281 completed, 132 recruiting, 131 unknown, 42 not yet recruiting. 704 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 704 | Completed 281, Recruiting 132, Unknown 131, Not yet recruiting 42, Terminated 36, Withdrawn 31, Active not recruiting 29, Enrolling by invitation 22 |
Follow Epilepsy: new trials by email Literature Review of Epilepsy trials Research Report on Epilepsy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| High-Intensity Focused Ultrasonic Ablation of the Centromedian Thalamic Nucleus for Treatment of Medically Refractory Generalized Epilepsy in Patients Ages 18 Years to 89 Years Intervention 1, Intervention 2 - Idiopathic Generalized Epilepsy | Not applicable | Not yet recruiting | Oregon Health and Science University | 10 | 2027-02-01 | 2026-10-28 |
| Sleep-Driven Adaptive Neuromodulation in Lennox-Gastaut Syndrome Personalized Adaptive Deep Brain Stimulation Therapy, Conventional Non-Personalized Deep Brain Stimulation Therapy - Lennox Gastaut Syndrome (LGS), Epilepsy | Not applicable | Not yet recruiting | University of Minnesota | 4 | 2027-01-01 | 2026-10-07 |
| CEST-based Biomarkers to Delineate the Epileptogenic Zone CEST sequence on a 7-Tesla MRI - Epilepsy (Treatment Refractory) | Not applicable | Not yet recruiting | Fondation Ophtalmologique Adolphe de Rothschild | 20 | 2027-01-01 | 2026-10-01 |
| Characterisation of Laryngeal Evoked Potentials Induced by Vagus Nerve Stimulation in Refractory Epilepsy Patients Increasing VNS Intensities Induced with Magnet - Refractory Epilepsy, Epilepsy | Not applicable | Not yet recruiting | Université Catholique de Louvain | 110 | 2027-01-01 | 2026-10-29 |
| Accelerated iTBS for Depression and Suicidality Accelerated Intermittent Theta Burst (aiTBS), Electroconvulsive therapy (ECT) - Major Depressive Disorder, Suicide | Not applicable | Not yet recruiting | University of Iowa | 50 | 2026-12-01 | 2025-05-20 |
| Epileptiform Potential of Fully Immersive Virtual Reality Virtual Reality Headset, display off, Virtual Reality Headset, Display only, Virtual Reality Headset, Display and Hand Control - Epilepsy, Seizure | Not applicable | Not yet recruiting | Dartmouth-Hitchcock Medical Center | 40 | 2026-12-01 | 2026-08-27 |
| Health Literacy Project Health Literacy Educational Session- Comparator, Health Literacy Educational Session - Epilepsy | Not applicable | Not yet recruiting | Duke University | 60 | 2026-11-01 | 2026-09-09 |
| Self-management for Youth With Epilepsy Pilot SMART-Y - Epilepsy | Not applicable | Not yet recruiting | University Hospitals Cleveland Medical Center | 18 | 2026-11-01 | 2026-10-15 |
| Acute Stimulation and Modulation of Stereotyped High-Frequency Oscillations Brain Interchange System - Epilepsy | Not applicable | Not yet recruiting | Mayo Clinic | 8 | 2026-11-01 | 2026-08-11 |
| Biomarker Targeted Stimulation for Epileptiform Events Biomarker Targeted Stimulation (BTS) - Epilepsy | Not applicable | Not yet recruiting | Cadence Neuroscience | 40 | 2026-11-01 | 2026-10-27 |
| Peri-procedural Weighted Blanket Use for ECT Weighted blanket, Usual Care Group - Post-ect Agitation, Post-ictal Agitation | Not applicable | Not yet recruiting | Mayo Clinic | 200 | 2026-11-01 | 2026-10-28 |
| Lily's Grace Temporal Interference TES-TI, Sham Stimulation, Structural and Functional MRI - Epilepsy | Not applicable | Not yet recruiting | University of Wisconsin, Madison | 24 | 2026-11-01 | 2026-10-30 |
| Electrophysiological Dose-Response to Anterior Thalamic Deep Brain Stimulation in Drug-Resistant Focal Epilepsy Anterior thalamic deep brain stimulation with a standardized amplitude schedule and acute stimulation challenges - Drug Resistant Epilepsy, Focal Epilepsy | Not applicable | Not yet recruiting | Yonsei University | 10 | 2026-11-01 | 2026-11-03 |
| EASEE® System Pivotal Study for the United States of America Implantable minimaly invasive brain stimulator - Drug-Resistant Focal Epilepsy | Not applicable | Not yet recruiting | Precisis US, Inc. | 200 | 2026-10-31 | 2026-08-28 |
| Overnight TI in TLE Non-invasive Temporal Interference (TI) Stimulation Targeting Bilateral Hippocampi - Temporal Lobe Epilepsy (TLE), Drug Resistant Epilepsy | Not applicable | Recruiting | Duke University | 20 | 2026-10-15 | 2026-10-16 |
| Sleep Disruption Pattern - Epilepsy Monitoring Unit Alarm system - Epilepsy Intractable | Not applicable | Not yet recruiting | Duke University | 75 | 2026-10-01 | 2026-09-08 |
| Sleep, Music, And Research Trial 2.0 Music-based intervention, Active Control Placebo - Epilepsy in Children, Epilepsy | Not applicable | Recruiting | National Taiwan University Hospital | 144 | 2026-10-01 | 2026-10-15 |
| Impact of Epilepsy on the Brainstem Adenosine Pathway and Its Relation With Arousal and Respiratory Reactivity 1 Hypercapnic challenge while participant is awake, PET/MRI acquisition - Epilepsy, Drug-resistant Focal Epilepsy | Not applicable | Recruiting | Hospices Civils de Lyon | 50 | 2026-10-01 | 2026-10-07 |
| The Effect of a Kolcaba's Comfort Theory-Based Educational Intervention on the Quality of Life of Patients With Epilepsy Kolcaba Comfort Theory-Based Educational Program - Epilepsy | Not applicable | Not yet recruiting | Ataturk University | 80 | 2026-09-30 | 2026-09-18 |
| Intracranial CArtography of Cortical Contribution to Respiratory Load Compensation in Epilepsy SEEG monitoring, Comprehensive respiratory monitoring, Cardio-respiratory monitoring - Epilepsy, SUDEP | Not applicable | Recruiting | Hospices Civils de Lyon | 20 | 2026-09-17 | 2026-09-23 |
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Drug Resistant Epilepsy (129) · Seizures (87) · Epilepsies, Partial (43) · Depression (33) · Epilepsy, Temporal Lobe (28) · Anxiety Disorders (16) · Cognitive Dysfunction (12) · Parkinson Disease (10) · Epilepsy, Generalized (9) · Migraine Disorders (9) · Brain Diseases (8) · Lennox Gastaut Syndrome (8) · Mental Disorders (8) · Motor Activity (8)
Central Nervous System Diseases (699) · Brain Diseases (696) · Nervous System Diseases (696) · Pathological Conditions, Signs and Symptoms (150) · Signs and Symptoms (132) · Neurologic Manifestations (123) · Behavior (75) · Mental Disorders (70) · Epileptic Syndromes (58) · Epilepsies, Partial (40) · Behavioral Symptoms (35) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (28) · Epilepsy, Generalized (21) · Pathologic Processes (21)
Transcranial Direct Current Stimulation (17) · Electroencephalography (12) · Deep Brain Stimulation (10) · Diet, Ketogenic (9) · Blood Specimen Collection (7) · Magnetic Resonance Imaging (7) · Levetiracetam (6) · Cognitive Behavioral Therapy (5) · Exercise (5) · Surveys and Questionnaires (5) · Therapeutics (5) · Transcranial Magnetic Stimulation (5) · Anterior Temporal Lobectomy (3) · Anticonvulsants (3) · Control Groups (3)
Hospices Civils de Lyon (20) · Assistance Publique Hopitaux De Marseille (17) · NYU Langone Health (17) · Mayo Clinic (16) · Dartmouth-Hitchcock Medical Center (15) · Xuanwu Hospital, Beijing (15) · University Hospital, Ghent (14) · Duke University (9) · Assistance Publique - Hôpitaux de Paris (8) · Ataturk University (8) · University Hospital, Grenoble (8) · Xijing Hospital (8) · Massachusetts General Hospital (7) · Stanford University (7) · The University of Texas Health Science Center, Houston (7)
United States (257) · France (91) · China (43) · United Kingdom (37) · Belgium (36) · Turkey (Türkiye) (33) · Canada (23) · Italy (20) · Germany (15) · Netherlands (12) · Denmark (11) · Switzerland (11) · Taiwan (11) · Australia (6) · Brazil (6)
Liankun Ren, MD (11) · Adam Mamelak, MD (4) · Edward F Chang, MD (4) · Ueli Rutishauser, PhD (4) · Anli Liu, MD (3) · Anli Liu, MD, MA (3) · Avani Modi, Ph.D. (3) · Barbara C Jobst, MD (3) · Heidi M. Munger Clary, MD, MPH (3) · Martha Sajatovic, MD (3) · Paul Boon, MD, PhD (3) · Robert P Turner, MD, MSCR (3) · Anny Reyes, PhD (2)
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1UG3NS112826-01 (1), 1UH3NS117944-01A1 (1), 2015 (1), 2019 (1), 2023 (1), 3OT2OD026545 (1), 5RC1MD004563-02 (1), DP1MH116506 (1), K23NS116110 (1), K23NS126495 (1), K23NS138682 (1), K99DC020235 (1), OT2OD028201 (1), R00DC020235 (1), R00NS126715 (1)