11 completed, 3 unknown, 1 active not recruiting, 1 not yet recruiting. 18 Phase 1, 7 Phase 2.
Follow Dystonia: new trials by email Literature Review of Dystonia trials Research Report on Dystonia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus) Glycerol Tributyrate - MELAS Syndrome, Lebers Hereditory Optic Neuropathy With Extra Ocular Symptoms (LHON-Plus) | Phase 1 / Phase 2 | Not yet recruiting | George Washington University | 24 | 2027-03-01 | 2026-10-05 |
| Pharmacogenomic Contributions to Trihexyphenidyl Biotransformation and Response in Children With Dystonic Cerebral Palsy Trihexyphenidyl - Pediatric Disorder, Genetic Predisposition | Phase 1 | Recruiting | Children's Mercy Hospital Kansas City | 40 | 2024-10-15 | 2026-06-24 |
| Single and Multiple Ascending Dose Study of MTR-601 in Healthy Individuals MTR-601 - Muscle Spasticity, Hypertonia, Muscle | Phase 1 | Completed | Motric Bio | 89 | 2023-09-11 | 2026-06-05 |
| Clinical Trial to Compare the Safety and Efficacy of Botulax® Versus Botox® in Patients With Cervical Dystonia Botulinum toxin type A injection, Botulinum Toxin Type A Injection [Botox] - Cervical Dystonia | Phase 1 | Completed | Hugel | 38 | 2020-05-26 | 2022-04-22 |
| Deep Brain Stimulation Surgery for Focal Hand Dystonia DBS surgery, Medtronic Activa Rechargeable System - Dystonia, Focal Dystonia | Phase 1 / Phase 2 | Active not recruiting | National Institute of Neurological Disorders and Stroke (NINDS) | 5 | 2018-01-17 | 2026-11-12 |
| Safety and Tolerability of Perampanel in Cervical Dystonia Perampanel - Cervical Dystonia | Phase 1 / Phase 2 | Completed | University Health Network, Toronto | 25 | 2017-09-01 | 2020-04-07 |
| ASIS for Botox in Cervical Dystonia Gadolinium, Efficacy of Botox intramuscularly at Week 6, Efficacy of Botox intramuscularly at Week 12 - Cervical Dystonia Adults ,, Abnormal Head Position and Neck Pain for These 7 Muscle Groups: Splenius,Scalene,Sterno-cleido-mastoid,Levator Scapulae,Semispinalis,Trapezius,and Longissimus. | Phase 1 / Phase 2 | Unknown | li nguyen | 60 | 2016-01-01 | 2015-06-24 |
| Multi-Target Pallidal and Thalamic Deep Brain Stimulation for Hemi-Dystonia Deep Brain Stimulation - Dystonia, Dystonia, Secondary | Phase 1 | Unknown | University of British Columbia | 4 | 2015-01-01 | 2020-11-02 |
| Pilot Trial of Botulinum Toxin and Occupational Therapy for Writer's Cramp BoNT Injections, Occupational Therapy - Dystonia | Phase 1 / Phase 2 | Completed | National Institute of Neurological Disorders and Stroke (NINDS) | 13 | 2013-12-03 | 2018-03-20 |
| Magnetic Resonance (MR) Guided Functional Ultrasound-Neurosurgery for Movement Disorders Non-invasive intervention with focused ultrasound (ExAblate 4000) - Essential Tremor, Dystonia | Phase 1 | Completed | University Children's Hospital, Zurich | 10 | 2012-11-01 | 2014-10-09 |
| Ampicillin for DYT-1 Dystonia Motor Symptoms Ampicillin, Sugar pill - DYT-1, Dystonia | Phase 1 | Completed | University of Florida | 2 | 2011-09-01 | 2017-07-05 |
| A Study of Acetyl Hexapeptide-8 (AH8) in Treatment of Blepharospasm Acetyl-Hexapeptide Topical Treatment, placebo - Focal Dystonia | Phase 1 / Phase 2 | Completed | National Institute of Neurological Disorders and Stroke (NINDS) | 24 | 2009-07-01 | 2012-09-06 |
| Botulinum Toxin Injection Efficiency Resistance training - Torticollis, Muscle Spasticity | Phase 1 | Unknown | Jyväskylä Central Hospital | 22 | 2008-09-01 | 2009-12-31 |
| PurTox (Botulinum Toxin Type A) for the Treatment of Adult Onset Spasmodic Torticollis/Cervical Dystonia Mentor Purified Toxin, Botulinum Toxn Type A, Purified Neurotoxin, Physiologic saline - Spasmodic Torticollis | Phase 1 | Completed | Mentor Worldwide, LLC | 70 | 2006-05-01 | 2016-03-29 |
| Deep Brain Stimulation to Treat Cervical Dystonia Electrodes - Cervical Dystonia | Phase 1 | Completed | National Institute of Neurological Disorders and Stroke (NINDS) | 40 | 2005-08-01 | 2006-07-06 |
| Comparative Trial of Botox in the Management of Children With Congenital Muscular Torticollis Botox - Torticollis | Phase 1 | Withdrawn | University of British Columbia | 2004-08-01 | 2015-05-06 | |
| Botulinum Toxin Type A (Botox) for the Treatment of Cervical Dystonia and Upper Thoracic Muscular Pain Botulinum Toxin Type A - Refractory Cervicothoracic Myofascial Pain Syndrome (CMPS), Cervical Dystonia | Phase 1 / Phase 2 | Completed | Vanderbilt University | 20 | 2004-03-01 | 2016-06-01 |
| Study of Air Stream in Voice Production airway interruption test - Spastic Dysphonia, Healthy | Phase 1 | Completed | National Institute of Neurological Disorders and Stroke (NINDS) | 30 | 2001-05-01 | 2008-03-04 |
Torticollis (8) · Dystonic Disorders (5) · Cerebral Palsy (2) · Muscle Spasticity (2) · Acidosis, Lactic (1) · Anxiety Disorders (1) · Blepharospasm (1) · Cognition Disorders (1) · Congenital torticollis (1) · Dysphonia (1) · Dystonia, Focal, Task-Specific (1) · Essential Tremor (1) · Genetic Predisposition to Disease (1) · Hearing Loss (1)
Dyskinesias (18) · Neurologic Manifestations (18) · Pathological Conditions, Signs and Symptoms (18) · Signs and Symptoms (18) · Nervous System Diseases (11) · Central Nervous System Diseases (8) · Movement Disorders (5) · Brain Diseases (4) · Musculoskeletal Diseases (3) · Neuromuscular Diseases (3) · Brain Damage, Chronic (2) · Cardiovascular Diseases (2) · Cerebrovascular Disorders (2) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2)
Botulinum Toxins, Type A (4) · Ampicillin (1) · Deep Brain Stimulation (1) · Electrodes (1) · Gadolinium (1) · Gadolinium DTPA (1) · Occupational Therapy (1) · Resistance Training (1) · Sugars (1) · Trihexyphenidyl (1) · perampanel (1)
National Institute of Neurological Disorders and Stroke (NINDS) (5) · University of British Columbia (2) · Children's Mercy Hospital Kansas City (1) · George Washington University (1) · Hugel (1) · Jyväskylä Central Hospital (1) · Mentor Worldwide, LLC (1) · Motric Bio (1) · University Children's Hospital, Zurich (1) · University Health Network, Toronto (1) · University of Florida (1) · Vanderbilt University (1) · li nguyen (1)
United States (13) · Canada (3) · Finland (1) · South Korea (1) · Switzerland (1)
Alan Hand, MD (1) · Anne Chiaramello, Ph.D. (1) · Carolyn Austin (1) · Chris Honey, MD,DPhil,FRCSC (1) · Debra J Ehrlich, M.D. (1) · Debra Regier, M.D., Ph.D. (1) · Irene Malaty, M.D. (1) · Jari Ylinen, MD, PhD (1) · Mark Hallett, M.D. (1) · Rose Gelineau-Morel, MD (1) · Stephen Tredwell, MD (1) · Susan H Fox, MRCP(UK), PhD (1) · Thomas L Davis, MD (1)
UH3TR003897 (1)