18 completed, 8 unknown, 5 recruiting, 1 not yet recruiting. 33 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 33 | Completed 18, Unknown 8, Recruiting 5, Not yet recruiting 1, Terminated 1 |
Follow Endodontic Disease: new trials by email Literature Review of Endodontic Disease trials Research Report on Endodontic Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Postoperative Pain After OCT or EDTA Irrigation in Regenerative Endodontic Treatment Regenerative Endodontic Treatment Using Different Irrigation Solutions - Apical Periodontitis, Endodontic Disease | Not applicable | Completed | TC Erciyes University | 40 | 2026-04-10 | 2026-10-23 |
| A Randomized Controlled Trial Evaluating Whether Pre-operative Trinase Reduces Post-operative Pain in Patients With Symptomatic Irreversible Pulpitis Compared to Placebo, Using VAS Scores and Analgesic Intake Over 48 Hours. Trinase, placebo capsule - Symptomatic Irreversible Pulpitis (SIP), Postoperative Pain After Endodontic Treatment | Not applicable | Completed | Fayoum University | 400 | 2025-08-01 | 2026-09-30 |
| Controlling Gag Reflex During Endodontic Diagnostic Radiography Periapical radiograph will be taken without VR, Periapical radiograph will be taken with VR - Gagging, Satisfaction, Patient | Not applicable | Completed | Qassim University | 30 | 2024-09-01 | 2026-01-16 |
| Effect of Photobiomodulation on Pain and Healing of the Vertical Releasing Incision After Endodontic Microsurgery PBM treatment, PBM sham treatment, EMS - Apical Periodontitis, Endodontically Treated Teeth | Not applicable | Recruiting | The University of Texas Health Science Center, Houston | 90 | 2024-08-20 | 2026-08-17 |
| Effect of Photobiomodulation to Reduce Post-operative Pain After Endodontic Surgery Ibuprofen, Photobiomodulation simulation, Photobiomodulation - Photobiomodulation, Endodontic Disease | Not applicable | Completed | University of Nove de Julho | 34 | 2024-06-30 | 2026-07-29 |
| Irrigation Activating Techniques on Irrigant Penetration Depth and Microbial Reduction Group1: A matching gutta-percha master cones will be used in up and down motion 2mm amplitude at a frequency of 100 strokes during approximately 1 min in each prepared canal., Group2: XP-endo Finisher activation: The XP-endo Finisher instrument will be used in continuous rotation for 1 mintute, Group 3:EasyClean system activation : EC instrument coupled to the countrangle handpiece and operated with a micromotor at approximately 20,000 rotations per minute in continuous rotation. - Irrigation Activation, Endodontic Disease | Not applicable | Recruiting | Tanta University | 30 | 2024-06-01 | 2024-10-28 |
| Role of GTR on Healing Outcome & Quality of Life in Combined Endo Perio Lesions With Communication Endodontic Micro-Surgery - Periapical Diseases, Endodontic Disease | Not applicable | Recruiting | Postgraduate Institute of Dental Sciences Rohtak | 30 | 2024-05-23 | 2025-01-08 |
| Effect of Different Modalities of Cryotherapy on Post-Operative Pain in Patients With Symptomatic Irreversible Pulpitis Saline - Endodontic Disease, Endodontically Treated Teeth | Not applicable | Completed | October 6 University | 45 | 2024-04-01 | 2025-11-19 |
| Postoperative Pain in Endodontic Therapy EDDY Group, PUI Group - Endodontic Disease, Postoperative Pain | Not applicable | Completed | Ordu University | 57 | 2024-02-12 | 2024-12-19 |
| Antimicrobial Efficacy of Nano-Based ICM on E.F antimicrobial efficacy of nano based intracanal medications on Enterococcus faecalis count reduction in secondary endodontic infection cases. - Enterococcus Faecalis Infection, Endodontically Treated Teeth | Not applicable | Unknown | Tanta University | 30 | 2024-01-02 | 2024-08-01 |
| Erbium, Chromium: Yttrium, Scandium, Gallium, Garnet (Er,Cr:YSGG) Laser in Root Canal Disinfection Waterlase Express™, BIOLASE®, Sodium Hypochlorite - Endodontic Disease, Root Canal Infection | Not applicable | Terminated | University of Pennsylvania | 56 | 2023-10-11 | 2025-10-09 |
| Treatment Outcome of Ortho MTA (BioMTA®) Cement vs AH Plus® Bioceramic Sealer (Dentsply). Ortho MTA cement, GP and AH Plus sealer - Endodontic Disease | Not applicable | Unknown | National University Hospital, Singapore | 70 | 2023-09-21 | 2024-08-28 |
| Endo-perio Disease - Treatment Outcomes Using Conventional and Hydraulic Calcium Silicate Sealer With or Without LPRF Experimental: RCT using hydraulic calcium silicate sealer and L-PRF + GTR, Experimental: RCT using conventional sealer and L-PRF + GTR, Experimental: RCT using hydraulic calcium silicate sealer and GTR - Endodontic Disease, Periodontitis | Not applicable | Not yet recruiting | King's College London | 115 | 2023-05-01 | 2023-01-12 |
| Evaluation of Postoperative Pain After Single Visit Retreatment of Symptomatic and Asymptomatic Teeth Endodontic Retreatment - Post-operative Pain, Retreatment | Not applicable | Completed | Saglik Bilimleri Universitesi | 80 | 2023-01-26 | 2024-04-17 |
| Comparison of Clinical Outcomes Between GentleWave® and Biolase® Irrisafe ip, GentleWave System, Waterlase iPlus - Endodontic Disease, Periapical Diseases | Not applicable | Completed | University of North Carolina, Chapel Hill | 120 | 2022-11-08 | 2026-08-19 |
| The 3-Dimensional Printed Guide in Endodontic Microsurgery 3-D printed Guide, Conventional Endodontic Micro-Surgery - Endodontic Disease, Endodontic Re-treatment Failure | Not applicable | Completed | Damascus University | 26 | 2022-04-15 | 2023-09-29 |
| Evaluation of Different Scaffolds in Regenerative Endodontic Treatment Injectable platelet-rich fibrin (i-PRF) scaffold, platelet-rich fibrin (PRF)scaffold, blood clot (BC) scaffold - Endodontic Disease, Regenerative Endodontics | Not applicable | Completed | British University In Egypt | 30 | 2021-09-01 | 2025-04-27 |
| Accuracy of Pulp Sensibility Test on Teeth With Deep Periodontal Pocket Orthopantomogram X-ray view, Endo-Ice, Electric Pulp Tester (EPT) - Periodontitis, Localized Aggressive, Periodontal Diseases | Not applicable | Unknown | Qassim University | 30 | 2020-02-25 | 2021-04-09 |
| Evaluation of Antimicrobial Efficacy and Postoperative Pain After Using Silver Nanoparticles and Chitosan Nanoparticles Against Enterococcus Faecalis and Candida Albicans Biofilm Silver Nanoparticles Irrigant, Chitosan Nanoparticles Irrigant - Endodontic Disease | Not applicable | Completed | Minia University | 78 | 2020-01-01 | 2023-12-15 |
| Guided Versus Conventional Periapical Endodontic Surgery 3D guide, Mock guide - Endodontic Disease, Endodontic Re-treatment Failure | Not applicable | Unknown | Cairo University | 26 | 2019-12-01 | 2019-10-22 |
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Dental Pulp Diseases (33) · Pain, Postoperative (6) · Tooth, Nonvital (5) · Periapical Diseases (3) · Periapical Periodontitis (3) · Pulpitis (3) · Periodontitis (2) · Alveolar Bone Loss (1) · Anxiety Disorders (1) · Bites and Stings (1) · Gagging (1) · Inflammation (1) · Pain (1) · Patient Satisfaction (1) · Periapical Granuloma (1)
Stomatognathic Diseases (33) · Tooth Diseases (33) · Pathological Conditions, Signs and Symptoms (8) · Signs and Symptoms (8) · Neurologic Manifestations (7) · Pathologic Processes (7) · Mouth Diseases (6) · Pain (6) · Postoperative Complications (6) · Periodontal Diseases (5) · Jaw Diseases (4) · Periodontitis (3) · Musculoskeletal Diseases (2) · Behavior (1) · Bone Cysts (1)
Root Canal Preparation (2) · Blood Coagulation (1) · Bone Substitutes (1) · Ibuprofen (1) · Low-Level Light Therapy (1) · Root Canal Obturation (1) · Serum Bactericidal Test (1) · Sodium Chloride (1) · Sodium Hypochlorite (1) · Therapeutic Irrigation (1) · proliferation regulatory factors, human urine (1)
King's College London (2) · Qassim University (2) · Tanta University (2) · Alexandria University (1) · British University In Egypt (1) · Cairo University (1) · Damascus University (1) · Fayoum University (1) · Heba Elasfouri (1) · Institucion Universitaria Colegios de Colombia (1) · Juan Gonzalo Olivieri (1) · King Abdullah University Hospital (1) · Mahidol University (1) · Minia University (1) · National University Hospital, Singapore (1)
Egypt (9) · Turkey (Türkiye) (4) · United States (4) · Saudi Arabia (2) · Spain (2) · United Kingdom (2) · Colombia (1) · India (1) · Jordan (1) · Mexico (1) · Singapore (1) · Syria (1) · Thailand (1) · Uruguay (1)
Abeer Darrag, Phd (1) · Aladdin A Al-Qudah, PhD (1) · Ali Mahmoud Farag, Phd (1) · Bekir Karabucak, DMD, MS. (1) · Dalia Abd Elhameed Sherif, Phd (1) · Dina Ali, phd (1) · Flavia Teles, DDS,MS,DMSc (1) · Francesco Mannocci, PhD (1) · Glenn Karunanayake, BDS, MS (1) · Huseyin Gurkan Gunec, Asst Prof (1) · Javier Caviedes-Bucheli (1) · Juliana Barros, DDS,MS (1) · Kareman Ahmed Ebrahim Eshra, Phd (1) · Radwa Abd Elmotaleb Eissa, phd (1)
PMID 23880259, PMID 24565651, PMID 25443280, PMID 28110920, PMID 28508244, PMID 32249441, PMID 32266988, PMID 33555456, PMID 33934366, PMID 34352304, PMID 40958962, PMID 41218940, PMID 42448657
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