11 completed, 8 recruiting, 7 unknown, 1 enrolling by invitation. 28 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 28 | Completed 11, Recruiting 8, Unknown 7, Enrolling by invitation 1, Withdrawn 1 |
Follow Epilepsy, Temporal Lobe: new trials by email Literature Review of Epilepsy, Temporal Lobe trials Research Report on Epilepsy, Temporal Lobe
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Overnight TI in TLE Non-invasive Temporal Interference (TI) Stimulation Targeting Bilateral Hippocampi - Temporal Lobe Epilepsy (TLE), Drug Resistant Epilepsy | Not applicable | Recruiting | Duke University | 20 | 2026-10-15 | 2026-10-16 |
| MRgLITT for mTLE: A PROBE Trial Resonance-guided Laser Interstitial Thermal Therapy (MRgLITT), Open Surgery - Temporal Lobe Epilepsy (TLE) | Not applicable | Recruiting | Beijing Tiantan Hospital | 120 | 2025-07-21 | 2026-01-21 |
| Spatial Memory and Temporal Lobe Epilepsy spatial memory test - Epilepsy Lobe Temporal, Healthy | Not applicable | Completed | Centre Hospitalier Metropole Savoie | 60 | 2025-02-26 | 2026-10-07 |
| A Pilot Study to Evaluate the Efficacy and Safety of NaviFUS™ System Neuromodulating Treatment for Patients With Drug Resistant Epilepsy Focused ultrasound (FUS) treatment - Drug Resistant Epilepsy, Epilepsy | Not applicable | Recruiting | NaviFUS Corporation | 16 | 2024-09-01 | 2026-04-09 |
| Spatial Scene Recognition Memory in Epilepsy Surgery Virtual Tour Recognition Memory Task, Intracranial EEG Recording with Research Electrodes (Aim III only), MRI Neuroimaging and Neuropsychological Assessment (Aim I) - Focal Epilepsy, Temporal Lobe Epilepsy | Not applicable | Recruiting | University of California, Davis | 620 | 2024-07-01 | 2026-05-12 |
| Transcranial Electrical Stimulation Targeting the Cerebellum for the Treatment of Refractory Temporal Lobe Epilepsy Transcranial Alternating Current Stimulation - Transcranial Electrical Stimulation, Temporal Lobe Epilepsy | Not applicable | Unknown | Xijing Hospital | 60 | 2024-06-08 | 2024-08-19 |
| Evaluation of the NaviFUS System in Drug Resistant Epilepsy NaviFUS System - Epilepsy, Temporal Lobe, Drug Resistant Epilepsy | Not applicable | Recruiting | Genovate-NaviFUS (Australia) Pty Ltd. | 18 | 2023-10-02 | 2026-09-10 |
| Minimally Invasive Surgical Epilepsy Trial for Temporal Lobe Epilepsy Functional anterior temporal lobectomy (FATL), Anterior temporal lobectomy (ATL) - Temporal Lobe Epilepsy, Open Surgery | Not applicable | Unknown | First Affiliated Hospital Xi'an Jiaotong University | 120 | 2023-04-25 | 2022-12-30 |
| Intensive Preoperative Speech Rehabilitation in Drug-Resistant Temporal Epilepsy Speech therapy, Speech therapy assessment - Epilepsy, Anomia | Not applicable | Recruiting | Assistance Publique Hopitaux De Marseille | 214 | 2023-03-30 | 2024-07-18 |
| Pre-operative Mapping of the Anterior Temporal Lobe Using Functional MRI Innovative Techniques in in Drug-resistant Epileptic Patients functional MRI - Epilepsy, Temporal Lobe, Cognitive Decline | Not applicable | Recruiting | Central Hospital, Nancy, France | 30 | 2022-06-10 | 2025-07-01 |
| Self-modulation of the Sense of Agency by Means of Real-time Neurofeedback Real Neurofeedback, Sham Neurofeedback - Psychogenic Seizure, Epilepsy, Temporal Lobe | Not applicable | Unknown | ETH Zurich | 225 | 2022-02-01 | 2022-04-01 |
| Evaluation of Memory and Forgetting in Patients With Epilepsy Computerised associative memory task using abstract words and landscape photographs - Epilepsy | Not applicable | Completed | Hospices Civils de Lyon | 83 | 2022-01-26 | 2025-06-04 |
| Stimulation of the Thalamus for Arousal Restoral in Temporal Lobe Epilepsy Central Thalamic Stimulation, Hippocampal Stimulation - Epilepsy, Temporal Lobe | Not applicable | Completed | Yale University | 5 | 2021-10-31 | 2025-12-26 |
| Pathophysiology, Psycho-emotional and Cognitive Functioning Associated With Tinnitus acoustics tests, Questionaries,, MRI - Tinnitus, Epilepsy, Temporal Lobe | Not applicable | Recruiting | Assistance Publique - Hôpitaux de Paris | 300 | 2021-06-15 | 2024-12-12 |
| Closed Loop Auditory Stimulus in Sleep and epilepsY Closed loop auditory stimulus - Temporal Lobe Epilepsy | Not applicable | Completed | Cardiff and Vale University Health Board | 17 | 2020-10-01 | 2021-12-16 |
| The GABAergic Inhibitory System in Drug Resistant Epilepsy Lovastatin 60 MG, Placebo - Drug Resistant Epilepsy, Temporal Lobe Epilepsy | Not applicable | Completed | University of Coimbra | 5 | 2020-01-12 | 2025-01-23 |
| SEEG Guided RF-TC v.s. ATL for mTLE With HS SEEG guided RF-TC, Anterior temporal lobectomy - Epilepsy, Temporal Lobe | Not applicable | Completed | Xuanwu Hospital, Beijing | 40 | 2019-08-05 | 2023-03-24 |
| Investigations of Amygdala Function Using Neurophysiological Recording and Stimulation Amygdala recording and stimulation using Neuropace RNS, Behavioral tasks - Fear, PTSD | Not applicable | Completed | Stanford University | 23 | 2019-04-24 | 2023-09-26 |
| Effects of tDCS on Depressive Symptoms of Participants With Temporal Lobe Epilepsy active tDCS, sham tDCS - Depressive Symptoms, Epilepsy, Temporal Lobe | Not applicable | Unknown | Hospital de Clinicas de Porto Alegre | 60 | 2018-07-01 | 2019-03-12 |
| Evaluation of Stress Sensitivity and Hyperemotivity in Epilepsy Compared to and a Group of Healthy Volunteers Measure of emotional stressors - Epilepsy | Not applicable | Unknown | University Hospital, Toulouse | 120 | 2018-03-08 | 2018-07-20 |
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Epilepsy (12) · Drug Resistant Epilepsy (5) · Depression (3) · Stress Disorders, Post-Traumatic (2) · Anomia (1) · Anxiety Disorders (1) · Brain Diseases (1) · Cognitive Dysfunction (1) · Epilepsies, Partial (1) · Memory Disorders (1) · Orientation, Spatial (1) · Panic Disorder (1) · Psychogenic Nonepileptic Seizures (1) · Seizures (1)
Central Nervous System Diseases (28) · Epileptic Syndromes (28) · Nervous System Diseases (28) · Brain Diseases (27) · Epilepsies, Partial (27) · Epilepsy (16) · Neurologic Manifestations (5) · Pathological Conditions, Signs and Symptoms (5) · Signs and Symptoms (5) · Behavior (4) · Behavioral Symptoms (3) · Mental Disorders (3) · Neurobehavioral Manifestations (2) · Stress Disorders, Traumatic (2) · Trauma and Stressor Related Disorders (2)
Anterior Temporal Lobectomy (2) · Antidepressive Agents (1) · Cognitive Behavioral Therapy (1) · Conversion to Open Surgery (1) · Lovastatin (1) · Neuronavigation (1) · Selective Serotonin Reuptake Inhibitors (1) · Speech Therapy (1) · Therapeutics (1) · Transcranial Direct Current Stimulation (1)
Duke University (2) · Xijing Hospital (2) · Andrew Parrent (1) · Assistance Publique - Hôpitaux de Paris (1) · Assistance Publique Hopitaux De Marseille (1) · Beijing Tiantan Hospital (1) · Beth Israel Deaconess Medical Center (1) · BrainSonix Inc. (1) · Cardiff and Vale University Health Board (1) · Central Hospital, Nancy, France (1) · Centre Hospitalier Metropole Savoie (1) · ETH Zurich (1) · El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez (1) · First Affiliated Hospital Xi'an Jiaotong University (1) · Genovate-NaviFUS (Australia) Pty Ltd. (1)
United States (8) · France (6) · China (5) · Australia (1) · Brazil (1) · Denmark (1) · Mexico (1) · Portugal (1) · Switzerland (1) · Taiwan (1) · United Kingdom (1)
Adam Williamson, PhD (1) · Andrew Parrent (1) · Barbara Jobst, MD, PhD (1) · Bernard S Chang, MD, MMSc (1) · Birgit Frauscher, MD / PD (1) · Daniel Crail-Melendez, MD (1) · Gregory Worrell, MD, PhD (1) · Guoguang Zhao, Doctor (1) · Hal Blumenfeld, MD, PhD (1) · Hua Zhang, PhD (1) · Jennifer Roebber, PhD (1) · Jiang Wen (1) · Khalid Hamandi, MRCP/Phd (1) · Mahendra Bhati, MD (1)
PMID 21391767, PMID 26143305, PMID 27354526, PMID 29208571, PMID 29502144, PMID 31666082, PMID 33860531, PMID 34187524, PMID 34198105, PMID 34955774, PMID 40543839, PMID 42425569
1UG3NS112826-01 (1), DP1MH116506 (1)