19 completed, 10 unknown, 4 recruiting, 4 terminated. 23 Not applicable, 5 Phase 2, 5 Phase 3, 5 Phase 4, 2 Phase 1.
Follow Nitrates: new trials by email Literature Review of Nitrates trials Research Report on Nitrates
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pilot Study of Nitrate-rich Beetroot Juice Supplementation in Patients With Idiopathic Pulmonary Fibrosis (IPF) nitrate-rich beetroot juice (70ml with approx. 400 mg nitrate) twice a day for 3 days - Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease | Not applicable | Recruiting | University Hospital Southampton NHS Foundation Trust | 16 | 2026-02-13 | 2026-07-06 |
| Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men Beetroot Juice - Active, Placebo Beetroot Juice Without Nitrate - Mitochondrial Energetics, Dietary Nitrate | Not applicable | Recruiting | Indiana University | 24 | 2026-01-30 | 2026-02-23 |
| Effects of Dietary Nitrate in Women With Secondary Amenorrhea Beetroot Juice - Active, Placebo Beetroot Juice Without Nitrate - Secondary Amenorrhea | Not applicable | Terminated | Indiana University | 3 | 2025-09-05 | 2026-06-12 |
| Improving Mobility After Revascularization in Peripheral Artery Disease Home Based Exercise, Nitrate Rich Beetroot Juice, Attention Control - Peripheral Artery Disease, Intermittent Claudication | Phase 3 | Recruiting | Northwestern University | 386 | 2025-08-04 | 2026-10-05 |
| Nitrate Formulations and Exercise Performance Nitrate - Nitrate, Nitrate/Citrulline | Not applicable | Completed | University of Greenwich | 15 | 2024-08-01 | 2025-03-27 |
| The Effect of Nitrate Supplement on the Oral Microbiome and Saliva in Dental Erosion Nitrate - Dental Erosion | Not applicable | Unknown | University of Portsmouth | 20 | 2023-11-01 | 2023-12-05 |
| Herbal Pralines - Oral Health herbal nitrate Pralines with nitrate, herbal nitrate Pralines without nitrate - Periodontitis, Gingivitis | Not applicable | Completed | Wuerzburg University Hospital | 44 | 2023-09-15 | 2024-07-24 |
| Effects of Dietary Nitrate Intake on Cardiovascular Performance in Response to Hand Grip Test in Bodybuilders Beetroot juice rich in nitrate, Beetroot juice depleted in nitrate - Steroid Abuse, Cardiovascular Abnormalities | Not applicable | Completed | University of Sao Paulo | 13 | 2023-04-17 | 2025-07-28 |
| Chlorhexidine Mouthwash and Oral Nitrate in Adults With Pulmonary Hypertension Nitrates, Chlorhexidine Gluconate Mouthwash, Placebo Mouthwash - Pulmonary Hypertension, Heart Failure With Normal Ejection Fraction | Phase 1 | Withdrawn | Gladwin, Mark, MD | 2022-12-01 | 2022-07-07 | |
| Effects of Nitrates and Citrulline Malate on Performance in Professional Professional Soccer Nitrates and Citrulline Malate, Control product - Supplementation | Not applicable | Completed | Universidad Católica San Antonio de Murcia | 40 | 2022-08-15 | 2023-11-27 |
| Effects of Dietary Nitrate Intake on Physical Performance of Middle-aged Women Beetroot juice rich in nitrate, Beetroot juice NO3 depleted - Postmenopausal; Menorrhagia, Physical Inactivity | Not applicable | Unknown | University of Sao Paulo | 15 | 2022-07-01 | 2023-06-13 |
| Effect of Colchicine on MMP-9, NOX2, and TGF-β1 in Myocardial Infarct Colchicine, Percutaneous Coronary Intervention, Optimal medical treatment including statin, aspirin, P2Y12 inhibitor, and nitrate. - ST Elevation Myocardial Infarction, Colchicine | Phase 4 | Unknown | RSD dr. Soebandi | 148 | 2022-06-01 | 2023-04-11 |
| NO3-rich Beet Juice and Exercise on Postmenopausal Women Cardiovascular Health Beetroot juice rich in nitrate - Arterial Hypertension, Postmenopausal; Menorrhagia | Not applicable | Unknown | University of Sao Paulo | 20 | 2022-05-31 | 2023-01-12 |
| Dietary Inorganic Nitrate and the Enteral Microbiome Nitrate, Control - Cardiovascular Health | Not applicable | Completed | University Hospital, Essen | 30 | 2021-11-22 | 2024-09-25 |
| Nitrate-based Nutritional Formula for Oxygen Saturation and Patient-reported Outcomes in Covid-19 NITRATE, PLACEBO - COVID-19 | Not applicable | Completed | University of Novi Sad, Faculty of Sport and Physical Education | 52 | 2021-09-01 | 2022-05-24 |
| The Effect of Beetroot Juice on Plasma Trimethylamine N-oxide Concentration beetroot juice, nitrate - Hypertension | Not applicable | Unknown | Poznan University of Physical Education | 20 | 2021-09-01 | 2023-11-15 |
| Effect of Ultimaster Stents Treated to the Most Dilated Coronary Vessels Nitrate - Vasodilation, Coronary Artery Disease | Not applicable | Unknown | Inha University Hospital | 400 | 2021-08-01 | 2021-06-18 |
| Preoperative Coadministration of Low-concentration Carbohydrate and Nitrates Loading vs Low- Concentration Carbohydrate Loading Alone in Patients Undergoing Open Gynecological Surgeries Low-concentration carbohydrate and nitrates, Low-concentration carbohydrate, Water with placebo capsules - Length of Hospital Stay | Phase 4 | Recruiting | Ain Shams University | 90 | 2021-08-01 | 2026-09-24 |
| Prognostic Value of Precision Medicine in Patients With MINOCA (PROMISE Trial). Coronary angiography, OCT imaging, Percutaneous coronary intervention (PCI): - Myocardial Infarction With Non-Obstructive Coronary Arteries | Phase 4 | Unknown | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 120 | 2021-07-01 | 2024-07-26 |
| Nutritional Supplementation and Insulin Sensitivity L-arginine + Nitrate / Nitrite, Placebo - Nitric Oxide, Insulin Sensitivity | Not applicable | Terminated | Maastricht University Medical Center | 1 | 2020-09-01 | 2021-06-11 |
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Coronary Artery Disease (3) · Hypertension (3) · Cardiovascular Diseases (2) · Heart Failure (2) · Menorrhagia (2) · Aneurysm (1) · Angina Pectoris, Variant (1) · Angina, Stable (1) · COVID-19 (1) · Camurati-Engelmann Syndrome (1) · Cardiovascular Abnormalities (1) · Colorectal Neoplasms (1) · Coronary Disease (1) · Diabetes Mellitus, Type 2 (1) · Gingivitis (1)
Indiana University (4) · Maastricht University Medical Center (3) · University of Sao Paulo (3) · University of Carabobo (2) · Ain Shams University (1) · Alere San Diego (1) · Burgos Nutrition (1) · Colorado State University (1) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (1) · Gladwin, Mark, MD (1) · Gruppo Italiano Multidisciplinare per lo Studio della Sincope (1) · Heinrich-Heine University, Duesseldorf (1) · Hospital de Clinicas de Porto Alegre (1) · Inha University Hospital (1) · Karolinska Institutet (1)
United States (8) · Brazil (4) · Netherlands (4) · United Kingdom (4) · Germany (3) · Italy (2) · Spain (2) · Sweden (2) · Venezuela (2) · Canada (1) · Egypt (1) · France (1) · Indonesia (1) · Iraq (1) · Ireland (1)
Andrew R Coggan, PhD (2) · Antonio J Delgado-Leon, MD (2) · Antonio R Delgado-Almeida, MD, FAHA, FACC, APS (2) · Carlos L Delgado-Leon, MD (2) · Peter J Joris, PhD (2) · Alan Maisel, MD (1) · Alison Morris, MD, MS (1) · Ana Sousa, PhD (1) · Andrew Coggan, PhD (1) · Carisi A Polanczyk, MD, ScD (1) · Cicero Jonas Rodrigues Benjamim, PhD Student (1) · Faris A Khazaal, FRCP (1) · Fernando Naclerio (1) · Jon Lundberg, MD, PhD (1)
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P01HL103455 (1)