16 completed. 16 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 16 | Completed 16 |
| Phase 2 | 1 | Completed 1 |
Follow Enterocolitis: new trials by email Literature Review of Enterocolitis trials Research Report on Enterocolitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Multi-center, Single-arm Trial Exploring the Safety and Clinical Effectiveness of RBX2660 Administered by Colonoscopy to Adults With Recurrent Clostridioides Difficile Infection RBX2660 - Clostridium Difficile Infection Recurrence | Phase 3 | Completed | Ferring Pharmaceuticals | 41 | 2023-04-21 | 2026-04-24 |
| Effect of Pentoxifylline Versus Probiotic on Preterm Neonates With Necrotizing Enterocolitis Pentoxifylline, Probiotic Formula - Necrotizing Enterocolitis | Phase 3 | Completed | Tanta University | 75 | 2022-06-30 | 2024-05-20 |
| Microbiota Restoration Therapy for Recurrent Clostridium Difficile Infection (PUNCH CD3-OLS) RBX2660 - Clostridium Difficile Infection, Infection | Phase 3 | Completed | Rebiotix Inc. | 793 | 2019-07-30 | 2024-08-07 |
| Microbiota Restoration Therapy for Recurrent Clostridium Difficile Infection (PUNCHCD3) RBX2660, Placebo, Open label RBX2660 (only for confirmed CDI recurrence) - Clostridium Difficile Infection (CDI) | Phase 3 | Completed | Rebiotix Inc. | 320 | 2017-07-31 | 2024-07-10 |
| The Efficacy of Symbiotic on Cytokines distilled water, symbiotic - Necrotising Enterocolitis | Phase 3 | Completed | Zeynep Kamil Maternity and Pediatric Research and Training Hospital | 70 | 2013-07-01 | 2014-08-08 |
| Role of Probiotics for Prevention of NEC in Preterm VLBW Infants Probiotics, Breast milk - Necrotizing Enterocolitis | Phase 3 | Completed | Sylhet M.A.G.Osmani Medical College | 60 | 2012-07-01 | 2016-01-08 |
| Lactobacillus Reuteri for Prevention of Necrotizing Enterocolitis in Very Low-birth Weight Infants Lactobacillus reuteri, Placebo - Necrotizing Enterocolitis, Very Low Birth Weight Infants | Phase 3 | Completed | Zekai Tahir Burak Women's Health Research and Education Hospital | 400 | 2012-02-01 | 2013-05-13 |
| Probiotics in the Management of Necrotizing Enterocolitis in HIV-exposed Premature Infants Probiotic, Placebo - Necrotizing Enterocolitis | Phase 3 | Completed | University of Stellenbosch | 184 | 2011-07-01 | 2013-07-22 |
| Effect of L-arginine and Glutamine on Preterm Glutamine, l-arginine - NEC, Sepsis | Phase 2 / Phase 3 | Completed | Ain Shams University | 75 | 2011-05-01 | 2014-04-15 |
| Effect of Vitamin A in the Treatment of Neonatal Sepsis and Necrotizing Enterocolitis Vitamin A - Sepsis, Necrotizing Enterocolitis | Phase 3 | Completed | Johns Hopkins University | 424 | 2006-12-01 | 2013-09-25 |
| A Study of GT267-004 Versus Vancomycin and GT267-004 Versus Metronidazole in Patients With C. Difficile-Associated Diarrhea Tolevamer potassium-sodium (GT267-004) - Clostridium Enterocolitis, Diarrhea | Phase 3 | Completed | Genzyme, a Sanofi Company | 520 | 2005-04-01 | 2014-03-19 |
| A Study of GT267-004 Versus Vancomycin and GT267-004 Versus Metronidazole in Patients With C.Difficile - Associated Diarrhea tolevamer potassium-sodium (GT267-004) - Clostridium Enterocolitis, Pseudomembranous Colitis | Phase 3 | Completed | Genzyme, a Sanofi Company | 520 | 2005-03-01 | 2015-03-05 |
| Effect of Oral Probiotic Supplementation on The Rate of Hospital Acquired Infection and Necrotizing Enterocolitis in Preterm Very Low Birth Weight Infants probiotics - Nosocomial Infection, Necrotizing Enterocolitis | Phase 3 | Completed | King Chulalongkorn Memorial Hospital | 160 | 2005-01-01 | 2011-04-22 |
| Efficacy of Metronidazole Versus Metronidazole and Rifampin in CDAD Treatment Metronidazole and Rifampin - Clostridium Enterocolitis, Antibiotic-Associated Diarrhea | Phase 3 | Completed | McMaster University | 100 | 2004-02-01 | 2018-08-15 |
| Compassionate Use of Nitazoxanide for the Treatment of Clostridium Difficile Infection Nitazoxanide - Clostridium Enterocolitis, Pseudomembranous Colitis | Phase 3 | Completed | Daniel M. Musher MD | 22 | 2004-01-01 | 2017-12-15 |
| Trial of Indomethacin Prophylaxis in Preterm Infants (TIPP) indomethacin, Indomethacin, Placebo - Infant, Very Low Birth Weight, Infant, Premature | Phase 3 | Completed | NICHD Neonatal Research Network | 1202 | 1993-11-01 | 2015-06-08 |
Enterocolitis, Necrotizing (9) · Enterocolitis, Pseudomembranous (7) · Diarrhea (4) · Clostridium Infections (2) · Premature Birth (2) · Sepsis (2) · Acquired Immunodeficiency Syndrome (1) · Communicable Diseases (1) · Cross Infection (1) · Ductus Arteriosus, Patent (1) · Infections (1) · Meningitis (1) · Pneumonia (1)
Digestive System Diseases (16) · Gastroenteritis (16) · Gastrointestinal Diseases (16) · Intestinal Diseases (16) · Infections (10) · Bacterial Infections (7) · Bacterial Infections and Mycoses (7) · Gram-Positive Bacterial Infections (7) · Pathological Conditions, Signs and Symptoms (7) · Clostridium Infections (5) · Pathologic Processes (4) · Signs and Symptoms (4) · Signs and Symptoms, Digestive (4) · Disease Attributes (2)
Probiotics (3) · Arginine (1) · Glutamine (1) · Indomethacin (1) · Metronidazole (1) · Milk, Human (1) · Pentoxifylline (1) · Rifampin (1) · Saline Solution (1) · Single Person (1) · Vitamin A (1) · nitazoxanide (1)
Genzyme, a Sanofi Company (2) · Rebiotix Inc. (2) · Ain Shams University (1) · Daniel M. Musher MD (1) · Ferring Pharmaceuticals (1) · Johns Hopkins University (1) · King Chulalongkorn Memorial Hospital (1) · McMaster University (1) · NICHD Neonatal Research Network (1) · Sylhet M.A.G.Osmani Medical College (1) · Tanta University (1) · University of Stellenbosch (1) · Zekai Tahir Burak Women's Health Research and Education Hospital (1) · Zeynep Kamil Maternity and Pediatric Research and Training Hospital (1)
United States (6) · Canada (4) · Egypt (2) · Turkey (Türkiye) (2) · Australia (1) · Austria (1) · Bangladesh (1) · Belgium (1) · Czechia (1) · Denmark (1) · France (1) · Germany (1) · Ireland (1) · Norway (1) · Portugal (1)
Teena Chopra, M.D., M.P.H. (2) · Avroy A. Fanaroff, MD (1) · Barbara J. Stoll, MD (1) · Barbara Schmidt, MD (1) · Charles R. Bauer, MD (1) · Christian L Coles, PhD (1) · Christine H Lee, MD (1) · Daniel M Musher, M.D. (1) · David K. Stevenson, MD (1) · Evette van Niekerk, M Dietetics (1) · Fahri Ovali (1) · GHada A. Saleh, MRCPCH (1) · Jon E. Tyson, MD MPH (1)
PMID 42286373, PMID 24799326, PMID 41245385, PMID 11430325, PMID 12622582, PMID 16647401, PMID 16769377, PMID 17188612, PMID 17307535, PMID 17636753, PMID 18245398, PMID 19117897, PMID 21727276, PMID 24309022, PMID 24919691, PMID 25861285, PMID 36287379, PMID 37564743, PMID 38236515, PMID 39172632, PMID 39180326, PMID 40177588, PMID 40321366, PMID 40552763, PMID 40672762, PMID 40784972, PMID 41115624, PMID 41230019, PMID 41647268, PMID 41653256, PMID 42840322
K01DK075478 (1), M01RR000070 (1), M01RR000997 (1), U10HD021364 (1), U10HD021373 (1), U10HD021385 (1), U10HD021397 (1), U10HD027851 (1), U10HD027880 (1), U10HD027881 (1), U10HD027904 (1), U10HD034216 (1)