30 recruiting, 24 unknown, 23 completed, 8 not yet recruiting. 58 Not applicable, 3 Phase 1, 3 Phase 2, 2 Phase 3, 2 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Coordinated Reset Deep Brain Stimulation for Parkinson's Disease DBS - Parkinson's Disease (PD), Deep Brain Stimulation | Phase 1 | Not yet recruiting | University of Minnesota | 24 | 2026-12-01 | 2026-10-13 |
| A Phase 1 Study of NCR201 in Parkinson's Disease Patients With Prior DBS NCR201 - PARKINSON DISEASE (Disorder), Cell Therapy | Phase 1 | Not yet recruiting | Nuwacell Biotechnologies Co., Ltd. | 12 | 2026-11-01 | 2026-10-26 |
| Quantifying Motor Network Dynamics to Predict and Enhance Outcomes in Pediatric Dystonia DBS - Dystonia, Pediatric | Not applicable | Recruiting | Children's Hospital Medical Center, Cincinnati | 75 | 2026-09-01 | 2026-10-20 |
| Investigating the Increased Risk of Falls in Individuals With Parkinson's Disease Treated With Deep Brain Stimulation DBS as part of standard of care - Deep Brain Stimulation, PARKINSON DISEASE (Disorder) | Not applicable | Recruiting | University of Alabama at Birmingham | 20 | 2026-08-01 | 2026-10-26 |
| Neural Mechanisms of Aerobic Exercise Benefits in PD With DBS Exercise - Parkinson's Disease, Deep Brain Stimulation | Phase 2 | Recruiting | The Cleveland Clinic | 36 | 2026-07-08 | 2026-10-26 |
| Safety and Tolerability of Patterned Stimulation for DBS in the Home Setting Biphasic deep brain stimulation, Conventional deep brain stimulation, Theta burst deep brain stimulation - Parkinson Disease, Deep Brain Stimulation | Not applicable | Recruiting | University of Florida | 60 | 2026-05-06 | 2026-07-06 |
| Comparing Biomarker-Guided DBS Programming With Standard Clinical Monopolar Programming Conventional DBS Programming (Monopolar Review), Objective-Guided DBS Programming (Imaging and Local Field Potential-Based) - Parkinson's Disease, Parkinson | Not applicable | Not yet recruiting | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 20 | 2026-03-01 | 2026-01-27 |
| Predictors of Clinical Outcomes of Deep Brain Stimulation in Parkinson's Disease DBS - Deep Brain Stimulation, PARKINSON DISEASE (Disorder) | Recruiting | Hong Kong University of Science and Technology | 30 | 2026-02-05 | 2026-02-24 | |
| Adaptive vs. Continuous Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease Adaptive DBS, Continue DBS - Deep Brain Stimulation, Parkinson Disease | Not applicable | Recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 130 | 2026-01-27 | 2026-01-29 |
| A Study of Buntanetap in Participants With PD buntanetap/posiphen - Parkinson's Disease (PD), Deep Brain Stimulation | Phase 2 / Phase 3 | Recruiting | Annovis Bio Inc. | 500 | 2026-01-09 | 2026-09-21 |
| LIFUS For Neurological Disorders LIFUS, Sham LIFUS - Parkinson's Disease (PD), Essential Tremor | Not applicable | Recruiting | University Health Network, Toronto | 50 | 2025-12-02 | 2026-08-13 |
| Testing of an Interface for Synchronizing tACS-DBS With a Phase-locked-loop DBS-coupled tACS - Deep Brain Stimulation, Parkinson's Disease (PD) | Not applicable | Completed | Universitätsklinikum Hamburg-Eppendorf | 2 | 2025-09-30 | 2026-06-30 |
| Effect of Mediterranean Diet on Nutrition in Parkinson's Disease Patients With Bilateral Subthalamic Deep Brain Stimulation Mediterranean diet - Parkinson Disease, Deep Brain Stimulation | Not applicable | Recruiting | Ankara University | 24 | 2025-09-25 | 2025-12-03 |
| Revision of Deep Brain Stimulator in Patients With Parkinson's Disease Patients who underwent surgery under general anesthesia, Patients who underwent surgery under regional anesthesia - Pain Management, Regional Anesthesia | Not applicable | Recruiting | Ankara Etlik City Hospital | 50 | 2025-09-20 | 2025-12-10 |
| Consensus Statements on Deep Brain Stimulation in Patients With Parkinson's Disease Delphi study - Deep Brain Stimulation, Parkinson Disease | Not yet recruiting | University Magna Graecia | 30 | 2025-09-15 | 2025-09-23 | |
| VC/VS for Apathy in PD Deep Brain Stimulation - Parkinson Disease, Deep Brain Stimulation | Not applicable | Not yet recruiting | Nora Vanegas | 5 | 2025-09-01 | 2025-05-31 |
| Cognitive Decline Following Deep Brain Stimulation: A DBS-fMRI Study DBS combined with fMRI - Deep Brain Stimulation, Parkinson Disease | Recruiting | Medical University of South Carolina | 55 | 2025-08-21 | 2026-10-08 | |
| EEG Measurements to Capture DBS-induced Electric Potentials EEG recording - Deep Brain Stimulation, Parkinson's Disease | Recruiting | Universitätsklinikum Hamburg-Eppendorf | 20 | 2025-07-11 | 2025-08-21 | |
| One-Year Effect on Levodopa Equivalent Daily Dose of Thalamic VIM Nucleus Stimulation Compared to Subthalamic Nucleus Stimulation in Patients With Parkinson's Disease Parkinson Disease (PD), Deep Brain Stimulation | Not yet recruiting | Central Hospital, Nancy, France | 94 | 2025-04-30 | 2025-04-25 | |
| Imaging Biomarkers of FOG Response to DBS fMRI - Freezing of Gait Symptoms in Parkinson's Disease, Deep Brain Stimulation | Phase 4 | Recruiting | Medical University of South Carolina | 54 | 2024-11-11 | 2026-08-10 |
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Parkinson Disease (57) · Essential Tremor (9) · Dystonia (6) · Emergence Delirium (4) · Movement Disorders (4) · Alzheimer Disease (3) · Gait Disorders, Neurologic (3) · Lethargy (3) · Obsessive-Compulsive Disorder (3) · Tourette Syndrome (3) · Alcoholism (2) · Chorea (2) · Cognitive Dysfunction (2) · Drug Resistant Epilepsy (2) · Dyskinesias (2)
Nervous System Diseases (78) · Central Nervous System Diseases (75) · Brain Diseases (68) · Neurodegenerative Diseases (65) · Movement Disorders (64) · Basal Ganglia Diseases (61) · Synucleinopathies (57) · Parkinsonian Disorders (55) · Pathological Conditions, Signs and Symptoms (28) · Signs and Symptoms (27) · Neurologic Manifestations (26) · Mental Disorders (20) · Dyskinesias (9) · Neurobehavioral Manifestations (9) · Neurocognitive Disorders (8)
Deep Brain Stimulation (12) · Saline Solution (3) · Dexmedetomidine (2) · Amyloid beta-Protein Precursor (1) · Anesthesia, General (1) · Conscious Sedation (1) · Diagnostic Imaging (1) · Diet, Mediterranean (1) · Esketamine (1) · Exercise (1) · Ketamine (1) · Magnetic Resonance Imaging (1) · Magnetoencephalography (1) · Memantine (1) · Microscopy, Fluorescence, Multiphoton (1)
Beijing Tiantan Hospital (7) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (5) · Ruijin Hospital (4) · University of British Columbia (4) · University of Minnesota (4) · Chinese PLA General Hospital (2) · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (2) · Jay Alberts (2) · Medical University of South Carolina (2) · Oregon Health and Science University (2) · Shanghai Mental Health Center (2) · Surgical Information Sciences Inc. (2) · The Cleveland Clinic (2) · University Health Network, Toronto (2) · University of California, Los Angeles (2)
United States (32) · China (24) · Germany (7) · Canada (6) · France (5) · Netherlands (5) · Spain (4) · Israel (2) · Italy (2) · Switzerland (2) · Taiwan (2) · Turkey (Türkiye) (2) · United Kingdom (2) · Austria (1) · Belgium (1)
Bomin Sun, PhD (2) · Jianguo Zhang, M.D., Ph.D. (2) · Min Zhao (2) · Andres M Lozano, MD, PhD (1) · Bettina C. Schwab, PhD (1) · Bhavana Patel, DO (1) · Bruno Ferraro, MD (1) · Carmela Tartaglia, MD (1) · Christopher R Honey, MD, DPhil (1) · Cletus Cheyuo, MD, PhD (1) · Cunming Liu (1) · Daniel Lench, PhD (1) · Darlene Lobel, MD (1) · Eero Pekkonen, M.D-, Ph.D. (1)
PMID 11391740, PMID 15097290, PMID 16107348, PMID 17151341, PMID 19452239, PMID 19633906, PMID 19940187, PMID 20926368, PMID 21384292, PMID 24112892, PMID 28304188, PMID 29274834, PMID 33862624, PMID 34924027, PMID 37253497, PMID 37433729, PMID 38251897, PMID 39384245, PMID 40877314, PMID 41109904, PMID 41189627, PMID 41253805, PMID 41923626, PMID 42102350, PMID 42239677, PMID 42363278, PMID 42472285
2019 (1), 2023 (1), K23NS149280 (1), K99NS131447 (1), R00NS131447 (1), R01AG073480 (1), R01AG092298 (1), R01NS109487 (1), R01NS131396 (1), R37NS116079 (1)