137 completed, 19 recruiting, 19 unknown, 8 terminated. 199 Phase 1, 64 Phase 2.
Follow Dyssomnias: new trials by email Literature Review of Dyssomnias trials Research Report on Dyssomnias
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Clinical Trial of Iron Supplementation for Youth With ADHD and Restless Sleep Ferrous Sulfate, Placebo - ADHD, Sleep Problems | Phase 1 / Phase 2 | Not yet recruiting | Hugo W. Moser Research Institute at Kennedy Krieger, Inc. | 70 | 2027-03-01 | 2026-05-04 |
| A Trial of ALN-6457 in Adult Participants With Symptomatic Prion Disease (PrD) ALN-6457 - Prion Disease | Phase 1 / Phase 2 | Not yet recruiting | Regeneron Pharmaceuticals | 60 | 2026-10-23 | 2026-09-22 |
| Combination Upper-Airway Electrical and Pharmacological Stimulation for Obstructive Sleep Apnea Combination device and drug: Unilateral hypoglossal nerve stimulation & atomoxetine-plus-oxybutynin (HGNS+AtoOxy), Unilateral hypoglossal nerve stimulation (HGNS), active comparator condition, Atomoxetine-plus-oxybutynin (80/5 mg) (AtoOxy), active comparator condition - Obstructive Sleep Apnea, Sleep-disordered Breathing | Phase 1 / Phase 2 | Recruiting | Brigham and Women's Hospital | 24 | 2026-09-01 | 2026-09-21 |
| The Optimal One-Month Dosing of Lemborexant for Moderate Obstructive Sleep Apnea (OSA) Patients With Low Arousal Threshold Lemborexant 5 MG [Dayvigo] Period 1, Placebo Period 1, Lemborexant 5 MG [Dayvigo] Period 2 - OSA - Obstructive Sleep Apnea | Phase 1 / Phase 2 | Not yet recruiting | Chulalongkorn University | 36 | 2026-09-01 | 2026-07-06 |
| Study of Single Doses of HBS-104 in Acutely Sleep-deprived Healthy Participants HBS-104, Placebo - Sleep Deprivation | Phase 1 | Recruiting | Harmony Biosciences Management, Inc. | 12 | 2026-08-28 | 2026-09-30 |
| PrP-targeting siRNA Safety & Mechanism Study PrP-siRNA - Prion Disease | Phase 1 | Recruiting | Broad Institute of MIT and Harvard | 45 | 2026-05-15 | 2026-10-16 |
| Mindfulness Meditation for Insomnia Instructed bedtime app-guided mindfulness meditation, Uninstructed app-guided mindfulness meditation, Sleep hygiene education - Sleep Initiation and Maintenance Disorders, Insomnia | Phase 1 / Phase 2 | Recruiting | Brigham and Women's Hospital | 30 | 2026-03-31 | 2026-06-23 |
| Novel Calcium Channel Modulators in RLS and Variants: Efficacy & Safety Crisugabalin - Restless Leg Syndrome (RLS), Variant Restless Legs Syndrome | Phase 1 | Recruiting | Beijing Friendship Hospital | 20 | 2026-03-10 | 2026-03-06 |
| Reliability of Standardized IQ Testing Under Modafinil, Racetam-Class Compounds, Sleep Restriction and Daily Activity Modafinil, Oxiracetam, Pramiracetam - Healthy, Cognition | Phase 1 | Completed | Abdulraheem Mohamed Gouda | 70 | 2026-03-09 | 2026-10-01 |
| Morning-Evening Specific Longevity Food Supplement Morning- and evening-specific compound food supplement, Control - Aging | Phase 1 | Active not recruiting | University of Primorska | 60 | 2026-03-07 | 2026-03-11 |
| Low-Tech Treatments for Obstructive Sleep Apnea High-Resistance Breathing and Drinking Exercises, Low-Resistance Breathing and Drinking Exercises - Obstructive Sleep Apnea (OSA), Traumatic Brain Injury (TBI) | Phase 1 / Phase 2 | Recruiting | Uniformed Services University of the Health Sciences | 60 | 2026-01-29 | 2026-09-10 |
| Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia PROSOMNIA Sleep Therapy™ (PSTx), Anesthesia-Induced Sleep Therapy, Diprivan (propofol), Astra-Zeneca - Chronic Insomnia, Sleep Deprivation | Phase 1 | Not yet recruiting | Nyree Penn | 100 | 2025-11-01 | 2025-05-28 |
| DRonabinol Treatment of OSA Dronabinol - Obstructive Sleep Apnea | Phase 1 / Phase 2 | Recruiting | VA Office of Research and Development | 120 | 2025-08-25 | 2026-11-05 |
| A Study of ORX142 in Healthy Adult Subjects, Including Subjects 18 to 80 Years of Age ORX142 Tablets, Placebo Tablets - Excessive Daytime Sleepiness | Phase 1 | Recruiting | Centessa Pharmaceuticals (UK) Limited | 208 | 2025-06-30 | 2025-12-24 |
| A Trial to Test the Safety and Tolerability of Lu AH69593 in Adults That Are Healthy or Have Narcolepsy Lu AH69593, Placebo - Narcolepsy | Phase 1 | Recruiting | H. Lundbeck A/S | 104 | 2025-06-13 | 2026-08-12 |
| A Study of HBS-201 (Pitolisant Delayed-release) HBS-201 - Narcolepsy | Phase 1 | Completed | Harmony Biosciences Management, Inc. | 46 | 2025-05-21 | 2025-12-12 |
| Impact of Nutritional Supplementation on Sleep Quality Sleep Supplements, Placebo - Sleep, Sleep Quality | Phase 1 | Completed | Pharmavite LLC | 376 | 2025-05-15 | 2026-02-27 |
| A Study to Investigate Efficacy, Safety, Tolerability, and Pharmacokinetics of JZP441 Compared With Placebo in Participants With Narcolepsy Type 1 JZP441, Matching Placebo - Narcolepsy | Phase 1 | Terminated | Jazz Pharmaceuticals | 6 | 2025-05-13 | 2026-04-06 |
| Impact of Exogenous Ketones on Sleep Apnea Ketone-IQ, Placebo - Obstructive Sleep Apnea, Sleep | Phase 1 / Phase 2 | Withdrawn | Johns Hopkins University | 2025-01-29 | 2026-09-21 | |
| Impact of Exogenous Ketones on Sleep Disruption in Vulnerable Populations Ketone-IQ (1,3 Butanediol) - Obstructive Sleep Apnea, Sleep | Phase 1 | Suspended | Johns Hopkins University | 30 | 2025-01-29 | 2026-06-23 |
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Sleep Initiation and Maintenance Disorders (79) · Sleep Apnea, Obstructive (57) · Sleep Apnea Syndromes (27) · Narcolepsy (16) · Restless Legs Syndrome (14) · Sleep Deprivation (11) · Disorders of Excessive Somnolence (9) · Depression (7) · Sleep Wake Disorders (7) · Anxiety Disorders (6) · Apnea (6) · Parasomnias (6) · Sleep Disorders, Circadian Rhythm (6) · Pulmonary Disease, Chronic Obstructive (4) · Attention Deficit Disorder with Hyperactivity (3)
Nervous System Diseases (198) · Sleep Wake Disorders (192) · Sleep Disorders, Intrinsic (187) · Mental Disorders (129) · Respiratory Tract Diseases (75) · Respiration Disorders (73) · Apnea (67) · Sleep Apnea Syndromes (46) · Pathological Conditions, Signs and Symptoms (39) · Signs and Symptoms (32) · Neurologic Manifestations (20) · Disorders of Excessive Somnolence (15) · Behavior (14) · Parasomnias (14)
Zolpidem (10) · Modafinil (7) · lemborexant (7) · suvorexant (6) · Atomoxetine Hydrochloride (5) · N-((1-((5-(4-fluorophenyl)-2-methyl-4-thiazolyl)carbonyl)-2-piperidinyl)methyl)-4-benzofurancarboxamide (5) · Acetazolamide (4) · Eszopiclone (4) · TAK-925 (4) · zopiclone (4) · 1-(((alpha-isobutanoyloxyethoxy)carbonyl)aminomethyl)-1-cyclohexaneacetic acid (3) · Melatonin (3) · Mirtazapine (3) · Oxygen (3) · Trazodone (3)
Brigham and Women's Hospital (16) · Merck Sharp & Dohme LLC (12) · Eisai Inc. (8) · GlaxoSmithKline (8) · Shanghai Haiyan Pharmaceutical Technology Co., Ltd. (6) · Eli Lilly and Company (4) · VA Office of Research and Development (4) · XenoPort, Inc. (4) · Johns Hopkins University (3) · Takeda (3) · Chulalongkorn University (2) · Harmony Biosciences Management, Inc. (2) · Idorsia Pharmaceuticals Ltd. (2) · Janssen Research & Development, LLC (2) · Mayo Clinic (2)
United States (113) · China (15) · Canada (10) · United Kingdom (10) · Germany (7) · Netherlands (7) · Australia (5) · Japan (5) · Belgium (4) · France (4) · Israel (4) · Finland (3) · Italy (2) · Spain (2) · Thailand (2)
Scott A Sands, PhD (3) · Gavin West, M.D. (2) · Jonathan Jun, MD (2) · Sarocha Vivatvakin, MD (2) · Alexandra Evancho, DPT (1) · Alison E Pritchard, PhD (1) · Amanda Jane J Lloyd, PhD, BSc (1) · Amy M Sawyer, PhD (1) · Andrew Krystal, M.D. (1)
PMID 40848323, PMID 18056558, PMID 19581560, PMID 21632834, PMID 21856678, PMID 21966064, PMID 22131599, PMID 22237311, PMID 22302299, PMID 22549286, PMID 22572632, PMID 22893765, PMID 24122944, PMID 24290737, PMID 24587571, PMID 24815497, PMID 25467190, PMID 25661282, PMID 25805361, PMID 26194728, PMID 26240742, PMID 27092703, PMID 29246264, PMID 30395486, PMID 31419329, PMID 31642731, PMID 32215834, PMID 32511726, PMID 32807158, PMID 33057694, PMID 33146953, PMID 33305817, PMID 33491327, PMID 34918637, PMID 35306405, PMID 35748777, PMID 35947827, PMID 36805833, PMID 36883238, PMID 37193566, PMID 37209427, PMID 37256193, PMID 37535419, PMID 37612115, PMID 37677076, PMID 38286618, PMID 38346816, PMID 39069967, PMID 39266012, PMID 39502777
2018 (2), 2005 (1), I01CX002632 (1), K23AT012475 (1), OT2NS138339 (1), P30DK072476 (1), R00NR011173 (1), R01HL065176 (1), R01LM012836 (1), R01NR004340 (1), R03MH062327 (1), R21NR009080 (1), R21NR010539 (1), R34MH070805 (1), R43NR010688 (1)