143 completed, 12 unknown, 9 terminated, 5 recruiting. 65 Phase 1, 34 Phase 3, 26 Not applicable, 25 Phase 4, 19 Phase 2.
Follow Ethinyl Estradiol: new trials by email Literature Review of Ethinyl Estradiol trials Research Report on Ethinyl Estradiol
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluation of the Contraceptive Efficacy and Safety of a New Concentration of an Antiandrogenic Progestogen Combined With a Reduced-Dose Estrogen (LUNA) Cyproterone Acetate 2 mg and Ethinyl Estradiol 0.02 mg - Contraception | Phase 3 | Not yet recruiting | Eurofarma Laboratorios S.A. | 1600 | 2027-05-31 | 2026-07-21 |
| A Drug-drug Interaction Study to Evaluate the Effects of Pelabresib on the Pharmacokinetics of Repaglinide, Midazolam, and Combined Oral Contraceptive in Patients With Advanced Malignancies pelabresib, repaglinide, midazolam - Advanced Malignancies | Phase 1 | Recruiting | Novartis Pharmaceuticals | 24 | 2026-06-12 | 2026-10-09 |
| Evaluate the Effect of Vimseltinib on Pharmacokinetics of Combined Oral Contraceptive (Ethinyl Estradiol/Levonorgestrel) Vimseltinib, Combined Oral Contraceptive (COC) (ethinyl estradiol [EE]/levonorgestrel [LNG]) - Healthy Participants | Phase 1 | Completed | Deciphera Pharmaceuticals, LLC | 27 | 2026-06-05 | 2026-10-15 |
| Efficacy of Oral Contraceptive, Progesterone, and Inositol on Menstrual Regulation in PCOS Combined Oral Contraceptive (Ethinylestradiol 0.03 mg + Drospirenone 3 mg), Inositol mid-level volume, Dydrogesterone Pill - Polycystic Ovary Syndrome (PCOS) | Not applicable | Recruiting | Ege University | 150 | 2025-12-01 | 2025-12-18 |
| An Ethno-bridging Study of Pergoveris in Healthy Premenopausal Participants of Japanese or Caucasian Origin Desogestrel and ethinylestradiol fixed dose combination, Follitropin alfa/lutropin alfa - Fertility | Phase 1 | Completed | Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany | 24 | 2025-11-24 | 2026-03-18 |
| Transdermal Ethinyl Estradiol and Norelgestromin for Irregular Bleeding in Contraceptive Implant Users Transdermal Ethinyl Estradiol/Norelgestromin Patch, Placebo Patch - Menstruation Disturbances, Metrorrhagia | Phase 2 | Recruiting | Chulalongkorn University | 40 | 2025-07-29 | 2025-12-10 |
| A Study to Investigate the Effect of AZD6234, AZD9550, and a Combination of AZD9550 and AZD6234 on Pharmacokinetics of Combined Oral Contraceptive Ethinyl Estradiol/Levonorgestrel in Healthy Female Participants Living With Overweight or Obesity AZD6234, Ethinyl estradiol/Levonorgestrel (EE/LEVO), Acetaminophen (APAP) - Healthy Participants | Phase 1 | Active not recruiting | AstraZeneca | 100 | 2025-06-04 | 2026-10-13 |
| A Drug-Drug Interaction Study Between HS-10374 Tablets and Drospirenone and Ethinyl Estradiol Tablets(Yasmin®) HS-10374 tablets, Drospirenone and Ethinyl Estradiol tablets - Psoriasis (PsO) | Phase 1 | Completed | Hansoh BioMedical R&D Company | 18 | 2025-05-28 | 2025-09-18 |
| Effect of Dienogest in Symptomatic Endometrioma in Comparison to Combined Oral Contraceptive Pill. Tab.Dienogest 2 mg, Combined oral contraceptive pill (ethinyl estradiol,30mcg+desogestrel,150mcg) tablet - Endometrioma | Not applicable | Completed | Mst.Sumyara Khatun | 60 | 2025-04-17 | 2026-08-18 |
| Effect of Elagolix in Symptomatic Endometrioma in Comparison to Combined Oral Contraceptive Pill. tab Elagolix 150mg, Combined oral contraceptive pill (ethinyl estradiol,30mcg+desogestrel,150mcg) tablet - Endometrioma | Not applicable | Completed | Mst.Sumyara Khatun | 60 | 2025-04-17 | 2026-08-13 |
| Oral Contraceptive Pill (OCP) Pharmacogenomics Desogestrel / Ethinyl Estradiol Pill - Contraception, Pharmacogenomic Drug Interaction | Phase 4 | Recruiting | Yale University | 700 | 2024-10-29 | 2026-07-16 |
| A Research Study Looking Into the Effect of NNC0519-0130 on Blood Levels of a Birth Control Pill and Emptying of the Stomach in Women After Menopause NNC0519-0130, Levonorgestrel + Ethinylestradiol, Paracetamol - Diabetes Mellitus, Type 2 | Phase 1 | Completed | Novo Nordisk A/S | 47 | 2024-07-18 | 2026-03-12 |
| A Research Study Looking at How the Compound NNC0487-0111 Works With Birth Control Pills and Affects Emptying of the Stomach in Women Not Able to Become Pregnant NNC0487-0111 A, NNC0487-0111 C, Levonorgestrel 150 μg + Ethinylestradiol 30 μg (Oral contraceptive OC) - Obesity | Phase 1 | Completed | Novo Nordisk A/S | 43 | 2024-06-14 | 2025-05-08 |
| "Quick-starting" of a Quadriphasic Contraceptive Pills, 1 - 3 mg Estradiol Valerate/ 2 - 3 mg Dienogest VS 20 mcg Ethinylestradiol/75 mcg Gestodene Focusing on Ovulation Inhibition Quadriphasic Estradiol valerate 1 - 3 mg/ Dienogest 2 - 3 mg (26/2), Ethinylestradiol (EE) 20 mcg/Gestodene 75 mcg (21/7) - Ultrasound Finding: Ovulation Inhibition, Ovarian Activities, Cervical Mucus | Not applicable | Completed | Chulalongkorn University | 40 | 2024-05-09 | 2026-08-25 |
| "Quick-starting" of a New Combined Hormonal Contraceptive Pills, 15 mg Estetrol/3 mg Drospirenone VS 20 mcg Ethinylestradiol/75 mcg Gestodene Focusing on Ovulation Inhibition Estetrol 15 mg/Drospirenone 3 mg (24/4), Ethinylestradiol (EE) 20 mcg/Gestodene 75 mcg (21/7) - Ultrasound Finding: Ovulation Inhibition, Ovarian Activities, Cervical Mucus | Not applicable | Completed | Chulalongkorn University | 36 | 2024-05-01 | 2025-05-20 |
| Evaluate the Pharmacokinetics of a Combined Oral Contraceptive (COC) With and Without Obicetrapib Obicetrapib, Obicetrapib + Drospirenone / Ethinyl Estradiol (COC), Drospirenone / Ethinyl Estradiol (COC) - Healthy Volunteers | Phase 1 | Completed | NewAmsterdam Pharma | 30 | 2024-02-05 | 2024-09-19 |
| A Research Study Looking at How the Compound NNC0194-0499 Works With Birth Control Pills in Women Not Able to Bear Children. NNC0194-0499, ethinylestradiol/levonorgestrel - Healthy Volunteers (Non-alcoholic Steatohepatitis) | Phase 1 | Completed | Novo Nordisk A/S | 34 | 2023-12-18 | 2025-02-18 |
| Prospective Evaluation on the Role Exerted by Hormonal Contraceptives on 24-h Blood Pressure. A Prospective Observational Study Ethynyl estradiol and Drospirenone, Drospirenone, Estetrol and Drospirenone - Cardiovascular System Diseases (&Amp; [Cardiac]) | Recruiting | Ospedale Policlinico San Martino | 96 | 2023-10-10 | 2025-07-11 | |
| A Study of LY3437943 in Postmenopausal Female Participants Who Are Overweight or Obese LY3437943, Ethinyl Estradiol, Drospirenone - Overweight | Phase 1 | Completed | Eli Lilly and Company | 46 | 2023-09-12 | 2024-07-26 |
| Comparing the Safety and Efficacy in the Use of Hormonal Therapy on Endometriosis Patients After Conservative Surgery Dienogest, Depo Medroxyprogesterone acetate, Leuprolide (as Leuprolide Acetate) - Endometriosis Ovary | Phase 3 | Completed | Universitas Diponegoro | 80 | 2023-09-04 | 2024-12-11 |
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Polycystic Ovary Syndrome (13) · Infertility (5) · Metrorrhagia (5) · Acne Vulgaris (4) · Insulin Resistance (4) · Diabetes Mellitus, Type 2 (3) · Endometriosis (3) · HIV Infections (3) · Hyperandrogenism (3) · Non-alcoholic Fatty Liver Disease (3) · Obesity (3) · Overweight (3) · Acquired Immunodeficiency Syndrome (2) · Anorexia Nervosa (2) · Bipolar Disorder (2)
Bayer (14) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (9) · Pfizer (7) · Organon and Co (6) · Janssen Research & Development, LLC (5) · Laboratorios Andromaco S.A. (5) · Nobelpharma (4) · Novo Nordisk A/S (4) · Teva Pharmaceuticals USA (4) · AstraZeneca (3) · Bristol-Myers Squibb (3) · Chulalongkorn University (3) · Massachusetts General Hospital (3) · Warner Chilcott (3) · Wyeth is now a wholly owned subsidiary of Pfizer (3)
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