32 completed, 2 terminated, 2 unknown, 2 withdrawn. 10 Not applicable, 8 Phase 2, 8 Phase 3, 5 Phase 1, 5 Phase 4.
Follow Hypericum extract LI 160: new trials by email Literature Review of Hypericum extract LI 160 trials Research Report on Hypericum extract LI 160
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| St. John's Wort Oil for Wound Healing and Pain After Cesarean Section Caesarean section scar dressing with St. John's wort oil - Wound Healing, Caesarean Section | Not applicable | Recruiting | Sakarya University | 80 | 2025-06-25 | 2025-06-10 |
| Comparison of Hypericum Perforatum, Topical Corticosteroids, and Hyaluronic Acid for Recurrent Aphthous Stomatitis Kenacort A Orabase® pomad , Bristol-Myers Squibb İlaçları Inc. İstanbul , Türkiye, Hyaluronic acid, Aftamed ® Oral jel , AktiFarma . İstanbul, Türkiye, Hypericum perforatum (St. John's wort oil, Zade Vital; Health&Fitness, Developed With Ege Üniversiesi Argefar) - Stomatitis, Aphthous | Not applicable | Completed | Batman University | 75 | 2025-02-01 | 2026-07-08 |
| Effect of St. John's Wort Oil on Skin Moisture in Intensive Care Patients St. John's wort oil, Barrier Cream - Skin Moisture | Not applicable | Completed | Eskisehir Osmangazi University | 140 | 2023-09-01 | 2024-08-09 |
| The Use of St. John's Wort Oil With Massage in the Perineum During Childbirth perineal massage with St. John's Wort oil - Perineal Injury | Not applicable | Unknown | Ankara City Hospital Bilkent | 60 | 2023-05-15 | 2024-07-31 |
| St. John's Wort Oil Versus Chlorhexidine Mouthwash for Gingival Problems After Rapid Maxillary Expansion St. John's Wort Oil, Chlorhexidine - Gingivitis, Maxillary Transversal Deficiency | Not applicable | Completed | Yuzuncu Yil University | 60 | 2019-06-10 | 2026-10-20 |
| Rivaroxaban Hypericum Trial St Johns Wort Extract, Rivaroxaban - Drug Interaction Study | Phase 1 | Completed | Insel Gruppe AG, University Hospital Bern | 12 | 2019-02-13 | 2020-11-03 |
| Effects of Hypericum Perforatum Oil on Promoting Skin Recovery in Different Human Skin Damage Models Hypericum perforatum oil, Placebo, SLS induced irritation - Skin Recovery in Different Human Skin Damage Models | Not applicable | Completed | University of Split, School of Medicine | 28 | 2019-02-04 | 2020-02-21 |
| Effect of St. John's Wort and Olive Oils on the Postoperative Complications Chlorhexidine Gluconate 0.12 % Mouthwash + benzydamine hydrochloride, St. John's wort oil, Virgin olive oil - Impacted Third Molar Tooth | Phase 4 | Completed | Yuzuncu Yil University | 90 | 2018-08-15 | 2021-11-01 |
| Pilot Study on Intra-abdominal Photodynamic Diagnosis in Peritoneal Carcinosis St. John's Wort, Photodynamic diagnostic and therapy - Peritoneal Carcinomatosis | Phase 3 | Unknown | University Hospital Tuebingen | 50 | 2017-07-31 | 2017-10-27 |
| The Acute Effect of Hypericum Perforatum on Short-Term Memory in Healthy Adults Hypericum perforatum extract - Subclinical Anxious Adults, Nootropic Potential of Hypericum and Alprazolam | Phase 4 | Completed | Prof. Eldad Yechiam | 104 | 2017-02-21 | 2018-09-14 |
| Pilot Pharmacokinetic Study of a Prolonged-release Formulation of St. John's Wort Extract Ze 117 St. John's wort prolonged-release tablet 500 mg, St. John's wort film coated tablets 250 mg - Healthy | Phase 1 | Completed | Max Zeller Soehne AG | 10 | 2015-11-01 | 2017-01-31 |
| Does the Natural Medicinal Plant St John's Wort Affect the Glucose Tolerance in Healthy Individuals St John's wort - Type 2 Diabetes | Phase 1 | Completed | University of Southern Denmark | 10 | 2013-09-01 | 2015-02-13 |
| Interaction Between St John's Wort and Metformin? St John's Wort, Metformin - Type 2 Diabetes, Depression | Phase 1 | Completed | University of Southern Denmark | 20 | 2013-01-01 | 2014-12-03 |
| Boceprevir and Ucalm (St John&Apos;s Wort) Boceprevir, St John's Wort - Hepatitis C | Phase 1 | Completed | St Stephens Aids Trust | 17 | 2012-08-01 | 2014-09-29 |
| Pharmacodynamic Study on Efficacy of Clopidogrel With St. John's Wort Placebo, St. Johns Wort - Acute Coronary Syndrome | Not applicable | Withdrawn | Lancaster General Hospital | 2011-04-01 | 2017-10-05 | |
| Influence of Cytochrome CYP3A4-induction by St. John's Wort on the Steady State Pharmacokinetics of Ambrisentan St. Johns wort - Drug Interactions | Completed | Gerd Mikus | 20 | 2011-03-01 | 2017-05-31 | |
| Influence of CYP3A4-induction by St. John's Wort on the Steady State Pharmacokinetics of Bosentan St. Johns Wort - Drug Interactions | Completed | Gerd Mikus | 13 | 2011-01-01 | 2017-05-31 | |
| St. John's Wort And Kava In The Treatment Of Major Depressive Disorder With Comorbid Anxiety Herbal medicine (St. John's wort and Kava) - Depressive Disorder, Major, Anxiety Disorders | Phase 2 | Completed | The University of Queensland | 50 | 2007-03-01 | 2008-05-19 |
| St. John's Wort in the Treatment of Raynaud's Phenomenon St. John's Wort, Lactose - Raynaud's Disease | Phase 3 | Completed | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 20 | 2007-03-01 | 2009-07-14 |
| St. John's Wort in Relieving Hot Flashes in Postmenopausal Women With Non-Metastatic Breast Cancer St. John's Wort - Breast Cancer, Hot Flashes | Phase 2 | Terminated | Wake Forest University Health Sciences | 9 | 2006-03-16 | 2021-09-29 |
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Depression (5) · Anxiety Disorders (4) · Pain (4) · Depressive Disorder, Major (3) · Psychological Well-Being (3) · Breast Neoplasms (2) · Diabetes Mellitus, Type 2 (2) · Phobia, Social (2) · Acute Coronary Syndrome (1) · Agnosia (1) · Attention Deficit Disorder with Hyperactivity (1) · Blast Crisis (1) · Brain Diseases (1) · Breast Carcinoma In Situ (1) · Burkitt Lymphoma (1)
National Center for Complementary and Integrative Health (NCCIH) (6) · Gerd Mikus (2) · Mayo Clinic (2) · National Institute of Mental Health (NIMH) (2) · University of Southern Denmark (2) · Wake Forest University Health Sciences (2) · Yuzuncu Yil University (2) · Alliance for Clinical Trials in Oncology (1) · Ankara City Hospital Bilkent (1) · Batman University (1) · Cassella-med GmbH & Co. KG (1) · Ceres Heilmittel AG (1) · Eskisehir Osmangazi University (1) · Insel Gruppe AG, University Hospital Bern (1) · Lancaster General Hospital (1)
United States (17) · Turkey (Türkiye) (6) · Germany (4) · Denmark (2) · Switzerland (2) · Australia (1) · Canada (1) · Croatia (1) · France (1) · Israel (1) · United Kingdom (1)
Gerd Mikus, Prof. Dr. (2) · Kenneth Kobak, PhD (2) · Amit Sood, M.D., MSc (1) · Andrew A. Nierenberg, M.D. (1) · Antonius A. Miller, MD (1) · Danny D. Shen, Ph.D. (1) · Dario Leskur, MPharm (1) · David J. Straus, MD (1) · Edward G. Shaw, MD (1) · Eldad Yechiam, PhD (1)
PMID 10853874, PMID 11939866, PMID 15876903, PMID 18544723, PMID 20590478, PMID 22053942, PMID 22592504, PMID 24232445, PMID 24610312, PMID 25544195, PMID 30382352, PMID 32686217, PMID 32959922, PMID 36999619, PMID 37230961
U10CA081851 (2), R01MH061394 (1), R01MH061757 (1), R01MH061758 (1), R21AT002297 (1)