31 completed, 13 unknown, 7 recruiting, 2 not yet recruiting. 33 Not applicable, 6 Phase 4, 5 Phase 2, 4 Phase 3, 2 Early Phase 1.
Follow Endodontic Disease: new trials by email Literature Review of Endodontic Disease trials Research Report on Endodontic Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Nanozymes in Endodontics Nanozyme treatment, Control (Standard treatment) - Apical Periodontitis, Endodontic Disease | Phase 4 | Enrolling by invitation | University of Pennsylvania | 72 | 2026-08-24 | 2026-10-13 |
| Postoperative Pain After OCT or EDTA Irrigation in Regenerative Endodontic Treatment Regenerative Endodontic Treatment Using Different Irrigation Solutions - Apical Periodontitis, Endodontic Disease | Not applicable | Completed | TC Erciyes University | 40 | 2026-04-10 | 2026-10-23 |
| The Antimicrobial Potential of Diclofenac Sodium as an Intracanal Medicament Diclofenac Sodium, Calcium hydroxide - Endodontic Disease, Pulp Disease, Dental | Phase 2 / Phase 3 | Recruiting | British University In Egypt | 48 | 2025-11-01 | 2025-05-30 |
| A Randomized Controlled Trial Evaluating Whether Pre-operative Trinase Reduces Post-operative Pain in Patients With Symptomatic Irreversible Pulpitis Compared to Placebo, Using VAS Scores and Analgesic Intake Over 48 Hours. Trinase, placebo capsule - Symptomatic Irreversible Pulpitis (SIP), Postoperative Pain After Endodontic Treatment | Not applicable | Completed | Fayoum University | 400 | 2025-08-01 | 2026-09-30 |
| Postoperative Pain and Incidence of Extrusion Following the Use of Two Intra-canal Medications in Retreatment of Single Rooted Teeth Bio-c Temp, Metapex - Endodontic Disease | Phase 2 | Not yet recruiting | Minia University | 30 | 2025-04-01 | 2025-04-06 |
| Postural and Muscle Fatigue Analysis of Endodontic Residents Musculoskeletal System Disease, Position Sense Disorders | Completed | Universidad Europea de Madrid | 10 | 2025-03-25 | 2026-04-29 | |
| Exploration of the Utility of Dental-dedicated MRI for Dentistry dental-dedicated MRI (ddMRI) - Dental Crowding, Dental Occlusion, Traumatic | Recruiting | University of Minnesota | 500 | 2025-03-17 | 2026-08-25 | |
| Post Operative Sensitivity of MTA Obturation MTA - Dental Pulp Disease, Endodontically Treated Teeth | Completed | TC Erciyes University | 54 | 2025-01-30 | 2026-01-02 | |
| Controlling Gag Reflex During Endodontic Diagnostic Radiography Periapical radiograph will be taken without VR, Periapical radiograph will be taken with VR - Gagging, Satisfaction, Patient | Not applicable | Completed | Qassim University | 30 | 2024-09-01 | 2026-01-16 |
| Effect of Photobiomodulation on Pain and Healing of the Vertical Releasing Incision After Endodontic Microsurgery PBM treatment, PBM sham treatment, EMS - Apical Periodontitis, Endodontically Treated Teeth | Not applicable | Recruiting | The University of Texas Health Science Center, Houston | 90 | 2024-08-20 | 2026-08-17 |
| Anti-bacterial Potential of Nano Calcium Hydroxide as an Intracanal Medication Calcium hydroxide, nano calcium hydroxide - Endodontic Disease, Pulp Disease, Dental | Phase 2 / Phase 3 | Unknown | British University In Egypt | 54 | 2024-08-01 | 2024-08-19 |
| Effect of Photobiomodulation to Reduce Post-operative Pain After Endodontic Surgery Ibuprofen, Photobiomodulation simulation, Photobiomodulation - Photobiomodulation, Endodontic Disease | Not applicable | Completed | University of Nove de Julho | 34 | 2024-06-30 | 2026-07-29 |
| the Efficacy of Ginger Powder as an Analgesic for Intraoperative and Post- Endodontic Pain Management Ginger powder capsule, Placebo - Endodontic Disease | Phase 3 | Unknown | Cairo University | 50 | 2024-06-15 | 2024-06-03 |
| Irrigation Activating Techniques on Irrigant Penetration Depth and Microbial Reduction Group1: A matching gutta-percha master cones will be used in up and down motion 2mm amplitude at a frequency of 100 strokes during approximately 1 min in each prepared canal., Group2: XP-endo Finisher activation: The XP-endo Finisher instrument will be used in continuous rotation for 1 mintute, Group 3:EasyClean system activation : EC instrument coupled to the countrangle handpiece and operated with a micromotor at approximately 20,000 rotations per minute in continuous rotation. - Irrigation Activation, Endodontic Disease | Not applicable | Recruiting | Tanta University | 30 | 2024-06-01 | 2024-10-28 |
| Role of GTR on Healing Outcome & Quality of Life in Combined Endo Perio Lesions With Communication Endodontic Micro-Surgery - Periapical Diseases, Endodontic Disease | Not applicable | Recruiting | Postgraduate Institute of Dental Sciences Rohtak | 30 | 2024-05-23 | 2025-01-08 |
| Effect of Different Modalities of Cryotherapy on Post-Operative Pain in Patients With Symptomatic Irreversible Pulpitis Saline - Endodontic Disease, Endodontically Treated Teeth | Not applicable | Completed | October 6 University | 45 | 2024-04-01 | 2025-11-19 |
| Postoperative Pain in Endodontic Therapy EDDY Group, PUI Group - Endodontic Disease, Postoperative Pain | Not applicable | Completed | Ordu University | 57 | 2024-02-12 | 2024-12-19 |
| Antimicrobial Efficacy of Nano-Based ICM on E.F antimicrobial efficacy of nano based intracanal medications on Enterococcus faecalis count reduction in secondary endodontic infection cases. - Enterococcus Faecalis Infection, Endodontically Treated Teeth | Not applicable | Unknown | Tanta University | 30 | 2024-01-02 | 2024-08-01 |
| Effect of Different Irrigation Solutions on Postoperative Pain and Lesion Healing Using ethylenediaminetetraacetic acid (EDTA), citric acid ((MONO/ANH) and etidronic acid (HEBP) to clean root canals during regenerative endodontic treatments - Endodontic Disease | Phase 4 | Unknown | TC Erciyes University | 39 | 2024-01-01 | 2024-04-26 |
| Microbial Load After Apical Enlargement in Asymptomatic Teeth With Periapical Lesion apical shaping size - Root Canal Infection, Periapical Diseases | Unknown | Istanbul Medipol University Hospital | 24 | 2023-12-01 | 2023-09-13 |
Showing 20 of 57. Sign in to see all of them.
Dental Pulp Diseases (57) · Pain, Postoperative (9) · Tooth, Nonvital (6) · Periapical Diseases (5) · Periapical Periodontitis (5) · Pulpitis (5) · Periodontitis (3) · Pain (2) · Periodontal Diseases (2) · Alveolar Bone Loss (1) · Anxiety Disorders (1) · Behavior (1) · Bites and Stings (1) · Crowding (1) · Dental Occlusion, Traumatic (1)
Stomatognathic Diseases (56) · Tooth Diseases (56) · Pathological Conditions, Signs and Symptoms (12) · Signs and Symptoms (12) · Mouth Diseases (11) · Neurologic Manifestations (11) · Pathologic Processes (11) · Pain (9) · Periodontal Diseases (9) · Postoperative Complications (9) · Jaw Diseases (8) · Periodontitis (5) · Periapical Diseases (3) · Behavior (2) · Musculoskeletal Diseases (2)
Calcium Hydroxide (4) · Edetic Acid (2) · Root Canal Preparation (2) · Sodium Hypochlorite (2) · Acetylcysteine (1) · Anesthetics, Local (1) · Blood Coagulation (1) · Bone Substitutes (1) · Chlorhexidine (1) · Citric Acid (1) · Device Removal (1) · Diclofenac (1) · Etidronic Acid (1) · Ferrosoferric Oxide (1) · Ibuprofen (1)
British University In Egypt (3) · TC Erciyes University (3) · Cairo University (2) · Istanbul Medipol University Hospital (2) · King's College London (2) · Minia University (2) · October 6 University (2) · Qassim University (2) · Tanta University (2) · University Hospital, Brest (2) · University of Bologna (2) · University of Minnesota (2) · University of North Carolina, Chapel Hill (2) · University of Pennsylvania (2) · Alexandria University (1)
Egypt (13) · Turkey (Türkiye) (9) · United States (8) · Spain (3) · France (2) · Saudi Arabia (2) · United Kingdom (2) · Austria (1) · Brazil (1) · Colombia (1) · India (1) · Jordan (1) · Mexico (1) · Pakistan (1) · Singapore (1)
Shehab Eldin M Saber, doctoral (2) · Abeer Darrag, Phd (1) · Aladdin A Al-Qudah, PhD (1) · Ali Mahmoud Farag, Phd (1) · Asma Khan, DDS (1) · Avina Paranjpe (1) · Bekir Karabucak, DMD, MS. (1) · Dalia Abd Elhameed Sherif, Phd (1) · David C Han, DDS, MS (1) · Dina Ali, phd (1) · Flavia Teles, DDS,MS,DMSc (1)
PMID 15676903, PMID 19659711, PMID 23880259, PMID 24283200, PMID 24565651, PMID 25443280, PMID 28110920, PMID 28508244, PMID 32249441, PMID 32266988, PMID 33555456, PMID 33934366, PMID 34352304, PMID 39815035, PMID 40958962, PMID 41218940, PMID 42098797, PMID 42448657
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