12 unknown, 11 completed, 3 not yet recruiting, 3 recruiting. 16 Phase 4, 7 Phase 2, 7 Phase 3, 4 Not applicable, 1 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Impact of Using Nicorandil for the Prevention of Doxorubicin-Induced Cardiotoxicity Nicorandil Oral Tablet, Adriamycin (Doxorubicin) - Doxorubicin Induced Cardiotoxicity, Doxorubicin Induced Cardiomyopathy | Phase 2 | Not yet recruiting | Universiti Sains Malaysia | 146 | 2026-10-01 | 2026-10-27 |
| The Effect of Nicorandil on Rheumatoid Arthritis Patients Nicorandil Oral Tablet, Placebo, conventional synthetic antirheumatic drugs (cDMARDs) - Rheumatoid Arthritis (RA) | Phase 2 / Phase 3 | Recruiting | Ain Shams University | 70 | 2026-09-06 | 2026-09-16 |
| Nicorandil in Atherosclerosis Risk in Patients With Rheumatoid Arthritis Nicorandil 10 MG Oral scored Tablet, DMARD maintenance - Rheumatoid Arthritis (RA, Atherosclerosis | Phase 3 | Not yet recruiting | Tanta University | 46 | 2026-09-01 | 2026-09-11 |
| Effects of Nicorandil on Microvascular Dysfunction in Patients With STEMI Undergoing Primary PCI nicorandil, Saline (NaCl 0,9 %) (placebo) - STEMI - ST-segment Elevation Myocardial Infarction | Phase 4 | Not yet recruiting | China National Center for Cardiovascular Diseases | 170 | 2026-03-01 | 2026-03-12 |
| Nicorandil as Anti-inflammatory in Rheumatoid Arthritis Nicorandil 5 MG Oral Tablet - Rhumatoid Arthisis | Phase 3 | Recruiting | Tanta University | 46 | 2024-11-01 | 2026-06-18 |
| Oral Nicorandil for Prevention of No Reflow Phenomenon in Anterior STEMI Patients Undergoing PPCI Nicorandil 20mg - No Reflow Phenomenon, Anterior STEMI | Phase 1 / Phase 2 | Completed | Ain Shams University | 300 | 2024-03-10 | 2025-08-24 |
| Effect of Nicorandil in Type 2 Diabetic Obese Patients Nicorandil 10 MG - Diabetes Mellitus, Type 2 | Phase 2 | Completed | Tanta University | 46 | 2023-11-01 | 2026-08-12 |
| Nephroprotective Effect of Nicorandil in Type 2 Diabetes Mellitus Nicorandil 10 MG Oral Tablet - Type2 Diabetes Mellitus | Phase 3 | Unknown | Tanta University | 46 | 2023-02-28 | 2024-05-28 |
| A Study to Evaluate the Impact of Pre-procedural Intracoronary Nicorandil Injection to PREVENT reductioN Of decREased TIMI FLOW in Patients Who Undergoing Percutaneous Coronary Intervention for the Coronary Artery Disease Nicorandil - No-Reflow Phenomenon, Coronary Artery Disease | Phase 4 | Recruiting | Korea University Anam Hospital | 458 | 2022-12-14 | 2026-09-08 |
| Intracoronary of Nicorandil and Verapamil to Reduce the Occurrence of Periprocedural Myocardial Injury Nicorandil, Saline - Coronary Artery Disease | Phase 2 | Unknown | The First Affiliated Hospital of Zhejiang Chinese Medical University | 150 | 2022-05-17 | 2022-06-01 |
| Safety and Modulation of ABCC9 Pathways by Nicorandil for the Treatment of Hippocampal Sclerosis of Aging Nicorandil, Placebo - Dementia, Mild Cognitive Impairment | Phase 2 | Active not recruiting | Gregory Jicha, MD, PhD | 64 | 2021-12-01 | 2025-12-15 |
| Clinical Efficacy and sAfety of Intravenous Infusion of Nicorandil During Primary Percutaneous Coronary Intervention Nicorandil, Placebo - ST Elevation Myocardial Infarction, Percutaneous Coronary Intervention | Phase 4 | Completed | Fudan University | 1500 | 2021-06-01 | 2025-03-11 |
| Oral Nicorandil in ST Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention Nicorandil 20 MG - Nicorandil | Unknown | Ahmed Abdel Nasser Abdel Rady | 300 | 2021-04-01 | 2021-01-05 | |
| Effect of Nicorandil on Cardiac Sympathetic Nerve for the Patients of Acute ST Segment Elevation Myocardial Infarction nicorandil, Placebo（normal saline） - Coronary Heart Disease | Phase 4 | Unknown | Xuzhou Central Hospital | 80 | 2021-04-01 | 2021-04-01 |
| Managing Endothelial Dysfunction in Critically Ill COVID-19 Patients at LAUMCRH Endothelial Protocol - Covid19, Endothelial Dysfunction | Phase 3 | Unknown | Lebanese American University Medical Center | 70 | 2021-01-20 | 2021-03-24 |
| Managing Endothelial Dysfunction in COVID-19 : A Randomized Controlled Trial at LAUMC Atorvastatin + L-arginine + Folic acid + Nicorandil + Nebivolol, Placebo - Covid19 | Phase 3 | Unknown | Lebanese American University Medical Center | 42 | 2021-01-10 | 2022-02-14 |
| Different Anti-Spastic Therapy Strategies After CABG Using Radial Artery Grafts Nicorandil 5mg tid, Diltiazem 180mg qd, Isosorbide Mononitrate 50mg qd - Coronary Artery Bypass Graft, Radial Artery Grafts | Phase 4 | Completed | Ruijin Hospital | 150 | 2020-06-02 | 2026-07-09 |
| The Effect of Nicorandil on Left Ventricular Myocardial Strain in Patients With Coronary Chronic Total Occlusion nicorandil - Coronary Artery Disease | Phase 4 | Completed | Peking University Third Hospital | 61 | 2019-04-08 | 2021-10-21 |
| Regulation of KATP Channels and Na+/K+ ATPase in Relation to Fatigue Development Placebo, Nicorandil - Insulin Resistance | Not applicable | Completed | University of Copenhagen | 16 | 2018-12-19 | 2023-07-06 |
| China-Administration of Nicorandil Group（CHANGE） Nicorandil, Placebo - Myocardial Infarction, Percutaneous Coronary Intervention | Phase 4 | Completed | Chinese PLA General Hospital | 238 | 2018-02-24 | 2021-11-24 |
Showing 20 of 34. Sign in to see all of them.
ST Elevation Myocardial Infarction (5) · Coronary Artery Disease (4) · Coronary Disease (4) · Angina, Stable (3) · Angina Pectoris (2) · Arthritis, Rheumatoid (2) · COVID-19 (2) · Myocardial Infarction (2) · No-Reflow Phenomenon (2) · Angina, Unstable (1) · Atherosclerosis (1) · Autoimmune Diseases (1) · Cardiomyopathies (1) · Cardiotoxicity (1) · Chest Pain (1)
Tanta University (4) · Merck KGaA, Darmstadt, Germany (3) · Ain Shams University (2) · Lebanese American University Medical Center (2) · Xuzhou Central Hospital (2) · Ahmed Abdel Nasser Abdel Rady (1) · China National Center for Cardiovascular Diseases (1) · Chinese PLA General Hospital (1) · Ferozsons Laboratories Ltd. (1) · Fudan University (1) · Gregory Jicha, MD, PhD (1) · Korea University Anam Hospital (1) · Kumamoto University (1) · Mashhad University of Medical Sciences (1) · National Cerebral and Cardiovascular Center, Japan (1)
China (10) · Egypt (7) · Japan (3) · Denmark (2) · Lebanon (2) · South Korea (2) · Pakistan (1) · United States (1)
Aya M El Shanshory, resident doctor (1) · Ayman A G, Prof (1) · Ben He, MD,PhD (1) · Cherry Ma, PhD (1) · Gregory A Jicha, MD, PhD (1) · Hisao Ogawa, MD, PhD (1) · Jun-Hyok Oh, MD (1) · Junbo Ge (1) · Kent L Christensen, MD, DrMSc (1) · Mario FL Gaudino, MD (1) · Masafumi Kitakaze, MD, PhD (1) · May A. Shawky, Assoc. Prof. (1)
PMID 11965271, PMID 17964349, PMID 24167609, PMID 31118574, PMID 36073634, PMID 10080465, PMID 10972541, PMID 11693742, PMID 12607706, PMID 15791442, PMID 16116055, PMID 17478142, PMID 19276198, PMID 23281415, PMID 24457276, PMID 26012474, PMID 27657471, PMID 28279370, PMID 28886621, PMID 28966311, PMID 29495982, PMID 29891250, PMID 31147987, PMID 33847683, PMID 34785173, PMID 35647043, PMID 37319341, PMID 40123490, PMID 42584383
R01AG061111 (1)