44 completed, 3 recruiting, 2 active not recruiting, 2 unknown. 36 Phase 1, 4 Phase 4, 2 Early Phase 1, 2 Not applicable, 1 Phase 2.
Follow Drug Interactions: new trials by email Literature Review of Drug Interactions trials Research Report on Drug Interactions
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Factors of Potentially Dangerous Drug Interactions in Patients With Cardiovascular Diseases and Multimorbidity Cardiovascular Diseases, Multimorbidity | Active not recruiting | National Medical Research Center for Therapy and Preventive Medicine | 120 | 2026-01-25 | 2026-06-16 | |
| Relationship Between Remimazolam and Etomidate in Induction of General Anesthesia Etomidate, Remimazolam, Remimazolam-etomidate - Induction Anesthesia, Drug Interactions | Early Phase 1 | Not yet recruiting | Second Hospital of Shanxi Medical University | 125 | 2025-06-12 | 2025-06-10 |
| LDL-C Optimization Using Inclisiran in Patients in Which Drug-Drug Interactions Limit LDL Lowering Inclisiran sodium 300 mg (equivalent to 284 mg inclisiran) in 1.5 mL - Drug Interactions, Primary Prevention | Phase 4 | Recruiting | University of California, San Diego | 100 | 2025-04-02 | 2026-07-13 |
| Opioid Drug Interaction Study Alprazolam, Oxycodone, Placebo - Drug Interactions, Drug Kinetics | Phase 1 / Phase 2 | Recruiting | Shanna Babalonis, PhD | 25 | 2025-04-01 | 2026-05-14 |
| Study to Determine Potential for Drug-drug Interactions When Co-administering Deupirfenidone (LYT-100) and Nintedanib Nintedanib 150 MG [Ofev] - Drug Interactions | Phase 1 | Completed | PureTech | 24 | 2024-12-17 | 2026-08-13 |
| KF2024#1-trial: Esketamine Interaction Study Esketamine Nasal Spray, Esketamine 28 mg, Cobicistat 150 MG - Drug Interactions, Food-drug Interaction | Phase 1 | Completed | Helsinki University Central Hospital | 12 | 2024-12-09 | 2026-03-05 |
| Shared Decision for Drug Interactions in Oral Anticoagulation Shared Decision Making Tool - Anticoagulants, Drug Interactions | Not applicable | Active not recruiting | University of Utah | 3691 | 2023-10-01 | 2026-06-26 |
| A Drug-drug Interaction Study to Evaluate the Effect of Rifampicin on the Pharmacokinetics of Methotrexate in Elderly Subjects Methotrexate Sodium, Rifampicin - Drug Interactions | Phase 1 | Unknown | Seoul National University Bundang Hospital | 10 | 2023-08-21 | 2023-10-31 |
| Drug-Drug Interaction Study of Pacritinib and CYP450,Transporter Substrates, and CYP450 3A4 in Healthy Male Subjects CYP450 Cocktail and Transporter Substrates with Pacritinib, Part 2 -Group A Bosentan 125 mg (CYP450 3A4 inducer) with Pacritinib, Part 2 Group B - Fluconazole (CYP450 3A4 inhibitor) with Pacritinib - Drug Interactions | Phase 1 | Completed | CTI BioPharma | 60 | 2023-01-03 | 2024-10-17 |
| Telecommunication Technology-based Online Survey Online Survey, Genetic Testing - Risk Factors, Polypharmacy | Recruiting | Tomsk National Research Medical Center of the Russian Academy of Sciences | 2000 | 2022-12-02 | 2026-01-27 | |
| Interactions Between Antihypertensive Drugs and Drugs Prescribed in the Emergency Room Drug Interactions, Hypertension | Completed | Instituto Mexicano del Seguro Social | 53 | 2021-01-01 | 2022-03-29 | |
| Evaluating the Effects of Omeprazole on the Pharmacokinetics of XS004 (Dasatinib) Tablets in Healthy Adult Subjects Under Fasting Conditions Dasatinib ASD, Omeprazole 40 MG - Pharmacokinetics, Drug Interactions | Phase 1 | Completed | Xspray Pharma AB | 17 | 2020-11-01 | 2022-06-27 |
| Study to Learn the Effect of Drug BAY1817080 on the Way the Body Absorbs, Distributes and Excretes Another Drug Rosuvastatin in Healthy Adult Participants Rosuvastatin, Rosuvastatin + BAY1817080 - Drug Interactions | Phase 1 | Completed | Bayer | 14 | 2020-03-02 | 2021-03-11 |
| Effect of Multiple Doses of Modafinil on the Pharmacokinetics of Single Dose Lorlatinib in Healthy Participants Lorlatinib 50 mg, Lorlatinib 75 mg, Lorlatinib 100 mg - Adult, Drug Interactions | Phase 1 | Completed | Pfizer | 16 | 2019-08-22 | 2020-01-18 |
| Modeling and Application of Triple Drug Response Surface Models Fentanyl, Bispectral index (BIS) and analgesia nociception index (ANI), alfentanil - Pharmacodynamics, Drug Interactions | Completed | Taipei Veterans General Hospital, Taiwan | 100 | 2019-06-12 | 2022-07-20 | |
| Study to Learn More About the Effect of Itraconazole (ITZ) Given Repeatedly by Mouth on the Way How the Study Drug BAY1902607 Given One Time by Mouth Acts in the Human Body of Healthy Male Participants BAY1902607, Itraconazole - Drug Interactions | Phase 1 | Completed | Bayer | 14 | 2019-01-08 | 2019-05-29 |
| A Drug-drug Interaction Study of SH229 Tablets and Daclatasvir Dihydrochloride Tablets in Healthy Subjects SH229, Daclatasvir dihydrochloride - Drug Interactions | Phase 1 | Completed | Nanjing Sanhome Pharmaceutical, Co., Ltd. | 28 | 2018-11-19 | 2019-08-13 |
| Drug-drug Interactions Between Antiretroviral Drugs and Cardiovascular Drugs in Elderly Patients Co-administration of darunavir with a cardiovascular drug - HIV Infections, Drug Interactions | Completed | Centre Hospitalier Universitaire Vaudois | 21 | 2018-04-23 | 2020-07-28 | |
| A Drug Interaction Study of BIIB074 and an Oral Contraceptive Regimen BIIB074, OC (ethinyl estradiol and levonorgestrel) - Drug Interactions | Phase 1 | Completed | Biogen | 36 | 2017-11-11 | 2018-09-25 |
| Effect of Anti-epileptic Drugs on Etonogestrel-releasing Implant Pharmacokinetics in Women With Epilepsy Carbamazepine-Implant, Topiramate-Implant, Implant - Contraception, Drug Interactions | Phase 4 | Suspended | University of Sao Paulo | 69 | 2017-11-01 | 2025-01-28 |
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Cardiovascular Diseases (2) · Gastrointestinal Hemorrhage (2) · HIV Infections (2) · Hypercholesterolemia (2) · Pain (2) · Acquired Immunodeficiency Syndrome (1) · Acute Coronary Syndrome (1) · COVID-19 (1) · Chronic Cough (1) · Coronary Disease (1) · Diabetes Mellitus, Type 2 (1) · Hepatitis C (1) · Hypertension (1) · Idiopathic Pulmonary Fibrosis (1) · Metabolic Syndrome (1)
Pathological Conditions, Signs and Symptoms (6) · Infections (4) · Metabolic Diseases (4) · Nutritional and Metabolic Diseases (4) · Pathologic Processes (4) · RNA Virus Infections (4) · Respiratory Tract Diseases (4) · Virus Diseases (4) · Blood-Borne Infections (3) · Communicable Diseases (3) · Digestive System Diseases (3) · Cardiovascular Diseases (2) · Dyslipidemias (2) · Gastrointestinal Diseases (2) · Genital Diseases (2)
Rifampin (5) · Midazolam (4) · Ethinyl Estradiol (3) · Ezetimibe (3) · Ketoconazole (3) · Omeprazole (3) · telotristat (3) · Caffeine (2) · Dextromethorphan (2) · Folic Acid (2) · Hypericum extract LI 160 (2) · Itraconazole (2) · Oxycodone (2) · Propofol (2) · Rosuvastatin Calcium (2)
Bayer (5) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (4) · Gerd Mikus (3) · Lexicon Pharmaceuticals (3) · University Medicine Greifswald (3) · Astellas Pharma Inc (2) · GlaxoSmithKline (2) · University of Utah (2) · Abbott (1) · Biogen (1) · CTI BioPharma (1) · Centre Hospitalier Universitaire Vaudois (1) · Gebro Pharma GmbH (1) · Helsinki University Central Hospital (1) · Insel Gruppe AG, University Hospital Bern (1)
United States (21) · Germany (9) · Belgium (2) · China (2) · Russia (2) · South Korea (2) · Switzerland (2) · Argentina (1) · Australia (1) · Austria (1) · Brazil (1) · Canada (1) · Egypt (1) · Finland (1) · Mexico (1)
Gerd Mikus, Prof. Dr. (3) · Suman Wason, MD (3) · Werner Siegmund, Prof (3) · Andrew A Monte, MD (1) · Antoinette Birs, MD (1) · Carolina S Vieira, MD (1) · Christian Joukhadar, MD (1) · Daniel C Malone, PhD (1) · Dirk RJ Kuypers, MD, PhD (1)
PMID 22782731, PMID 32564301, PMID 33124006, PMID 33937953, PMID 34623637, PMID 42031608
2014 (2), 2018 (1), 2019 (1), R01DA016718 (1), R21AT002073 (1)