41 completed, 8 recruiting, 7 unknown, 5 terminated. 33 Not applicable, 9 Phase 2, 4 Phase 1, 4 Phase 4, 3 Phase 3.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Distinguishing Tics and Functional Tics Using Clinical Neurophysiological Techniques Tics, Functional Tics | Recruiting | National Institute of Neurological Disorders and Stroke (NINDS) | 75 | 2026-10-26 | 2026-10-21 | |
| Teen and Adult Tic TMS Study cTBS (accelerated continuous theta burst stimulation) - Tic Disorder | Not applicable | Recruiting | University of California, San Francisco | 40 | 2026-06-01 | 2026-09-24 |
| The Incidence of Early Trauma Induced Coagulopathy and Hyperfibrinolysis in Severely Injured Trauma Patients in the Emergency Room: a Retrospective Cohort Study Early Trauma Induced Coagulopathy, Tic | Completed | Medical University of Graz | 263 | 2025-05-25 | 2026-01-28 | |
| Cognitive-psychophysiological Treatment for Tics in Young People With Tourette's Syndrome With or Without Biofeedback Cognitive psychophysiological, Cognitive psychophysiological and Biofeedback - Tourette Syndrome, Tics | Not applicable | Recruiting | Université du Québec a Montréal | 150 | 2025-04-15 | 2025-07-08 |
| CBIT+TMS R33 Phase CBIT +cTBS, CBIT +sham cTBS - Tics, Tourette Syndrome | Phase 2 | Recruiting | University of Minnesota | 60 | 2025-02-27 | 2026-05-20 |
| Investigating Changes in Premonitory Urges During Habit Reversal Training for Tics Habit Reversal Training - Tics, Tourette Disorder | Not applicable | Recruiting | University of Utah | 6 | 2025-02-11 | 2025-05-28 |
| Multitarget Stereotactic Electrophysiological Recording and Stimulation for Tourette Syndrome New Target DBS, CM-DBS, Sham Stimulation - Tourette Syndrome, Deep Brain Stimulation | Not applicable | Recruiting | Beijing Tiantan Hospital | 5 | 2024-10-01 | 2025-05-22 |
| Clinical Characteristics and Temporal Properties of Individual Tics in Persistent Tic Disorder Habit Reversal Training (HRT) - Tics, Tic Disorders | Not applicable | Unknown | University of Utah | 12 | 2024-04-04 | 2024-04-26 |
| Evaluation of an Online Comprehensive Behavioral Intervention for Tics (CBIT) Therapist Training Program Behavior Therapy Training Institute, CBIT-Trainer - Tics, Tic Disorders | Not applicable | Completed | University of Utah | 284 | 2023-06-27 | 2026-10-05 |
| Forehead Temperature-Regulating Therapy for Insomnia in Adults With Tourette's Disorder Forehead Temperature-Regulating Therapy - Tourette's Disorder, Insomnia | Not applicable | Recruiting | University of California, Los Angeles | 25 | 2023-04-27 | 2025-03-17 |
| Tourette Discrimination (TD) Stigma Scale Tourette Syndrome, Tourette Syndrome in Children | Completed | Wake Forest University Health Sciences | 43 | 2023-03-04 | 2025-09-10 | |
| Investigating Distress Tolerance in Adults With Tourette Syndrome Distress Tolerance Skills Training - Tourette Syndrome, Tic Disorders | Not applicable | Completed | Johns Hopkins University | 9 | 2022-06-02 | 2024-06-07 |
| Mobile App-assisted Behavioral Treatment in Children and Adolescents With Tics Mobile app-assisted behavioral treatment, Mobile app-assisted psychoeducation - Tic Disorders | Not applicable | Recruiting | Aarhus University Hospital | 60 | 2022-04-01 | 2025-02-21 |
| Open-label MNS for Tourette Syndrome Active, self-directed electrical stimulation of the median nerve - Tourette Syndrome, Tic Disorder, Chronic Motor or Vocal | Not applicable | Completed | Washington University School of Medicine | 31 | 2021-11-18 | 2023-10-05 |
| Online-Delivered Comprehensive Behavioral Intervention for Tics-Enhanced (CBIT-E) Comprehensive Behavioral Intervention for Tics - Enhanced (CBIT-E) - Persistent Tic Disorders, Tourette Disorder | Not applicable | Unknown | Marquette University | 30 | 2021-09-15 | 2021-10-08 |
| Neural Correlates of Sensory Phenomena in Tourette Syndrome Electroencephalogram (EEG) testing procedure, Autonomic function testing procedure - Tourette Syndrome, Sensory Disorders | Enrolling by invitation | Vanderbilt University Medical Center | 50 | 2021-07-20 | 2026-01-14 | |
| Median Nerve Stimulation Pilot Rhythmic median nerve stimulation, Arrhythmic median nerve stimulation - Tourette Syndrome, Tic Disorders | Not applicable | Completed | Washington University School of Medicine | 34 | 2021-07-15 | 2023-10-05 |
| Transcranial Magnetic Stimulation to Augment Behavior Therapy for Tics Comprehensive Behavioral Intervention for Tics (CBIT), Repetitive Transcranial Magnetic Stimulation (rTMS), Continuous Theta Burst Stimulation (cTBS) - Tic Disorders, Tics | Not applicable | Completed | University of Minnesota | 50 | 2020-11-01 | 2025-03-07 |
| The Effects of Breathing Exercises and Virtual Reality Applications During Pregnancy and Labor. Breathing Exercise, Virtual Reality - Labor Pain, Labor Onset | Not applicable | Completed | Semra Çevik, phD | 114 | 2020-10-15 | 2023-05-10 |
| Extinction Learning in Adults With Tourette Syndrome Habit Reversal Training - Tourette Syndrome, Habit Reversal Training | Not applicable | Completed | Johns Hopkins University | 10 | 2020-09-18 | 2023-10-23 |
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Tourette Syndrome (56) · Tic Disorders (26) · Obsessive-Compulsive Disorder (4) · Bronchiolitis Obliterans Syndrome (3) · Movement Disorders (3) · Basal Ganglia Diseases (2) · Brain Diseases (2) · Central Nervous System Diseases (2) · Mental Disorders (2) · Sensation Disorders (2) · Hemostatic Disorders (1) · Hypersensitivity (1) · Ketosis (1) · Kidney Calculi (1)
Dyskinesias (64) · Neurologic Manifestations (64) · Pathological Conditions, Signs and Symptoms (64) · Signs and Symptoms (64) · Nervous System Diseases (63) · Neurodevelopmental Disorders (59) · Mental Disorders (58) · Central Nervous System Diseases (57) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (56) · Genetic Diseases, Inborn (56) · Heredodegenerative Disorders, Nervous System (56) · Movement Disorders (56) · Neurodegenerative Diseases (56) · Basal Ganglia Diseases (54) · Brain Diseases (54)
Aripiprazole (2) · Transcranial Magnetic Stimulation (2) · Acamprosate (1) · Acetylcysteine (1) · Azithromycin (1) · Behavior Therapy (1) · Biofeedback, Psychology (1) · Breathing Exercises (1) · Clonidine (1) · Demography (1) · Dronabinol (1) · Electroencephalography (1) · Fatty Acids, Omega-3 (1) · Galantamine (1) · Guanfacine (1)
Johns Hopkins University (6) · National Institute of Neurological Disorders and Stroke (NINDS) (6) · University of Utah (5) · Yale University (5) · University of Cologne (3) · Karolinska Institutet (2) · Otsuka Pharmaceutical Development & Commercialization, Inc. (2) · University of California, Los Angeles (2) · University of Minnesota (2) · Vanderbilt University Medical Center (2) · Washington University School of Medicine (2) · Aarhus University Hospital (1) · Beijing Tiantan Hospital (1) · Children's Hospital Medical Center, Cincinnati (1) · Detroit Clinical Research Center (1)
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Michael H. Bloch, MD, MS (3) · Barbara J Coffey, MD, MS (2) · Emily J Ricketts, PhD (2) · Eva Kohegyi, MD (2) · Harvey S Singer, MD (2) · Joseph F McGuire, PhD (2) · Michael Himle, PhD (2) · Andreas Hartmann, MD (1) · Andrew M Lee (1) · Barry S Fogel, MD (1) · Christine Conelea (1) · Christine Conelea, PhD (1) · Christopher Lind, FRACS (1) · David Isaacs, MD, MPH (1)
PMID 15758742, PMID 20483969, PMID 21555779, PMID 22585765, PMID 24001701, PMID 24144615, PMID 25988365, PMID 26763495, PMID 27027204, PMID 27445874, PMID 28202705, PMID 28686474, PMID 29029679, PMID 30772854, PMID 33231786, PMID 34593015, PMID 35969401, PMID 36040329, PMID 36778375, PMID 37048598, PMID 37048629, PMID 37398344, PMID 37400828, PMID 38700867, PMID 41579326, PMID 42856611
UL1TR002345 (2), K23MH113884 (1), P50MH077248 (1), R01MH070802 (1), R34MH085844 (1)