4 completed, 3 recruiting, 2 terminated, 2 withdrawn. 12 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 12 | Completed 4, Recruiting 3, Terminated 2, Withdrawn 2, Active not recruiting 1 |
Follow Craniofacial Abnormalities: new trials by email Literature Review of Craniofacial Abnormalities trials Research Report on Craniofacial Abnormalities
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Optimizing Perioperative Analgesia to Lower Pain Following Cleft Palate Surgery Methadone hydrochloride, Fentanyl/Hydromorphone - Cleft Palate, Pain | Phase 4 | Recruiting | Duke University | 60 | 2025-06-04 | 2026-04-14 |
| Nebulized Dexmedetomidine Combined With Ketamine Versus Nebulized Dexmedetomidine for Cleft Palate Nebulization of dexmedetomidine and ketamine, Nebulization of dexmedetomidine - Sedation, Emergence Delirium | Phase 4 | Recruiting | Assiut University | 60 | 2024-04-10 | 2025-10-03 |
| Effects of Antiemetic Agents in Orthognathic Surgery Patients Intravenous drug - Emesis, Postoperative, Maxillofacial Abnormalities | Phase 4 | Completed | Bezmialem Vakif University | 66 | 2020-04-14 | 2024-06-12 |
| The Use of Fibrin Sealant to Reduce Post Operative Pain in Cleft Palate Surgery Tisseel - Cleft Palate | Phase 4 | Withdrawn | University of Alberta | 2019-09-01 | 2022-05-20 | |
| Evaluation of Trigeminal Nerve Blockade Ropivacaine, Sham Comparator - Mouth Abnormalities, Cleft Palate | Phase 4 | Active not recruiting | University of Florida | 40 | 2018-11-20 | 2026-07-21 |
| A Study of Crisaborole Ointment 2%; Crisaborole Vehicle; TCS and TCI in Subjects Aged ≥ 2 Years, With Mild-moderate AD Crisaborole ointment, 2%, Hydrocortisone butyrate cream, 0.1%, Pimecrolimus cream, 1% - Atopic Dermatitis | Phase 4 | Terminated | Pfizer | 237 | 2018-04-27 | 2022-01-10 |
| Dexmedetomidine vs Placebo for Pediatric Cleft Palate Repair Dexmedetomidine, Placebo - Cleft Palate | Phase 4 | Withdrawn | Baylor College of Medicine | 2017-12-31 | 2019-02-05 | |
| Human Fibrinogen Concentrate in Pediatric Cardiac Surgery RiaStAP, Saline - Hypofibrinogenemia, Afibrinogenemia | Phase 4 | Completed | Nicklaus Children's Hospital f/k/a Miami Children's Hospital | 30 | 2017-06-01 | 2021-09-16 |
| The Efficacy and Population Pharmacokinetics of Tranexamic Acid for Craniosynostosis Surgery high dose TXA, Low dose TXA - Craniosynostosis | Phase 4 | Completed | Boston Children's Hospital | 66 | 2014-08-01 | 2020-01-31 |
| Acid Tranexamic Effectiveness in Reducing the Intraoperative Bleeding in Palatoplasty Tranexamic Acid, Saline - Cleft Palate, Hemorrhage | Phase 4 | Completed | Professor Fernando Figueira Integral Medicine Institute | 66 | 2013-12-01 | 2015-04-21 |
| Tranexamic Acid for Craniofacial Surgery Tranexamic acid, saline - Craniosynostosis, Bleeding | Phase 4 | Terminated | University of Pittsburgh | 20 | 2008-07-01 | 2017-02-15 |
| The Psychiatric and Cognitive Phenotypes in Velocardiofacial Syndrome methylphenidate, fluoxetin, risperidone - Velocardiofacial Syndrome, Williams Syndrome | Phase 4 | Recruiting | The Chaim Sheba Medical Center | 400 | 2001-05-01 | 2026-03-18 |
Cleft Palate (6) · Craniosynostoses (2) · Hemorrhage (2) · Pain (2) · Afibrinogenemia (1) · Agnosia (1) · Congenital Abnormalities (1) · Dermatitis, Atopic (1) · DiGeorge Syndrome (1) · Emergence Delirium (1) · Fragile X Syndrome (1) · Heart Defects, Congenital (1) · Hemostatic Disorders (1) · Mandibulofacial Dysostosis (1) · Maxillofacial Abnormalities (1)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (12) · Musculoskeletal Abnormalities (12) · Musculoskeletal Diseases (12) · Congenital Abnormalities (11) · Stomatognathic Diseases (7) · Stomatognathic System Abnormalities (7) · Jaw Abnormalities (6) · Jaw Diseases (6) · Maxillofacial Abnormalities (6) · Mouth Diseases (6) · Pathological Conditions, Signs and Symptoms (6) · Mouth Abnormalities (5) · Neurologic Manifestations (5) · Bone Diseases (4)
Sodium Chloride (4) · Tranexamic Acid (3) · Dexmedetomidine (1) · Fentanyl (1) · Fibrin Tissue Adhesive (1) · Fibrinogen (1) · Fluoxetine (1) · Hydromorphone (1) · Infusion Pumps (1) · Ketamine (1) · Methadone (1) · Methylphenidate (1) · Risperidone (1) · Ropivacaine (1) · Saline Solution (1)
Assiut University (1) · Baylor College of Medicine (1) · Bezmialem Vakif University (1) · Boston Children's Hospital (1) · Duke University (1) · Nicklaus Children's Hospital f/k/a Miami Children's Hospital (1) · Pfizer (1) · Professor Fernando Figueira Integral Medicine Institute (1) · The Chaim Sheba Medical Center (1) · University of Alberta (1) · University of Florida (1) · University of Pittsburgh (1)
United States (6) · Canada (1) · Egypt (1) · Germany (1) · Israel (1) · Italy (1) · Poland (1) · Sweden (1) · Switzerland (1) · Turkey (Türkiye) (1) · United Kingdom (1)
Cameron R Smith, MD, PhD (1) · Chris D. Glover, MD (1) · Christopher Tirotta, MD (1) · Guilherme C Arantes (1) · Jaret L Olson, MD FRCSC (1) · Lisa M. Einhorn, M.D. (1) · Nicola Disma, MD (1) · Susan Goobie, MD (1)
PMID 32620262, PMID 35305111, PMID 39824505
2018 (1)