35 completed, 7 unknown, 2 active not recruiting, 2 recruiting. 35 Not applicable, 4 Phase 2, 4 Phase 4, 3 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 35 | Completed 25, Unknown 4, Active not recruiting 2, Recruiting 2, Terminated 2 |
| Phase 2 | 4 | Completed 3, Unknown 1 |
| Phase 4 | 4 | Completed 2, Unknown 2 |
| Phase 1 | 3 | Completed 3 |
Follow Chocolate: new trials by email Literature Review of Chocolate trials Research Report on Chocolate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cocoa Extract for Migraine Trial Cocoa extract, Cocoa extract placebo - Migraine | Not applicable | Recruiting | Brigham and Women's Hospital | 114 | 2025-06-23 | 2026-06-29 |
| The Impact of Pectin Supplementation on Systematic Inflammation Pathway, Gut Microbiome, and Metabolic Health in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Pectin, Cocoa Powder, Magnetic Resonance Imaging with Contrast - Nonalcoholic Fatty Liver Disease, Nonalcoholic Fatty Liver Disease (NAFLD) | Not applicable | Recruiting | University of Nottingham | 45 | 2025-06-10 | 2026-07-29 |
| Effect of a Food Supplement with Natural Extracts of Cocoa, Amaranth Seed and Ginger in Overweight or Obese Patients Cocoa, amaranth seed and ginger, Amaranth seed, Cocoa - Oxidative Stress, Inflammation Biomarkers | Not applicable | Active not recruiting | University of Guadalajara | 40 | 2023-08-20 | 2025-01-10 |
| Effects of Cacao Flavonoids in Long COVID-19 Patients (FLALOC) Flavonoids - Long Covid19, Fatigue Syndrome, Chronic | Not applicable | Completed | Guillermo Ceballos Reyes | 46 | 2023-08-01 | 2024-10-01 |
| Polyphenols, Prebiotics, the Gut Microbiome and Stress Blueberry, cranberry, green tea extract, cocoa, GOS, Inulin, RS2, prebiotics and polyphenols - Stress, Psychological, Gut Bacteria | Not applicable | Completed | University of Reading | 20 | 2022-01-01 | 2023-03-07 |
| Effect of Nutritional Supplements on Clinical Outcomes in Patients With Prediabetes and Obesity Ivital Control, lifestyle intervention - PreDiabetes, Obesity | Not applicable | Unknown | Ningbo No. 1 Hospital | 100 | 2021-06-11 | 2022-06-09 |
| Effect of Cocoa Supplementation Peripheral and Autonomic Diabetic Neuropathy Cocoa, Placebo - Diabetic Neuropathies | Not applicable | Completed | Anahuac University | 39 | 2021-06-04 | 2025-05-01 |
| COcoa Supplement and Multivitamin Outcomes Study: Effects on Falls and Physical Performance Cocoa extract, Cocoa extract placebo, Multivitamin - Fall, Physical Performance | Not applicable | Active not recruiting | Brigham and Women's Hospital | 21442 | 2021-05-15 | 2026-04-13 |
| The Effect of Cocoa on Platelet Function Profiles in Patients Cocoa - Platelet Dysfunction | Not applicable | Completed | The University of The West Indies | 25 | 2020-09-01 | 2023-08-25 |
| Effect of Cocoa Supplementation in Training Athletes Microbiota and Metabolome cocoa, Placebo - Healthy Athletes | Not applicable | Completed | Universidad Europea de Madrid | 40 | 2020-07-01 | 2020-11-04 |
| The Chocolate Study 2.0 Chocolate - Normal Weight | Completed | USDA Grand Forks Human Nutrition Research Center | 20 | 2019-07-25 | 2025-04-11 | |
| Brain's Response to Chocolate Chocolate - Overweight, Obesity | Completed | USDA Grand Forks Human Nutrition Research Center | 20 | 2018-01-17 | 2023-12-08 | |
| The Effects of Dark Chocolate Implementation in Elite Athletes Dark Chocolate (85% cocoa), White/Milk chocolate (<35% cocoa) - Oxidative Stress, Athletes Heart | Not applicable | Completed | University of Roma La Sapienza | 24 | 2017-09-25 | 2019-04-17 |
| A Nicotine Pharmacokinetics and Smoking Behaviour Study Examining Cigarette Ingredients Reference cigarette, Cigarette with carob bean extract, Cigarette with cocoa powder - Healthy Volunteers, Smoking | Not applicable | Completed | British American Tobacco (Investments) Limited | 40 | 2017-09-12 | 2022-12-07 |
| Can a Flavonoid-rich Pure Cocoa Reduce Fatigue in People With Parkinson's (PD) Cocoa - Parkinson Disease, Fatigue | Not applicable | Completed | Oxford Brookes University | 30 | 2017-07-01 | 2019-09-06 |
| Cocoa to Improve Walking Performance in Peripheral Artery Disease Cocoa, Placebo - Peripheral Artery Disease | Not applicable | Completed | Northwestern University | 44 | 2017-01-01 | 2020-08-06 |
| Investigating the Effects of Cocoa Flavanol on Cognition Assessed Online Cocoa Extract, Cocoa Extract Placebo, Multivitamin - Aging, Cognitive Change | Not applicable | Completed | Columbia University | 3959 | 2016-08-26 | 2023-04-07 |
| Effects of Chocolate Consumption in Elderly Patients With Cancer in Palliative Care Chocolate - Nutrition Related Cancer, Aging | Not applicable | Completed | University of Sao Paulo | 45 | 2016-04-15 | 2020-04-29 |
| Interventional Testing of Gene-environment Interactions Via the Verifomics Mobile Application Vitamin A, Vitamin B6, Vitamin C - Obesity, Rhinitis | Not applicable | Terminated | Verifomics LLC | 16 | 2016-03-01 | 2017-10-02 |
| Cocoa Supplementation, Inflammaging, and Epigenetic Aging Cocoa extract, Multivitamin, Cocoa extract placebo - Aging, Inflammation | Phase 4 | Unknown | Augusta University | 21442 | 2015-06-01 | 2022-08-22 |
Showing 20 of 48. Sign in to see all of them.
Obesity (8) · Cardiovascular Diseases (7) · Diabetes Mellitus (4) · Diabetes Mellitus, Type 2 (3) · Hypertension (3) · Inflammation (3) · Overweight (3) · Parkinson Disease (3) · Fatigue (2) · Migraine Disorders (2) · Motor Activity (2) · Neurodegenerative Diseases (2) · Peripheral Arterial Disease (2) · Prediabetic State (2) · Acne Vulgaris (1)
Brigham and Women's Hospital (6) · Heinrich-Heine University, Duesseldorf (2) · Hospital Clinic of Barcelona (2) · Technische Universität Dresden (2) · USDA Grand Forks Human Nutrition Research Center (2) · University of Nottingham (2) · Anahuac University (1) · Augusta University (1) · British American Tobacco (Investments) Limited (1) · Clinica Universidad de Navarra, Universidad de Navarra (1) · Columbia University (1) · Griffin Hospital (1) · Guillermo Ceballos Reyes (1) · Hospital Universitario Pedro Ernesto (1) · Hull University Teaching Hospitals NHS Trust (1)
United States (17) · United Kingdom (7) · Germany (5) · Italy (4) · Spain (4) · Mexico (3) · Brazil (1) · China (1) · France (1) · Switzerland (1) · Trinidad and Tobago (1)
Shanon Casperson, PhD (2) · Adam M. Brickman, PhD (1) · Aedin MM Cassidy, PhD (1) · Alex Reed (1) · Andrew P Neilson, PhD (1) · Bethan E Phillips, PhD (1) · Brian Berman, M.D., Ph.D. (1) · Brody Holohan, PhD (1) · Caroline Caperton, M.D., M.S.P.H. (1) · Carolyn Crandall, MD, MS (1) · Christian Heiss, MD (1) · David L Katz, MD (1) · Ebrahim Barkouadh, M.D., M.P.H. (1) · Eliot Brinton, MD (1)
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R01HL089570 (1), R21AG050897 (1), U01AT012611 (1)