140 completed, 31 unknown, 26 recruiting, 17 terminated. 98 Not applicable, 45 Phase 2, 21 Phase 3, 15 Phase 1, 9 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Transcranial Ultrasound Stimulation for Tourette Syndrome Focused ultrasound stimulation, Sham stimulation - Tourette Syndrome | Phase 1 | Not yet recruiting | University of Calgary | 20 | 2026-08-01 | 2026-07-13 |
| Integrating Exposure and Response Prevention and Habit Reversal Techniques to Treat a Tourettic Subtype of Obsessive-Compulsive Disorder (Tourettic OCD) Exposure and Response Prevention (ERP), Habit Reversal Training (HbRT, Psychoeducation and Supportive Intervention - Obsessive - Compulsive Disorder, Tic Disorder, Chronic Motor or Vocal | Not applicable | Recruiting | University College London Hospitals | 40 | 2026-07-08 | 2026-07-27 |
| SCI-110 in the Treatment of Tourette Syndrome SCI-110, Placebo - Tourette Syndrome | Phase 2 | Not yet recruiting | Neurothera Labs Inc. | 164 | 2026-06-01 | 2026-04-21 |
| Characterising Sleep Disorders in Children With Tourette Syndrome Tourette Syndrome | Not yet recruiting | Steffi Baker | 34 | 2026-03-01 | 2026-03-04 | |
| Where Wild Things Grow: Nature- and Activity-based Group Interventions for Neurodivergent Children and Youth Universal approach, Selective approach, Outdoor therapy - Neurodevelopmental Outcomes, ADHD - Attention Deficit Disorder With Hyperactivity | Not applicable | Recruiting | Sorlandet Hospital HF | 240 | 2025-09-01 | 2025-10-02 |
| Cognitive-psychophysiological Treatment for Tics in Young People With Tourette's Syndrome With or Without Biofeedback Cognitive psychophysiological, Cognitive psychophysiological and Biofeedback - Tourette Syndrome, Tics | Not applicable | Recruiting | Université du Québec a Montréal | 150 | 2025-04-15 | 2025-07-08 |
| Trajectories of Change in Tourette Syndrome Comprehensive Behavioral Intervention for Tics - Tourette Syndrome, Tic Disorders | Not applicable | Recruiting | University of Minnesota | 30 | 2025-03-31 | 2026-07-17 |
| Sensorimotor Integration in Patients With Tourette Syndrome Tourette Disorder, Sensory Gating | Completed | I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio | 60 | 2025-03-20 | 2025-12-18 | |
| CBIT+TMS R33 Phase CBIT +cTBS, CBIT +sham cTBS - Tics, Tourette Syndrome | Phase 2 | Recruiting | University of Minnesota | 60 | 2025-02-27 | 2026-05-20 |
| Multimodal Electrophysiological Study of Cortico-subcortical Biomarkers of Tics in Tourette Syndrome Multimodal electrophysiological recordings - Tourette Syndrome | Not applicable | Recruiting | University Hospital, Bordeaux | 10 | 2025-02-17 | 2025-04-03 |
| Investigating Changes in Premonitory Urges During Habit Reversal Training for Tics Habit Reversal Training - Tics, Tourette Disorder | Not applicable | Recruiting | University of Utah | 6 | 2025-02-11 | 2025-05-28 |
| Effect of RNS in Treatment-refractory Tourette's Syndrome Responsive Neurostimulation (RNS) - Tourette Syndrome | Not applicable | Recruiting | Xuanwu Hospital, Beijing | 10 | 2025-02-05 | 2025-01-21 |
| Sensorimotor and Psychosocial Trajectories in Adolescents With Tic Disorder This study involves no intervention. - Tourette Syndrome, Tic Disorder | Recruiting | Vanderbilt University Medical Center | 351 | 2024-10-24 | 2025-11-24 | |
| Multitarget Stereotactic Electrophysiological Recording and Stimulation for Tourette Syndrome New Target DBS, CM-DBS, Sham Stimulation - Tourette Syndrome, Deep Brain Stimulation | Not applicable | Recruiting | Beijing Tiantan Hospital | 5 | 2024-10-01 | 2025-05-22 |
| Effectiveness of Symptom Management Application on Parental Care Ability of Children With Tourette Syndrome Symptom Management APP group, health education instructions group - Tourette Syndrome, Tic Disorder | Not applicable | Unknown | National Taipei University of Nursing and Health Sciences | 180 | 2024-09-25 | 2024-10-03 |
| Serotonin Control of Impulsivity in Tourette Disorder Administration of a PET radiotracer - Tourette Disorder | Phase 2 | Recruiting | Hospices Civils de Lyon | 25 | 2024-09-24 | 2024-12-04 |
| Sertraline vs. Placebo in the Treatment of Anxiety in Children and AdoLescents With NeurodevelopMental Disorders Sertraline, Placebo - Neurodevelopmental Disorders, Autism | Phase 2 | Recruiting | Holland Bloorview Kids Rehabilitation Hospital | 130 | 2024-09-16 | 2026-07-27 |
| Efficacy and Safety of Gemlapodect (NOE-105) in Adults and Adolescents With Tourette Syndrome Gemlapodect, Placebo - Tourette Syndrome | Phase 2 | Active not recruiting | Noema Pharma AG | 164 | 2024-09-10 | 2026-03-09 |
| A Multicenter Pediatric Deep Brain Stimulation Registry Dystonia, Epilepsy in Children | Recruiting | Boston Children's Hospital | 100 | 2024-07-30 | 2026-03-18 | |
| Remote Delivery of a Mindfulness-based Intervention for Tics mindfulness-based intervention for tics (MBIT), psychoeducation with relaxation and supportive therapy (PRST) - Tourette Syndrome, Tourette's Disorder | Not applicable | Recruiting | Johns Hopkins University | 150 | 2024-05-23 | 2026-05-11 |
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Aripiprazole (10) · valbenazine (8) · Deep Brain Stimulation (6) · Transcranial Magnetic Stimulation (6) · ecopipam (5) · deutetrabenazine (4) · Behavior Therapy (3) · Palliative Care (3) · ABX-1431 (2) · Biofeedback, Psychology (2) · Cycloserine (2) · Demography (2) · Dronabinol (2) · Electroencephalography (2) · Guanfacine (2)
National Institute of Neurological Disorders and Stroke (NINDS) (12) · Johns Hopkins University (9) · Neurocrine Biosciences (8) · University of Florida (8) · Yale University (8) · Emalex Biosciences Inc. (6) · Otsuka Pharmaceutical Development & Commercialization, Inc. (6) · Vanderbilt University Medical Center (6) · National Center for Research Resources (NCRR) (5) · National Institute of Mental Health (NIMH) (5) · University of Minnesota (5) · University of Utah (5) · Children's Hospital Medical Center, Cincinnati (4) · Karolinska Institutet (4) · Massachusetts General Hospital (4)
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Eva Kohegyi, MD (5) · David A Isaacs, MD, MPH (3) · Emily J Ricketts, PhD (3) · Joseph F McGuire, PhD (3) · Michael H. Bloch, MD, MS (3) · Michael Okun, MD (3) · Shannon Bennett, PhD (3) · Barbara J Coffey, MD, MS (2) · Christine Conelea, PhD (2) · David Isaacs, MD, MPH (2) · Donald Gilbert, MD (2)
PMID 20483969, PMID 22868933, PMID 24001701, PMID 24144615, PMID 25988365, PMID 26763495, PMID 28202705, PMID 29029679, PMID 11202129, PMID 11235929, PMID 11530448, PMID 11886028, PMID 12541004, PMID 12723873, PMID 12874491, PMID 14980369, PMID 15107196, PMID 15965209, PMID 16259942, PMID 16387997, PMID 16393016, PMID 16554257, PMID 16970874, PMID 18307557, PMID 18348596, PMID 18625864, PMID 18696285, PMID 19170198, PMID 19242384, PMID 19284553, PMID 19864199, PMID 19913651, PMID 20331933, PMID 20579510, PMID 20841416, PMID 20885982, PMID 21445724, PMID 21555779, PMID 22585765, PMID 22741094, PMID 23044532, PMID 23538086, PMID 23572168, PMID 23731910, PMID 24021518, PMID 24832397, PMID 24856571, PMID 24906033, PMID 25325069, PMID 25546850
2016 (3), 2023 (3), 2017 (2), 2018 (2), UL1TR002345 (2), 2008 (1), 2019 (1), F31MH096375 (1), K23MH113884 (1), K24MH087913 (1), P50MH077248 (1), R01AT012455 (1), R01MH045358 (1), R01MH045802 (1), R01MH069877 (1)