70 completed, 26 unknown, 17 recruiting, 14 active not recruiting. 53 Not applicable, 27 Phase 2, 17 Phase 3, 10 Phase 1, 3 Phase 4.
Follow Spinocerebellar Ataxias: new trials by email Literature Review of Spinocerebellar Ataxias trials Research Report on Spinocerebellar Ataxias
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Umbilical Cord Mesenchymal Stem Cells Therapy (19#iSCLife®-SA) for Patients With Spinocerebellar Ataxia Intravenous infusion, Intrathecal injection, umbilical cord mesenchymal stem cell - Spinocerebellar Ataxia Type 1, Spinocerebellar Ataxia Type 2 | Phase 2 | Not yet recruiting | Sclnow Biotechnology Co., Ltd. | 45 | 2026-12-31 | 2026-04-23 |
| Multi-Modal Digital Monitoring of Disease Symptoms in Spinocerebellar Ataxia Spinocerebellar Ataxia (SCA) | Not yet recruiting | BioSensics | 25 | 2026-12-15 | 2026-10-01 | |
| Biomarkers for Babies and Young Children With Ataxia Telangiectasia Ataxia Telangiectasia | Not yet recruiting | University of Nottingham | 56 | 2026-09-01 | 2026-07-16 | |
| Rare Disease Registry Database for Movement Disorders in Southern Anhui Province Motor Neuron Diseases, Spinocerebellar Ataxias | Active not recruiting | First Affiliated Hospital of Wannan Medical College | 180 | 2026-08-25 | 2026-09-24 | |
| Pivotal Study of N-acetyl-L-leucine for CACNA1A N-Acetyl-L-Leucine, Placebo - CACNA1A, Spinocerebellar Ataxia Type 6 | Phase 3 | Recruiting | IntraBio Inc | 60 | 2026-08-17 | 2026-09-08 |
| Optimizing Parameters of Transcranial Temporal Interference Stimulation for Spinocerebellar Ataxia Type 3 Transcranial Temporal Interference Stimulation (tTIS) - Spinocerebellar Ataxia Type 3 | Not applicable | Not yet recruiting | First Affiliated Hospital of Fujian Medical University | 24 | 2026-08-07 | 2026-09-01 |
| Safety and Efficacy of Mutation-targeted Precision Genetic Therapy for Ataxia-Telangiectasia (A-T) Antisense oligonucleotide targeting the ATM gene - Ataxia Telangiectasia | Phase 1 / Phase 2 | Recruiting | Timothy Yu | 10 | 2026-08-01 | 2026-05-28 |
| Interposed Nucleus aDBS for Ataxia Deep Brain Stimulation - Spinocerebellar Ataxia (SCA), Spinocerebellar Ataxia Type 6 | Not applicable | Recruiting | University of Florida | 5 | 2026-06-02 | 2026-07-20 |
| Deep Brain Stimulation for Spinocerebellar Ataxia Deep Brain Stimulation (DBS) - Spinocerebellar Ataxia (SCA), Spinocerebellar Ataxia Type 6 | Not applicable | Recruiting | University of California, San Francisco | 5 | 2026-04-27 | 2026-07-13 |
| Use of a New Smartphone Application to Determine Changes in Eyeblink Conditioning From Home Training in Individuals With Spinocerebellar Ataxia Aerobic Training, Balance Training - Spinocerebellar Ataxias | Not applicable | Withdrawn | Columbia University | 2026-01-01 | 2026-05-07 | |
| Autosomal Dominant Spinocerebellar Ataxias and Social Cognition tests - Autosomal Dominant Spinocerebellar Ataxia (SCA1, 2,3,6,7,27B) | Not applicable | Recruiting | University Hospital, Angers | 160 | 2025-12-09 | 2026-07-20 |
| An Phase Ib/II Clinical Trial of TCC1727 Combination Therapy in Advanced Solid Tumors TCC1727 tablet 90mg, TCC1727 tablet 120mg, TCC1727 tablet 160mg - Solid Cancers, NSCLC (Advanced Non-small Cell Lung Cancer) | Phase 1 / Phase 2 | Recruiting | Beijing Tide Pharmaceutical Co., Ltd | 266 | 2025-12-03 | 2026-01-28 |
| Ophthalmological Disorders in Dominant Spinal-cerebellar Ataxias Neurological assessment, Ophthalmological assessment - Spinocerebellar Ataxia | Not applicable | Recruiting | University Hospital, Montpellier | 60 | 2025-10-10 | 2025-11-20 |
| Structural Validity and Inter-rater Reliabitiliy of the Ataxia Trunk, Lower And Upper Extremity Scale (ATLAS) New Scale to evaluate ataxia motor symptoms - Ataxia, Cerebellar, Ataxia, Gait | Not yet recruiting | Haute Ecole de Santé Vaud | 64 | 2025-09-01 | 2025-08-13 | |
| Stemchymal® for Polyglutamine Spinocerebellar Ataxia Stemchymal, Placebo - Spinocerebellar Ataxias | Phase 2 | Not yet recruiting | Steminent US, Inc. | 20 | 2025-06-01 | 2024-05-02 |
| Efficacy of Cerebellar Transcranial Magnetic Stimulation to Treat Hereditary Spinocerebellar Ataxias navigated iTBS (Intermittent theta-burst stimulation) targeting the cerebellum - Spinocerebellar Ataxias | Not applicable | Not yet recruiting | Xijing Hospital | 80 | 2025-03-20 | 2025-03-27 |
| A Pivotal Study of N-Acetyl-L-Leucine on Ataxia-Telangiectasia (A-T) N-Acetyl-L-Leucine, Placebo - Ataxia-Telangiectasia, Ataxia-Telangiectasia (A-T) | Phase 3 | Active not recruiting | IntraBio Inc | 60 | 2025-03-18 | 2025-07-03 |
| Study of ARO-ATXN2 Injection in Adults With Spinocerebellar Ataxia Type 2 ARO-ATXN2 Injection, Placebo - Spinocerebellar Ataxia Type 2 | Phase 1 | Active not recruiting | Arrowhead Pharmaceuticals | 39 | 2024-12-17 | 2026-06-29 |
| Open-Label Extension of EryDex Study IEDAT-04-2022 Dexamethasone sodium phosphate - Ataxia Telangiectasia | Phase 3 | Terminated | Quince Therapeutics S.p.A. | 101 | 2024-12-11 | 2026-05-05 |
| Cycling-Based Priming Coordination Training for Enhancing Ataxia Recovery and Brain Plasticity Cycling Training - Spinocerebellar Ataxias | Not applicable | Recruiting | Chang Gung University | 40 | 2024-10-04 | 2024-10-08 |
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Ataxia Telangiectasia (42) · Machado-Joseph Disease (32) · Ataxia (24) · Cerebellar Ataxia (15) · Spinocerebellar Degenerations (12) · Huntington Disease (6) · Multiple System Atrophy (6) · Neurodegenerative Diseases (5) · Friedreich Ataxia (4) · Spinocerebellar Ataxia 10 (4) · Spinocerebellar ataxia 8 (4) · Spinocerebellar ataxia, autosomal recessive 1 (4) · Telangiectasis (4) · Cerebellar Diseases (3)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (148) · Brain Diseases (147) · Central Nervous System Diseases (147) · Dyskinesias (147) · Neurologic Manifestations (147) · Genetic Diseases, Inborn (146) · Nervous System Diseases (146) · Cerebellar Diseases (145) · Cerebellar Ataxia (133) · Ataxia (124) · Heredodegenerative Disorders, Nervous System (111) · Spinal Cord Diseases (109) · Neurodegenerative Diseases (106) · Spinocerebellar Degenerations (96)
Blood Specimen Collection (4) · acetylleucine (4) · Deep Brain Stimulation (3) · Lithium Carbonate (3) · Transcranial Direct Current Stimulation (3) · Transcranial Magnetic Stimulation (3) · nicotinamide-beta-riboside (3) · Heptavalent Pneumococcal Conjugate Vaccine (2) · IB1001 (2) · Immunoglobulins, Intravenous (2) · Magnetic Resonance Spectroscopy (2) · Riluzole (2) · Specimen Handling (2) · Spinal Puncture (2) · Trehalose (2)
Johann Wolfgang Goethe University Hospital (6) · Chang Gung University (5) · Hospital de Clinicas de Porto Alegre (5) · Columbia University (4) · IntraBio Inc (4) · Johns Hopkins University (4) · Kissei Pharmaceutical Co., Ltd. (4) · Quince Therapeutics S.p.A. (4) · Assistance Publique - Hôpitaux de Paris (3) · Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (3) · Biohaven Pharmaceuticals, Inc. (3) · Changhua Christian Hospital (3) · Institut National de la Santé Et de la Recherche Médicale, France (3) · University of Chicago (3) · University of Florida (3)
United States (52) · Germany (18) · United Kingdom (16) · Italy (15) · France (14) · Israel (10) · Taiwan (10) · Spain (9) · Brazil (8) · China (7) · Australia (6) · Switzerland (6) · Belgium (4) · Japan (4) · Netherlands (4)
Stefan Zielen, Prof. Dr. (5) · Theresa Zesiewicz, MD (4) · Alberto Benussi, MD (3) · Barbara Borroni, MD (3) · Carlos Gordon, Prof. (2) · Cherie Marvel, PhD (2) · David Coman, MBBS FRACP (2) · Dirk Thye, MD (2) · Laura B. Jardim, MD, PhD (2) · Vikram Shakkottai, MD, PhD (2) · Ahmad Yasa MD (1) · Alessandro Filla, MD (1) · Alexander F. Karelin, PhD (1)
PMID 24780882, PMID 34115419, PMID 34477998, PMID 40739200, PMID 15313841, PMID 15365159, PMID 16055926, PMID 16193476, PMID 16501573, PMID 16763896, PMID 16934683, PMID 17098887, PMID 17597328, PMID 17605047, PMID 17957230, PMID 18378516, PMID 18853458, PMID 19841031, PMID 22144182, PMID 22491195, PMID 22875082, PMID 22927201, PMID 23707147, PMID 24236946, PMID 24399647, PMID 25434572, PMID 25449974, PMID 25656498, PMID 25773989, PMID 26297649, PMID 26321318, PMID 26377379, PMID 26417459, PMID 26433381, PMID 26547562, PMID 26644294, PMID 26645295, PMID 26851119, PMID 26943780, PMID 27848087, PMID 28365204, PMID 28601294, PMID 28871440, PMID 28969699, PMID 29057148, PMID 29089256, PMID 29106465, PMID 29110179, PMID 29553382, PMID 29922574
2018 (2), 2025 (2), 2017 (1), R01DC016275 (1), R21NS085491 (1), R21NS094946 (1), R21NS125546 (1), U01NS106670 (1)