114 completed, 17 unknown, 16 terminated, 9 recruiting. 58 Phase 4, 42 Phase 3, 25 Phase 2, 23 Phase 1, 14 Not applicable.
Follow Ramipril: new trials by email Literature Review of Ramipril trials Research Report on Ramipril
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ramipril vs. Amlodipine in Pediatric Hemodialysis Patients Ramipril tablet, Amlodipine tablet - Endothelial Dysfunction, End-Stage Renal Disease | Phase 3 | Not yet recruiting | Ain Shams University | 50 | 2026-11-01 | 2026-10-21 |
| Rapid and Simultaneous Initiation of Four Guideline-Directed CKD Therapies (RAPID-CKD) Finerenone, Semaglutide, Lotensin - Chronic Kidney Disease, Type 2 Diabetes | Phase 4 | Enrolling by invitation | Baylor Research Institute | 64 | 2026-04-08 | 2026-10-13 |
| Single and Twice-daily Dosing of Ramipril on Renal Function in Chronic Kidney Disease Patients With Reduced Ejection Fraction Heart Failure Ramipril - Chronic Kidney Disease, Heart Failure With Reduced Ejection Fraction (HFrEF) | Phase 4 | Recruiting | Evi Liliek Wulandari | 80 | 2025-06-30 | 2025-12-10 |
| Colchicine Versus Beta-blockers, Angiotensin-converting Enzyme Inhibitors, and Statins for Prevention of Chemotherapy-Induced Cardiomyopathy Carvedilol, Ramipril, Rosuvastatin - Chemotherapy Induced Systolic Dysfunction | Phase 1 | Unknown | Arab Contractors Medical Centre | 150 | 2024-05-01 | 2024-03-12 |
| Effect of Continuing vs. Discontinuing ACE Inhibitors on Renal Function After Coronary Angiography Continuing Ramipril, Withholding Ramipril - Contrast-Induced Nephropathy, Coronary Angiography | Not applicable | Completed | Tanta University | 44 | 2024-02-01 | 2025-09-22 |
| Comparative Assessment of Efficacy & Safety of Sacubitril/Valsartan Versus Ramipril in Patients With Renal Dysfunction Hospitalized With Acute Decompensated Heart Failure Sacubitril / Valsartan, Ramipril (ACE-inhibitor) - Acute Decompensated Heart Failure (ADHF), Chronic Kidney Disease (CKD) | Phase 2 / Phase 3 | Completed | National Heart Institute, Egypt | 515 | 2023-11-01 | 2026-08-13 |
| Open-label inteRventional Clinical Trial to Assess Efficacy and Safety of the exteMporaneous combInation of Nebivolol and Ramipril in hypertenSIve pAtients Nebivolol 5 mg, Ramipril 2.5/5/10 mg - Hypertension | Phase 4 | Completed | Menarini International Operations Luxembourg SA | 266 | 2023-10-02 | 2025-04-24 |
| The Effect of Sacubitril/Valsartan Versus Ramipril on Left Ventricular Function and Remodeling in Patients With Ischemic Heart Failure With Mid-range Ejection Fraction Sacubitril / Valsartan, Ramipril - Heart Failure With Moderately Reduced Ejection Fraction | Phase 3 | Recruiting | John Paul II Hospital, Krakow | 488 | 2023-07-13 | 2026-07-31 |
| Multicentre Clinical Study to Evaluate the Effect of Personalized Therapy on Patients With Immunoglobulin A Nephropathy. Corticosteroid, Renin-angiotensin sytem blockers, Sodium-glucose cotransporter 2 inhibitor - Glomerulonephritis, Immunoglobulin A Nephropathy | Phase 4 | Recruiting | Fondazione Schena | 878 | 2023-05-01 | 2025-04-02 |
| Effect of Dapagliflozin on Cardiac Structure, Function and Secondary Mitral Regurgitation in Patients with Left Ventricle Dysfunction Dapagliflozin Farxiga®, Ramipril Tritace®, Carvedilol Carvid®,and Spironolactone Aldactone® - Dilated Cardiomyopathy | Phase 3 | Completed | October 6 University | 150 | 2023-04-27 | 2024-10-16 |
| Pentoxifylline on Inflammatory Markers in Non-Diabetic Chronic Kidney Disease Patients Angiotensin-converting enzyme inhibitors (Ramipril), Pentoxifylline - Pentoxifylline, Inflammatory Markers | Not applicable | Completed | Ain Shams University | 42 | 2023-02-01 | 2026-01-02 |
| Bioequivalence Study of Two Formulations of Tablets Ramipril/Hydrochlorothiazide 10 mg/25 mg in Healthy Volunteers Under Fasting Conditions Ramipril/Hydrochlorothiazide tablet 10 mg/25 mg, Tritace® Plus tablet 10 mg/25 mg - Bioequivalence | Phase 1 | Completed | Pharmtechnology LLC | 50 | 2022-12-28 | 2024-01-08 |
| Cross-over Study of Coronary Risk Factors With a Polypill Polypill of acetylsalicylic acid, ramipril and atorvastatin, Drugs taken separately: acetylsalicylic acid, ramipril and atorvastatin - Coronary Artery Disease | Phase 4 | Recruiting | Fundación EPIC | 88 | 2022-10-14 | 2025-08-05 |
| Bioequivalence Study of Two Formulations of Tablets Ramipril 10 mg in Healthy Volunteers Under Fasting Conditions Ramipril tablet 10 mg, Tritace® tablet 10 mg - Bioequivalence | Phase 1 | Completed | Pharmtechnology LLC | 50 | 2022-06-17 | 2023-06-29 |
| Safety and Efficacy of ACEI in Alport Syndrome Patients With COL4A3/COL4A4/COL4A5 Variants Ramipril - Alport Syndrome | Not applicable | Not yet recruiting | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | 510 | 2022-01-01 | 2021-11-24 |
| Continuing or Discontinuing ACE/ARBs in Patients With Chronic Kidney Disease Undergoing Coronary Angiography Continue ACEI or ARBs ( Enalapril , Ramipril , Valsartan , Candesartan, Losartan ), Hold ACEI or ARBs - Contrast-induced Nephropathy, Chronic Kidney Diseases | Not applicable | Unknown | An-Najah National University | 600 | 2021-06-01 | 2023-06-06 |
| Ramipril for the Treatment of COVID-19 Ramipril 2.5 MG Oral Capsule, Placebo oral capsule - COVID-19 | Phase 2 | Completed | University of California, San Diego | 160 | 2020-05-11 | 2023-09-28 |
| Coronavirus (COVID-19) ACEi/ARB Investigation Thiazide or Thiazide-like diuretics, Calcium Channel Blockers, ACE inhibitor - Hypertension, COVID-19 | Phase 4 | Suspended | National University of Ireland, Galway, Ireland | 2414 | 2020-04-30 | 2020-06-30 |
| Nutraceuticals and Drug Treatment in Frail Older Adults Nutraceuticals - Frailty | Unknown | University of Campania Luigi Vanvitelli | 485 | 2020-04-01 | 2022-05-10 | |
| Explorative Study for Treating Persistent Developmental Stuttering With Ramipril Ramipril 2.5 MG - Persistent Developmental Stuttering | Phase 3 | Active not recruiting | HaEmek Medical Center, Israel | 10 | 2020-03-15 | 2025-03-13 |
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Hypertension (49) · Diabetes Mellitus, Type 2 (12) · Renal Insufficiency, Chronic (12) · Cardiovascular Diseases (9) · Diabetes Mellitus (9) · Diabetic Nephropathies (6) · Metabolic Syndrome (6) · Atherosclerosis (5) · Essential Hypertension (5) · Proteinuria (5) · Coronary Artery Disease (4) · Coronary Disease (4) · Heart Failure (4) · Obesity (4) · Albuminuria (3)
Boehringer Ingelheim (11) · Novartis Pharmaceuticals (6) · Sanofi (6) · Vanderbilt University (6) · Novartis (5) · Ferrer Internacional S.A. (4) · Pfizer (4) · Actavis Inc. (3) · Ain Shams University (3) · Gulhane School of Medicine (3) · Teva Pharmaceuticals USA (3) · Brigham and Women's Hospital (2) · Dr. Reddy's Laboratories Limited (2) · Gerstein, Hertzel, MD (2) · Mario Negri Institute for Pharmacological Research (2)
United States (44) · Italy (20) · Germany (18) · Canada (16) · Spain (16) · France (15) · India (11) · United Kingdom (11) · Poland (9) · Egypt (8) · Netherlands (8) · Russia (8) · Argentina (7) · Australia (7) · Brazil (7)
Daniel V. Freeland,, D.O., CCI (3) · Richard Larouche, M.D. (3) · Bronwyn A Kingwell, PhD (2) · Daniel V Freeland, D.O. (2) · Mr. Charu Gautam, MD, DNB (2) · Nancy J Brown, MD (2) · Ramon C Hermida, PhD (2) · Roberto Fogari, MD (2) · Sergey Filatov (2) · Steven Herrmann, M.D., PhD (2)
PMID 33089502, PMID 38682786, PMID 25193393, PMID 26494370, PMID 32905623, PMID 36398903, PMID 38299639, PMID 39082471, PMID 11386927, PMID 12435255, PMID 12479763, PMID 14630977, PMID 14744931, PMID 15106785, PMID 15253732, PMID 15647341, PMID 15772249, PMID 15851648, PMID 16093916, PMID 16208639, PMID 16670135, PMID 16980380, PMID 16997664, PMID 17339550, PMID 17533019, PMID 17667984, PMID 17978307, PMID 18268075, PMID 18378520, PMID 18391085, PMID 18427133, PMID 18463672, PMID 18537808, PMID 18539917, PMID 18551027, PMID 18707986, PMID 18757085, PMID 18824641, PMID 19100670, PMID 19104516, PMID 19211665, PMID 19433778, PMID 19451556, PMID 19463506, PMID 19477351, PMID 19506526, PMID 19571790, PMID 19571791, PMID 19683638, PMID 19770395
2009 (4), R01HL065193 (2), 2015 (1), 2016 (1), 2017 (1), 2023 (1), 3UG1CA189824-04S1 (1), N01HC95178 (1), N01HC95179 (1), N01HC95180 (1), N01HC95181 (1), N01HC95182 (1), N01HC95183 (1), N01HC95184 (1), P60AR047782 (1)