93 completed, 42 unknown, 26 recruiting, 16 active not recruiting. 87 Not applicable, 32 Phase 2, 18 Phase 3, 14 Phase 1, 3 Phase 4.
Follow Cerebellar Ataxia: new trials by email Literature Review of Cerebellar Ataxia trials Research Report on Cerebellar Ataxia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Umbilical Cord Mesenchymal Stem Cells Therapy (19#iSCLife®-SA) for Patients With Spinocerebellar Ataxia Intravenous infusion, Intrathecal injection, umbilical cord mesenchymal stem cell - Spinocerebellar Ataxia Type 1, Spinocerebellar Ataxia Type 2 | Phase 2 | Not yet recruiting | Sclnow Biotechnology Co., Ltd. | 45 | 2026-12-31 | 2026-04-23 |
| Multi-Modal Digital Monitoring of Disease Symptoms in Spinocerebellar Ataxia Spinocerebellar Ataxia (SCA) | Not yet recruiting | BioSensics | 25 | 2026-12-15 | 2026-10-01 | |
| Rare Disease Registry Database for Movement Disorders in Southern Anhui Province Motor Neuron Diseases, Spinocerebellar Ataxias | Recruiting | First Affiliated Hospital of Wannan Medical College | 180 | 2026-09-30 | 2026-10-23 | |
| Biomarkers for Babies and Young Children With Ataxia Telangiectasia Ataxia Telangiectasia | Not yet recruiting | University of Nottingham | 56 | 2026-09-01 | 2026-07-16 | |
| Pivotal Study of N-acetyl-L-leucine for CACNA1A N-Acetyl-L-Leucine, Placebo - CACNA1A, Spinocerebellar Ataxia Type 6 | Phase 3 | Recruiting | IntraBio Inc | 60 | 2026-08-17 | 2026-09-08 |
| Optimizing Parameters of Transcranial Temporal Interference Stimulation for Spinocerebellar Ataxia Type 3 Transcranial Temporal Interference Stimulation (tTIS) - Spinocerebellar Ataxia Type 3 | Not applicable | Not yet recruiting | First Affiliated Hospital of Fujian Medical University | 24 | 2026-08-07 | 2026-09-01 |
| Safety and Efficacy of Mutation-targeted Precision Genetic Therapy for Ataxia-Telangiectasia (A-T) Antisense oligonucleotide targeting the ATM gene - Ataxia Telangiectasia | Phase 1 / Phase 2 | Recruiting | Timothy Yu | 10 | 2026-08-01 | 2026-05-28 |
| Individualized Neuro-Modulation Paired With Cerebellar Therapy Therapy - Cerebellar Ataxia, Cerebellar Diseases | Not applicable | Recruiting | Hugo W. Moser Research Institute at Kennedy Krieger, Inc. | 30 | 2026-06-30 | 2026-06-11 |
| Interposed Nucleus aDBS for Ataxia Deep Brain Stimulation - Spinocerebellar Ataxia (SCA), Spinocerebellar Ataxia Type 6 | Not applicable | Recruiting | University of Florida | 5 | 2026-06-02 | 2026-07-20 |
| Deep Brain Stimulation for Spinocerebellar Ataxia Deep Brain Stimulation (DBS) - Spinocerebellar Ataxia (SCA), Spinocerebellar Ataxia Type 6 | Not applicable | Recruiting | University of California, San Francisco | 5 | 2026-04-27 | 2026-07-13 |
| At Home Use of Stimulation Suits for Managing MS Symptoms electro-stimulation suit, Usual Care - Multiple Sclerosis, MS (Multiple Sclerosis) | Not applicable | Recruiting | Daphne Kos | 70 | 2026-03-16 | 2026-10-08 |
| Use of a New Smartphone Application to Determine Changes in Eyeblink Conditioning From Home Training in Individuals With Spinocerebellar Ataxia Aerobic Training, Balance Training - Spinocerebellar Ataxias | Not applicable | Withdrawn | Columbia University | 2026-01-01 | 2026-05-07 | |
| Autosomal Dominant Spinocerebellar Ataxias and Social Cognition tests - Autosomal Dominant Spinocerebellar Ataxia (SCA1, 2,3,6,7,27B) | Not applicable | Recruiting | University Hospital, Angers | 160 | 2025-12-09 | 2026-07-20 |
| An Phase Ib/II Clinical Trial of TCC1727 Combination Therapy in Advanced Solid Tumors TCC1727 tablet 90mg, TCC1727 tablet 120mg, TCC1727 tablet 160mg - Solid Cancers, NSCLC (Advanced Non-small Cell Lung Cancer) | Phase 1 / Phase 2 | Recruiting | Beijing Tide Pharmaceutical Co., Ltd | 266 | 2025-12-03 | 2026-01-28 |
| Ophthalmological Disorders in Dominant Spinal-cerebellar Ataxias Neurological assessment, Ophthalmological assessment - Spinocerebellar Ataxia | Not applicable | Recruiting | University Hospital, Montpellier | 60 | 2025-10-10 | 2025-11-20 |
| rTMS for Cerebellar Ataxia in Children Repetitive Transcranial Magnetic Stimulation, Sham Repetitive Transcranial Magnetic Stimulation - Cerebellar Ataxia | Not applicable | Not yet recruiting | The University of Hong Kong | 20 | 2025-10-01 | 2025-10-08 |
| Structural Validity and Inter-rater Reliabitiliy of the Ataxia Trunk, Lower And Upper Extremity Scale (ATLAS) New Scale to evaluate ataxia motor symptoms - Ataxia, Cerebellar, Ataxia, Gait | Not yet recruiting | Haute Ecole de Santé Vaud | 64 | 2025-09-01 | 2025-08-13 | |
| Stemchymal® for Polyglutamine Spinocerebellar Ataxia Stemchymal, Placebo - Spinocerebellar Ataxias | Phase 2 | Not yet recruiting | Steminent US, Inc. | 20 | 2025-06-01 | 2024-05-02 |
| Evaluation of Urinary Dysfunction in CANVAS Patients Evaluation of urinary dysfunction in patients with CANVAS - Cerebellar Ataxia, Neuropathy | Not applicable | Recruiting | Centre Hospitalier Universitaire de Nice | 40 | 2025-03-21 | 2025-03-26 |
| Efficacy of Cerebellar Transcranial Magnetic Stimulation to Treat Hereditary Spinocerebellar Ataxias navigated iTBS (Intermittent theta-burst stimulation) targeting the cerebellum - Spinocerebellar Ataxias | Not applicable | Not yet recruiting | Xijing Hospital | 80 | 2025-03-20 | 2025-03-27 |
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Spinocerebellar Ataxias (92) · Ataxia Telangiectasia (42) · Ataxia (36) · Machado-Joseph Disease (32) · Spinocerebellar Degenerations (17) · Multiple System Atrophy (9) · Neurodegenerative Diseases (9) · Motor Activity (7) · Cerebellar Diseases (6) · Gait Ataxia (6) · Huntington Disease (6) · Parkinson Disease (6) · Genetic Diseases, Inborn (5) · Friedreich Ataxia (4)
Brain Diseases (201) · Central Nervous System Diseases (201) · Dyskinesias (201) · Neurologic Manifestations (201) · Nervous System Diseases (200) · Cerebellar Diseases (196) · Ataxia (166) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (158) · Genetic Diseases, Inborn (152) · Heredodegenerative Disorders, Nervous System (118) · Neurodegenerative Diseases (115) · Spinal Cord Diseases (115) · Pathological Conditions, Signs and Symptoms (101) · Spinocerebellar Degenerations (96)
Transcranial Magnetic Stimulation (7) · Blood Specimen Collection (5) · Transcranial Direct Current Stimulation (5) · acetylleucine (4) · Deep Brain Stimulation (3) · Immunoglobulins, Intravenous (3) · Lithium Carbonate (3) · Magnetic Resonance Spectroscopy (3) · Riluzole (3) · nicotinamide-beta-riboside (3) · Heptavalent Pneumococcal Conjugate Vaccine (2) · IB1001 (2) · Magnetic Resonance Imaging (2) · Specimen Handling (2) · Spinal Puncture (2)
Johann Wolfgang Goethe University Hospital (6) · Chang Gung University (5) · Columbia University (5) · Hospital de Clinicas de Porto Alegre (5) · Hugo W. Moser Research Institute at Kennedy Krieger, Inc. (5) · Institut National de la Santé Et de la Recherche Médicale, France (4) · IntraBio Inc (4) · Johns Hopkins University (4) · Kissei Pharmaceutical Co., Ltd. (4) · Quince Therapeutics S.p.A. (4) · University of Florida (4) · Assistance Publique - Hôpitaux de Paris (3) · Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (3) · Biohaven Pharmaceuticals, Inc. (3) · Changhua Christian Hospital (3)
United States (66) · France (22) · Germany (18) · Italy (18) · United Kingdom (18) · Spain (13) · Brazil (12) · Israel (12) · Taiwan (12) · China (10) · Belgium (6) · Netherlands (6) · Switzerland (6) · Australia (5) · Canada (5)
Stefan Zielen, Prof. Dr. (5) · Theresa Zesiewicz, MD (4) · Alberto Benussi, MD (3) · Amy J Bastian, PhD, PT (3) · Barbara Borroni, MD (3) · Carlos Gordon, Prof. (2) · Cherie Marvel, PhD (2) · David Coman, MBBS FRACP (2) · Didier Hannequin, MD, PhD (2) · Dirk Thye, MD (2) · Jean-Philippe Azulay, MD, PhD (2) · Laura B. Jardim, MD, PhD (2) · Patrick Calvas, MD, PhD (2)
PMID 15313841, PMID 15365159, PMID 16193476, PMID 24780882, PMID 30135258, PMID 34115419, PMID 34477998, PMID 40739200, PMID 12925365, PMID 12925368, PMID 14506070, PMID 14705117, PMID 14736755, PMID 14770181, PMID 15574463, PMID 15596607, PMID 15747371, PMID 15786464, PMID 15895558, PMID 15895562, PMID 15956167, PMID 16055926, PMID 16325416, PMID 16401858, PMID 16434418, PMID 16501573, PMID 16511635, PMID 16518257, PMID 16534102, PMID 16612642, PMID 16682547, PMID 16699786, PMID 16763896, PMID 16934683, PMID 17098887, PMID 17130408, PMID 17205300, PMID 17273843, PMID 17321752, PMID 17322883, PMID 17344386, PMID 17503452, PMID 17515546, PMID 17597328, PMID 17605047, PMID 17957230, PMID 18079167, PMID 18098276, PMID 18332254, PMID 18378516
2018 (2), 2025 (2), R01HD040289 (2), 2015 (1), 2017 (1), K23NS121518 (1), P2CHD086844 (1), R01DC016275 (1), R01DC017091 (1), R21AG044449 (1), R21NS085491 (1), R21NS094946 (1), R21NS125546 (1), U01NS106670 (1)