8 completed, 4 recruiting, 1 terminated, 1 unknown. 14 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 14 | Completed 8, Recruiting 4, Terminated 1, Unknown 1 |
Follow Death, Sudden: new trials by email Literature Review of Death, Sudden trials Research Report on Death, Sudden
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The FINTEPLA as an Anti-SUDEP Therapy in Dravet Syndrome Project Fenfluramine treatment (Fintepla), Hypercapnia Challenge using the device (RespirAct) - Dravet Syndrome | Phase 4 | Recruiting | The University of Texas Health Science Center, Houston | 25 | 2026-04-27 | 2026-07-15 |
| Comparative Effectiveness of Carvedilol Versus Metoprolol Succinate in Heart Failure Patients With an Implantable Cardioverter Defibrillator Metoprolol Succinate, Carvedilol - Heart Failure With Reduced Ejection Fraction (HFrEF), Sudden Cardiac Death | Phase 4 | Recruiting | University of Rochester | 2000 | 2025-08-17 | 2025-09-18 |
| Epinephrine Dose: Optimal Versus Standard Evaluation Trial Epinephrine - Cardiac Arrest, Out-Of-Hospital, Sudden Cardiac Arrest | Phase 4 | Recruiting | Unity Health Toronto | 1250 | 2023-05-24 | 2026-10-02 |
| Implantable Cardioverter Defibrillator Versus Optimal Medical Therapy In Patients With Variant Angina Manifesting as Aborted Sudden Cardiac Death Implantable Cardioverter Defibrillator, Optimal Medical Therapy - Angina Pectoris, Variant, Sudden Cardiac Death | Phase 4 | Recruiting | Kee-joon Choi | 140 | 2016-11-29 | 2026-06-25 |
| Sodium Bicarbonate in Cardiopulmonary Resuscitation sodium bicarbonate - Sudden Cardiac Arrest | Phase 4 | Unknown | Rambam Health Care Campus | 2130 | 2011-12-01 | 2011-11-08 |
| COOL-Trial: Outcome With Invasive and Non-invasive Cooling After Cardiac Arrest Coolgard, ArcticSun, Conventional treatment - Cardiac Arrest, Hypothermia | Phase 4 | Completed | University of Leipzig | 120 | 2008-04-01 | 2010-02-02 |
| Survival of Patients With Primary Prophylactic ICD Indication Intensified diagnostic and treatment measures following 1st appropriate ICD therapy, Standard follow-up - Primary Prevention, Tachycardia, Ventricular | Phase 4 | Completed | Biotronik SE & Co. KG | 504 | 2008-02-01 | 2015-01-12 |
| 'Effect of CRT on Defibrillation Threshold Estimates' Study Cardiac Resynchronization Therapy - Defibrillator (CRT-D) - Sudden Cardiac Death | Phase 4 | Completed | Abbott Medical Devices | 77 | 2008-01-01 | 2019-02-05 |
| Safety and Clinical Outcomes in Hunter Syndrome Patients 5 Years of Age and Younger Receiving Idursulfase Therapy Idursulfase - Hunter Syndrome, Mucopolysaccharidosis II | Phase 4 | Completed | Shire | 28 | 2007-12-31 | 2021-06-08 |
| Predictive Risk Stratification Through T Variability in ICD Patients Without Pacing Indications Ovatio VR 6250 or DR6550 - Sudden Cardiac Death | Phase 4 | Completed | LivaNova | 198 | 2007-12-01 | 2015-01-12 |
| Pharmacokinetics of Retapamulin in Pediatric Subjects With Uncomplicated Skin Infections. Retapamulin Ointment, 1% - Skin Infections, Bacterial | Phase 4 | Completed | GlaxoSmithKline | 60 | 2007-09-01 | 2016-12-28 |
| POWER (Pulse Width Optimized Waveform Evaluation Trial) Implantable Cardioverter Defibrillator (ICD), Cardiac Resynchronization Therapy (CRT-D) - Sudden Cardiac Death | Phase 4 | Completed | Abbott Medical Devices | 217 | 2006-08-01 | 2019-02-20 |
| CORE: Study to Evaluate the Conducted AF-Response-Algorithm in Patients Suffering From Heart Failure and Atrial Fibrillation Conducted AF-Response Algorithm (CAFR) On, Conducted AF-Response Algorithm (CAFR) Off - Heart Failure, Sudden Cardiac Death | Phase 4 | Terminated | Medtronic Cardiac Rhythm and Heart Failure | 100 | 2003-12-01 | 2025-07-03 |
| Protective Effect of EPA on Cardiovascular Events Eicosapentaenoic acid ethyl ester(EPADEL Capsule 300 TM) - Myocardial Infarction, Unstable Angina Pectoris, Sudden Cardiac Death, Stroke, Peripheral Artery Disease | Phase 4 | Completed | Kobe University | 18000 | 1996-11-01 | 2015-11-20 |
Death, Sudden, Cardiac (11) · Heart Failure (3) · Heart Arrest (2) · Sudden Infant Death (2) · Ventricular Fibrillation (2) · Angina Pectoris, Variant (1) · Angina, Unstable (1) · Arrhythmias, Cardiac (1) · Atrial Fibrillation (1) · Cardiomyopathies (1) · Cellulitis (1) · Coronary Artery Disease (1) · Epilepsies, Myoclonic (1) · Epilepsy (1) · Hypothermia (1)
Death (14) · Pathologic Processes (14) · Pathological Conditions, Signs and Symptoms (14) · Cardiovascular Diseases (11) · Heart Diseases (11) · Heart Arrest (9) · Nervous System Diseases (4) · Arrhythmias, Cardiac (3) · Neurologic Manifestations (3) · Signs and Symptoms (3) · Angina Pectoris (2) · Brain Diseases (2) · Central Nervous System Diseases (2) · Chest Pain (2)
Defibrillators, Implantable (2) · Cardiac Resynchronization Therapy (1) · Carvedilol (1) · Epinephrine (1) · Fenfluramine (1) · Metoprolol (1) · Sodium Bicarbonate (1) · idursulfase (1)
Abbott Medical Devices (2) · Biotronik SE & Co. KG (1) · GlaxoSmithKline (1) · Kee-joon Choi (1) · Kobe University (1) · LivaNova (1) · Medtronic Cardiac Rhythm and Heart Failure (1) · Rambam Health Care Campus (1) · Shire (1) · The University of Texas Health Science Center, Houston (1) · Unity Health Toronto (1) · University of Leipzig (1) · University of Rochester (1)
United States (6) · Germany (5) · Canada (2) · Israel (2) · Poland (2) · Spain (2) · Taiwan (2) · Argentina (1) · Austria (1) · Brazil (1) · Chile (1) · Costa Rica (1) · Czechia (1) · Hungary (1) · Japan (1)
Amir Hedayati, MD (1) · Christian Perings, MD (1) · Gad Bar-Joseph (1) · Holger Thiele, Associate Professor (1) · Michael Gold, MD, PhD (1) · Mitsuhiro Yokoyama, MD, PhD. (1) · Paul Dorian, MD, MSc (1) · Robert Hatala, Prof. MUDr. (1) · Samden Lhatoo, MD, FRCP (1) · Shephal Doshi, MD (1) · Steve Lin, MD, MSc (1) · Undine Pittl, MD (1)
PMID 17398308, PMID 18451347, PMID 18667204, PMID 19423946, PMID 19447387, PMID 20145342, PMID 20484828, PMID 21315841, PMID 25902842