286 completed, 195 recruiting, 153 unknown, 124 active not recruiting. 424 Phase 2, 291 Not applicable, 217 Phase 1, 95 Phase 3, 18 Early Phase 1.
Follow Radiosurgery: new trials by email Literature Review of Radiosurgery trials Research Report on Radiosurgery
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Adding Surgery and Radiation to the Usual Treatment for HER2-Positive Breast Cancer That Had Already Spread at Diagnosis Biopsy Procedure, Biospecimen Collection, Breast Conservation Treatment - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic HER2-Positive Breast Carcinoma | Phase 3 | Recruiting | SWOG Cancer Research Network | 562 | 2027-03-09 | 2026-10-13 |
| Testing the Addition of an Anti-Cancer Drug, Camonsertib, to Radiation Therapy for Recurrent Head and Neck Squamous Cell Carcinoma Biospecimen Collection, Camonsertib, Computed Tomography - Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Recurrent Head and Neck Squamous Cell Carcinoma | Phase 1 | Recruiting | National Cancer Institute (NCI) | 39 | 2027-02-13 | 2026-09-03 |
| SBRT Plus Anlotinib and Bimepolizumab in Locally Advanced or Metastatic Renal Cell Carcinoma Stereotactic Body Radiation Therapy (SBRT), Anlotinib, Bemarituzumab - Locally Advanced or Metastatic Renal Cell Carcinoma | Phase 2 | Not yet recruiting | Fujian Cancer Hospital | 27 | 2027-02-01 | 2026-10-01 |
| Adaptive SBRT Plus Chemoimmunotherapy for ES-SCLC Durvalumab 50 MG/1 ML Intravenous Solution, Etoposide Injection, Cisplatin - Extensive-stage Small-cell Lung Cancer | Phase 1 | Suspended | University of Maryland, Baltimore | 50 | 2027-01-30 | 2026-09-14 |
| Trastuzumab Deruxtecan + Stereotactic Radiosurgery (SRS) in HER2+ Breast Cancer Brain Metastases Trastuzumab Deruxtecan, Stereotactic Radiosurgery - Breast Cancer, HER2-positive Breast Cancer | Phase 1 | Not yet recruiting | Baptist Health South Florida | 20 | 2027-01-01 | 2026-10-01 |
| SOLIS: Single-Dose Radiotherapy With Omission of Lumpectomy for Intact Small Breast Cancers Stereotactic Radiation Therapy, Endocrine Therapy - Breast Cancer, Early-Stage Breast Carcinoma | Not applicable | Not yet recruiting | Renaissance Institute of Precision Oncology and Radiosurgery | 30 | 2027-01-01 | 2026-09-28 |
| Phase II Trial Comparing Stereotactic Body Radiotherapy Versus Active Surveillance for Oligometastatic Adenoid Cystic Carcinoma Stereotactic body radiotherapy (SBRT) - Adenoid Cystic Carcinoma, Oligometastatic | Phase 2 | Not yet recruiting | All India Institute of Medical Sciences | 90 | 2026-12-20 | 2026-09-28 |
| The APRIL Trial Evaluating Upfront Stereotactic Body Radiotherapy in Stage III Advanced Non-small Cell Lung Cancer SBRT in stage III NSCLC - Non Small Cell Lung Cancer | Not applicable | Not yet recruiting | All India Institute of Medical Sciences | 20 | 2026-12-19 | 2026-09-24 |
| CA-4948 in Combination With Pembrolizumab and Stereotactic Radiosurgery to Improve Treatment of Melanoma Brain Metastases Emavusertib, Pembrolizumab, Stereotactic Radiosurgery - Metastatic Malignant Neoplasm in the Brain, Metastatic Melanoma | Phase 1 / Phase 2 | Suspended | Mayo Clinic | 23 | 2026-11-30 | 2026-10-20 |
| Short Interval Postoperative Stereotactic Body Radiation Therapy (SBRT) After Surgical Intervention for Spine Metastases Stereotactic Body Radiation Therapy (SBRT), Computed Tomography (CT) Simulation, Magnetic Resonance Imaging (MRI) - Spine Metastasis, Stereotactic Body Radiation Therapy (SBRT) | Not applicable | Not yet recruiting | University of California, San Francisco | 50 | 2026-11-01 | 2026-09-15 |
| Phase II Study of Upfront SRT Plus Ivonescimab/Chemotherapy vs Ivonescimab/Chemotherapy in NSCLC Brain Mets Ivonescimab, Carboplatin, Pemetrexed - Non Small Cell Lung Cancer | Phase 2 | Not yet recruiting | European Organisation for Research and Treatment of Cancer - EORTC | 158 | 2026-11-01 | 2026-06-04 |
| Navigation Bronchoscopy Guided Microwave Ablation Versus SBRT in Early NSCLC Navigation Bronchoscopy-Guided Microwave Ablation, Stereotactic Body Radiotherapy (SBRT) - Lung Cancer (NSCLC) | Phase 2 | Not yet recruiting | Chinese University of Hong Kong | 100 | 2026-11-01 | 2026-10-21 |
| Safety and Efficacy of Radiotherapy Combined With Immunochemotherapy in Pre-treated SCLC Patients With Liver Metastases Immunotherapy, Chemotherapy (Etoposide, Nab-paclitaxel, Irinotecan, or Lurbinectedin), low-dose radiation - Lung Cancer (SCLC) | Phase 2 | Not yet recruiting | Sichuan University | 30 | 2026-10-31 | 2026-05-05 |
| SBRT Combined With Iparomlimab and Tuvonralimab (QL1706) and Bevacizumab for Hepatocellular Carcinoma Stereotactic Body Radiotherapy, Bevacizumab, Iparomlimab and Tuvonralimab - Hepatocellular Carcinoma (HCC) | Phase 2 | Not yet recruiting | Peking University Cancer Hospital & Institute | 33 | 2026-10-15 | 2026-10-20 |
| SRT Combined With Envafolimab and Endostar in the First-line Treatment of Advanced NSCLC Stereotactic Radiation Therapy, Envafolimab, Endostar - Non Small Cell Lung Cancer, Lung Neoplasms | Phase 2 | Not yet recruiting | The First People's Hospital of Lianyungang | 61 | 2026-10-01 | 2026-09-14 |
| Stereotactic Radiotherapy for SPinal Metastases With Limited Extent of Epidural Disease Stereotactic Body Radiotherapy (SBRT), Conventional External Beam Radiotherapy - Epiduritis, Vertebral Bone Metastasis | Not applicable | Not yet recruiting | Institut Cancerologie de l'Ouest | 167 | 2026-10-01 | 2026-06-18 |
| Atezolizumab in Combination With Stereotactic Body Radiation Therapy (SBRT) and Surgery for Relapsed Osteosarcoma Surgical Resection, Stereotactic Body Radiation Therapy (SBRT), Atezolizumab - Osteosarcoma, Pulmonary Recurrence of Osteosarcoma | Phase 1 | Recruiting | Emory University | 12 | 2026-10-01 | 2026-09-30 |
| PSMA PET/CT-Guided SBRT Plus Darolutamide in mHSPC Stereotactic Body Radiotherapy (SBRT), Darolutamide 600 mg twice daily, Androgen Deprivation Therapy (ADT) - Metastatic Hormone-Sensitive Prostate Cancer (mHSPC) | Phase 2 | Not yet recruiting | West China Hospital | 254 | 2026-09-15 | 2026-09-10 |
| Concurrent Immunotherapy and Systemic Therapy With Stereotactic Body Radiation Therapy (SBRT) for Stage IV Cancers (COINSSS IV) Stereotactic Body Radiation Therapy (SBRT), Pembrolizumab, Nivolumab - Head and Neck Cancer, Non-Small Cell Lung Cancer | Phase 2 | Recruiting | Mark Bernard | 35 | 2026-09-09 | 2026-10-14 |
| Study Comparing Neoadjuvant Versus Adjuvant Stereotactic Radiotherapy of Brain Metastases stereotactic radiotherapy, Excision surgery - Brain Metastases, Adult | Not applicable | Not yet recruiting | GCS Ramsay Santé pour l'Enseignement et la Recherche | 68 | 2026-09-01 | 2026-08-25 |
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Carcinoma, Non-Small-Cell Lung (137) · Brain Neoplasms (130) · Prostatic Neoplasms (111) · Neoplasm Metastasis (88) · Lung Neoplasms (77) · Carcinoma, Hepatocellular (74) · Pancreatic Neoplasms (70) · Breast Neoplasms (51) · Melanoma (45) · Carcinoma, Renal Cell (36) · Neoplasms (34) · Colorectal Neoplasms (26) · Squamous Cell Carcinoma of Head and Neck (25) · Glioblastoma (24) · Liver Neoplasms (20)
M.D. Anderson Cancer Center (36) · Memorial Sloan Kettering Cancer Center (25) · Case Comprehensive Cancer Center (19) · Jonsson Comprehensive Cancer Center (18) · National Cancer Institute (NCI) (18) · Stanford University (17) · University of Texas Southwestern Medical Center (17) · Mayo Clinic (16) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (15) · University Health Network, Toronto (14) · H. Lee Moffitt Cancer Center and Research Institute (13) · NRG Oncology (13) · Sun Yat-sen University (13) · City of Hope Medical Center (12) · Fudan University (11)
United States (529) · China (119) · Canada (85) · France (41) · Italy (41) · Netherlands (29) · United Kingdom (24) · Belgium (22) · South Korea (22) · Switzerland (19) · Australia (16) · Germany (16) · Spain (14) · Hong Kong (13) · Poland (13)
Robert D. Timmerman, MD (7) · Amar Kishan (5) · David A Clump, MD (5) · Jing Li (5) · Wenyin Shi, MD, PhD (5) · Albert Koong (4) · Asal Rahimi, MD (4) · Laura Dawson, MD (4) · Mian Xi, MD (4) · Paul D. Brown, MD (4) · Amol J. Ghia, MD (3) · Arya Amini (3) · Daniel Spratt, M.D. (3) · Daniel T Chang (3) · James Welsh (3)
PMID 26104945, PMID 33096027, PMID 20233825, PMID 23332384, PMID 23547075, PMID 25819287, PMID 29366520, PMID 31227373, PMID 31996395, PMID 32736936, PMID 34810130, PMID 34903471, PMID 35602670, PMID 36529152, PMID 37478883, PMID 39305910, PMID 39699905, PMID 41534788, PMID 10549493, PMID 110740, PMID 11134209, PMID 11442533, PMID 12192016, PMID 12393820, PMID 12925241, PMID 15001240, PMID 15158627, PMID 15183474, PMID 15540287, PMID 16029795, PMID 16062084, PMID 16112300, PMID 16314647, PMID 16360786, PMID 16437480, PMID 16575331, PMID 16698099, PMID 16723887, PMID 16750317, PMID 17008704, PMID 17257702, PMID 17706308, PMID 18351348, PMID 18374511, PMID 18455252, PMID 19056184, PMID 19184641, PMID 19190462, PMID 19251095, PMID 19269519
U10CA180868 (12), P30CA033572 (10), P30CA043703 (9), P30CA138292 (6), P30CA016672 (4), P30CA036727 (4), U10CA021661 (4), 2018 (3), P30CA013330 (3), P30CA014089 (3), P30CA015704 (3), U10CA180821 (3), 2014 (2), 2017 (2), 2023 (2)