Death, Sudden: Clinical Trials

259 completed, 92 unknown, 73 recruiting, 32 terminated. 150 Not applicable, 41 Phase 3, 31 Phase 2, 17 Phase 1, 14 Phase 4.

By phase and status

Phase	Trials	Status
Not applicable	150	Completed 82, Recruiting 22, Unknown 18, Terminated 11, Not yet recruiting 8, Active not recruiting 4, Withdrawn 4, Enrolling by invitation 1
Phase 3	41	Completed 28, Active not recruiting 4, Terminated 4, Unknown 3, Enrolling by invitation 1, Recruiting 1
Phase 2	31	Completed 14, Active not recruiting 5, Terminated 5, Recruiting 3, Withdrawn 2, Enrolling by invitation 1, Unknown 1
Phase 1	17	Completed 10, Active not recruiting 2, Recruiting 2, Terminated 2, Withdrawn 1
Phase 4	14	Completed 8, Recruiting 4, Terminated 1, Unknown 1
Early Phase 1	1	Recruiting 1

Follow Death, Sudden: new trials by email Literature Review of Death, Sudden trials Research Report on Death, Sudden

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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Cardiovascular Pre-participation Screening in Children and Adolescents Pre-participation clinical evaluation, Diagnostic Test: Resting 12-lead electrocardiogram, Diagnostic Test: Step test (Harvard step test) - Sudden Cardiac Death, Cardiac Arrhythmias		Not yet recruiting	University of Sao Paulo	334	2027-02-01	2026-10-15
Social Media and Risk-reduction Training for Preterm Infant Care Practices Safe Sleep NICU Quality Improvement Campaign, Shared Reading NICU Quality Improvement Campaign, Safe Sleep TodaysNICUBaby videos and messages - Safe Sleep Education, SUID	Not applicable	Not yet recruiting	University of Massachusetts, Worcester	1600	2027-01-01	2026-05-13
Intracranial CArtography of Cortical Contribution to Respiratory Load Compensation in Epilepsy SEEG monitoring, Comprehensive respiratory monitoring, Cardio-respiratory monitoring - Epilepsy, SUDEP	Not applicable	Recruiting	Hospices Civils de Lyon	20	2026-09-17	2026-09-23
Study of the Link Between Structural Alterations in the Hypothalamus and Cardiac Dysautonomia in Drug-resistant Epilepsy MRI scan, electrocardiogram - Epilepsy, Hypothalamus	Not applicable	Recruiting	Centre Hospitalier Universitaire, Amiens	20	2026-09-10	2026-10-22
Supply Induced Demand in Intensive Care Unit: a Retrospective Trial Intensive Care (ICU), Intensive Care Unit (ICU) Admission		Not yet recruiting	Saint Camillus International University of Health Sciences	1500	2026-08-20	2026-08-17
Cor360: Clinician-Facing Broad-Spectrum Cardiac Phenotyping and Risk Assessment Using COR® Wearable ECG to Inform Outcomes-Oriented Care Pathways COR Wearable ECG Monitoring, Cor360 Clinician-Facing Decision-Aid Reporting - Cardiovascular Diseases, Cardiovascular Diseases Risk		Enrolling by invitation	Peerbridge Health, Inc	1000	2026-08-20	2026-08-21
Infant Safe Sleep in Pediatric Emergency Depratment Safe Sleep Education, Behavior habit tracking - Infant Safe Sleep Practices, SIDS	Not applicable	Not yet recruiting	State University of New York at Buffalo	214	2026-08-17	2026-08-21
Mitral Valve Prolapse Arrhythmic Risk Risk prediction model - Mitral Valve Prolapse, Ventricular Arrhythmias and Cardiac Arrest		Recruiting	Oslo University Hospital	500	2026-08-07	2026-09-29
AI-guided Prediction and Treatment of Cardiac Arrest Machine learning-guided cardiac arrest prediction device - Sudden Cardiac Arrest	Not applicable	Not yet recruiting	MetroHealth Medical Center	68	2026-08-01	2026-03-16
FEMART-1 Pilot Study Prehospital Ultrasound-Guided Femoral Arterial Sheath Placement - Sudden Cardiac Arrest, Out-of-hospital Cardiac Arrest (OHCA)	Not applicable	Recruiting	Emergency Medical Service, Prague	60	2026-05-11	2026-05-20
A PET-MRI Study of Serotoninergic Brainstem Pathway in Patients With Dravet Syndrome [18F]MPPF PET-MRI - Epilepsy, Dravet Syndrome	Not applicable	Recruiting	Hospices Civils de Lyon	30	2026-05-04	2026-05-08
The FINTEPLA as an Anti-SUDEP Therapy in Dravet Syndrome Project Fenfluramine treatment (Fintepla), Hypercapnia Challenge using the device (RespirAct) - Dravet Syndrome	Phase 4	Recruiting	The University of Texas Health Science Center, Houston	25	2026-04-27	2026-07-15
Digital MEDIcal TWIN for the Prediction of Arrhythmic Sudden Cardiac Death After a Myocardial Infarction Programmed ventricular stimulation, Cardiac CT scan - Sudden Cardiac Death, Myocardial Infarction	Not applicable	Not yet recruiting	University Hospital, Bordeaux	1000	2026-04-15	2026-04-14
Functional Substrate-Only Guided VT Ablation Functional Substrate-Only Mapping without VT Induction, Standard-of-Care Mapping/Imaging - Ventricular Tachycardia, Sudden Cardiac Death	Not applicable	Enrolling by invitation	VA Office of Research and Development	36	2026-03-18	2026-03-25
Skeletal Muscle Multi-omics Analysis and Risk Tailoring in Sudden Cardiac Death Sudden Cardiac Death		Not yet recruiting	China National Center for Cardiovascular Diseases	421	2026-03-16	2026-03-17
Dilated Cardiomyopathy - Unknown Therapeutic Risk Reduction by Contempary Medication and Implantable Cardioverter-Defibrillators (DUTCH-ICD) ICD implantation - Sudden Cardiac Death	Not applicable	Not yet recruiting	University Medical Center Groningen	720	2026-03-01	2026-02-17
PRE-hospital Cooling to improvE carDiac arrEst Neurological outComEs (PRECEDENCE) CarbonCool® Cooling Vest - Out-Of-Hospital Cardiac Arrest, Cardiopulmonary Resuscitation	Not applicable	Recruiting	Singapore General Hospital	50	2026-02-01	2026-04-29
Cardiac Magnetic Resonance - PROgnostic HEart Scar for Sudden Cardiac Death Prediction StudY Sudden Death, Cardiac, Myocardial Scarring		Recruiting	Beijing Anzhen Hospital	1000	2026-01-01	2025-08-22
Loop Recorder Implantation in Patients With Mitral Annular Disjunction loop recorder implantation - Mitral Annular Disjunction, Mitral Valve	Not applicable	Recruiting	Gottsegen National Cardiovascular Institute	20	2025-12-05	2026-03-02
RGX-121-3102 Gene Therapy in Participants With MPS II (Hunter Syndrome) RGX-121-3102 - MPS II, Hunter Syndrome (MPS II)	Phase 3	Active not recruiting	REGENXBIO Inc.	2	2025-11-25	2026-06-04

Showing 20 of 513. Sign in to see all of them.

Narrower conditions

Death, Sudden, Cardiac (363)  ·  Arrhythmias, Cardiac (79)  ·  Sudden Infant Death (79)  ·  Heart Failure (75)  ·  Tachycardia, Ventricular (61)  ·  Heart Arrest (60)  ·  Ventricular Fibrillation (56)  ·  Myocardial Infarction (53)  ·  Cardiovascular Diseases (47)  ·  Heart Diseases (34)  ·  Mucopolysaccharidosis II (33)  ·  Cardiomyopathies (30)  ·  Epilepsy (26)  ·  Sudden Unexpected Death in Epilepsy (23)

Broader conditions

Pathological Conditions, Signs and Symptoms (513)  ·  Pathologic Processes (510)  ·  Death (501)  ·  Heart Diseases (368)  ·  Cardiovascular Diseases (356)  ·  Heart Arrest (307)  ·  Nervous System Diseases (105)  ·  Congenital, Hereditary, and Neonatal Diseases and Abnormalities (99)  ·  Arrhythmias, Cardiac (95)  ·  Cardiac Conduction System Disease (87)  ·  Vascular Diseases (86)  ·  Infant Death (74)  ·  Genetic Diseases, Inborn (64)  ·  Neurologic Manifestations (64)

Interventions

Defibrillators, Implantable (23)  ·  Blood Specimen Collection (8)  ·  Standard of Care (7)  ·  idursulfase (7)  ·  Amiodarone (5)  ·  Surveys and Questionnaires (5)  ·  Cardiopulmonary Resuscitation (4)  ·  Defibrillators (4)  ·  Electrocardiography (4)  ·  Exercise Test (4)  ·  Domperidone (3)  ·  Echocardiography (3)  ·  Epinephrine (3)  ·  Genetic Testing (3)  ·  Sotalol (3)

Sponsors

National Heart, Lung, and Blood Institute (NHLBI) (18)  ·  Hospices Civils de Lyon (12)  ·  Johns Hopkins University (9)  ·  Abbott Medical Devices (8)  ·  University College, London (8)  ·  Shire (7)  ·  Zoll Medical Corporation (7)  ·  Assistance Publique - Hôpitaux de Paris (6)  ·  Boston Scientific Corporation (6)  ·  Medtronic Cardiac Rhythm and Heart Failure (6)  ·  REGENXBIO Inc. (6)  ·  University Hospital, Bordeaux (5)  ·  Biotronik SE & Co. KG (4)  ·  Centro Medico Teknon (4)  ·  Denali Therapeutics Inc. (4)

Countries

United States (181)  ·  France (61)  ·  Germany (53)  ·  Canada (44)  ·  United Kingdom (42)  ·  Italy (30)  ·  Spain (25)  ·  Netherlands (21)  ·  China (19)  ·  Brazil (17)  ·  Israel (14)  ·  Denmark (13)  ·  Poland (12)  ·  South Korea (11)  ·  Switzerland (11)

Top investigators

Rachel Y Moon, MD (4)  ·  Antonio Berruezo, MD, PhD (3)  ·  Derek V Exner, MD, MPH (3)  ·  Holger Thiele, Associate Professor (3)  ·  Jason D Roberts, MD MAS (3)  ·  Nikolaos Dagres, MD (3)  ·  Undine Pittl, MD (3)  ·  Alfred Hallstrom (2)  ·  Christian Meyer, MD (2)  ·  Christine M Albert, M.D., M.P.H. (2)  ·  Gerhard Hindricks, MD (2)  ·  Grzegorz Opolski, Professor (2)

Results publications

PMID 18565399, PMID 21087331, PMID 21403098, PMID 22267750, PMID 25589197, PMID 29370708, PMID 35579938, PMID 42379878, PMID 10716483, PMID 11136691, PMID 12030525, PMID 12892358, PMID 12914883, PMID 12975406, PMID 1309182, PMID 14510658, PMID 14625108, PMID 14760317, PMID 15324318, PMID 15337224, PMID 15454078, PMID 15778204, PMID 15898165, PMID 16009809, PMID 16022960, PMID 16105845, PMID 16338936, PMID 16461041, PMID 16714188, PMID 16755342, PMID 17045899, PMID 17389270, PMID 17398308, PMID 17911537, PMID 18068035, PMID 18371559, PMID 18381485, PMID 18451347, PMID 18499938, PMID 18547438, PMID 18565861, PMID 18566171, PMID 18667204, PMID 18687248, PMID 18761215, PMID 18768277, PMID 18940888, PMID 18984889, PMID 19017345, PMID 19185315

NIH funding

U54NS065768 (3), 2014 (2), 2016 (2), 2023 (2), 2004 (1), 2019 (1), K24RR023681 (1), M01RR006022 (1), OT2OD028201 (1), R01HD064770 (1), R01HD072815 (1), R01HD072821 (1), R01HD080544 (1), R01HD095060 (1), R01HD110568 (1)