27 completed. 27 Phase 2, 11 Phase 1, 4 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 27 | Completed 27 |
| Phase 1 | 11 | Completed 11 |
| Phase 3 | 4 | Completed 4 |
Follow Endothelial Dysfunction: new trials by email Literature Review of Endothelial Dysfunction trials Research Report on Endothelial Dysfunction
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| COMP-4 Supplementation and Brachial Artery FMD COMP-4 - Aging, Endothelial Dysfunction | Phase 1 / Phase 2 | Completed | University of California, Los Angeles | 32 | 2023-06-01 | 2026-03-09 |
| A Phase 1/ Phase 2 Study of TTHX1114(NM141) TTHX1114(NM141), Vehicle (placebo) - Corneal Endothelial Dystrophy, Fuchs Endothelial Corneal Dystrophy | Phase 1 / Phase 2 | Completed | Trefoil Therapeutics, Inc. | 22 | 2020-08-19 | 2023-10-30 |
| Wild Blueberries and Cardiovascular Health in Middle-aged/Older Men and Postmenopausal Women Blueberry Powder, Placebo Powder - Hypertension, Aging | Phase 1 / Phase 2 | Completed | Colorado State University | 60 | 2020-01-01 | 2026-10-30 |
| Adrecizumab in Cardiogenic Shock Adrecizumab, Placebo - Cardiogenic Shock, Endothelial Dysfunction | Phase 2 / Phase 3 | Completed | Dr. med. Mahir Karakas | 150 | 2019-04-04 | 2021-10-08 |
| Subarachnoid Hemorrhage and Soluble Epoxide Hydrolase Inhibition Trial GSK2256294, Placebo - Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia | Phase 1 / Phase 2 | Completed | Oregon Health and Science University | 20 | 2018-05-02 | 2021-01-22 |
| CD36 in Nutrient Delivery and Its Dysfunction Sildenafil Citrate in G allele carrier, Sildenafil Citrate in non G allele carrier - Insulin Resistance, Endothelial Dysfunction | Phase 1 / Phase 2 | Completed | Vanderbilt University Medical Center | 26 | 2017-01-01 | 2022-11-30 |
| Atherosclerosis, Immune Mediated Inflammation and Hypoestrogenemia in Young Women 17beta Estradiol, Transdermal placebo patch, Progesterone - Estrogen Deficiency, Cardiovascular Disease (CVD) | Phase 2 | Completed | Cedars-Sinai Medical Center | 29 | 2017-01-01 | 2025-03-13 |
| Effect of Febuxostat on Endothelial Dysfunction in Hemodialysis Patients. Febuxostat, Placebo - Endothelial Dysfunction, Endstage Renal Disease | Phase 2 / Phase 3 | Completed | Ain Shams University | 57 | 2016-08-01 | 2018-01-02 |
| Trial of Oral Glutamine on Mitochondrial Function in CKD First Intervention (14 days), Washout (3 weeks), Second Intervention (14 days) - Cardiovascular Disease, Sarcopenia | Phase 2 | Completed | University of Washington | 11 | 2016-02-25 | 2022-07-14 |
| Reduction of Venous Emboli Load After Breathing Normobaric Oxygen Compared to Air Oxygen, Air - Hyperbaric, Diving Medicine | Phase 2 / Phase 3 | Completed | Göteborg University | 48 | 2015-05-01 | 2022-05-27 |
| N-acetylcysteine to Reduce Oxidative Stress and Improve Endothelial Function in HIV-infected Older Adults PharmaNAC (N-acetylcysteine), Matching placebo - HIV, Endothelial Dysfunction | Phase 1 / Phase 2 | Completed | Indiana University | 24 | 2013-10-01 | 2016-02-08 |
| Impact of Oranges on Cardiovascular Health Citrus supplement, Placebo - Blood Pressure, Endothelial Dysfunction | Phase 1 / Phase 2 | Completed | University of Leeds | 25 | 2013-06-01 | 2014-04-01 |
| Effects of Dietary Nitrate on Age-related Vascular Function Nitrate, Placebo - Endothelial Dysfunction | Phase 1 / Phase 2 | Completed | Heinrich-Heine University, Duesseldorf | 20 | 2012-10-01 | 2013-12-09 |
| Targeting Inflammation to Treat Cardiovascular Aging Salsalate, Placebo (for salsalate) - Vascular Stiffness, Endothelial Dysfunction | Phase 2 | Completed | Gary L. Pierce | 59 | 2012-09-01 | 2018-05-31 |
| A Clinical Trial for People HIV+ Age > 50 at Risk for Heart Disease Telmisartan - Endothelial Dysfunction | Phase 2 | Completed | University of California, Los Angeles | 17 | 2012-08-01 | 2014-12-08 |
| Cardiovascular Effects of Aerosols in Residences Study HEPA Filter, HEPA Filtration Placebo - Endothelial Dysfunction, Systemic Inflammation | Phase 2 | Completed | Simon Fraser University | 83 | 2011-11-01 | 2014-04-14 |
| Cocoa Flavanols in Renal Disease Cocoa - End Stage Renal Disease, Endothelial Dysfunction | Phase 1 / Phase 2 | Completed | Klinik für Kardiologie, Pneumologie und Angiologie | 22 | 2011-08-01 | 2013-11-13 |
| Impact of Smoking Cessation and γ-Tocopherol to Restore Vascular Endothelial Function Nicotine Replacement Therapy (NRT), Gamma-Tocopherol, Placebo - Endothelial Dysfunction | Phase 1 / Phase 2 | Completed | University of Connecticut | 67 | 2011-01-01 | 2015-01-21 |
| Diabetes & Vardenafil Vardenafil, Placebo - Type 2 Diabetes Mellitus (T2DM), Endothelial Dysfunction | Phase 2 | Completed | Azienda USL Modena | 54 | 2010-03-01 | 2014-08-19 |
| Darusentan Effect on PET Uptake Heterogeneity darusentan 100 mg - Coronary Artery Disease, Endothelial Dysfunction | Phase 2 | Completed | K.Lance Gould | 40 | 2009-06-01 | 2014-08-15 |
Showing 20 of 27. Sign in to see all of them.
Cardiovascular Diseases (7) · Inflammation (5) · Atherosclerosis (3) · Hypertension (3) · Insulin Resistance (3) · Coronary Artery Disease (2) · Amenorrhea (1) · Corneal Dystrophy, Posterior Polymorphous, 1 (1) · Decompression Sickness (1) · Diabetes Mellitus, Type 2 (1) · Erectile Dysfunction (1) · Fuchs' Endothelial Dystrophy (1) · Glucose Intolerance (1) · Kidney Diseases (1) · Kidney Failure, Chronic (1)
Pathological Conditions, Signs and Symptoms (10) · Pathologic Processes (9) · Vascular Diseases (7) · Cardiovascular Diseases (6) · Metabolic Diseases (5) · Nutritional and Metabolic Diseases (5) · Glucose Metabolism Disorders (4) · Arterial Occlusive Diseases (3) · Arteriosclerosis (3) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (3) · Genetic Diseases, Inborn (3) · Heart Diseases (3) · Hyperinsulinism (3) · Male Urogenital Diseases (3) · Myocardial Ischemia (3)
salicylsalicylic acid (2) · Acetylcysteine (1) · Air (1) · Amlodipine (1) · Ascorbic Acid (1) · Chocolate (1) · Corn Oil (1) · Estradiol (1) · Exercise (1) · Febuxostat (1) · Folic Acid (1) · N-((4-cyano-2-(trifluoromethyl)phenyl)methyl)-3-((4-methyl-6-(methylamino)-1,3,5-triazin-2-yl)amino)cyclohexanecarboxamide (1) · Nicotine (1) · Nicotine Replacement Therapy (1) · Nitrates (1)
University of California, Los Angeles (2) · Ain Shams University (1) · Azienda Ospedaliera San Camillo Forlanini (1) · Azienda USL Modena (1) · BioMarin Pharmaceutical (1) · Cedars-Sinai Medical Center (1) · Colorado State University (1) · Dr. med. Mahir Karakas (1) · Gary L. Pierce (1) · Göteborg University (1) · Heinrich-Heine University, Duesseldorf (1) · Indiana University (1) · Insel Gruppe AG, University Hospital Bern (1) · K.Lance Gould (1) · Klinik für Kardiologie, Pneumologie und Angiologie (1)
United States (16) · Germany (3) · Italy (2) · Canada (1) · Netherlands (1) · Sweden (1) · United Kingdom (1)
Abdurrahman M Sweidan (1) · Chrisandra Shufelt, MD (1) · Corrilynn O Hileman, MD (1) · Cyndya Shibao, MD (1) · Don Nwose, MD (1) · Gary L Pierce, PhD (1) · Grace A Mccomsey, M.D. (1) · Jonathan Himmelfarb, MD (1) · Jordan E. Lake, MD (1) · K Lance Gould, MD (1) · Kerstin Wustmann, MD (1) · Mahir Karakas, MD, MBA (1) · Manuela Simoni, MD, PhD (1) · Maria TE Hopman, MD, PhD (1) · Mikael Gennser, PhD (1)
PMID 20613460, PMID 23359371, PMID 24075893, PMID 24400341, PMID 25361769, PMID 25578927, PMID 25896330, PMID 26485680, PMID 27658740, PMID 34873674, PMID 34895483, PMID 37610989, PMID 37916745, PMID 39503770
K23DK099442 (1)