University of Florida | 5 | 2026-06-02 | 2026-07-20 |
| Evaluation of the Safety and Preliminary Efficacy of Neuroinduced Mesenchymal Stem Cells and Exosome Therapy in Patients With Spinocerebellar Palsy Intrathecal infusion, Intranasal infusion - Spinocerebellar Ataxia - All Sub-types | Phase 1 / Phase 2 | Not yet recruiting | Biocells Medical | 90 | 2026-06-01 | 2026-03-12 |
| Balloon Inflation in Biofeedback Inflating anorectal catheter balloon to defecatory desired volume during push manoeuvres in biofeedback therapy., No intervention - Constipation, Chronic Constipation | Not applicable | Completed | Hull University Teaching Hospitals NHS Trust | 8 | 2026-05-13 | 2026-09-22 |
| Deep Brain Stimulation for Spinocerebellar Ataxia Deep Brain Stimulation (DBS) - Spinocerebellar Ataxia (SCA), Spinocerebellar Ataxia Type 6 | Not applicable | Recruiting | University of California, San Francisco | 5 | 2026-04-27 | 2026-07-13 |
| At Home Use of Stimulation Suits for Managing MS Symptoms electro-stimulation suit, Usual Care - Multiple Sclerosis, MS (Multiple Sclerosis) | Not applicable | Recruiting | Daphne Kos | 70 | 2026-03-16 | 2026-10-08 |
| Use of a New Smartphone Application to Determine Changes in Eyeblink Conditioning From Home Training in Individuals With Spinocerebellar Ataxia Aerobic Training, Balance Training - Spinocerebellar Ataxias | Not applicable | Withdrawn | Columbia University | 2026-01-01 | 2026-05-07 |
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Spinocerebellar Ataxias (92) · Cerebellar Ataxia (69) · Ataxia Telangiectasia (42) · Machado-Joseph Disease (32) · Spinocerebellar Degenerations (18) · Parkinson Disease (17) · Friedreich Ataxia (15) · Movement Disorders (13) · Multiple Sclerosis (13) · Neurodegenerative Diseases (12) · Stroke (11) · Gait Ataxia (10) · Dystonia (9) · Motor Activity (9)
Neurologic Manifestations (307) · Dyskinesias (305) · Nervous System Diseases (303) · Central Nervous System Diseases (246) · Brain Diseases (240) · Pathological Conditions, Signs and Symptoms (209) · Cerebellar Diseases (208) · Signs and Symptoms (200) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (182) · Genetic Diseases, Inborn (174) · Neurodegenerative Diseases (142) · Heredodegenerative Disorders, Nervous System (137) · Cerebellar Ataxia (133) · Spinal Cord Diseases (129)
Transcranial Magnetic Stimulation (7) · Blood Specimen Collection (5) · Deep Brain Stimulation (5) · Transcranial Direct Current Stimulation (5) · acetylleucine (4) · Biofeedback, Psychology (3) · Immunoglobulins, Intravenous (3) · Lithium Carbonate (3) · Magnetic Resonance Spectroscopy (3) · Riluzole (3) · Weights and Measures (3) · nicotinamide-beta-riboside (3) · Amantadine (2) · Control Groups (2) · Exercise Therapy (2)
Hacettepe University (6) · Johann Wolfgang Goethe University Hospital (6) · National Institute of Neurological Disorders and Stroke (NINDS) (6) · Assistance Publique - Hôpitaux de Paris (5) · Cairo University (5) · Chang Gung University (5) · Columbia University (5) · Hospital de Clinicas de Porto Alegre (5) · Hugo W. Moser Research Institute at Kennedy Krieger, Inc. (5) · University of Florida (5) · Institut National de la Santé Et de la Recherche Médicale, France (4) · IntraBio Inc (4) · Johns Hopkins University (4) · Kissei Pharmaceutical Co., Ltd. (4) · Quince Therapeutics S.p.A. (4)
United States (111) · France (31) · Italy (29) · United Kingdom (26) · Germany (25) · Spain (19) · Brazil (15) · Turkey (Türkiye) (14) · Israel (13) · Taiwan (12) · China (10) · Australia (9) · Canada (9) · Belgium (8) · Netherlands (8)
Stefan Zielen, Prof. Dr. (5) · Barbara Borroni, MD (4) · Theresa Zesiewicz, MD (4) · Alberto Benussi, MD (3) · Amy J Bastian, PhD, PT (3) · Alan Percy, MD (2) · Carlos Gordon, Prof. (2) · Cherie Marvel, PhD (2) · David Coman, MBBS FRACP (2) · Didier Hannequin, MD, PhD (2) · Dirk Thye, MD (2)
PMID 40739200, PMID 1444775, PMID 15137564, PMID 15313841, PMID 15365159, PMID 16193476, PMID 19026963, PMID 21211990, PMID 24780882, PMID 30135258, PMID 34115419, PMID 34477998, PMID 37460385, PMID 38363467, PMID 9094050, PMID 12218749, PMID 12925365, PMID 12925368, PMID 14506070, PMID 14705117, PMID 14736755, PMID 14770181, PMID 15574463, PMID 15596607, PMID 15706558, PMID 15747371, PMID 15786464, PMID 15895558, PMID 15895562, PMID 15956167, PMID 16055926, PMID 16325416, PMID 16401858, PMID 16434418, PMID 16501573, PMID 16511635, PMID 16518257, PMID 16534102, PMID 16612642, PMID 16682547, PMID 16699786, PMID 16763896, PMID 16902175, PMID 16934683, PMID 17098887, PMID 17130408, PMID 17205300, PMID 17273843, PMID 17321752, PMID 17322883
2018 (2), 2025 (2), R01HD040289 (2), 2015 (1), 2017 (1), K23NS121518 (1), P2CHD086844 (1), R01DC016275 (1), R01DC017091 (1), R01DK057048 (1), R01DK132090 (1), R01HD075813 (1), R21AG044449 (1), R21DK113487 (1), R21NS085491 (1)